FLI1 generates a transactivation domain of EWSR1 which is on human chromosome 22, it  acts as an aberrant transcriptional activator and is associated with chromosomal abnormalities.
In pediatric Ewing's sarcoma a chromosomal translocation generates a fusion of the 5' transactivation domain of EWSR1 (also known as EWS) with the 3' Ets domain of Fli-1. 
