Kammala jumla mai zuwa: Lokacin da Operation Barbarossa ya fara a ranar 22 ga Yuni, 1941, sai Manjo Seryugin ya umurci rundunar a kan Kudu maso Yammacin Yamma, ya jagoranci shi a cikin Border Battles yammacin Stanislav da kuma a cikin Vinnytsia yankin kudu da Uman. A watan Satumba an ba shi umurnin rundunar 124th Rifle Division amma ba a dauki umurnin ba saboda an kama 124th a cikin kewaye. A maimakon haka an nada Seryugin a matsayin shugaban ma'aikata na rukunin 'yan bindiga na 212, wanda ya yi yaƙi da shi a cikin Donbass Defensive da
Barvenkovo<unk>Lozovaya kai hari a matsayin wani ɓangare na rundunar soja ta 6 na Kudu maso Yammacin Yamma. A watan Mayu na shekarar 1942 an nada Kanar Seryugin mataimakin kwamandan sashen, yayin da ya ci gaba da zama shugaban ma'aikatanta. Ya yi yaƙi da shi a cikin Yaƙin Kharkov na biyu, lokacin da aka kewaye sashin. A farkon watan Yuni Seryugin ya ɓace daga kewaye kuma ya haye zuwa gabashin bankin Seversky Donets tare da ragowar 212th.