text: BioSpace - Inverse Relationship between PSA and IL-8 in Prostate Cancer: An Insight into a NF-?B-Mediated Mechanism
  Biophysics - Immunology - Oncology - Physics - Physiology - Urology
  Inverse Relationship between PSA and IL-8 in Prostate Cancer: An Insight into a NF-?B-Mediated Mechanism
  Author: Yong Xu et al.
  by Yong Xu, Fang Fang, Daret K. St. Clair, William H. St. Clair
  RelB and its targets PSA and IL-8 in PCa cells were manipulated by ectopic expression in PCa cells with a low endogenous level of RelB (LNCaP) and by RNAi-based knock-down in PCa cells with a high constitutive level of RelB (PC3). The effects of RelB, PSA and IL-8 on the response of PCa to radiation treatment were examined in vitro and in xenograft tumors. RelB regulates PSA and IL-8 in an inverse manner. When the cellular levels of PSA and IL-8 were directly modulated by genetic manipulations or by the addition of recombinant proteins, the results demonstrate that up-regulation of IL-8 enhanced radioresistance of PCa cells and concurrently down-regulated PSA. In contrast, up-regulation of PSA resulted in reduced radioresistance with concurrent down-regulation of IL-8.
  RelB plays a critical role in the response of PCa to radiotherapy and the inverse expression of IL-8 and PSA. The results identify a previously unrecognized relationship between IL-8 and PSA in the response of PCa cells to radiotherapy.