I've had treatment resistant depression for years and have been using SSRI and SNRI to manage it to a certain extent. It does work, but only slightly, even at maximal dose. I've been on and off the medication because I kept feeling worse long-term due to inability to work.

I want to be on SSRI, but I keep running into the issue of my dopamine getting completely drained, to the point where I lose my productivity &amp; creativity. I run my own business and I'm generally very happy with my work but on SSRI I simply can't keep up without forcing myself to "be creative" and it's taking a toll on me.

I've tried a MAO-B inhibitor *(to also treat suspected Parkinson's Disease)* and I felt my creativity, productivity, libido and happiness returning, and my social anxiety is the lowest it's ever been. The highs are great for once, instead of my usual numb mood.

The lows are still low though, and I want to be on SSRI. Mixing my MAO-B inhibitor (for Dopamine) and SSRI is not considered safe, and I want to find some other medication that fits me better. I need to bring this up with my doctor, but I want to do some research on my own first. I've tried to find information about medicines that support dopamine, but also allow me to use SSRI safely.

Thanks in advance!