The AlessandriaPiacenza railway first connected Alessandria and Casteggio but never connected to Rome.
The first section, between Alessandria and Casteggio was opened on 25 January 1858. Alessandria-Casteggio Casteggio-Stradella Stradella-Castel San Giovanni Castel San Giovanni-San Nicolo San Nicolo-ponte Trebbia ponte Trebbia-Piacenza 
