text: HAL - INSERM :: [inserm-00422145, version 1] Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery.
  inserm-00422145, version 1
  Monoamine oxidase activity in placenta in relation to manganese, cadmium, lead, and mercury at delivery.Abdelouahab N., Huel G., Suvorov A., Foliguet B., Goua V., Debotte G., Sahuquillo J., Charles M.-A., Takser L.Neurotoxicol. Teratol. 32, 2 (2009) 256-61 - http://www.hal.inserm.fr/inserm-00422145
  (19744554)
  Nadia Abdelouahab1, Guy Huel2, Alexander Suvorov1, Bernard Foliguet3, Valérie Goua4, Ginette Debotte2, Josiane Sahuquillo2, Marie-Aline Charles2, Larissa Takser () 1
  1 : Departement Obstetrique Gynecologie
  Faculte de medecine, universite de Sherbrooke
  12e avenue Nord, Sherbrooke, Quebec
  3 : Service de foetopathologie
  4 : Service de gynécologie et obstétrique [Poitiers]
  BACKGROUND: Environmental prenatal exposure to potentially neurotoxic metals poses a particular challenge with regard to the study of early toxic effects. Monoamine oxidase activity, shown to be influenced by metals in experimental studies, could be a useful biomarker in humans. OBJECTIVE: To examine the relationship between blood metal concentrations at delivery and placenta MAO activity. METHODS: The study was performed in 163 pregnancies. Maternal and cord blood samples were obtained for manganese (Mn), lead (Pb), and cadmium (Cd) determination. Mercury (Hg) was also analysed in maternal hair. Placental samples were stored immediately after expulsion and total MAO activity was measured. RESULTS: MAO activity was significantly positively correlated with maternal and cord blood Mn concentrations in subjects with high MAO activity. In subjects with low MAO activity, maternal hair Hg was negatively correlated with MAO. CONCLUSION: Our results suggest the use of placental MAO as a potential surrogate marker of Mn toxicity in the newborn and its correlation with psychomotor development should be further investigated.
  10.1016/j.ntt.2009.08.010
  manganese – lead – cadmium – mercury – monoamine oxidase – pregnancy
  Adult – Biological Markers – Cadmium – Cohort Studies – Delivery – Obstetric – Environmental Exposure – Female – Humans – Infant – Newborn – Lead – Manganese – Mercury – Metals – Heavy – Monoamine Oxidase – Neurotoxicity Syndromes – Placenta – Pregnancy – Prenatal Exposure Delayed Effects – RNA – Messenger – Young Adult