Ka kammala wannan magana: Duk da nasarar da Pizarro ya yi da sauri, 'yan Indiya sun soma tawaye kuma sun ci gaba da yin hakan a kai a kai a lokacin mulkin mallaka. A shekara ta 1537 Manco Inca, wanda Mutanen Espanya suka naɗa a matsayin sarki ɗan raɗaɗi, ya yi tawaye da sababbin sarakuna kuma ya sake kafa jihar "neo-Inca". Wannan jihar ta ci gaba da ƙalubalantar ikon Spain har ma bayan da Mutanen Espanya suka danne tawayen kuma suka fille kan Túpac Amaru a dandalin Cuzco a shekara ta 1572. Daga baya tawaye a tsaunukan Bolivia galibi dattawan al'umma ne suka shirya su kuma sun kasance na gida ne, ban da
babban tawayen Túpac Amaru II a karni na goma sha takwas.