I am currently prescribed Hydroxyzine (Vistaril) for anxiety. I also take Mirtazapine (Remeron) and Olanzapine (Zyprexa) and two other meds.

The Hydroxyzine has little to no effect unless I stop taking the Mirtazapine and Olanzapine for a few days. I've had a few psychiatrists in the past years and none of them knew why this happens.

Has anyone else experienced this? I have also been prescribed benzodiazepines in the past, and the same thing: little to no effect unless I stop taking the Mirtzapine for a few days.

My doctors don't know why, and I can't find any information online about this.

Thanks any responses/help.