Rubuta ci gaba don wannan sakin layi - Honda ya shiga Formula One a matsayin mai tsarawa a karo na farko a kakar 1964 a gasar Grand Prix ta Jamus tare da Ronnie Bucknum a motar. 1965 ya ga Richie Ginther ya kara da tawagar, wanda ya zira kwallaye na farko na Honda a Grand Prix na Belgium, da kuma nasarar farko ta Honda a Grand Prix na Mexico. 1967 ya ga nasararsu ta gaba a Grand Prix na Italiya
tare da John Surtees a matsayin direba. A 1968, an kashe Jo Schlesser a cikin Honda RA302 a Grand Prix na Faransa. Wannan bala'in tseren, haɗe da wahalar kasuwancin su na sayar da motoci a Amurka, ya sa Honda ta janye daga duk wasannin motsa jiki na duniya a wannan shekarar.