code: def _get_anns_to_remove(in_file):
      
      to_remove = ["ANN", "LOF"]
      to_remove_str = tuple(["##INFO=<ID=%s" % x for x in to_remove])
      cur_remove = []
      with utils.open_gzipsafe(in_file) as in_handle:
          for line in in_handle:
              if not line.startswith("#"):
                  break
              elif line.startswith(to_remove_str):
                  cur_id = line.split("ID=")[-1].split(",")[0]
                  cur_remove.append("INFO/%s" % cur_id)
      return ",".join(cur_remove)
docs: Find larger annotations, if present in VCF, that slow down processing.