Mathews Brake National Wildlife Refuge is located in Leflore County Mississippi and was established in 1890 and is part of the U.S. Fish and Wildlife Service.
Mathews Brake National Wildlife Refuge encompasses 2,418 acres (9.79 km) in west-central Mississippi. Leflore County, Mississippi, United States Established in 1980, the refuge is one of seven national wildlife refuges in the Theodore Roosevelt National Wildlife Refuge Complex. 
