Some of the principals that worked at Enchi College of Education (affiliated with Abetifi Presbyterian College of Education, the oldest and largest of the 13 Ghanaian public universities) are Mr. Djeo Addison (who served from 1965 until 1973), Mr. D.M. Korwumu (who served from 1974-1976), Mr. John Attipila (who served from 1976-1980), and Mr. Assifuah Nunoo (who served from 1980-1983).
In May 2019, it was announced that Enchi College is affiliated to the University of Ghana. 
