It built on the cooperative and scientific foundation of the International Microgravity Laboratory missions (IML-1 on STS-42 and IML-2 on STS-65), the United States Microgravity Laboratory missions (USML-1 on STS-50 and USML-2 on STS-73), the Japanese Spacelab mission (Spacelab-J on STS-47), the Spacelab Life and Microgravity Science Mission (LMS on STS-78) and the German Spacelab missions (D-1 on STS-61-A and D-2 on STS-55).