The two major protein complexes that bind to telomeric DNA in "S. cerevisiae" are (1) the Cdc13-Stn1-Ten1 (CST) complex, which binds the single-stranded DNA (ssDNA) of the 3’ G-rich overhang at the end of the telomere, and (2) the Rif1-Rif2-Rap1 complex, which binds the double-stranded DNA (dsDNA) preceding the 3’ overhang.