Concentrations of total mercury in several fishes from Delaware Bay, 1975. Mercury levels in eleven species of fishes collected from lower Delaware Bay in April 1975 ranged from 0.018 to 0.321 microgram/g and averaged 0.092 microgram/g. Raja eglanteria, the clearnose skate, had the highest mean mercury concentration (0.214 microgram/g). No correlation was found with feeding habits. These assays provide baseline data for future measurement of mercury accumulation by fishes in this region.


Influence of environmental factors on pesticide levels in sport fish. The extent of pesticide contamination of sport fish from lakes and reservoirs in Indiana is described. Environmental and water quality factors significantly influenced the concentration of pesticides in fish. The influence of these factors was different between natural lakes and humanmade reservoirs. Largmouth bass (Micropterus salmoides), sunfish (Lepomis sp), and bullheads (Ictalurus sp.) were collected and analyzed for dieldrin, aldrin, DDT, DDE, heptachlor, and heptachlor epoxide. The collections and concurrent lake surveys were made during 1972-73. Soil and decaying plant particles appeared to influence the levels of dieldrin and sigma DDT taken up by largemouth bass. Strong correlations were observed between lake turbidity and true color and residue levels in the fish. Residue concentrations were also observed to vary between fish species, the seasons of the year, and watershed land uses.


Mirex residues in nontarget organisms after application of 10-5 bait for fire ant control, northeast Florida--1972-74. The 10-5 bait formulation of mirex insecticide was applied to a 20,000-acre area of northeast Florida. For 24 months after application, samples of a wide variety of fauna were collected and analyzed for mirex content. Insects accumulated mirex to the greatest extent in the first 6 months after application; most residues had decreased greatly by 12 months. Other invertebrates showed low mirex levels during the first 9 months after application and none after 12 months. Fish possessed low levels of insecticides for 9 months; amphibians showed mirex residues for 12 months after application. In general, reptiles had low levels throughout the 24-month period and mammals had higher levels, particularly in fat tissues. Birds consistently had low to moderate mirex levels. After a single application of 10-5 mirex bait, only relatively low levels of insecticide were detected in exposed fauna. After 24-months, mirex was found infrequently and at low levels.


[The relationship between parathormone and calcium blood levels in primary hyperparathyroidism. Diagnostic value (authors transl)]. The results of radio-immunoassay of parathormone in peripheral venous blood (using an anti-serum preferentially recognising fragments from the carboxyl-terminal pole) were compared with those of blood calcium measured on the same day in 33 cases of primary hyperparathyroidism. In the 28 patients with hypercalcaemia, PTH was invariably high (27 cases) or at the upper limit of normal (1 case). In the 5 patients with normal blood calcium levels, it was normal in 3 cases. It is thus important to take blood calcium levels into account in the interpretation of PTH estimation, that latter being more valid during a hypercalcaemic phase.


Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series. Penta-acetyl-gitoxin is a suitable prodrug of gitoxin since it shows--side-effect latentiation, due to its inactive application form;--bioavailability, due to its improved solubility and thus good enteral absorption and--bioactivation, due to rapid de-acetylation in the body after absorption.


Synthesis and pharmacological testing on some theophylline esters. Esters of theophylline-7-acetic acid with different amino alcohols were prepared as possible atropine substitutes, together with esters of some hydroxy acids with beta-hydroxyethyl theophylline. Moreover, esters possessing both theophyllinyl and piperazinyl moieties were prepared with the hope that their spasmolytic activity might be increased. Some of the prepared compounds proved to possess atropine-like activity.


Polarographic determinations of nimetrazepam in serum and whole blood. In the elaborated polarograhic technique, serum has been shown the best biological material for the direct determination of nimetazepam.]


Kinetics of drug decomposition Part 51: Kinetics of indometacine photodegradation. Indometacine aqueous solution degradation was studied under the influence of UV light. Spectrophotometric readings of absorbances at lambdamax = 270 nm were taken in order to follow changes of the indometacine solutions as a function of irradiation time. It was found that the degradation of indometacine under influence of UV light proceeds according a sequential reaction A k2 leads to B k2 leads to C k3 leads to D in which each individual step is a zero-order process Individual zero-order rate constants were calculated for indomatacine photodegradation under anaerobic and aerobic conditions. They indicate the first step (A leads to B) to be oxygen independent and the other processes (B leads to C leads to D) to be oxygen catalyzed.


The use of aromatic carbonyl derivatives in pharmaceutical analysis. Part 1. The pharmaceutical analytical utility of one the aromatic carbonyl derivatives, namely 2-hydroxy-1-naphthaldehyde isonicotinyl hydrazone, was investigated. It was prepared and utilized for the colorimetric determination of Fe2+ in the presence of other metals, and for the determination of Fe3+. It was also utilized in the determination of Fe2+ in the presence of Fe3+, vitamins hormones, and tablet ingredients likely to be present in combination with Fe2+ in geriatric mixtures. A proposed colorimetric assay for ferrous sulphate tablets is presented and compared with the Brit. Ph 1968 method. The reaction of the chelating agent with other metal ions is described, and its chelate-combining ratio with iron Fe2+ and Fe3+ was determined.


Correlation between the hydrolysis constants and spasmolytic activities of some isoquinolines. Correlation was found between the hydrolysis constant and spasmolytic potency of some isoquinoline derivatives measured on isolated guinea-pig's ileum: the greater the hydrolysis constant the greater was the antispasmodic activity. On the basis of the results obrained the influence of pH on the pharmacologic activity of these compounds may be explained.


Pharmacological study of the activity of a group of piperizine esters and changes in action relative to their chemical structure. A group of original symmetrical and asymmetrical piperazine compounds containing ester function have been synthesized and pharmacologically characterized. All compounds are pharmacologically active. Some relationships between their chemical structure and biological activity are discussed. Analgesic and coronary dilatory and especially spasmolytic effects are marked for all asymmetrical esters. A number of the compounds are interesting for further investigations relative to their possible application in medical practice.