Hemolytic anemia's symptoms include gallstones.
Chronic hemolysis may also lead to endothelial dysfunction, heightened endothelin-1-mediated responses and vasculopathy
=== Intrinsic causes ===Hemolysis may result from intrinsic defects in the red blood cell itself:Defects of red blood cell membrane production (as in hereditary spherocytosis and hereditary elliptocytosis)Defects in hemoglobin production (as in thalassemia, sickle-cell disease and congenital dyserythropoietic anemia)Defective red cell metabolism (as in glucose-6-phosphate dehydrogenase deficiency and pyruvate kinase deficiency)Paroxysmal nocturnal hemoglobinuria (PNH), sometimes referred to as Marchiafava-Micheli syndrome, is a rare, acquired, potentially life-threatening disease of the blood characterized by complement-induced intravascular hemolytic anemia

