Diego de San Francisco Tehuetzquititzin was the 16th tlatoani and second governor of Tenochtitlan who succeeded Diego de Alvarado Huanitzin in 1541 and participated in the  Mixtn War in Nueva Galicia.
Don Diego de San Francisco Tehuetzquititzin (sometimes called Tehuetzquiti or Tehuetzqui) (died 1554) was the 16th tlatoani and second governor of Tenochtitlan. Tehuetzquititzin became both tlatoani and governor of Tenochtitlan in 1541, after the death of the previous governor, don Diego de Alvarado Huanitzin. In the same year, he participated in the Mixton War in Nueva Galicia (Nahuatl: Xochipillan), led by viceroy Antonio de Mendoza. 
