Cika wannan magana: A shekara ta 2005, ya jagoranci White Sox zuwa gasar zakarun Amurka ta farko
pennant tun 1959, da kuma su na farko World Series nasara tun 1917 tare da 4-game sweep na Houston Astros. Guillén ya yi iƙirarin cewa zai iya yin ritaya bayan kakar wasan 2005 idan White Sox ta lashe gasar cin kofin duniya, amma a lokacin faretin bikin Gasar Zakarun Duniya ya sami farin ciki daga magoya bayan lokacin da ya sanar da cewa zai dawo ya jagoranci kakar wasa mai zuwa. White Sox ya karbi zaɓi na 2006 a kan kwangilarsa, ya kara da shekaru biyu kuma ya hada da wani zaɓi don kakar 2009. A watan Nuwamba, Guillén an zabe shi a matsayin Manajan Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin Wasannin.