Rubuta ci gaba don wannan sakin layi - Antonio Nariño ne ya fara motsi, wanda ya yi adawa da tsarin mulkin Spain kuma ya jagoranci adawa da Viceroyalty. Cartagena ta zama mai zaman kanta a watan Nuwamba 1811. A cikin 1811 an ayyana lardunan United na New Granada, wanda Camilo Torres Tenorio ya jagoranta. Fitowar ra'ayoyi daban-daban guda biyu a tsakanin 'yan kishin kasa (federalist da centralism) ya haifar da wani lokaci na rashin kwanciyar hankali. Ba da daɗewa ba bayan yaƙe-yaƙe na Napoleonic ya ƙare, Ferdinand VII, wanda aka mayar da shi a kan kursiyin Spain, ba zato ba tsammani ya yanke shawarar aika sojojin soja
don dawo da mafi yawan arewacin Kudancin Amirka. An dawo da mataimakin sarki a karkashin umarnin Juan Sámano, wanda mulkinsa ya hukunta waɗanda suka shiga cikin ƙungiyoyin kishin ƙasa, ba tare da la'akari da nuances na siyasa na juntas ba. Hukuncin ya haifar da sabon tawaye, wanda, tare da raunana Spain, ya ba da damar samun nasarar tawaye wanda aka haife shi Simón Bolívar, wanda aka haife shi a Venezuela, wanda a karshe ya ayyana 'yancin kai a 1819. An ci nasara da juriya na Mutanen Espanya a 1822 a yankin Colombia na yanzu kuma a 1823 a Venezuela.