Rubuta ci gaba don wannan sakin layi - A lokacin rayuwar annabin musulunci Muhammad, wasu daga cikin abokansa na kusa sun kasance 'yan kabilar Kalb, kamar Zayd ibn Harithah da Dihya al-Kalbi, amma yawancin kabilar sun kasance Krista a lokacin mutuwar Muhammad a 632. Kalb ya kafa alaƙar siyasa da aure tare da dangin Umayyad, kuma su ne babban tushen ikon soja da siyasa a lokacin mulkin Khalifan Umayyad Mu'awiya I, Yazid I, Mu'awiya II da Marwan I. A lokacin mulkin Umayyad na farko Kalb ya zama babban mai yaƙi a cikin rikici mai tsawo na Qays<unk>Yaman a matsayin babban kabilar ƙungiyar ƙabilar Yaman. A karkashin jagorancin su, Yaman ya yi mummunan rauni ga Qays a yakin Marj Rahit.
a cikin 684. A lokacin Kalb sun fi mayar da hankali ne a cikin filayen da ke kusa da Homs da Palmyra kuma Qays sun kore su daga Samawah a ƙarshen 680s.