His original and anti-dogmatic vision made it possible to discover how to transform a malignant cell into a normal cell, (1982) with medical doctors in Shanghai (China) including Wang Zhen Yi and Chen Zhu in the case of the most severe acute leukaemia (acute promyelocytic leukaemia) which is now easily and permanently cured in all "standard" cases with two natural products, a vitamin A derivative and Arsenic, without chemotherapy or bone marrow transplantation, opening a new approach to cancer treatment (malignant cell differentiation treatment, personalized medicine, precision treatments, targeted treatments) that has won several international awards, including the General Motors Prize, the most prestigious award for cancer research.