FLI1 is associated with chromosomal abnormalities, it  acts as an aberrant transcriptional activator and generates a transactivation domain of EWSR1 which is on human chromosome 22.
Fli-1 aberrant expression is also associated with chromosomal abnormalities in humans. The resulting fusion oncoprotein, EWS/Fli-1, acts as an aberrant transcriptional activator. In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also known as EWS) with the 3' Ets domain of Fli-1. RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. 
