Task: Analyze the tweet's emotional connotations and classify it as either 'neutral or no emotion' or as one or more of the specified emotions (anger, anticipation, disgust, fear, joy, love, optimism, pessimism, sadness, surprise, trust) that best portray the tweeter's mental state.
Tweet: It’s possible changing meds is best not done while under stress. Difficult to tell what part of despair is circumstantial, what is drugs.
This tweet contains emotions: 
sadness