Hi all,

For some context, I’ve been on 25mg Zoloft for about a year, with the occasional 20mg dose of Propranolol as needed. Zoloft has been a miracle drug for me. I’ve felt practically no anxiety since I’ve been on it, which has allowed me to achieve things I don’t think I could have without it. 

However, taking Zoloft has has some downsides. Mainly fatigue and a significant loss of libido. The fatigue has definitely affected my ability to time manage as a grad student (since I have to nap regularly to stay energized). Furthermore, as someone who enjoys sex, the complete loss of libido has been extremely frustrating.

To help counter these side effects, I decided to talk to my doctor about adding a low dose of Wellbutrin to my regimen. That said, I started this medication almost 2 weeks ago. The first week I felt amazing and my sex drive came back in full force. However, this week has been harder. I started to feel anxiety for the first time in over a year, and that was so scary. In fact, I thought I was going to have a panic attack at a concert I went to yesterday (I ended up being fine but it was still not a pleasant experience).

I read that Wellbutrin can cause some initial anxiety as your body gets used to it, but I’m unsure of when I should expect this side effect to fade. I’m concerned that 150mg of Wellbutrin may be too much considering my SSRI is only 20mg. I’m not sure how long I should wait before asking my doctor if I should decrease the dose of the Wellbutrin. 

It would suck to have to make this choice, but I would choose not experiencing anxiety over having amazing sex and feeling rested. 

Has anyone else been in a similar situation?