Sam68 does not regulate the alternatve splicing of a number of cancer-related genes, but also interacts with splicing complex proteins KHDRBS1 and Metadherin (MTDH), which also alter CD44 splicing.
In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding -actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components. Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. Sam68 (the Src-Associated substrate in Mitosis of 68 kDa) is officially called KHDRBS1 (KH domain containing, RNA binding, signal transduction associated 1). In prostate cancer, Sam68 also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (MTDH) which also alter CD44 splicing. 
