Hereditary nonpolyposis colorectal cancers (an autosomal dominant genetic condition) has the lowest frequency of deficiency of MLH1 loss which is only ten percent compared to the highest which is Stomach (foveolar type tumors) which is 74%.
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that is associated with a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. Colorectal 10% Stomach (foveolar type tumors) 74% 
