text: Metabolite 'Lac-Phe' suppresses hunger, may help treat obesity -
  Physical activity , the risk for obesity, metabolic disease, and all-cause mortality.
  Further tests found that Lac-Phe levels were highest after sprinting — remaining above baseline for three hours — followed by endurance exercise and resistance training.
  When asked further about these mechanisms, Jon Long, Ph.D.assistant professor of pathology at Stanford University and one of the study's authors, told Medical NewsToday, "We think Lac-Phe acts in the brain to control feeding. But we don't have much of an idea right now. We are now trying to understand what are the brain circuits that Lac-Phe turns on, and what is the brain Lac-Phe receptor."
  To the same question, dr Paresh Dandona, Ph.D.distinguished professor and head of Endocrinology, Diabetes and Metabolism at the University at Buffalo, the State University of New York (SUNY), not involved in the study, told MNT:
  "However, studies need to be carried out in humans either with Lac-Phe infusions or with its stable analogues in the future. I am sure the pharmaceutical industry will jump at this opportunity. This is the beginning of a novel story and mechanism for weight loss, and I hope that it will work out," Dr. Dandona continued.
  When asked about limitations to the findings, dr Lawrence J Cheskinprofessor and chair of the Department of Nutrition and Food Studies at George Mason University, not involved in the study, told MNT:
  dr Cheskin added that while these findings may outline a potential mechanism for curbing food intake, more research is needed.
  Nonetheless, Dr. Long hopes that drugs targeting the Lac-Phe pathway will one day be able to "capture" the anti-obesity effects of exercise and thus serve as an alternative treatment for obesity.