&gt;We conducted a clinical trial of the mood stabiliser “lamotrigine” for people with BPD who were using mental health services. We compared the effects of lamotrigine with those of a placebo (a dummy pill that did not contain any active drug) so that neither the researchers nor the participants knew what treatment they had been given until after we had completed an initial analysis of the results of the study. We assessed mental health, social functioning, quality of life, side effects and use of services in the year after people entered the study.


​&gt;A total of 276 participants took part and 195 were followed up one year later. Less than half the participants (39%) were taking trial medication regularly at one year. We found no difference in mental health or any of the other outcomes we measured between those prescribed lamotrigine and those prescribed the placebo. We checked to see if the results were affected by whether people were taking their medication regularly or not; and found no difference between those taking lamotrigine and those taking the placebo. On the basis of the results of this study, we do not recommend the use of lamotrigine for people with BPD. Further research is needed to find out how best to help improve the mental health of people with this condition.

[Full link here](https://www.labile.org/news)

It's a sad day for me, I was really hopeful that this could be a good treatment for BPD and previous less-controlled studies have shown that Lamotrigine was a promising drug for monotherapy but unfortunately not.


:(