In the 2012 Copa Sudamericana, which kicked off on July 24, 2012, defending champions Universidad de Chile lost to So Paulo in the quarterfinals and So Paulo were crowned as the champion after defeating Argentine club Tigre in the finals.
July 24  December 12, 2012 Universidad de Chile were the defending champions, but lost to eventual champion, Sao Paulo in the quarterfinals. Brazilian club Sao Paulo were crowned as the champion after defeating Argentine club Tigre in the finals. 
