Sorry in advance for the garbage formatting and likely grammar/spelling mistakes - in on the ol’ cell phone.

The short story is I have depression, anxiety, and ptsd. I’ve been on Wellbutrin for over a year and I found it very helpful up until recently. Events in my life and in my community have been super tumultuous lately (which describes everyone living through a pandemic I suppose) and I’ve been struggling for this last month in particular, to the point where it’s affecting my relationship. I finally bit the bullet and went and saw my doctor today who is moving me onto Effexor. The last time I took a serotonin reuptake inhibitor, I felt super manic depressive. The idea that my medication needs to be switched is causing me *massive* panic. I also smoke weed and see that that can have negative interactions with Effexor. I’ve also been told to take 4 weeks off, and I feel so damn terrible doing it. I got shifted to a different yet similar position within my job (think lateral move), which moved me to a different location in the city. I have new coworkers, new everything. We are horribly underfunded at this new location. So a lot of stress and anxiety has been coming from work, and it’s already a job that dishes out a lot of flak.  I truly love my work and what I do (sorry I’m being vague, there are reasons), but lately the nature of my job is shifting and becoming more corporate, a bit more kill or be killed, definitely set up for the “haves” and not the “have nots”. That, plus taking time off makes me feel like I’m a failure at this job or I’m not meant to do it. Which makes me feel terrible guilt and shame, I’ve spent so much money and time on this dream, and here I am sitting at home unable to work at all, wondering what to do now. 

I’m not sure what I need, other than for my job to become reasonable again and a dose of confidence I guess? Has anyone here ever smoked weed on Effexor? What kinds of side effects have you all felt?