Ka cika wannan jumla: Mayawa ne suka fara zama a inda Guatemala City take a yau, kuma suka gina birnin Kaminaljuyu. Ƙungiyar
Mutanen Espanya masu mulkin mallaka sun kafa wani ƙaramin gari, wanda aka mai da shi babban birni a shekara ta 1775. A wannan lokacin an gina Babban Filin tare da Cathedral da Royal Palace. Bayan 'yancin kai na Amurka ta Tsakiya daga Spain, garin ya zama babban birnin lardunan Amurka ta Tsakiya a 1821.