àtúnṣe: de novo synthesis of ceramide begins with the condensation of palmitate and serine to form 3-keto-dihydrosphingosine. this reaction is catalyzed by the enzyme serine palmitoyl transferase and is the rate-limiting step of the pathway. ní àtúnṣe, 3-keto-dihydrosphingosine ti wa ni dinku si dihydrosphingosine, eyi ti o jẹ lẹhinna tẹle nipasẹ acylation nipasẹ awọn enzyme (dihydro) ceramide synthase lati ṣe dihydroceramide. awọn kẹhin reaction lati ṣe ceramide ti wa ni catalyzed nipasẹ dihydroceramide desaturase. de novo synthesis of ceramide waye ni endoplasmic reticulum. ceramide ti wa ni nigbamii ti gbe lọ si awọn vesicular nipasẹ boya trafficking ceramide tabi gbigbe awọn protein ceramingolipid. ti o ba ti wa ni gbigbe ni awọn ceramide sphydrolipids, bi awọn ceramide ti wa ni siwaju metabolized ni awọn apparatus.
(dihydro) ceramide synthase (dihydro) ceramide synthase)