Rubuta ci gaba don wannan sakin layi - Rikicin da ya daɗe ya ƙare tattalin arzikin Jamhuriyar, wanda ya dogara da cinikin riba tare da Daular Ottoman. A cikin 1660s, duk da karuwar taimako daga sauran ƙasashen Kirista, gajiyar yaƙi ta fara. Ottomans a gefe guda, sun sami damar ci gaba da dakarun su a Crete kuma sun sake samun ƙarfi a ƙarƙashin ƙwarewar jagorancin dangin Köprülü, sun aika da babban kamfen na ƙarshe a cikin 1666 a ƙarƙashin kulawar kai tsaye na Grand Vizier. Wannan ya fara mataki na ƙarshe kuma mafi zubar da jini na Siege na Candia, wanda ya ɗauki fiye da shekaru biyu. Ya ƙare tare da mika wuya na sansanin soja, yana rufe makomar tsibirin kuma ya kawo karshen yakin a nasarar Ottoman. A cikin yarjejeniyar zaman lafiya ta ƙarshe, Venice ta ci gaba da riƙe da ƙananan tsibirin tsibirin Crete, kuma ta sami wasu nasarorin ƙasa a Dalmatia. Burin Venetian na "ramako" zai haifar, bayan shekaru 15 kawai, zuwa sabon yaƙi
, daga abin da Venice zai fito da nasara. Crete, duk da haka, zai kasance a ƙarƙashin ikon Ottoman har zuwa 1897, lokacin da ya zama ƙasa mai cin gashin kanta; a ƙarshe ya haɗu da Girka a shekara ta 1913.