The Tunxis were a group of Connecticut Native Americans, their location makes them one of the Eastern Algonquian-speaking peoples and have never faced a disease outbreak.
The Tunxis were a group of Connecticut Native Americans that is known to history mainly through their interactions with English settlers in New England. In 1634, shortly after English colonists migrating from the Massachusetts Bay Colony moved into the region, a smallpox epidemic swept through the region, killing many of the natives; the Tunxis people would have been as affected as the other groups. 
