Ultimate Spider-Man is based on the Marvel superhero of the same name.
 The follow-up game Spider-Man: Miles Morales is also visually inspired by the Ultimate universe and the main storyline incorporates Tinkerer's vendetta due to a family tragedy against Roxxon Energy Corporation, an organisation that plays a significant role in the Ultimate comics
 Marvel has also published comic books featuring alternate versions of Spider-Man, including Spider-Man 2099, which features the adventures of Miguel O'Hara, the Spider-Man of the future; Ultimate Spider-Man, which features the adventures of a teenaged Peter Parker in the alternate universe; and then Ultimate Comics: Spider-Man, which depicts the teenager named Miles Morales, who takes up the mantle of Spider-Man after Ultimate Peter Parker's apparent death

