Kammala jumla mai zuwa: Da farko an kafa shi a matsayin "Squadron na 22nd (Interceptor) " a cikin 1939, an fara tura shi zuwa Caribbean kafin a tura shi zuwa Ingila da Turai daga 1944. Bayan yakin duniya na biyu, rukunin ya koma aikinsa na farko na kare kariya
Canal na Panama, kafin a sake turawa zuwa Turai a 1948. Ya kasance a can har zuwa 1991, lokacin da wasu sassan rundunar suka koma Saudi Arabiya da Turkiyya. An kashe rundunar a shekarar 2010 don hadawa da rundunar mayakan ta 23 kuma an sake sanya ta a matsayin rundunar mayakan ta 480. A lokuta daban-daban a lokacin da yake wanzu, rundunar ta tafi da sunayen da ake kira "Stingers", "Adlers", "Bees", "Bumblebees" da kuma "The BIG 22: Last of the Red Hot Fighter Squadrons".