### Instruction:

Extract the cause and effect entities from the following sentence:
Business Rules: While the class ManufacturerOfTradeItem is optional, the party identification for the manufacturer is required when the manufacturer of trade item is populated

### Assistant:

NOT_RELEVANT: Business Rules:
KEYWORD: when
VARIABLE: the manufacturer of trade item
CONDITION: is populated
CAUSE_1: the class ManufacturerOfTradeItem is optional
EFFECT_1: the party identification for the manufacturer is required
CAUSE_2: the manufacturer of trade item is populated

