Grapevine leafroll disease threatens the economic sustainability of the grape and wine industry in the United States and around the world. This viral disease reduces yield, delays fruit ripening, and affects wine quality. Although there is new information on the disease spatial-dynamic diffusion, little is known about profit-maximizing control strategies. Using cellular automata, we model the disease spatial-dynamic diffusion for individual plants in a vineyard, evaluate nonspatial and spatial control strategies, and rank them based on vineyard expected net present values.

In order to cope with the frequent unpredictable changes that may occur in manufacturing systems, and to optimize given performance criteria, the assignment of workers can be decided online in a dynamic manner, whenever the worker is released. Several studies, in the ergonomics literature, have shown that individuals' performances decrease because of their fatigue in work. In manufacturing context, the workers’ fatigue impacts the task durations. Therefore, we propose to solve the online workers assignment problem through a heuristic, which takes this workers' fatigue into consideration, so as to minimize the mean flowtime of jobs.

In this experiment, game theory was used to assess the interactions between three cell phenotypes usually found in cancer. The three defined cells were autonomous growth cells, invasive and motile malignant cells, and cells that performed anaerobic glycolysis. Based on preset variables in the payoff matrix, analytical equations were deduced that allowed for the analysis of the proportion of autonomous growth and malignant cells in a tumor. AnyLogic was also used to simulate the interactions between cancerous and normal cells.

One of the most common operations to any construction project is earthwork. In fact, most, if not all, construction projects begin with earthwork activities. These activities require heavy equipment, are generally quite costly and consume a considerable amount of time.

The objective of this paper is to propose and test a framework for integrated assessment of infrastructure systems at the interface between the dynamic behaviors of assets, agencies, and users. For the purpose of this study a hybrid agent-based/mathematical simulation model is created and tested using a numerical example related to a roadway network.

This research proposes and tests an integrated framework for bottom-up simulation of performance in construction projects. The proposed framework conceptualizes construction projects as systems-of-systems in which the abstraction and micro-simulation of dynamic behaviors are investigated at the base-level consisting of the following elements: human agents, information, and resources.

A hierarchical production planning structure enables manufacturing systems to handle customer
disturbances with different measures on different planning levels. Two different kinds of customer order
behavior can be observed and are as well discussed in literature.

Projects in mechanized tunneling frequently do not reach their targeted production performance. Reasons
are often related to an undersized or disturbed supply-chain management of the surface jobsite. Due to
the sensitive interaction of production and logistic processes, planning and analyzing the supply-chain is
a challenging task.

Many complex real-world problems which are difficult to understand can be solved by discrete or continuous
simulation techniques, such as Discrete-Event-Simulation, Agent-Based-Simulation or System Dynamics.
In recently published literature, various multilevel and large-scale hybrid simulation examples have been
presented that combine different approaches in common environments.