I have had some luck in treating hypomania with Risperidone, but my depression only got worse on it. Nothing else has really worked without side effects too severe to continue. (I consider 3 things too severe: relentless nausea/vomiting/diarrhea, psychosis, or sexual dysfunction that goes beyond ED)

In the past, like a decade ago I was on Seroquel:

* caused me excessive rage. (possibly my first mixed episode? I dunno), terrifying sleep paralysis, first bedwetting incidents since I was a teen (now that seems to be back anyway so whatever)...but if it induced mixed borderline-psychotic violent episodes, that's not "better".

In the last 2 years (from multiple doctors):

* Amitriptyline - microscopic dose induced severe mania (not hypomania) and complete dissociation. Some chest pains. (took for a couple weeks)
* Lamictal - first dose induced psychosis. (took for 1 day!)
* Risperidone - (WORKED for mania+psychotic symptoms, but *INCREASED DEPRESSION*). Fainting spells, complete inability to feel pleasure of any kind, and orgasm dysfunction, but I stayed on it for 9 months.
* Escitalopram - (WORKED) Instant hypomania that went away in a few days (thanks to risperidone). Took for 6 weeks. Only stopped because it induced violent diarrhea that got worse over time, and was not "making it" so I could no longer leave my house. No other side effects. If I remember correctly, I took it while on risperidone to counter the hypomania.
* Duloxetine - (WORKED?) vomiting, every single time I took it. Took it for 1 week. Loved how it helped my mental health, felt bubbly and giggly like a 12 year old schoolgirl, but I was fading into underweight territory and I despise throwing up. It also created/aggravated stomach ulcers.
* Desvenlofaxine (DID NOT WORK) The higher the dose, the more depressed I got! Also caused the most severe sexual problems. No other side effects, but it was useless.
* Trintellix - (DID NOT WORK) nausea all the time. Threw up sometimes. On it 6 weeks - nausea never went away, and not once did I feel better on it. Never could get up to a therapeutic dose.
* Lurasidone (NO IDEA!) - Been on this for 2 weeks... I feel so sick all the time. I'm usually dizzy even when sitting, and almost fell over entirely. Can't leave my house anymore, and have to sit or lye down on and off all day. Chest pains. Collapsing. Gastro issues.

&amp;#x200B;

... I just don't think there's anything worth taking that's left.... I feel like such a write off and I want to cry.... Is there anything that I can actually take? I've been taking half of the smallest doses on the ones that made me sick and that didn't help.