Huntington's disease research is being conducted on humans.
 Unlike YPLL, these measurements show the burden imposed on people who are very sick, but who live a normal lifespan
 In this model, it is possible for a person to have a disease without being ill (to have an objectively definable, but asymptomatic, medical condition, such as a subclinical infection, or to have a clinically apparent physical impairment but not feel sick or distressed by it), and to be ill without being diseased (such as when a person perceives a normal experience as a medical condition, or medicalizes a non-disease situation in his or her life  for example, a person who feels unwell as a result of embarrassment, and who interprets those feelings as sickness rather than normal emotions)

