The doctor put me on Seroquel extended release 50mg for about 2 weeks but then changed me to the 100mg immediate release because I felt extremely tired the next day and a few other reasons. I've been taking the 100mg  immediate release for the past 3 days. What's happening now is I'm consuming  coffee and 5 hour energy and smoking cigs like crazy.  Normally I smoke a pack a day but the past few days I've been smoking almost 2 packs. I was put on this due to having anxiety,depression,bipolar/ocd and I  was having to many side effects when on antidepressants. For the most part i feel like the Seroquel is helping me but this constant need to smoke cigs and pound caffeine and 5 hours is kind of crazy and just making this worse. Has this happen to anyone either on Seroquel or other medications before? I curious as to why this is happening and if it can be fixed.