Kammala jumla mai zuwa: A ranar 4 ga Yuli, 2010, Sabathia ya sami zaɓin All-Star na huɗu, kuma na farko a matsayin Yankee. A lokacin hutu na All-Star, Sabathia ya kasance 12<unk>3 tare da 3.09 ERA a cikin wasan kwaikwayo 131 (19 farawa). A ranar 22 ga watan Agusta, Sabathia ya yi rikodin farawa na 16 a jere na akalla innings shida yana ba da gudummawar gudummawa uku ko ƙasa da haka, ya karya dangantaka da Ron Guidry (daga Cy Young Award-winning 1978 season) don mafi tsawo a cikin tarihin franchise. An karya layinsa a farkon farkonsa a ranar 28 ga watan Agusta, inda ya ba da izini biyar a cikin wasanni bakwai zuwa Chicago White Sox. Lokacin 2010 shine na farko a cikin aikin Sabathia wanda ya lashe wasanni 20. Ya ƙare kakar wasa tare da nasara 21, mafi yawa a cikin manyan wasannin, a kan asarar 7 kawai. A cikin wasannin da aka buga, Sabathia ya buga 3.18 ERA da 1.19 WHIP, ya ba da 209 hits, ya buga 197 batters a kan 74 tafiya, ya jefa wasanni biyu cikakke, kuma ya riƙe abokan adawar zuwa.239 batting average. 26 daga cikin farawa 34 sun kasance farawa na inganci, mafi girma a cikin aiki. Yankees sun lashe AL Wild Card bayan sun gama na biyu a AL Gabas zuwa Tampa Bay Rays tare da rikodin 95 <unk> 67. Duk da buga rikodin 2<unk>0 a cikin wasanni uku na wasan kwaikwayo a wannan shekara, Sabathia ya buga 5.63 ERA a cikin 16 innings kamar yadda Yankees suka ci nasara a cikin
ALCS da Texas Rangers a wasanni shida. Ya gama na uku a cikin AL Cy Young Award da aka zaɓa bayan Félix Hernández da David Price, da kuma na 13 a cikin MVP.