Kammala jumla mai zuwa: Shekaru aru-aru, har zuwa Rarraba Poland, Opatów ya kasance muhimmiyar cibiyar yanki na Kananan Poland. A lokacin mamayewar Tatars (1502), an lalata garin. A shekara ta 1514, an canja shi zuwa Krzysztof Szydłowiecki, wanda ya maido da shi, ya kewaye shi da katanga mai kariya, ya gina kagara da ofisoshi ga karamar hukumar, kuma ya inganta samar da ruwa ga mazauna. Opatów yana da bukukuwa biyu na shekara-shekara da ranakun kasuwa biyu a mako. Birni ne mai zaman kansa, wanda ke cikin gundumar Sandomierz a cikin Sandomierz Voivodeship a lardin Lesser Poland na Poland Crown. A karni na 16, Opatów yana da yawan mutane kusan 4,000 kuma shine birni mafi girma a lardin, har ma ya fi Sandomierz girma. Garin ya kasance cibiyar rayuwar siyasa ta Voivodeship; a nan Janar Sejmiks na Lesser Poland Szlachta nobility ya faru. A cikin 1551 Opatów ya ƙone kusan gaba ɗaya. Babban wuta ya nuna raguwar garin a hankali. A shekara ta 1655, an lalata Opatów a cikin
mamayewar Sweden zuwa Poland. Har ila yau, garin ya sha wahala a lokacin wasu rikice-rikice da suka hada da Babban Yakin Arewa, da Bar Confederation, da Yakin Poland da Rasha na 1792, da kuma Kościuszko Rising. Ya kasance na iyalai masu daraja da yawa (Iyalin Tarnowski, dangin Ostrogski, dangin Lubomirski, dangin Potocki, da dangin Karski), kuma ya kasance a hannun masu zaman kansu har zuwa 1864.