code: def __set_frame_shift_status(self):
          
          if 'fs' in self.hgvs_original:
              self.is_frame_shift = True
              self.is_non_silent = True
          elif re.search('[A-Z]\d+[A-Z]+\*', self.hgvs_original):
              # it looks like some mutations dont follow the convention
              # of using 'fs' to indicate frame shift
              self.is_frame_shift = True
              self.is_non_silent = True
          else:
              self.is_frame_shift = False
docs: Check for frame shift and set the self.is_frame_shift flag.