An ce aikin Newton ya "ci gaba da ci gaba da kowane reshe na ilmin lissafi sannan ya yi nazari". Ayyukansa a kan batun da ake kira fluxions ko lissafi, wanda aka gani a rubuce-rubuce na Oktoba 1666, yanzu an buga shi a cikin takardun lissafin lissafin Newton. Marubucin rubutun De analysi per aequationes numero terminorum infinitas, wanda Isaac Barrow ya aika wa John Collins a watan Yuni na 1669, Barrow ya gano shi a cikin wasika da aka aika wa Collins a watan Agusta na wannan shekarar a matsayin "[...] na gwaninta da ƙwarewa a cikin waɗannan abubuwa". Newton daga baya ya shiga cikin rikici tare da Leibniz a kan fifiko a ci gaban lissafi (Leibniz<unk>Newton gardama). Yawancin masana tarihi na zamani sun yi imanin cewa Leibniz da Leibniz sun ci gaba da kansu, kodayake tare da nau'ikan lissafin lissafi daban-daban. Ba a buga shi a ƙarƙashin takardun lissafi na lissafin lissafin lissafi ba. Newton ya ba da cikakken bayani game da wannan hanyar lissafin lissafin lissafi ba har sai bayan 1684 a cikin littafin
Newton da Leibniz