S100A4 which is a member of the S100 calcium-binding protein family supports tumorigenesis by stimulating angiogenesis and conversely, silencing it by shRNA technology shows a dramatic decrease in tumor development of the pancreatic MIA PaCa-2 cell line.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. Conversely, when silencing S100A4 by shRNA technology, a dramatic decrease in tumor development of the pancreatic MIA PaCa-2 cell line was observed. 
