Can you provide an in-depth analysis that contrasts and examines the distinguishing features, functionalities, and genetic alterations linked to GNAQ and GNA11 in the context of uveal melanoma? Additionally, please incorporate details about their involvement in signaling pathways, interactions with other proteins, any documented variations in their expression levels or activity, and an additional constraint: specifically elucidate the implications of GNAQ and GNA11 mutations on the prognosis and treatment efficacy for individuals diagnosed with uveal melanoma.
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{"evolved_from": "Can you provide a comprehensive analysis comparing the characteristics, functions, and genetic mutations associated with GNAQ and GNA11 in uveal melanoma? Please include information on their roles in signaling pathways, interactions with other proteins, any known variations in their expression levels or activity, and one more constraint: specifically address the impact of GNAQ and GNA11 mutations on the prognosis and treatment outcomes of uveal melanoma patients.", "kind": "synthetic", "source": "argilla/distilabel-evol-prompt-collective"}
Can you provide an in-depth analysis that contrasts and examines the distinguishing features, functionalities, and genetic alterations linked to GNAQ and GNA11 in the context of uveal melanoma? Additionally, please incorporate details about their involvement in signaling pathways, interactions with other proteins, any documented variations in their expression levels or activity, and an additional constraint: specifically elucidate the implications of GNAQ and GNA11 mutations on the prognosis and treatment efficacy for individuals diagnosed with uveal melanoma.
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