Kammala wannan jumla: DeChambeau ya fara wasan farko na PGA Tour a matsayin mai son a watan Yunin 2015 a FedEx St. Jude Classic kusa da Memphis, Tennessee, kuma ya gama a matsayi na 45. Ya buga wasan farko a gasar zakarun Turai a
US Open a Chambers Bay, amma ya rasa yankewa ta hanyar bugun jini hudu. DeChambeau bai iya kare taken NCAA a 2016 ba bayan da NCAA ta ba da sashen wasannin motsa jiki na SMU. Ya yanke shawarar yin watsi da kakar wasan sa ta farko don yin wasa a wasu abubuwan da suka faru kafin ya zama kwararre. A Masters na Australiya na 2015 a watan Nuwamba, DeChambeau ya kasance mai tsere tare da John Senden da Andrew Evans, harbi biyu a bayan mai nasara Peter Senior. Ya kasance mafi ƙarancin mai son a Masters a 2016 kuma ya daidaita a matsayi na 21.