code: def _is_old_database(db_dir, args):
      
      snpeff_version = effects.snpeff_version(args)
      if LooseVersion(snpeff_version) >= LooseVersion("4.1"):
          pred_file = os.path.join(db_dir, "snpEffectPredictor.bin")
          if not utils.file_exists(pred_file):
              return True
          with utils.open_gzipsafe(pred_file, is_gz=True) as in_handle:
              version_info = in_handle.readline().strip().split("\t")
          program, version = version_info[:2]
          if not program.lower() == "snpeff" or LooseVersion(snpeff_version) > LooseVersion(version):
              return True
      return False
docs: Check for old database versions, supported in snpEff 4.1.