Rubuta ci gaba don wannan sakin layi - Ya taba zama magajin garin Bilbao tsakanin 1938 da 1939, a lokacin yakin basasar Spain. Bayan 'yan Nationalists sun ci yaƙin an nada shi jakadan Faransa tsakanin 1939 da 1944. Ya fifita Nazi Jamus a lokacin Yaƙin Duniya na Biyu, kuma ya rubuta rahotannin anti-Semitic game da Firayim Minista Édouard Daladier da magajinsa Paul Reynaud. Daga baya Philippe Petain ya yi amfani da de Lequerica a matsayin mai shiga tsakani don neman tsagaita wuta
daga Wehrmacht. A cikin shekarar da ta gabata ta yakin an nada shi Ministan Harkokin Waje, kuma ya yanke dangantakar diflomasiyya da Masarautar Japan a matsayin ramuwar gayya ga kisan kiyashi na Manila. Ya ci gaba da aiki a matsayin jakada a Amurka tsakanin 1951 da 1954, kuma ya kasance mai tasiri a cikin tsara Yarjejeniyar Madrid. Daga nan ya yi aiki a matsayin wakilin dindindin na Spain a Majalisar Dinkin Duniya tsakanin 1956 da 1963.