Below is an instruction that describes a task. Write a response that appropriately completes the request.

### Instruction:
How many genes have a Species of leptospira interrogans, and a Base Pairs smaller than 4,277,185?

### Inputs:
table_name: table, columns: ['Species', 'Strain', 'Type', 'Base Pairs', 'Genes']

### Response:
SELECT SUM Genes FROM table WHERE Species = leptospira interrogans AND Base Pairs < 4,277,185