I suffer from severe depression &amp; anxiety, and was recently diagnosed with inattentive ADHD. My main issue is anxiety and a constant feeling of tension, complete inability to relax as well as racing thoughts. To help with this, this is what I've tried so far:

* Escitalopram 10mg. I took this for 3ish years &amp; tried 15mg too. No effect.
* Voxra 150mg. Took this for about a month. No effect.
* (for ADHD) Concerta. Took this for a few weeks and occasionally on a few days. 18mg: no effect. 36mg: increased anxiety. No positive effect. 54mg: VERY intense anxiety. No positive effect.
* 5-HTP 490mg. No effect.
* CBD oil 100-120mg. No effect.

The only thing that's had an effect is my current new medication, Sertraline 50mg which I've been taking for 2 weeks now. I feel more calm and optimistic, but it's a very slight effect so I may ask to have the dose increased in my next assessment.

But I'm wondering, why is it that so many things that other people have had great results with, have none with me? I understand everyone is different but I find it so odd that I literally feel nothing with so many of these. I do not and will never take any drugs, I felt uneasy even with 5-HTP and CBD oil, so it's not a tolerance thing.

To add, before someone points this out as the obvious solution, I am trying my best with maintaining a healthy lifestyle (sleeping &amp; eating well) and exercise does make me feel better but it's mainly a confidence thing, it doesn't help much with my anxiety.

Any insight would be greatly appreciated!