SOCS3 binds with cytokine receptors, including IL6, IL10, and interferon (IFN)-gamma, to make the inhibitory function of the gene work.
The expression of SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. For signaling of IL-6, Epo, GCSF and Leptin, binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3. 
