I'm Bipolar I and have been attempting to medicate for over 4 years on and off.
I've tried:
Abilify
Lexapro
Hydroxizine 
Trazedone
Klonopin
Lamictal
Abilify AGAIN
And Ativan
All seem to do nothing for me. My manic agitation is getting to be too much to handle again so we're trying Zyprexa. 
I just feel like I'll never be normal or healthy or happy. How do you guys cope with the hopelessness of finding the right medications?