Kammala jumla mai zuwa: Shiga tsakani a Latin Amurka ya kasance ƙaramin batun kamfen; Harding ya yi magana game da shawarar Wilson na aika sojojin Amurka zuwa Jamhuriyar Dominica, kuma ya kai wa dan takarar mataimakin shugaban kasa na Democrat, Franklin D. Roosevelt hari saboda rawar da ya taka a cikin
Shiga tsakani na Haiti. Sakataren Harkokin Wajen Hughes ya yi aiki don inganta dangantakar da kasashen Latin Amurka wadanda suka yi taka tsantsan game da amfani da Amurka na Monroe Doctrine don tabbatar da sa hannu; a lokacin da aka rantsar da Harding, Amurka kuma tana da sojoji a Cuba da Nicaragua. Sojojin da ke zaune a Cuba don kare bukatun Amurka sun janye a 1921, amma sojojin Amurka sun kasance a cikin sauran ƙasashe uku ta hanyar shugabancin Harding. A watan Afrilu na 1921, Harding ya sami amincewa da Yarjejeniyar Thomson <unk> Urrutia tare da Colombia, yana ba wa wannan al'umma $ 25,000,000 a matsayin sasantawa don juyin juya halin Panamanian da Amurka ta haifar a 1903. Kasashen Latin Amurka ba su gamsu sosai ba, yayin da Amurka ta ƙi yin watsi da shiga tsakani, kodayake Hughes ya yi alƙawarin iyakance shi ga ƙasashen da ke kusa da Canal na Panama kuma ya bayyana abin da burin Amurka yake.