to the passage below and then answer the question afterwards in the same language as the passage: Passage: As a bioactive lipid, ceramide has been implicated in a variety of physiological functions including apoptosis, cell growth arrest, differentiation, cell senescence, cell migration and adhesion. Roles for ceramide and its downstream metabolites have also been suggested in a number of pathological states including cancer, neurodegeneration, diabetes, microbial pathogenesis, obesity, and inflammation.Ceramides induce skeletal muscle insulin resistance when synthesized as a result of saturated fat activation of TLR4 receptors. Unsaturated fat does not have this effect. Ceramides induce insulin resistance in many tissues by sign inhibition of AktP/KBaling. Aggregation of LDL cholesterol by ceramide causes LDL retention in cervical walls, leading to atherosclerosis. Ceramides at the end of the coronary artery. Ceramides at the end of the coronary artery. Ceramides at the end of the coronary
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