Hello friends! I have a question regarding the effects of lithium on bupropion. I started bupropion (100mg SR, once daily) 3 days ago was already taking 600mg lithium carbonate daily. I started with a small dose of bupropion because it’s known to cause anxiety, and mine is pretty crazy.

I read in a few posts that people taking bupropion started feeling energized and motivated almost immediately. However, I haven’t felt any noticeable difference yet. I am wondering if lithium dulls bupropion’s effects. Should I ask for a decrease in my lithium dosage? My main problem currently is anxiety and depressive states and haven’t gone into mania. My mood just switches from normal to depressive and so on. 

By the way, I asked my psychiatrist about this, but he wasn’t very clear and said we will discuss it later, so I just want to know more about this interaction.

Thank you for reading 🙏