Depp ni a bi ni Owensboro, Kentucky, awọn youngest ti mẹrin omo ti Betty Sue Palmer (née Wells), a waiter, ati John Christopher Depp, a civil engineer. Depp gbe nigbagbogbo nigba ti o wà kekere. Oun ati awọn arakunrin rẹ gbe ni diẹ ẹ sii ju 20 orisirisi awọn ibi, nikẹhin yanju ni Miramar, Florida ni 1970. Depp ká obi kọ ni 1978 nigbati o wà 15.
Ọdún 1970