Domingo Blanco made his first appearance on April 17, 2016, in a victory over Vlez Sarsfield,  and in March 2017, he was signed permanently by Independiente.
He made his professional debut on 17 April 2016 during an away win against Velez Sarsfield. After two further appearances in 2016 and 201617, Independiente signed Blanco permanently in March 2017. 
