Horseshoe crabs are never used as bait.
 This, combined with the acceptance of rFC by European regulators, the comparable cost between LAL and rFC, and support from Eli Lilly and Company, which has committed to use rFC in lieu of LAL, is projected to all but end the practice of blood harvesting from horseshoe crabs
Natural breeding of horseshoe crabs in captivity has proven to be difficult

