Kammala jumla mai zuwa: Bayan asarar Cyprus ga Ottomans a cikin Ottoman <unk> Venetian War na huɗu (1570 <unk> 1573), tsibirin Crete ("Masarautar Candia") ita ce babbar mallaka ta ƙarshe ta Venice. Matsayinta mai mahimmanci ya sanya ta a bayyane manufa don fadada Ottoman a nan gaba, yayin da girmansa da ƙasa mai ni'ima, tare da mummunan yanayin kagarai, ya sanya shi kyauta mai ban sha'awa fiye da Malta. A bangaren Venetian, "Serenissima", tare da rauni na soja da kuma dogaro da cinikayya ba tare da katsewa ba, ya damu da kada ya tsokane Ottomans. Saboda haka Venice ta kiyaye sharuddan yarjejeniyarta da Ottomans, ta tabbatar da dangantakar zaman lafiya na shekaru sittin. Bugu da ƙari, a farkon ƙarni na 17, ikon Venetian ya ragu sosai. Tattalin arzikinta, wanda ya taɓa bunƙasa saboda ikonsa kan kasuwancin kayan ƙanshi na Gabas, ya sha wahala sakamakon buɗe sabbin hanyoyin kasuwanci na Atlantic, da kuma asarar babbar kasuwar Jamus saboda Yaƙin Shekaru talatin. Bugu da ƙari, Jamhuriyar ta shiga cikin jerin yaƙe-yaƙe a arewacin Italiya kamar
Yaƙin Mantuan kuma ya ƙara raunana ta hanyar barkewar annobar cutar a 1629 <unk> 1631.