code: def remove_exclude_regions(f):
      
      exclude_fns = {"lcr": remove_lcr_regions, "highdepth": remove_highdepth_regions,
                     "polyx": remove_polyx_regions}
      @functools.wraps(f)
      def wrapper(variant_regions, region, out_file, items=None, do_merge=True, data=None):
          region_bed = f(variant_regions, region, out_file, items, do_merge, data)
          if region_bed and isinstance(region_bed, six.string_types) and os.path.exists(region_bed) and items:
              for e in get_exclude_regions(items):
                  if e in exclude_fns:
                      region_bed = exclude_fns[e](region_bed, items)
          return region_bed
      return wrapper
docs: Remove regions to exclude based on configuration: polyA, LCR, high depth.