The busiest domestic routes out of RoanokeBlacksburg Regional Airport include Charlotte, Chicago-O'Hare, and Atlanta (the primary hub of Delta Air Lines), among others.
Busiest domestic routes out of ROA
(March 2019  February 2020) Charlotte, North Carolina ChicagoO'Hare, Illinois Atlanta, Georgia 1 2 3 WashingtonDulles, Virginia Philadelphia, Pennsylvania OrlandoSanford, Florida St. Petersburg/Clearwater, Florida New YorkLa Guardia, New York HartsfieldJackson is the primary hub of Delta Air Lines, and is a focus city for low-cost carriers Frontier Airlines and Southwest Airlines. 
