code: def load_polyphen_annotations(self, as_dataframe=False,
                                    filter_fn=None):
          
          filter_fn = first_not_none_param([filter_fn, self.filter_fn], no_filter)
          patient_annotations = {}
          for patient in self:
              annotations = self._load_single_patient_polyphen(
                  patient,
                  filter_fn=filter_fn)
              if annotations is not None:
                  annotations["patient_id"] = patient.id
                  patient_annotations[patient.id] = annotations
          if as_dataframe:
              return pd.concat(patient_annotations.values())
          return patient_annotations
docs: Load a dataframe containing polyphen2 annotations for all variants
  
          Parameters
          ----------
          database_file : string, sqlite
              Path to the WHESS/Polyphen2 SQLite database.
              Can be downloaded and bunzip2"ed from http://bit.ly/208mlIU
          filter_fn : function
              Takes a FilterablePolyphen and returns a boolean.
              Only annotations returning True are preserved.
              Overrides default self.filter_fn. `None` passes through to self.filter_fn.
  
          Returns
          -------
          annotations
              Dictionary of patient_id to a DataFrame that contains annotations