# General Info

Antipsychotics are a type of psychiatric medication available with a prescription to treat psychosis (delusions, hallucinations, paranoia, or disordered thought). Sometimes referred to as neuroleptics or major tranquilizers, They are licensed to treat specific mental health problems whose symptoms include psychotic experiences. Most drugs are in oral dosage forms (tablets, dry powder, and capsules), while some can be intramuscular and intravenous injections.

First Generation (Haldol/Haloperidol, Thorazine/Chlorpromazine)

* Mainly used to treat distress, acute obsession, and other psychotic conditions.
   * Associated with a higher risk of neurological side effects.
   * These include tardive dyskinesia, extrapyramidal symptoms, dystonia, and weight gain.
   * Primarily block specific Dopamine receptors (D2)

Second Generation (Zyprexa/Olanzapine, Seroquel/Quetiapine)

* Known to have fewer neurological side effects compared to Gen 1.
   * Primarily block specific Dopamine receptors and also act on specific Serotonin receptors (D2 and 5HT2A)
   * Less extrapyramidal symptoms compared to Gen 1.

Third Generation (Abilify/Aripiprazole)

* Reduced sedation and weight gain compared to Gen 2.
   * Partial Dopamine and Serotonin antagonists (D2 and 5HT1A)
   * Unlike Gen 1 and 2, this group does not bind to Histamine receptors resulting in:
      * no sedation
      * lowered cardiac and metabolic risks
      * significantly reduced, if not zero, weight gain
* Others
   * Symbyax
      * A combination of olanzapine and fluoxetine used in the treatment of Bipolar Disorder.

 

# Common side effects

* Blurred vision
* Dry mouth
* Drowsiness
* Muscle spasms or tremors
* Weight gain

\---

Please use the thread below to add your experience with these medications. If we have missed a medication, please let us know, and we will add it.

Thanks!