Passage: The precise mechanisms underlying gestational diabetes remain unknown. The hallmark of GDM is increased insulin resistance. Pregnancy hormones and other factors are thought to interfere with the action of insulin as it binds to the insulin receptor. The interference probably occurs at the level of the cell signaling pathway beyond the insulin receptor. Since insulin promotes the entry of glucose into most cells, insulin resistance prevents glucose from entering the cells. As a result, glucose remains in the bloodstream, where glucose levels rise. More insulin is needed to overcome this resistance; about 1.5<unk>2.5 times more insulin is produced in a normal pregnancy. Insulin resistance is a normal phenomenon emerging in the second trimester of pregnancy, which in progress of GDM is increased insulin resistance to levels there seen in a non-pregnant person with type 2 diabetes. It is thought to interfere with the action of insulin as it binds to the insulin receptor. Interference probably occurs at the level of the cell signaling pathway beyond the insulin receptor. Since insulin promotes the entry of glucose into most cells, insulin resistance prevents glucose from ent
Upinzani wa insulini