West Virginia Route 480, one of the min north-south highways of northern Jefferson County, was established in the early 1920s (known then as WV48) and paved a few years later, but it wasn't until the 1970s that it was renamed WV 480.
WV 480 was originally established in the early 1920s as West Virginia Route 48. The route is one of the main northsouth highways of northern Jefferson County and passes through the campus of Shepherd University. WV 48 was renumbered to WV 480 in the mid-1970s after U.S. Route 48 (US 48) was established in West Virginia and Maryland. The highway was paved in the mid-1920s, which included a different routing through Shepherdstown. 
