For the past 6 days I’ve been using Sam-E with vit B12 and folic acid for my persistent depressieve disorder (dysthymia). I have upped my dose on day 3 from 200 mg in the Morning to 400mg. Ever since I have been experiencing muscle/tendon pains and restless legs. I stopped taking Sam-E per today and the RLS and muscle pain have improved a little. 

1. Has anyone experienced similar side effects before? 
2. What did you do about it?