[Name] Neuro-Immuno Deficiency Syndrome (N.I.D.S.) [Source] Sonic The Hedgehog (series)Sonic The Hedgehog [Symptoms] 
A rare, incurable, and fatal disease. Shortly after Prof. Gerald Robotnik refused G.U.N.'s request for him to discover the secret to immortality, his granddaughter Maria contracted N.I.D.S., causing Gerald to reconsider and begin Project Shadow. The cure was never found, despite Gerald's success at creating the ultimate life form. Maria later died of a gunshot wound during G.U.N.'s extermination of all involved in the project.