Ka kammala wannan furcin: Manzo Bulus ya yi amfani da wannan hanyar a tafiyarsa ta biyu na wa'azi a ƙasashen waje sa'ad da ya yi tafiya daga Filibi zuwa Tasalonika (Ayyukan Manzanni 16-17). Hakanan ya taka muhimmiyar rawa a lokuta da yawa a cikin tarihin Roman: sojojin Julius Kaisar da Pompey sun yi tafiya tare da Via Egnatia a lokacin yakin basasa na Kaisar, kuma a lokacin
Mark Antony da Octavian sun bi Cassius da Brutus tare da Via Egnatia zuwa haɗuwarsu mai ban mamaki a yakin Philippi. Wasu abubuwa da suka wanzu sun nuna cewa sarki Trajan ya yi gyare-gyare mai yawa a kan hanyar kafin yaƙin da ya yi da mutanen Parthia a shekara ta 113. Koyaya, a ƙarni na 5 AD hanyar ta ɓace sosai sakamakon tashin hankali a cikin yankin. Wani ɗan tarihi na ƙarni na biyar ya lura cewa ɓangarorin yamma na Via Egnatia sun lalace sosai da ba za a iya wucewa ba.