A 1856 Kekulé ya zama Privatdozent a Jami'ar Heidelberg. A 1858 aka hayar da shi a matsayin cikakken farfesa a Jami'ar Ghent, sa'an nan a 1867 aka kira shi zuwa Bonn, inda ya kasance ga sauran aikinsa. Bisa ga ra'ayoyinsa game da wadanda suka riga ya kasance kamar Williamson, Edward Frankland, William Odling, Auguste Laurent, Charles-Adolphe Wurtz da sauransu, Kekulé shi ne babban mai tsara ka'idar tsarin sunadarai (1857<unk>58). Wannan ka'idar ta fito ne daga ra'ayin atomic valence, musamman ma tetravalence na carbon (wanda Kekulé ya sanar a ƙarshen 1857) da kuma ikon carbon atoms don haɗawa da juna (wanda aka sanar a cikin wata takarda da aka buga a 1858), duk da haka an kira shi a matsayin farfesa a Jami'ar Ghent, sa'an nan kuma a 1867 aka kira shi zuwa Bonn, inda ya kasance har yanzu yana aiki a matsayin farfesa a jami'ar ilimin kimiyyar kwayoyin halitta. Amma duk da haka, a farkon shekarun 1858 ya bayyana a matsayin mai amfani da irin
Tsarin sunadarai