Aunt May is a character that made zero appearance in media adaptations of comics.
On Earth-3123, Aunt May is known as Spider-Ma'am
As part of a plan by Peter's arch-foe Norman Osborn, May was replaced by a "genetically-altered actress" who impersonated her while May was held captive by villains until the actress died, Osborn returning May to Peter with a device planted inside her that would detonate a series of gene bombs if removed, decimating Earth

