I am currently on 1500 mg of lithium daily, 200 to 300 mg of Seroquel at night, Vyvanse 40 mg in the morning.  I’ve been fighting significant depression due to relationship and seasonal issues for the last few months. I’ve had to miss some work and I spent several days a week in tears. I’m currently taking Wellbutrin XR 300 mg, for the last month and a half and it doesn’t seem to be doing anything for the depression. I’m also in therapy. Any recommendations for medication that might be more effective or that you have found it to be effective for yourself?  Also always walking that fine line between lifting the depression and not shifting into a manic episode.  Any thoughts are appreciated in advance!