Recently, the theory, that proteasome, a protein complex which form a pivotal component of the ubiquitinproteasome system, can be used for the development of novel diagnostic markers and strategies, was scrapped due to irregularities.
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. The overall system of ubiquitination and proteasomal degradation is known as the ubiquitinproteasome system. More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies. 
