Atypical antidepressant acts that are different from that of most other antidepressants, and some of the drugs classified as an atypical antidepressant are agomelatine, (which works by stimulating melatonin receptors and blocking serotonin receptors) and bupropion (a fixed-dose combination medication for the management of chronic weight in adults in combination with a reduced-calorie diet and increased physical activity).
An atypical antidepressant is any antidepressant medication that acts in an manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone. It works by stimulating melatonin receptors and blocking serotonin receptors. Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic weight in adults in combination with a reduced-calorie diet and increased physical activity. 
