Close friend of mine is 35, and has had moderate to severe treatment resistant depression, anxiety, and ADHD his entire life to the point where most days he can barely manage to do things he WANTS to do nevermind things he NEEDS to do. He lives with his parents, has never had a job, and desperately just wants to live his life and be independent but despite still seeking treatment that will work for him, the latest med has done nothing but make things worse. He is at the point now where he has run out of new meds to try. 

Anyone in a similar position/have known someone in similar position who found their way out/treatment after a very long battle? Am unsure what words to offer him that are at all meaningful, and honestly as a realist I have trouble seeing a good outcome for him even if I know it is technically possible.

As someone who struggles with depression, I do understand on some level, but I have always managed to still live my life through it. This is on a whole different level and I can only imagine the amount of suffering he's gone through.