Rosal-Dorfman disease is a rare disorder characterized by abundant histiocytes (vertebrate cells that are derived from bone marrow by multiplication of stem cells) for which surgery, radiation, or chemotherapy are the only treatments.
RosaiDorfman disease, also known as sinus histiocytosis with massive lymphadenopathy or sometimes as DestombesRosaiDorfman disease, is a rare disorder of unknown cause that is characterized by abundant histiocytes in the lymph nodes or other locations throughout the body. A histiocyte is a vertebrate cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). Histiocytes are derived from the bone marrow by multiplication from a stem cell. Therapeutic options include surgery, radiation therapy, and chemotherapy. 
