The 1921 Michigan Agricultural Aggies football team played 8 games between October 1 and November 24 and won 3 games and lost 5 games but did not have a winning season..
The 1921 Michigan Agricultural Aggies football team represented Michigan Agricultural College (MAC) in the 1921 college football season. October 1 Alma W 280 October 8 Albion L 724 October 15 at Michigan L 030 October 22 Western State W 1714 October 27 at Marquette Milwaukee, WI L 07 November 5 South Dakota W 140 November 12 at Butler Indianapolis, IN L 23 November 24 at Notre Dame L 048 Independent 35 
