A friend of mine who I was close to in college, although we now live in different cities, was going through a rough time lately between fights with her boyfriend and graduate school applications. I was gladly helping her with both of those things, proofreading essays and being a shoulder to cry on.  In our second to last conversation, she was saying a bunch of sappy stuff about how I'm a great friend to her. Our last conversation was this very minimal thing about cute animals. She didn't seem upset with me at all. Then on Friday I sent her a joke about how Minnesota accidentally legalized weed. She hasn't responded nor opened the message since Friday.

I'm both worried if she is OK and worried if I did something to upset her that I wasn't aware about. Like I mentioned in the title this is the third friend in 2 years to ghost me, so I feel like I must be doing something to cause this, but I have no clue what it would be. We didn't seem to argue before she just stopped responding. Should I reach out to mutual friends to make sure she's okay? Would that be bad if she was upset with me?

Sorry if this doesn't make a ton of sense I'm a little high right now but freaking out.