text: Biological markers in osteoarthritis | Semantic Scholar
  DOI:10.1038/ncprheum0508
  Corpus ID: 13168927
  Biological markers in osteoarthritis
  @article{Rousseau2007BiologicalMI,
  title={Biological markers in osteoarthritis},
  author={J-C. Rousseau and Pierre Dominique Delmas},
  journal={Nature Clinical Practice Rheumatology},
  pages={346-356}
  J. Rousseau, P. Delmas
  Osteoarthritis (OA) is a progressive disorder characterized by destruction of articular cartilage and subchondral bone, and by synovial changes. The diagnosis of OA is generally based on clinical and radiographic changes, which occur fairly late during disease progression and have poor sensitivity for monitoring disease progression. Progression of joint damage is likely to result primarily from an imbalance between cartilage degradation and repair, so measuring markers of these processes would…
  J. Rousseau, P. Garnero
  The BIPED classification that appeared in 2006 for OA markers is used to describe the potential usage of a given marker and the combination of specific markers seems to improve the prediction of disease progression at the individual level.
  Prognostic biomarkers in osteoarthritis
  M. Attur, Svetlana Krasnokutsky-Samuels, J. Samuels, S. Abramson
  Prognostic biomarkers may be used in clinical knee osteoarthritis to identify subgroups in whom the disease progresses at different rates to facilitate the understanding of the pathogenesis and allow us to differentiate phenotypes within a heterogeneous knee osteOarthritis population.
  Biomarkers for osteoarthritis: investigation, identification, and prognosis
  G. Zhai, E. A. Eshghi
  This review summarizes the data on the investigation of biochemical and genetic markers in OA and highlights the new biomarkers that are recently reported and their application and limitation in the management of OA.
  The available species and models of OA are reviewed and their potential utility discussed and this approach represents a cornerstone for the development of new anti-OA therapeutic targets and drugs.
  Applications of Proteomics to Osteoarthritis, a Musculoskeletal Disease Characterized by Aging
  The relevance and potential of proteomics for studying age-related musculoskeletal diseases such as OA are discussed and the contributions of key investigators in the field are reviewed.
  M. Lotz, J. Martel-Pelletier, +18 authors J. Reginster
  Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation, and there are a number of promising candidates, notably urinary C-terminal telopeptide of collagen type II and serum cartilage oligomeric protein.
  Contributions of inflammation and angiogenesis to structural damage and pain in osteoarthritis
  Data from animal studies indicates that conversion of acute inflammation to chronic inflammation may be due to the stimulation of angiogenesis, and these data provide evidence that synovitis contributes to joint pathology and pain behaviour in the rat MNX model of OA.
  Biomarkers of (osteo)arthritis
  A. Mobasheri, Y. Henrotin
  This Special Issue of Biomarkers is dedicated to recent progress in the field of OA biomarkers and reviews the current state-of-the-art and discusses the utility of Oa biomarkers as diagnostic and prognostic tools.
  This review of recent progress in the area of OA biochemical marker research stimulates further research into OA biomarkers and contributes to the development of new and innovative tests for early disease diagnosis, facilitating individualised treatment and improving clinical outcome.
  New biochemical markers of osteoarthritis
  P. Garnero
  New specific and sensitive biochemical markers of cartilage and synovial tissue turnover, including assays for Type II collagen synthesis and degradation, have been developed and recent prospective studies indicate that blood and urine levels of these new markers are associated with the progression of joint damage.
  Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study.
  I. Meulenbelt, M. Kloppenburg, +5 authors P. Slagboom
  Using a large well-characterized study and eight biochemical markers, the data suggested that these components contribute differently to ROA at different joint sites.
  Review: Collagen markers in early arthritic diseases.
  K. Elsaid, C. Chichester
  Few markers are of considerable utility in early detection and monitoring of arthritic diseases and the current challenge is to improve the discriminatory power of these markers so they can be used to guide therapeutic decisions.
  O. Bruyère, J. Collette, +5 authors J. Reginster
  The 3-year radiological progression of knee OA could be predicted by a 1 year increase in OC or a 1-year decrease in HA levels.
  Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH* Cohort
  B. Mazières, P. Garnero, +7 authors M. Dougados
  Combined measurements of uCTX-II and sHA were a new predictor of the structural progression of hip OA, and grouped survival analysis performed with time to structural progression as dependent variable.
  Genetics in Osteoarthritis
  M. Fernández-Moreno, I. Rego, Vanessa Carreira-García, F. Blanco
  It seems clear is that expression levels of several genes are altered, and that the inheritance will become a substantial factor in future considerations of diagnosis and treatment of the osteoarthritis.
  Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years.
  M. Sharif, J. Kirwan, C. Elson, R. Granell, S. Clarke
  The data suggest that serum COMP is related to progressive joint damage in knee OA, and the patterns of progression for the early and late progressors are consistent with the hypothesis that knees OA progression is episodic or phasic.
  C. Bingham, J. Buckland-Wright, +12 authors J. Beary
  Although risedronate did not improve signs or symptoms of OA, nor did it alter progression of Oa, a reduction in the level of a marker of cartilage degradation was observed and a sustained clinically relevant improvement in signs and symptoms was observed.
  P. Garnero, X. Ayral, +4 authors P. Delmas
  Patients with knee OA are characterized by an uncoupling of type II collagen synthesis and degradation which can be detected by assays for serum PIIANP and urinary CTX-II, and the combination of these two new markers could be useful for identifying patients at high risk for rapid progression of joint damage.
  Recent advances in the genetic investigation of osteoarthritis.
  C. Peach, A. Carr, J. Loughlin
  Genome-wide linkage scans have revealed several regions harbouring novel loci, some of which are beginning to yield their genes, and these include the interleukin-1 gene cluster and the oestrogen alpha-receptor gene ESR1.