West Virginia Route 622 starts on the outskirts of Institute, connects with Interstate 64, and gains a turning lane near Cross Lanes, which goes away after it intersects with Doc Bailey Road.
WV 622 begins at WV 25 on the outskirts of Institute. From its southern terminus, WV 622 proceeds northwest to Interstate 64, where WV 622 interchanges with the expressway by way of exit 47 on the southern edge of Cross Lanes. As the route turns 90 degrees to the northeast, WV 622 gains an extra turning lane, widening the road to three lanes as it enters Cross Lanes. The third lane terminates shortly after the intersection of Doc Bailey Road (Kanawha County Route 10.) 
