He was married to Françoise Fouchard (hepatologist) on 16 December 1971 with whom he had three children Juliette Barbarin (lawyer at Total), Cecile Petit-Degos (scenographer), and Vincent Degos (Professor of Anesthesia Resuscitation) and 9 grandchildren (Arthur, Maylis, Paul Barbarin, Jules, Zelie, Tom Petit and Oscar, Augustin, Felix Degos).