Kammala jumla mai zuwa: Bayan kakar wasa ta 2004 wanda Cardinals ya jagoranci NL a cikin gudu (855) yayin da ya ba da izinin mafi ƙarancin (659), La Russa's Cardinals ya ci Los Angeles Dodgers a cikin National League Division Series, wasanni 3 zuwa 1. Daga nan sai St. Louis ya dauki Houston Astros a cikin
Gasar Zakarun Ƙasa. A cikin jerin rikice-rikice tare da dan wasan da ke adawa da Roger Clemens a saman wasan nasa, dan wasan Cardinals na uku Scott Rolen ya buga wasan da ya lashe wasan biyu daga Clemens a wasan na 7 bayan Jim Edmonds ya ci nasara. Wannan gida ya aika da Cardinals zuwa gasar cin kofin duniya a karo na farko tun 1987. Koyaya, sun haɗu da ƙungiyar Boston Red Sox waɗanda suka shawo kan raunin 3-0 a kan New York Yankees waɗanda suka share su a wasanni huɗu.