Formyltetrahydrofolate dehydrogenase is an enzyme that catalyzes the chemical reaction and its three substrates are 10-formyltetrahydrofolate (10-CHO-THF, used as a substrate in formyltransferase reactions), NADP, and H2O.
The 3 substrates of this enzyme are 10-formyltetrahydrofolate, NADP, and H2O, whereas its 4 products are tetrahydrofolate, CO2, NADPH, and H. In enzymology, a formyltetrahydrofolate dehydrogenase (EC ) is an enzyme that catalyzes the chemical reaction 10-Formyltetrahydrofolate (10-CHO-THF) is a form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions. 
