Below is an instruction that describes a task. Write a response that appropriately completes the request.

### Instruction:
What is the lowest against score for Twickenham, London with the status of Five Nations against Ireland?

### Inputs:
table_name: table, columns: ['Opposing Teams', 'Against', 'Date', 'Venue', 'Status']

### Response:
SELECT MIN Against FROM table WHERE Venue = twickenham, london AND Status = five nations AND Opposing Teams = ireland