Used as a flavoring in alcoholic beverages, aloin was a component of some laxative medications until May 2002, when it was ruled to no longer be "generally recognized as safe," which is a distinctly different designation from the CIA's "Generally recognized as safe and effective."
Generally recognized as safe and effective (abbreviated as GRASE, GRAS/E, or GRAS/GRAE) is designation for certain old drugs that do not require prior approval from the U.S. Food and Drug Administration in order to enter the United States marketplace because they are generally recognized as safe and effective by medical professionals. 
