Kammala wannan magana: A 1499, Louis XII na Faransa ya kaddamar da yakin Italiya na biyu, ya mamaye Lombardy kuma ya kama Duchy na Milan. Sai ya ƙulla yarjejeniya da Ferdinand na I na Spain don ya raba birnin Naples. A shekara ta 1502, sojojin Faransa da na Spain sun kame mulkin; rashin jituwa game da sharuddan rabuwa ya haifar da yaƙi tsakanin Louis da Ferdinand. A shekara ta 1503, Louis, da aka ci nasara a
Yaƙin Cerignola da Yaƙin Garigliano, an tilasta masa janyewa daga Naples, wanda aka bari a ƙarƙashin ikon mai mulkin Spain, Gonzalo Fernández de Córdoba. A halin yanzu, Paparoma Alexander VI ya yi ƙoƙari ya sassaƙa jihar Borgia daga Romagna ta hanyar ƙoƙarin Cesare Borgia.