Ka cika wannan jumla: An yi ta muhawara ko an yi nufin Otranto ta zama tushe don ƙarin nasara. A kowane hali, sultan Ottoman ba su daina burinsu na karɓar tsibirin Italiya ba kuma a ƙarshe su kafa mulkin Islama bayan cin Constantinople. Bayan cin nasarar Ragusa (Dubrovnik) da Hungary a 1526 da kuma cin nasarar sojojin Turkiyya a
Vienna a 1529, jiragen ruwa na Turkiyya sun sake kai hari kan kudancin Italiya. An kori Reggio a cikin 1512 ta shahararren ɗan corsair na Turkiyya Khayr al-Din, wanda aka fi sani da laƙabi na Barbarossa; a cikin 1526 Turks sun sake kai wa Reggio hari, amma a wannan lokacin sun sami koma baya kuma an tilasta su juya idanunsu zuwa wani wuri. A shekara ta 1538 suka ci sojojin Venetian. A cikin 1539 'yan fashin teku na Barbary sun mamaye Nice (kewaye da Nice), amma yunƙurin Turkawa ya sauka a Sicily ya gaza, kamar yadda yunkurin cin nasarar Pantelleria a 1553 da kewaye da Malta a 1565.