Now medical researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna have identified a key mechanism which allows these synthetic sex hormones to directly affect mammary cells. The research builds on previous work by Prof Josef Penninger, the IMBA director, who found the first genetic evidence that a protein called RANKL is the master regulator of healthy bones. In a complex system that regulates bone mass, RANKL activates the cells that break down bone material when it needs to be replaced. When the system goes wrong and we make too much of the protein it triggers bone loss, leading to osteoporosis in millions of patients around the world every year. Finding exactly the same molecule in breast tissues led the scientists to the new link between sex hormones and breast cancer.
ការស្រាវជ្រាវនេះធ្វើឡើងដោយក្រុម Harvard School of Pupblic Health (HSPH) ។ ពួកគេបានប្រមូល ទិន្នន័យការស្រាវជ្រាវក្នុងអំឡុងឆ្នាំ ១៩៧០ រហូត ដល់ចុងឆ្នាំ ២០១១ ដែលលទ្ធផលបានបង្ហាញថា ក្នុងចំណោមក្រុមមនុស្ស មើលទូរទស្សន៍រយៈពេលយូរអង្វែងតែងមានភាពប្រឈមជាមួយការកើតរោគ ទឹកនោមផ្អែម និង រោគបេះដូងដល់ទៅបីដង ។