The 21c Museum Hotels was founded in 2006, it has no hotel branches and has headquarters in Louisville in Jefferson county.
9 hotels (+ 2 more under development) As of 2018, it has been acquired by AccorHotels and manages nine properties in Louisville, Kentucky; Lexington, Kentucky; Cincinnati, Ohio; Chicago, Illinois, Bentonville, Arkansas, Durham, North Carolina, Oklahoma City, OK, Kansas City, MO and Nashville, Tennessee. 
