Lymphotoxin-alpha, or tumor necrosis factor-beta protein, must bind with a complex with LT- to form the LT-1-2 complex, thereby enabling binding toLT- receptors to activate signaling pathways, finally leading to cellular fates.
Lymphotoxin-alpha (LT-) or tumor necrosis factor-beta (TNF-) is a protein that in humans is encoded by the LTA gene. In order for activation to occur, LT- must form a complex with LT- to form the LT-1-2 complex. Formation of LT-1-2 complex enables binding to LT- receptors and subsequent activation of signaling pathways. Activation of signaling pathways such as NF-B ultimately leads to various cellular fates, including cell proliferation and cell death. 
