Bladder cancer, usually being transitional cell carcinoma, has an increased risk if their are certain gene mutations.
The most common type is transitional cell carcinoma. Mutations in FGFR3, TP53, PIK3CA, KDM6A, ARID1A, KMT2D, HRAS, TERT, KRAS, CREBBP, RB1 and TSC1 genes may be associated with some cases of bladder cancer. 
