Just asking for some opinions on my wife switching from Lexapro 20mg to Pristiq 50mg. Wife has been on Lexapro for 6 years and she is being recommended to switch to Pristiq as Lexapro isn't working anymore. Dr has said to taper down to 10mg Lexapro for 7 days, then one 10mg Lexapro every second day for 7 days and then switch straight to 50mg Pristiq daily from then. As I said just putting it out there for opinions and if anyone has switched from Lexapro to Pristiq? Any suggestions/stories are greatly appreciated.