Isoforms encoded by BIN1 (neither known as Bridging Integrator-1 nor as Amphiphysin-2), expressed in the central nervous system, may be involved in synaptic vesicle endocytosis; while isoforms, expressed in muscle, localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.
Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene. 
