Particularly Zayd Ibn Ali, the great grandson of the Caliph Ali lead the failed revolt of 740 AD against the Caliph Hisham ibn Abd al Malik and the next generation from which the dynasty descends also revolted in the form of Isa ibn Zayd, who revolted against the Caliph Al Mansur in 762 AD, commanding the forces of Muhammad Nafs az Zakiya and was consequently poisoned by the Caliph Al Mahdi at the age of 45.