Kammala jumla mai zuwa: Sojojin saman Amurka, gami da Air Force Reserve da Air National Guard, sun tashi F-16 a yaƙi yayin Operation Desert Storm a 1991 da kuma a Balkans daga baya a cikin 1990s. F-16s kuma sun yi sintiri a wuraren da ba a tashi ba a Iraqi a lokacin Ayyukan Arewacin Tsaro da Kudancin Tsaro kuma sun yi aiki a lokacin yaƙe-yaƙe a Afghanistan (Operation Enduring Freedom) da Iraki (Operation Iraqi Freedom) daga 2001 da 2003 bi da bi. A shekara ta 2011, F-16s na Sojan Sama sun shiga cikin
shiga tsakani a Libya.