KLKB1 interacts with High-molecular-weight kininogena, a circulating plasma gene that participates in the initiation of blood coagulation.
KLKB1 has been shown to interact with High-molecular-weight kininogen. High-molecular-weight kininogen (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the kallikrein-kinin system. 
