The malignant B-cells in the disease commonly have mutations in several genes such as: 1) "JUNB" which codes for JunB, a protein that regulates cell growth and survival and is highly expressed in other lymphocyte malignancies; 2) "DUSP2" (a gene suspected of being a tumor suppressor) which codes for dual specificity protein phosphatase 2, a protein that regulates several components of the ERK/MAPK signaling pathway that controls cell proliferation; 3) "SGK1" which codes for serine/threonine-protein kinase, a protein that regulates several signaling pathways that control cell proliferation and survival; 4) "SOCS1", a known oncogene and tumor suppressor which codes for suppressor of cytokine signaling 1; and 5) CREBBP, a gene that is commonly mutated in other DLBCL subtypes as well as other lymphomas and codes for the transcription coregulator, CREB-binding protein.