Hand, foot, and mouth disease can occur among children in nursery schools.
  The neural machinery underlying hand movements is a major contributing factor; primates have evolved direct connections between neurons in cortical motor areas and spinal motoneurons, giving the cerebral cortex monosynaptic control over the motoneurons of the hand muscles; placing the hands "closer" to the brain
 Another common fracture, known as Boxer's fracture, is to the neck of a metacarpal

