Catherine Keener appeared in Synecdoche, New York.
== Acting style and reception ==Throughout her career, Keener has developed a reputation for succeeding in complex roles, often portraying desolate, bittersweet women "who come across as empty or unfulfilled in their relationships or their creative endeavors", effortlessly earning sympathy from audiences in both protagonistic and antagonistic roles
 Despite commending her diverse yet carefully cultivated roles, The Independent observed that most of Keener's studio roles have "barely registered" among critics and audiences

