*Tl;dr: what have your experiences been with Fetzima for treatment resistant anxiety? Did it work? How have the side effects been, in terms of sweating, sleep disturbances, and sexual side effects (the last especially for women)?*

I'm looking at getting on to Fetzima and I was wondering if any of you could share your experiences with this med. I know that people react to these medicines differently, but I'd still like to hear from you.

Some info about me: 35F, with intense social anxiety, panic attacks, GAD, agoraphobia, in order of intensity - I always deal with the SA, but when I'm doing ok it's manageable, and when I'm not the others ramp up, which is where I am now. I also have dysthymia, anhedonia and MDD, also in order of intensity. I tend to find that the depression symptoms ramp up when the anxiety does, probably as a result of how much the anxiety restricts my life. This has been a problem since I was 13, and I've been medicated since then. It ebbs and flows, but it's always there.

Medication, when it works, tends to get me to baseline functioning or even a little better, for a little while, then it "poops out" after a year or two and I have to switch to something else. I've tried most of the SSRIs... they worked a little when I was younger but gave me intense hypersomnia. SNRIs have worked better, but eventually they stop working too, and I tend to develop side effects like hyperhidrosis, sexual side effects (though less than with SSRIs), poor sleep and eventually the most alarming one, SHRIEKING MYSELF AWAKE in my sleep!

I've tried most of the SSRIs, and Cymbalta and Effexor. Cymbalta seemed to work best, but it started pooping out last December, and the sleep side effects got really bad. I switched to Lexapro (which I had taken before), and it helped a bit, but it made me sleep until 4pm most days. I then switched to Trintellix, which I had high hopes for, but ultimately everything got worse. I'm now trying ketamine therapy, but it hasn't seemed to help much with anxiety. I also take Yaz continuously without breaks, due to endometriosis and mood swings, and I take Lamictal as a mood stabilizer, though I'm not sure I need it.

I'm thinking about Fetzima since SNRIs have worked well in the past, and I'm wondering if there's any chance that the side effect profile is more bearable. What have your experiences been like?