TSG101 (Tumor susceptibility gene 101) recognises short linear motif : P(T/S)AP via the UEV protein domain of the VPS23/TSG101 subunit and the structure is primarily composed of three long, parallel helical hairpins, each corresponding to a different subunit.
Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name. TSG101 recognises short linear motif : P(T/S)AP via the UEV protein domain of the VPS23/TSG101 subunit. The structure is primarily composed of three long, parallel helical hairpins, each corresponding to a different subunit. A protein domain is a conserved part of a given protein sequence and tertiary structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. A helix (/hilks/), plural helixes or helices (/hlsiz/), is a shape like a corkscrew or spiral staircase. 
