Rubuta ci gaba don wannan sakin layi - A cikin 1627, layin kai tsaye na dangin Gonzaga ya ƙare tare da Vincenzo II mara kyau da rauni, kuma Mantua a hankali ya ragu a ƙarƙashin sabbin masu mulki, Gonzaga-Nevers, reshen Faransa na dangin. Yaƙin Gasar Mantuan
ya ɓarke, kuma a cikin 1630 rundunar Imperial na 36,000 Landsknecht sojoji suka kewaye Mantua, kawo annoba tare da su. Ferdinand Carlo IV, mai mulki mara kyau, wanda kawai sha'awarsa shine gudanar da bukukuwa da wasan kwaikwayo, ya haɗu da Faransa a cikin War of Succession na Spain. Bayan da Faransa ta sha kaye, ya nemi mafaka a Venice kuma ya tafi da hotuna dubu. Bayan mutuwarsa a shekara ta 1708, an ayyana Duke na Mantua a matsayin wanda aka tsige shi kuma danginsa na Gonzaga sun rasa Mantua har abada a cikin Habsburgs na Austria.