text: Our commitment to our corporate mission lies in our experience in chemical synthesis processes. MENADIONA is a well established European manufacturer with extensive experience in Regulatory affairs.
  WHO WE ARE, HISTORY & FIGURES, MANUFACTURING SITES, CSR
  Founded in 1970, MENADIONA is an independent privately-owned company.
  Ever since, the company specializes in manufacturing active ingredients (APIs) and key intermediates for the Pharmaceutical, Veterinary, Plant Health and Nutraceutical industries.
  In addition, Aziridine and its derivatives is one of the most outstanding business units for MENADIONA.
  We offer custom and contract manufacturing services through our Fine Chemical Division.
  "...our experience in constantly improving chemical synthesis processes."
  Our commitment to our corporate mission lies in our wide experience and constant improvement of chemical synthesis processes. We achieve our aims by providing:
  An open product list of active substances and fine chemicals that fully comply with current pharmacopoeias and industry standards.
  Customer manufacturing services for exclusive products with special requirements.
  MENADIONA's Foundation
  MENADIONA was founded by Mr. Carlos Cosin Roviralta in order to produce Vitamin K3 which was recognized as a new and interesting product the for veterinary market.
  Veterinary products: MENADIONA's roots
  MENADIONA started in Barcelona. At that moment, it had just one product, one reactor and one customer.
  The product was Vitamin K3, commonly known as MENADIONA.
  Production capacity increase: Production Building NF-I
  MENADIONA enjoyed great success and outgrew its initial production site and so had to set up to a new plant in Palafolls. A complete production building was created (NF-I) end equipped with 11 reactors, 3 centrifuges and 2 dryers.
  MENADIONA started to become a well known Veterinary intermediates manufacturer, consolidating its good reputation year after year.
  Production capacity increase: Production Building NF-II
  In 1982 a new production building was constructed. This time, 13 reactors, 6 centrifuges and 2 more dryers were acquired, increasing MENADIONA's overall reaction capacity to more than 150 m3.
  INVEMA acquisition in Malaga
  MENADIONA acquired a backup plant in the south of Spain, Málaga. This plant was currently producing also Veterinary intermediates and became the ideal solution for the continually increasing growth of MENADIONA's production demands. INVEMA, the name of this plant in Málaga, was maintained. Nowadays many updates and optimizations have been made to the Invema plant, which makes it a key production site for MENADIONA.
  Step change: Aziridine!
  An important event in MENADIONA's history is the addition of Aziridine and Aziridine Chemistry to its expertise, and portfolio.
  Since then, Aziridine and Aziridine Derivatives have become a core business.
  Aziridine Crosslinkers era:
  MENADIONA acquired expertise and full control of the Aziridine chemistry and technology, and started developing and producing Aziridine derivatives used as Crosslinkers for many different applications such as coatings, resins, lubricants, leather, paints…
  MENADIONA gained a substantial market share and became a trusted partner for the most important companies in the resins and coatings sector.
  Nowadays MENADIONA is proud to be the global leader in Aziridine Chemistry.
  Production capacity increase: Production Building NF-III
  Business continued growing and so the company invested in a new production building with 2 reactors, 7 distillers, and 1 more centrifuge. "Production Building NF-III" is cexclusively dedicated to Aziridines and Crosslinkers.
  Pharmaceutical Intermediates arrival
  At the beginning of the 90s, MENADIONA entered the Pharmaceuticals Intermediates sector. Each of the three production buildings was assigned a particular activity. Building 1 and 2 where dedicated to Veterinary and Pharmaceutical Intermediates while Building 3 was dedicated to Performance Products.
  2nd Generation Managing the company
  MENADIONA is a family owned company. The second generation of Cosins, who were involved in the company for many years before, started managing the company with fresh ideas and the ambition to drive the company to the best ever results in its history.
  Plant Health: ACT-2
  MENADIONA's roots belong in Vitamin K, and so the company developed a product addressed to the agricultural market, ACT-2, applying unique technology for formulations based on Vitamin K.
  Production capacities increase: Production Building NF-V (ISO 8): APIs
  MENADIONA always had a strong ambition to grow, and for this reason a full clean room, ISO 8 classified production area was built.
  This workshop was equipped with 7 reactors, 2 centrifuges and 4 dryers, and it is specifically dedicated to the manufacture of APIs.
  MENADIONA moved one step forward and started producing API's for Pharma and Veterinary. This, far from being a small change, brought big differences to the organization of the company, and the way of understanding production, quality & regulatory and SHE.
  MENADIONA was GMP certified, and FDA, PDMA and KFDA approved, so a new window opened for the company.
  With 5 production buildings, and more than 50 reactors and 400m3 overall reaction capacity, MENADIONA started manufacturing key Intermediates and APIs for third parties.
  With this new business opportunity, MENADIONA tightened relationships with some of its customers and started long term partnership with some others.
  Becoming progressively one of the most well known European Contract Manufacturers nowadays.
  Trade companies in Asia and Worldwide were created.
  Always with the vision of growing and adapting to the world's changes, MENADIONA founded two trade companies to distribute its products. One of them located in China for the Asian Market, and the other one operating around the world.
  MENADIONA had the opportunity to enlarge its total surface by acquiring the adjacent piece of land, increasing its total surface to 60.000 m2. Nowadays 15.600 m2 are constructed, but Menadiona has assured its possibility to expand.
  Production technology increase: Hydrogenation
  MENADIONA has invested in a new technology; Hydrogenation. For that, a new production building has been constructed and a new Hydrogenator has been acquired.
  "The overall reaction capacity is more than 400,000 liters ..."
  MENADIONA's two production plants are located in Spain, the headquarters are situated in the North of the country in Palafolls, 60Km far from Barcelona, and the second plant INVEMA is located in Málaga in the South. Málaga site, have all necessary equipment and capabilities to be a reliable backup plant for Menadiona.
  The overall reaction capacity is more than 400,000 liters and both manufacturing plants are equipped with modern production facilities.
  A detailed and studied design concedes to MENADIONA an extensive combination possibility with all different pieces of equipment, dealing with both, liquid and solid products and with the main goal of accomplishing further product quality assurance, personnel safety and environmental protection.
  Furthermore, all manufacturing operations are carried out in accordance to the current Good Manufacturing Practices (GMP) and European environmental laws.