Its been 7 years since I started being properly medicated and my stomach hasn't been having a great time. I'm aware of meds being particularly harsh on stomach lining and early last year I started developing food allergies, stomach cramps, reflux, and painful nausea.  

The dietician I consulted had me do tests which showed my gut was very high with Streptococcus but that I also had a mutated MTFHR gene. Apparently this gene is responsible for helping with nutrient absorption and metabolic processes. Working on the theory that my meds have wrecked my stomach I'm try some herbal remedies for the Strep (with my psych's permission) and making diet changes. Its going well and alleviating most of the symptoms however as I'll be taking meds forever my stomach will always be irritated. 

I was also offered another supplement called 5-Methylfolate - this is activated folate which supposedly replaces what my body can't create itself due to the MTFHR mutation. The science is inconclusive on this one but I'm trialling it now and having a very strong hypo reaction to it... however I feel better physically and generally my focus is sharper. Its a real catch-22. I'd like to keep taking it for a few more months to see if it really makes a change but the hypo is concerning. 

Is anyone else using 5-Methylfolate? What is your experience and how did it mesh with your bipolar meds?