sentence1: European route E75 runs through the city and connects Chania with the three other major cities of Heraklion : Agios Nikolaos , Crete , and Rethymno .
sentence2: The European route E75 runs through the city and connects Chania with the three other major cities of Heraklion : Agios Nikolaos , Crete and Rethymno .