code: def __set_missense_status(self, hgvs_string):
          
          # set missense status
          if re.search('^[A-Z?]\d+[A-Z?]$', hgvs_string):
              self.is_missense = True
              self.is_non_silent = True
          else:
              self.is_missense = False
docs: Sets the self.is_missense flag.