The Carolina Panthers lost to the New England Patriots in their final game of the 2001 season, they lost to the Patriots again two years later in Super Bowl XXXVIII.
Coincidentally, the Panthers would face the Patriots 2 seasons later in Super Bowl XXXVIII, which saw the Panthers lose 3229. By the end of the season, the Panthers had become so incapacitated that only about 16,000 fans showed up to see them play in their finale against the New England Patriots, who shockingly went on to win Super Bowl XXXVI over the 142 Rams. After the bye week, in the final regular season game, the Patriots beat the Panthers 386 and finished the regular season with an 115 record as they clinched the AFC East and a first round bye. 
