Osteolysis is the active breakdown of the bone matrix by osteoclasts during the normal formation of healthy bone. Osteolysis can be thought of as a reversible process of bone formation. This breakdown usually occurs in the proximal portion of the prosthesis due to either an immune response or changes in the structural load of the bone. Diseases such as bone tumors, cysts, and chronic inflammation can cause osteolysis. Although osteolysis is often associated with a variety of diseases or joint problems, the term "osteolysis" generally refers to a common problem in artificial joint replacements such as total hip replacements, total knee replacements, and total shoulder replacements. Osteolysis can also be associated with radiographic changes seen in a person with biphosphate-related osteonecrosis of the jaw. There are several biological mechanisms that may lead to osteolysis. In total hip replacements, the generally accepted explanation for osteolysis involves wear particles. As the body attempts to clean these particles, it causes an autoimmune reaction that in turn leads to soft tissue damage. Osteolysis can occur as early as 12 months after implantation and is often progressive. This may require revision surgery. Although clinically asymptomatic, osteolysis can result in implant loss or bone fractures, which can lead to serious medical problems. Distal clavicle dissection is often associated with weightlifters' problems with the acromioclavicular joints resulting from the high stresses placed on the clavicle at its junction with the acromion. This condition is often referred to as "weightlifter's shoulder." Ultrasonography readily depicts resorption of the distal clavicle as irregular cortical erosions, whereas the acromion remains intact. Associated findings include a swollen joint capsule, soft tissue swelling, and joint instability. On physical examination, the joint is tender and the adduction maneuver toward the horizontal axis is painful. The acromioclavicular joint is usually stable but may have a crackling sound. The range of motion of the glenohumeral joint should be complete. The differential diagnosis may include metabolic, 1. autoimmune, and 2. malignant causes. Since distal clavicle degeneration usually involves a single joint, the presence of inflammation suggests that both joints are involved. Patients who fail conservative treatment are first restricted in their activities and may be considered for surgical treatment. Surgery is generally avoided in cases where surgery is contraindicated. Most operations are performed under general anesthesia, so nonsurgical treatment is continued for those patients who may be at risk from anesthesia. A common surgical procedure for distal clavicle degeneration involves resection of the distal portion of the clavicle and then removal of a few millimeters of bone from the distal end. Medications may be given to relieve pain and inflammation, and medications may be used to help the body form new bone cells more quickly. Follow-up with your doctor should be done if you feel that the medication is not working or if you experience side effects. He should also be informed in case of any allergy to any medication and keep a list of all medications, vitamins and herbs that are taken with the doses, and keep it with the patient at all times for emergencies. Exercise with caution and know the types of sports that can be practiced, as sports that require physical contact increase the chance of bone fractures. You should contact your doctor in case of: 8 Feeling pain in the chest, back, hip, groin, knee or foot with sudden movement or during rest. You should go to the emergency room in case of: