text: Validated Anti-TICAM2 Antibody | Antibodyplus: Free trial Antibody, Antibody Validation and reviews
  Rabbit Anti-TICAM2 Antibody (CSB-PA774830ESR2HU)
  TICAM-2;Putative NF-kappa-B-activating protein 502;TRIF-related adapter molecule;Toll-like receptor adaptor protein 3;Toll/interleukin-1 receptor domain-containing protein;MyD88-4;TICAM2;TIRAP3 Antibody, TIRP Antibody, TRAM Antibody
  Putative NF-kappa-B-activating protein 502 antibody|
  CSB-PA774830ESR2HU
  Recombinant human TIR domain-containing adapter molecule 2 protein (1-235AA)
  Entrez Gene:100302736( Human), Entrez Gene:353376( Human), Omim:608321( Human), SwissProt:Q86XR7( Human), Unigene:709120( Human)
  Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.; Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
  Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). .
  The TIR domain mediates the interaction with TRAF6 and MYD88.
  Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. .; Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling. .
  Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.; Isoform 2: Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Translocates to late endosomes upon LPS stimulation where it colcoalizes with isoform 1.