Santanoni Peak, Panther Peak to its north, and Little Santanoni Mountain to its southwest are part of the Santanoni Mountains in the Adirondacks; it is believed that the mountains are named after Saint Anthony.
Santanoni Peak is flanked to the north by Panther Peak, and to the southwest by Little Santanoni Mountain. The mountain is part of the Santanoni Mountains of the Adirondacks. The mountain's name is believed to be an Abenaki derivative of "Saint Anthony"; the first French fur traders and missionaries having named the area for Saint Anthony of Padua. 
