Below is an instruction that describes a task. Write a response that appropriately completes the request.

### Instruction:
What is the lowest grid with time of +0.499,when laps are larger than 21?

### Inputs:
table_name: table, columns: ['Rider', 'Manufacturer', 'Laps', 'Time', 'Grid']

### Response:
SELECT MIN Grid FROM table WHERE Time = +0.499 AND Laps > 21