Can muscle twitching in the face be caused by anxiety? I've had eye twitching before due to lack of sleep but the other day I had to introduce myself to a group of about 10 people and it felt like I lost control of all the muscles in my face. It was almost like a throbbing cramp, where it felt like something was crawling under my skin. I'm sure I looked weird as hell but nobody said anything. It was so hard to speak knowing everyone could see it.