[Name] Hemopure [Sponsor] Biopure Corp [Description] 
Current approved for Phase III trials in the United States and was more widely approved in South Africa but regulatory status is now uncertain. Hemopure is Biopure’s first-in-class product for human use, and is a Haemoglobin-Based Oxygen Carrier (HBOC) solution. It is made of chemically stabilized, cross-linked bovine (cow) haemoglobin in a salt solution. Many safety measures are taken to render free of pathogens, including herd control and monitoring. Hemopure molecules can be up to 1/1,000 the size of RBCs, facilitating oxygen transport and off-loading to the tissues. Hemopure is currently in Phase III clinical trials in the US, and is approved for use in South Africa in surgical patients who are anemic, thereby reducing or eliminating the need for blood transfusions for these patients. Biopure Corp. terminated most of its workforce in November 2008 for financial reasons.[20] In November 2008 the company’s sales personnel in South Africa were laid off. Sales are continuing, but the company is not actively marketing to customers. In addition, the South Africa regulatory authority notified the company in October 2008 that it had decided to revoke its marketing authorization for Hemopure. The company is appealing that decision. The appeal may take one year to complete and, in the meantime, the company is permitted to market product.[21]