text: Theragnostics, which is developing molecular radiotherapy for imaging and treating a broad range of cancers, announces the appointments of Dr. Alex Jackson as Head of Research and Development and of Archie Hale as Director of Clinical Operations. This announcement follows the recent appointment of radiopharmaceutical drug development expert Dr. Daniel Stevens as Chief Medical Officer.
  Dr. Jackson has over 20 years' experience of conducting and overseeing research activities in both academia and industry. He joins Theragnostics from GE Healthcare where he was responsible for the discovery phase of immune-oncology PET projects and for a multi-centre late stage clinical PET tracer development programme. Alex holds a PhD in Synthetic Chemistry from the University of Warwick and he is the author of 15 publications on molecular imaging and radiochemistry.
  Archie Hale is a seasoned pharmaceutical industry professional with extensive experience across all stages of drug development for several leading companies including Biogen, BTG and Roche as well as smaller biotech companies and she will be conducting Theragnostics' various clinical programmes.
  Greg Mullen, Chief Executive Officer of Theragnostics, said: "I'm delighted to welcome Alex and Archie to the team as we continue to grow with the aim of bringing novel targeted therapies to cancer patients. This year, we have made great progress in strengthening our platform and expanded our team. As we enter 2020 and prepare for the new year ahead, we are well placed to submitting an NDA for Tc-99m-DMSA, initiating a PhI/II I-123 PARPi therapeutic trial and commencement of a F-18 PARP PhII and Ga-68 PSMA PhIII diagnostic clinical studies."
  Theragnostics' technology platform enables the development of molecular radiotherapy based on a PARPi for imaging and treating cancer. Theragnostics modifies a PARPi drug molecule with a radioactive atom to create a radionuclide PARPi (rPARPi). This can either be used to image PARP in a cancer patient for diagnostic use or the radioactive isotope can be used to deliver a therapeutic dose of radiation into tumour cells, which offers the potential to molecularly target the radiation in order to hit and kill tumour cells whilst avoiding damage to healthy cells and associated side effects.