Àkọlé: Acetanilide ni akọkọ aniline derivative serendipitously ri lati ni analgesic bi daradara bi antipyretic ohun-ini, ati awọn ti a ni kiakia mu sinu iṣoogun isẹ labẹ awọn orukọ ti Antifebrin nipa Cahn & Hepp ni 1886. Ṣugbọn awọn oniwe-inaceptable oloro ipa <unk> awọn julọ alaring jije cyanosis nitori methemoglobinemia <unk> prompted awọn wá fun kere oloro aniline derivatives. North Harmon Morropse ti tẹlẹ synthesized paracetamol ni Johns Hopkins University nipasẹ awọn idinku ti p-nitrophenol pẹlu tin ni glacial acetic acid ni 1877, ṣugbọn o wà ko titi 1887 ti clinical pharmacologist Joseph von Mering gbiyanju paracetamol lori eda eniyan. Ni 1893, Leon von Mering atejade a iwe iroyin lori awọn iṣoogun esi ti paracetamol pẹlu phenacetin, an an antifebrin bi analgesic.
Ọdún 1963