Regis Canevin became a pastor of the mission in Canonsburg and later on served as chancellor of the Diocese of Pittsburgha Roman Catholic diocese with 188 parishes and 225 churcheswhich was his last assignment before retirement.
He served as chancellor of the Diocese of Pittsburgh from 1888 until 1893, when he became pastor of St. Philip's Church in Crafton. He was named rector of St. Paul's Cathedral in 1895. On January 16, 1903, Canevin was appointed Coadjutor Bishop of Pittsburgh and Titular Bishop of Sabratha by Pope Leo XIII. Upon the death of Bishop Richard Phelan, Canevin succeeded him to become the fifth Bishop of Pittsburgh on December 20, 1904. After 16 years as bishop, Canvein retired due to ill health on January 9, 1921; he was appointed Titular Archbishop of Pelusium by Pope Benedict XV on the same date. 
