I have been struggling lately with fatigue from clozapine and hitting the caffeine hard. Then, by chance, last week I searched for fatigue and clozapine and discovered all this research that shows how caffeine raises clozapine levels. So, essentially, I was addicted to caffeine seeing it as necessary to staying awake, but I was shooting myself in the foot and making it worse because I was making the clozapine higher, and therefore more sedating. The thing is, you don’t want it to get to be toxic levels. 

I saw my psychiatrist this week, and we came up with a plan for reducing my caffeine habits and making other lifestyle changes. He was surprised to learn of this connection. Now I’m rethinking my caffeine intake and changing my sleeping habits. I wanted to pass it along here in case it helps someone else find a healthier path. You might be making yourself more tired just by trying to stay awake.