Andika mwendelezo wa aya hii - Mwishowe alipoteza taji lake mnamo 1985 kwa Garry Kasparov, ambaye mtindo wake wa mbinu ya fujo ulikuwa tofauti kabisa na mtindo wa msimamo wa Karpov. Wawili wao walipigana mechi tano za ushindani wa dunia, Mashindano ya Dunia ya Chess ya 1984
(majadiliano kumalizika bila matokeo na Karpov kuongoza +5 −3 =40), World Chess Championship 1985 (ambayo Kasparov alishinda cheo, 13<unk>11), World Chess Championship 1986 (kwa uchache alishinda na Kasparov, 121⁄2<unk>111⁄2), World Chess Championship 1987 (iliyochorwa 12<unk>12, Kasparov kuhifadhi cheo), na World Chess Championship 1990 (tena kwa uchache alishinda na Kasparov, 121⁄2<unk>111⁄2).