Rubuta ci gaba don wannan sakin layi - Suleiman the Magnificent (1520<unk>1566) ya kama Belgrade a 1521, ya ci kudancin da tsakiyar sassan Masarautar Hungary a matsayin wani ɓangare na Ottoman-Hungarian Wars, kuma, bayan nasararsa ta tarihi a Yaƙin Mohács a 1526, ya kafa mulkin Ottoman a yankin Hungary na yanzu (ban da yammacin) da sauran yankunan Turai ta Tsakiya. Sa'an nan kuma ya kewaye Vienna
a 1529, amma ya kasa kama birnin. A shekara ta 1532, ya sake kai hari kan Vienna, amma an sake shi a Siege of Güns. Transylvania, Wallachia da, lokaci-lokaci, Moldavia, sun zama masu ba da gudummawa ga Daular Ottoman. A gabas, Turks na Ottoman sun kwace Baghdad daga Farisa a 1535, suna samun iko da Mesopotamiya da kuma damar jirgin ruwa zuwa Tekun Fasha. A shekara ta 1555, an raba Caucasus a hukumance a karo na farko tsakanin Safavids da Ottomans, "yanayin da ake ciki" wanda zai kasance har zuwa ƙarshen Yaƙin Russo-Turkish (1768<unk>1774). Ta hanyar wannan rarrabuwa na Caucasus kamar yadda aka sanya hannu a cikin Zaman Lafiya na Amasya, Yammacin Armenia, yammacin Kurdistan, da Yammacin Georgia (ciki har da yammacin Samtskhe) sun fada hannun Ottoman, yayin da kudancin Dagestan, Gabashin Armenia, Gabashin Georgia, da Azerbaijan suka kasance Farisa.