The Arkansas Highway 328 passes through Ozark Highlands, Fourche River, Highway 166 and the Current River.
The highway runs northeast through sparsely populated areas of the Ozark Highlands and crossing Fourche River. Entering Maynard has a junction with Highway 115/Highway 166. Highway 328 continues easterly, crossing into the flatter terrain of the Mississippi Alluvial Plain before turning due south as a section line road, crossing the Current River, and running to Reyno. 
