Passage: The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses, although there may be an exception in the prefrontal cortex, where evidence points to a possibly larger role of the norepinephrine transporter.DAT is implicated in a number of dopamine-related disorders, including attention deficit hyperactivity disorder, bipolar disorder, clinical depression, and alcoholism. Gene ambayo inajumuisha protini ya binadamu inayopatikana kwenye kromosomu ya DAT 5, inajumuisha kromosomu 15 za dopamine na kutolewa baadaye. Uthibitisho wa DAT unaweza kuelezewa kwa muda mrefu kama kiunganishi cha maumbile kati ya aina ya protini ya dopamine, ambayo inaweza kuelezewa
Jeni ambayo encodes protini DAT iko katika binadamu chromosome 5, ina 15 encoding exons, na ni takriban 64 kbp kwa muda mrefu