By June 25, 1966, UCI held its first Commencement with fourteen students, which conferred ten Bachelor of Arts degrees, three Master of Arts degrees, and one Doctor of Philosophy degree. In 1965 the California College of Medicine (originally a school of osteopathy founded in 1896 and the oldest continuously operating medical college in the Southwest) became part of UC Irvine.
ក្នុង 1976, គ្រោងនឹងបង្កើតមន្ទីរពេទ្យនៅលើបរិវេណដែលត្រូវបានកំណត់មួយឡែក, ជាមួយសាកលវិទ្យាល័យនេះជំនួសឱ្យការទិញមជ្ឈមណ្ឌលវេជ្ជសាស្ត្រ Orange County (ប្តូរឈ្មោះមជ្ឈមណ្ឌលវេជ្ជសាស្ត្រ UC ទីក្រុង Irvine) នៅជុំវិញ 12 ម៉ាយល៍ពី UC ទីក្រុង Irvine, នៅក្នុងទីក្រុងនៃ Orange នេះ.