[Name] Van Horton's Syndrome [Source] Saturday Night Live [Symptoms] 
In the October 4, 2005 episode, Van Horton's Syndrome is a fictional condition also called Voice Imodulation or VI. This is a disease in which the people affected cannot control the pitch or volume of their voice. This disease also affects many Americans, including What's Happening!! actor Ernest Lee Thomas and tennis player Pete Sampras.