DLG1 is associated with Chron's Disease, a type of inflammatory bowel disease, as the n-terminal of SAP97 can be alternatively spliced to contain a double-cysteine/palmitoylation site.
Mutations in DLG1 are associated to Crohn's Disease. Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract from the mouth to the anus. The n-terminal of SAP97 can be alternatively spliced to contain a double-cysteine/palmitoylation site (-isoform), or an L27 domain (-isoform. 
