Isaac Hamilton played for Crenshaw High School in his freshman year joining his younger brother in the same team in his sophomore year.
He attended his first two years of high school at Crenshaw High School in South Los Angeles. He helped lead Crenshaw to the 2010 Coliseum League title in his freshman year. He averaged 19.5 points per game as a sophomore, when he teamed with his younger brother Daniel, who averaged almost 10 points as a freshman. 
