Hugues de Thé has received numerous national and international awards: the Mandé Prize From the French Academy of Medecine (1996), Rosen Prize from the Fondation pour la Recherche Médicale (FRM) (1999), Mergier-Bourdeix Prize from the French Academy of sciences (2004), Griffuel Prize from the Association de recherche en Cancérologie (ARC) (2010), Claude Bernard Prize of the City of Paris (2010), the Chinese Office Science and Technology International Cooperation Prize (2011), the Ernest Beutler Award of the American Society of Hematology (2016) and the Sjoberg Prize of the Royal Swedish Academy of Sciences (2018).