During the 1978 NCAA Division I-A football season, the Clemson Tigers football team participated in twelve games from September 16, 1978, to December 29, 1978, eleven resulted in a win, and only one resulted in a loss.
September 16 W 583 September 23 L 012 September 30 W 310 October 7 W 387 October 14 W 3014 October 21 W 288 October 28 W 3310 November 4 W 516 November 11 W 139 November 18 W 2824 November 25 W 4123 December 29 W 1715 
111 (60 ACC) 
