### Instruction:

Extract the cause and effect entities from the following sentence:
In a more general sense it is stated that parameters must be used that are both mechanistically important and measurable (Ostle et al

### Assistant:

NOT_RELEVANT: (Ostle et al
KEYWORD: that
CONDITION: are
AND: both
VARIABLE: parameters
EFFECT_1: parameters must be used
CAUSE_1: mechanistically important
CAUSE_2: measurable

