It was not until 1761, when he was in his eightieth year, that he brought out the great work which, once for all, made pathological anatomy a science, and diverted the course of medicine into new channels of exactness or precision—the "De Sedibus et causis morborum per anatomem indagatis" "Of the seats and causes of diseases investigated through anatomy", in five books printed as two folio volumes, which during the succeeding ten years, notwithstanding its bulk, was reprinted several times (thrice in four years) in its original Latin, and was translated into French (1765, republished 1820), English (1769), and German languages (1771).