[0] Thiazolidinediones Pioglitazone (TZDs) Pioglitazone (Actos) [1] Usually taken once a day; take at the same time each day. [2] Makes the body more sensitive to the effects of insulin. [4] Increases the amount of glucose taken up by muscle cells and keeps the liver from overproducing glucose; may improve blood fat levels. Talk with your healthcare provider if you have the following symptoms: nausea, vomiting, fatigue, loss of appetite, shortness of breath, severe edema or dark urine. [3] 
May cause side effects such as swelling (edema) or fluid retention. Do not cause low blood sugar when used alone. Increased risk of congestive heart failure in those at risk.