My friend and boss Liam (fake name of course) told me a while back he stopped taking his medication for BPD around 8-9 months ago when he started taking testosterone and that he's felt fine. The thing is, for the past couple of weeks he's been showing pretty heavy signs of being in a manic episode, which combined with a recent traumatic event and changing duties from upper management has been pretty severe. It's bad enough that we've had one employee quit due to not being willing to work with Liam like that since he's a lot harsher and stern when he's manic than he thinks he is, and we have multiple others planning to leave the company. He cares a lot about his career, and as both his friend and coworker I don't want him to throw it all away because he didn't realize he was manic. At the same time, it's hard to talk to him when he's like this; when I brought up that he was being a bit more stern than he realized he got very upset and told me I was being unprofessional and that it was 'my only warning'. Does anyone know how I can maybe broach the subject with someone who's in an angry manic state without them going off the handle?