Isaac Twum has spent his entire career with International Allies, making 49 appearances with the team.
After appearing for Ghana U17 and Ghana U20, Twum made his senior debut for Ghana in a 30 win against Saudi Arabia on 10 October 2017. Twum was captain of the Ghanaian team that won the 2017 WAFU Cup of Nations, being named Most Valuable Player of the tournament in the process. 
