Passage: De novo synthesis of ceramide begins with the condensation of palmitate and serine to form 3-keto-dihydrosphingosine. Mmenyuko huu ni catalyzed na enzyme serine palmitoyl transferase na ni kasi-kuzuia hatua ya njia. Kwa upande wake, 3-keto-dihydrosphingosine ni kupunguzwa kwa dihydrosphingosine, ambayo ni kisha ikifuatiwa na acylation na enzyme (dihydro) ceramide synthase kuzalisha dihydroceramide. Mwisho mmenyuko wa kuzalisha ceramide ni catalyzed na dihydroceramide desaturase. De novo synthesis of ceramide hutokea katika endoplasmic reticulum. Ceramide ni baadaye kusafirishwa kwa vesicular kwa ama ceramide trafficking au kuhamisha protini spingolipid.
(dihydro) ceramide synthase