Has anybody been diagnosed with TDR?  I have been battling depression and anxiety for over 20 years and has only gotten worse. With in the past 5 years it has gotten really bad.  I have been on so many different medications and nothing ever worked. I’ve tried everything. therapy doesn’t help and have tried lots of different therapists. I’ve tried changing routines, lifestyle, you name it I’ve tried it.  The only thing I can now think of is that maybe I have TRD. So if anyone has been diagnosed with this , what is done differently in treating it.  I’ve read a lot about it but would like to hear some first hand knowledge.   I just don’t know how much longer I can take feeling like this , the hopelessness is just not worth it.