He disinherited his son (by his first wife "Tiphane") William de Cantilupe, 4th Baron Cantilupe (1325-c.1375), last in the male line who was predeceased by his two sons, Nicholas de Cantilupe (1342-1371) of Greasley, eldest son and heir of his grandfather, slain at Avignon trying to petition the pope into reversing the annulment of his marriage which had been obtained by his wife Katherine Paynel, supposedly on the grounds of impotence.