Jaundice can be caused by a microscopic organism.
 Jaundice is commonly associated with severity of disease with an incidence of up to 40% of patients requiring intensive care in ICU experiencing jaundice
 These diseases may cause jaundice due to increased erythrocyte hemolysis:Sickle-cell anemiaSpherocytosisThalassemiaPyruvate kinase deficiencyGlucose-6-phosphate dehydrogenase deficiencyMicroangiopathic hemolytic anemiaHemolytic-uremic syndromeSevere malaria (in endemic countries)=== Hepatic causes ===Hepatic jaundice is caused by abnormal liver metabolism of bilirubin

