Creutzfeldt-Jakob disease is one of the clinically known prion diseases. The disease occurs sporadically due to a mutation in the gene encoding the prion protein PRNP and occurs in about 20% of cases. It is transmitted from one person to another in certain cases: 1- Corneal transplant. 2- When using human growth hormone. 3- It may be transmitted through electrodes that may be implanted on the surface of the brain in the affected person, for diagnostic or therapeutic purposes. There are diseases similar to Cotzfeldt-Jakob that fall under the name of spongiform encephalopathies, which are: 1- Kuru disease, which is transmitted among tribes in New Guinea that eat human flesh 2- A familial form called fatal familial anxiety 3- The form transmitted from infected animals to humans, which was called mad cow disease in the nineties 4- A very rare hereditary form, Gersmann-Strauss disease 1- Cognitive disorders, which are an important aspect of the disease and without which the diagnosis is not made, the most important of which are: They are different and are seen in 42% of cases, such as: optic neuritis, depression, anxiety, delusions, hallucinations, and unstable behavioral changes. The disease may develop into a state, and coma may appear within 7 months, then death within a year of the onset of manifestation.