Kammala wannan jumla: A watan Oktoba na 2020, kamfanin kera injuna Honda ya ba da sanarwar cewa zai kawo karshen cikakken aikinsa a cikin Formula One a ƙarshen kakar 2021. Verstappen yana da kwangila don ci gaba da yin tsere don ƙungiyar tare da ƙwararren ɗan Meziko Sergio Pérez ya zama abokin aikinsa yayin da Albon ya ɗauki matsayin direba na ajiya. Verstappen ya ɗauki matsayi na farko a gasar Bahrain Grand Prix da aka buɗe kakar. Verstappen daga baya ya wuce Sergio Pérez a gasar cin kofin duniya.
2021 Emilia Romagna Grand Prix, amma ya ci gaba da lashe tseren kuma ya kasance maki ɗaya kawai a bayan Lewis Hamilton a cikin gasar zakarun Turai. A Grand Prix na Monaco, Red Bull Racing ya jagoranci gasar zakarun Turai a karo na farko tun bayan Grand Prix na Brazil na 2013 sakamakon wani nasarar Verstappen da kuma mummunan sakamako ga Mercedes. Verstappen ya kuma jagoranci gasar a karon farko a rayuwarsa bayan tseren. A Grand Prix na Azerbaijan Verstappen ya jagoranci mafi yawan tseren kuma ya yi nasara kafin ya yi tseren taya wanda ya haifar da tutar ja. Abokin Verstappen Pérez ya lashe tseren bayan kuskuren Hamilton a sake farawa. Verstappen sannan ya ɗauki matsayi na farko kuma ya ci tsere uku masu zuwa yayin da Pérez ya ɗauki ƙarin podium a Faransa don haɓaka jagorancin Red Bull. Sannan a Silverstone Red Bull an doke su a ranar Juma'a amma Verstappen ya lashe gasar farko ta F1 a ranar Asabar don samun matsayi na 4 a jere. A lokacin tseren, duk da haka, Hamilton da Verstappen sun yi karo a Copse corner wanda ya haifar da babbar hadari na 51G. An kai Verstappen asibiti don binciken kariya amma an dauke shi ba shi da rauni. A Hungary duka Red Bulls sun sha wahala sosai a hatsarin farko da aka fara da Mercedes-Valtteri Bottas. Pérez ya fita daga tseren, Verstappen ya sami damar ceton wurin 9th. A Spa Verstappen ya ɗauki matsayi na farko kuma ya lashe tseren da aka rage ruwan sama wanda aka ba da rabin maki. Wannan ita ce tsere mafi guntu a tarihin F1.