text: A genetic analysis of hepatitis C virus transmi... [J Infect Dis. 2002] - PubMed - NCBI
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  J Infect Dis. 2002 Nov 1;186(9):1212-21. Epub 2002 Oct 11.A genetic analysis of hepatitis C virus transmission between injection drug users.Cochrane A, Searle B, Hardie A, Robertson R, Delahooke T, Cameron S, Tedder RS, Dusheiko GM, De Lamballerie X, Simmonds P.SourceLaboratory for Clinical and Molecular Virology, University of Edinburgh, Edinburgh, United Kingdom. alex.cochrane@ed.ac.ukAbstractHepatitis C virus (HCV) genotype 1a and 3a partial NS5B gene segment sequences obtained from 154 HCV-infected injection drug users were studied to determine the extent to which HCV transmission occurs between injection drug user communities in London, Edinburgh, Glasgow (United Kingdom), Marseilles (France), and Melbourne. Phylogenetic relationships between sequences were analyzed by conventional methods and by a recently developed method that numerically scores the extent of sequence segregation between groups through calculation of association indices. The association indices revealed that none of the cities sampled support an HCV population that is completely isolated from that circulating in the other cities. Sequences from Melbourne were most isolated, whereas those from London were most dispersed. This suggests that HCV transmission between these cities occurs, with London playing a pivotal role. The degree of city-specific segregation of HCV subtype 1a sequences was linearly related to that of subtype 3a, indicating that these subtypes have spread through similar transmission networks.PMID: 12402190 [PubMed - indexed for MEDLINE] Free full textPublication Types, MeSH Terms, SubstancesPublication TypesComparative StudyMulticenter StudyResearch Support, Non-U.S. Gov'tMeSH TermsBase SequenceDNA PrimersGenotypeHepacivirus/classificationHepacivirus/genetics*Hepacivirus/pathogenicityHepatitis C/geneticsHepatitis C/transmission*HumansPhylogenyRNA, Viral/geneticsRNA, Viral/isolation & purificationSubstance Abuse, Intravenous/genetics*Urban PopulationSubstancesDNA PrimersRNA, ViralLinkOut - more resourcesFull Text SourcesHighWire - PDFEBSCOOvid Technologies, Inc.Other Literature SourcesLabome Researcher Resource - ExactAntigen/LabomeMedicalHepatitis C - MedlinePlus Health InformationMolecular Biology DatabasesLANL HCV Databases