Kammala jumla mai zuwa: Grand Duchy na Moscow karkashin Vasili III ya kama Smolensk a 1514, amma ya sake rasa shi a 1611 a lokacin Yakin Poland-Muscovite na 1605-1618 sakamakon Siege na Smolensk (1609-1611). An haɗa yankin a cikin Polish-Lithuanian Commonwealth a matsayin tashin tashin Smolensk Voivodeship. A karni na 17, Rus 'a karkashin ikon Rasha ya yi kokarin kawo birnin a cikin fadada jihar sake, kuma duk da shan kashi a cikin "
Smolensk War" (1632<unk>1634) Tsardom na Rasha ya kama garin a 1654 a lokacin da tawayen Dnieper Cossacks a cikin Khmelnytsky Rising (1648<unk>1657) ya shagaltar da Commonwealth.