I am just sharing something that has put my TR-MDD into complete remission. It is a hack of Axsome Therapeutics AXS-05. Very short background-30+ yrs TR-MDD, never found relief. Underwent ECT 3 times over the lat 30 yrs to keep from killing myself, but this just brought me up from suicidal to miserable as fuck. I was a poster child for SSRI roulette.

About 2 yrs ago I was getting ready to go back into the hospital for the 4th round of ECT. I discovered Spravato and was able to get started on that instead, and it worked significantly better than ECT ever did. I still had major depression going on, I was just able to function significantly better than I had been able top for a few decades. About a year ago my Dr. brought up AXS-05 to me and encouraged me to reearch it, which I did. It is a new drug that should be released Q2 or Q3 2022. It is just a combination of 105mg bupropion and 45mg DXM (dextromethorphan). Dextromethorphan is the DM is Robitussin DM. I was already taking 300mg bupropion XL daily anyway so we changed it to 150mg bupropion XL and 45mg DXM in the am and the same in the PM. It costs all of $1.50/day!!!

My depression was in complete remission within weeks and has remained there! It has been life-changing for me. I don't remember ever not being depressed before. See below link and google Axsome AXS-05 for more info.

[https://www.mdedge.com/psychiatry/article/212142/depression/dextromethorphan/bupropion-combo-remarkably-fast-acting](https://www.mdedge.com/psychiatry/article/212142/depression/dextromethorphan/bupropion-combo-remarkably-fast-acting)

The safety profile is extremely safe as DXM is OTC and both have been around forever. Proceed at your own risk if you decide to try this, of course. Be VERY CAUTIOUS if taking SSRI's. Serotonin syndrome is very serious, can be fatal.