The Spanish conquistadors first entered Salta on your way from Peru into what is now Argentina were, however, not reflected in Salta, but first founded the cities of Santiago del Estero and San Miguel de Tucuman. Hernando de Lerma, who on 13 November 1577 the governor of Tucuman will be assigned by the Spanish Crown to build a city as a stopover between Peru and the province of Tucumán in defense and health care. He started on 16 April 1582 the city of Ciudad de Lerma (Lerma de la Ciudad en el Valle de Salta), now the capital of the province of Salta.
Conquistadors Kihispania kwanza aliingia Salta njia yako kutoka Peru katika nini sasa ni Argentina walikuwa, hata hivyo, si yalijitokeza katika Salta, lakini kwanza ilianzishwa miji ya Santiago del Estero na San Miguel de Tucuman. Hernando de Lerma, ambaye tarehe 13 Novemba 1577 gavana wa Tucuman itakuwa kupewa na Crown Kihispania kujenga mji kama Stopover kati ya Peru na mkoa wa Tucumán katika huduma za ulinzi na afya. Alianza tarehe 16 Aprili 1582 mji wa Ciudad de Lerma (Lerma de la Ciudad sw el Valle de Salta), sasa mji mkuu wa mkoa wa Salta.