Rubuta ci gaba don wannan sakin layi - Bayan zaben 2013 ya haifar da sakamako mara kyau, kuma bayan tattaunawar tsakanin shugabannin jam'iyyun, Shugaba Giorgio Napolitano ya baiwa Letta aikin kafa gwamnatin hadin kan kasa da ta kunshi PD dinsa, da 'yanci na' yanci na 'yanci (PdL) da kuma Civic Choice na tsakiya, don rage matsalolin tattalin arziki da zamantakewa da ke damun Italiya sakamakon Babban koma bayan tattalin arziki. Bayan yarjejeniya tsakanin bangarorin, Letta ya yi murabus a matsayin Mataimakin Sakataren PD kuma an nada shi Firayim Ministan Italiya a ranar 28 ga Afrilu 2013. Gwamnatinsa ta yi ƙoƙarin haɓaka farfadowar tattalin arziƙi ta hanyar tabbatar da yarjejeniyar kuɗi daga Tarayyar Turai don sauƙaƙa rashin aikin yi na matasa, kuma ta kuma kawar da tallafin jihar ga jam'iyyun siyasa, wani abu da aka gani a matsayin lokacin da ake amfani da shi don siyasar siyasar Italiya wanda shekaru da yawa ya dogara da kudaden jama'a. Letta kuma ta fuskanci farkon matakan rikicin bakin haure na Turai, gami da hatsarin jirgin ruwa mafi muni
a cikin tarihin kwanan nan na Tekun Bahar Rum; a matsayin martani, Letta ya aiwatar da Operation Mare Nostrum don yin sintiri a kan iyakokin teku da kuma ceton bakin haure.