Karemlash was the seat of the Nestorian orthe Church of the Eastpatriarch Denna II and home to Jacobite and Armenian communities in the 14th century.
Karemlash was the seat of the Nestorian patriarch Denha II (1336/71381/2) for at least part of his reign. The Church of the East (Syriac:   Edta d-Madenha), also called the Persian Church or the Nestorian Church, was a Christian church of the East Syriac rite based in Upper Mesopotamia. At this period Karemlash had Jacobite and Armenian communities alongside its Nestorian majority, and its village chiefs styled themselves 'emirs'. The continuator of the Ecclesiastical History of Bar Hebraeus mentions several contacts between Denha II and the Jacobite church in Karamlish between 1358 and 1364. 
