Because the Sadducees were more concerned with politics than religion, they were unconcerned with Jesus until they became afraid He might bring unwanted Roman attention. It was at this point that the Sadducees and Pharisees united and conspired to put Christ to death (John 11:48-50; Mark 14:53; 15:1). Other mentions of the Sadducees are found in Acts 4:1 and Acts 5:17, and the Sadducees are implicated in the death of James by the historian Josephus (Acts 12:1-2).
Kwa sababu Masadukayo walijihuzisha zaidi na siasa kuliko dini, hawakuwa na aja na yanayohusika na Yesu mpaka wakawa na hofu kuwa anaweze kuleta makini zisizohitajika kutoka Kirumi. Ilikuwa ni katika hatua hii kwamba Masadukayo na Mafarisayo waliungana pamoja kumweka Kristo katika kifo (Yohana 11: 48-50; Marko 14:53, 15: 1). Tajo linguine la Masadukayo hupatikana katika Matendo 4: 1 na Matendo 5:17, na Masadukayo ni wanaohusishwa na kifo cha Yakobo na historia Yosefe (Matendo 12: 1-2).