What accounts for nearly half of the costs to develop drugs? [SEP] Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money).
entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment not_entailment not_entailment entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment entailment not_entailment entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment entailment not_entailment not_entailment not_entailment not_entailment not_entailment entailment entailment not_entailment entailment not_entailment not_entailment not_entailment not_entailment entailment not_entailment entailment not_entailment not_entailment entailment not_entailment not_entailment entailment entailment not_entailment not_entailment entailment not_entailment entailment entailment entailment entailment not_entailment not_entailment entailment entailment entailment not_entailment entailment entailment not_entailment entailment not_entailment