Kammala jumla mai zuwa: Tare da Jonathan Palmer ya yi ritaya daga tuki a ƙarshen 1989 da sabon abokin aiki a Satoru Nakajima, Alesi ya zama babban direban Tyrrell a 1990 don abin da zai zama shekararsa ta farko a cikin tseren Grand Prix (kafin farkon kakar 1990, Alesi yana da tsere 8 kawai a cikin Formula One). A taron farko, United States Grand Prix a Phoenix, ya jagoranci zagaye 25 a gaban Ayrton Senna tare da motar da ke amfani da Ford V8 na abokin ciniki wanda aka yi la'akari da cewa ya fi ƙasa da V10 Honda a McLaren na Senna, kuma ya sake wuce Senna bayan da Brazilian ya fara jagorantar jagorancin. Na biyu a cikin
Monaco Grand Prix ya biyo bayan matsayi na biyu da aka samu a Phoenix, kuma a tsakiyar kakar, manyan kungiyoyi sun yi kira ga ayyukansa a 1991. Wani yanayi mai rikitarwa ya ɓarke, tare da Tyrrell, Williams, da Ferrari duk suna da'awar sun sanya hannu kan direban a cikin ɗan gajeren lokaci. Sakamakon ya ragu a lokacin sauran kakar 1990, kuma Alesi ya gama na tara a gasar, tare da maki 13.