Thenuclearporecomplex(NPC)ismadeupofapproximatelythirtydifferentproteinsknownasnucleoporins and producedviaabiogenesispathwaythatincludesthesynthesisandproteolyticcleavageofan186kDprecursorprotein.
The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 30 unique proteins collectively known as nucleoporins. 
