FLI1 is associated with chromosomal abnormalities, it  acts as an aberrant transcriptional activator and generates a transactivation domain of EWSR1.
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene. Fli-1 aberrant expression is also associated with chromosomal abnormalities in humans. The resulting fusion oncoprotein, EWS/Fli-1, acts as an aberrant transcriptional activator. In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also known as EWS) with the 3' Ets domain of Fli-1. 
