Ka cika wannan jumla: D'Escoto ya ji an kira shi ya zama firist kuma ya shiga makarantar Maryknoll Missionary Society a shekara ta 1953. An naɗa shi firist na Society a 1961 kafin ya shiga siyasa. Ya sami digiri na biyu na digiri na digiri daga Jami'ar Columbia Graduate School of Journalism a shekara mai zuwa, kuma ya kasance muhimmin adadi a cikin kafa gidan buga littattafai na Maryknoll, Orbis Books, a 1970. Ya yi aiki a matsayin jami'in Majalisar Coci na Duniya. A matsayin mai bin tauhidin 'yanci, ya shiga Sandinistas a ɓoye. D'Escoto ya kafa Gidauniyar Nicaraguan don Ci gaban Al'umma na Ciki (FUNDECI) a watan Janairun 1973 don inganta martanin da ba na gwamnati ba ga dubban mutane da suka yi hijira a yankin.
Girgizar kasa ta Managua a watan Disamba na shekara ta 1972. Ya ci gaba a matsayin Shugaban FUNDECI, wanda ke aiki a sassan da dama a Nicaragua har zuwa mutuwarsa a shekarar 2017.