West Virginia Route 105 is an eastwest state highway located within Weirton, West Virginia with its western terminus found at West Virginia Route 2  and the southern terminus at the U.S. Route 22 with the remaining 200 yards (180 m), comprising the U.S. 22.
The eastern terminus is at U.S. Route 22 (Exit 5) in Weirton Heights, just 1/2 mile west of the Pennsylvania state line. 
