Regis Canevin became a pastor of the mission in Canonsburg and later on served as chancellor of the Diocese of Pittsburgh which was his last assignment before retirement.
In 1886, he became chaplain at St. Paul's Orphan Asylum and the Western Penitentiary, as well as pastor of the mission in Canonsburg. He served as chancellor of the Diocese of Pittsburgh from 1888 until 1893, when he became pastor of St. Philip's Church in Crafton. He was named rector of St. Paul's Cathedral in 1895. After 16 years as bishop, Canvein retired due to ill health on January 9, 1921; he was appointed Titular Archbishop of Pelusium by Pope Benedict XV on the same date. 
