Rubuta ci gaba ga wannan sakin layi - Daga baya aka daukaka Mistrangelo zuwa babban bishop na Florence a ranar 19 ga Yuni 1899, kuma ya yi aiki a matsayin babban janar na Piarists daga 1900 zuwa 1904 kuma. Paparoma Benedict XV ya sanya shi babban firist-firist na S. Maria degli Angeli a cikin babban taron ranar 6 ga Disamba, 1915. Ya kasance ɗaya daga cikin 'yan majalisa waɗanda suka halarci taron 1922 na papal conclave
, wanda ya zaɓi Paparoma Pius XI.