Rubuta ci gaba ga wannan sakin layi - An kira Núñez zuwa manyan majalisa a karo na farko a ranar 19 ga Agusta, 2010 bayan da aka sanya Lance Berkman a cikin jerin nakasassu na kwanaki 15. Núñez ya fara wasa a wannan ranar, ya maye gurbin Jeter a zagaye na bakwai kuma ya yi laifi a cikin bayyanarsa ta farantin kawai. Núñez ya sami lokacin wasa a matsayin mai cikawa ga Jeter da kuma Alex Rodriguez wanda ya ji rauni a lokacin. A ranar 21 ga watan Agusta, Núñez ya yi rikodin babban wasansa na farko, wanda ya ci gaba da RBI a filin dama. Núñez ya buga wasan farko a wasan da ya yi da Chicago White Sox a ranar 28 ga Agusta, 2010. Har ila yau, ya sace aikinsa na farko a wannan rana. A cikin wasanni 30 don Yankees, Núñez ya buga.280, tare da gudu guda ɗaya, RBIs bakwai, kuma ya zira kwallaye 12. Lokacin da Mark Teixeira ya ji rauni a lokacin gasar zakarun Amurka ta 2010
, Yankees sun maye gurbinsa a jerin sunayensu na postseason tare da Núñez. Bayan kakar wasa, "Baseball America" ya kimanta shi a matsayin na takwas mafi kyawun fata a cikin kungiyar Yankees, yayin da kuma ya sanya shi a matsayin "Mafi kyawun Mai Tsaron Tsaro" da "Mafi kyawun Infield Arm" a cikin kungiyar Yankees.