Hi everyone, I’m a first time poster on reddit (long time lurker) and new to this subreddit. I’ve been taking Seroquel for about 7 years and have been weening off it for about a year, so I’m currently on 50mg. I’ve been taking lamotrigine as a mood stabiliser as well for the same amount of time. For exactly a week I’ve started on a new medication I hadn’t heard of before which is Saphris, it tastes rubbish and you can’t eat or drink for 10 minutes after dissolving under your tongue. 

I’m struggling with it though and need a place to vent I guess. Since starting it I was experiencing respiratory depression as a result of the two sedatives about 15 minutes after taking them. If you haven’t experienced that before it’s extremely unpleasant - like you can’t get enough oxygen in. Because I’ve had this before with Seroquel at a higher dose I stopped taking it for two nights to see if it was actually the cause, and now I’m suffering from withdrawals. I haven’t had the breathing issues since but I feel gross and also feel generally uncomfortable between the time I take Saphris until I manage to fall asleep. It makes me too tired to stay up but too restless to sleep. I’ve also been waking up at 3 am with unbearable paranoia since ceasing the Seroquel. 

I guess I need encouragement to push through or advice to manage the nausea. Has anyone tried Saphris? (Asenapine). I’ve also contacted my psychiatrist letting her know what’s happening and she hasn’t gotten back to me. Yay for doctors that cost hundreds and don’t reply for days!