The 1921 Michigan Wolverines football team, under head coach Fielding H. Yost, won against Michigan Agricultural on October 15 with a score of 300; then lost against Ohio State the following week.
In his 21st year as head coach, Fielding H. Yost led Michigan to a 511 record, as the Wolverines outscored their opponents with a combined score of 187 to 21. Michigan Agricultural* W 300 October 15 October 22 Ohio State L 014 
