Some important histological features that favor the diagnosis of THRLBCL over NLPHL include the presence of: 1) <10% neoplastic B-cells; 2) CD163-expressing histiocytes (cases of THRLBCL in which histiocytes are absent appear to take a less aggressive course than cases in which these cells are present); 3) a diffuse rather than nodular cell infiltration pattern with any nodular infiltrates present in THRLBCL containing follicular dendritic cells; 5) PD-1-, CD4-, and CD57-expressing T-cells; 6) cells strongly expressing the BAT3/BAG6 ubiquitin domain-containing protein; and 7) few or no small lymphocytes, variant Hodgkin i.e.