I (f41) used to take anticonvulsants for ten years before they stopped working, leading into manic episodes. I was prescribed Lithium at the hospital and have been taking it since November, 900mg daily. My levels are consistently 6.0. I have been depressed since the day I started taking it, but I am urged to stay on it. My dr added 150 mg of Wellbutrin about a month and a half ago. Nothing changed, so a few days ago she raised it to 300mg. I noticed that caffeine has absolutely no affect on me since starting Lithium. Saying that to ask, could Lithium blunt the affect of the antidepressant? Anyone with experience or input? I would be grateful to hear.