[Name] Despair Disease [Source] Danganronpa 2: Goodbye Despair [Symptoms] 
A pathogen created by Monokuma in order to drive the students into paranoia and irritability. It's effects depend on the person it infects: Nagito Komaeda's symptoms caused him to impulsively lie, Akane Owari became a coward, Ibuki Mioda became emotionless and gullible, and it caused Mikan Tsumiki to remember the events prior to having her memory erased. The disease wore off once there was another victim in the killing game.