A shekara ta 2004, Seyfried ta fara fitowa a fim din a cikin wasan kwaikwayo na matasa Mean Girls. Ayyukan da ta biyo baya sun kasance a fina-finai masu zaman kansu, irin su wasan kwaikwayo Nine Lives (2005) da kuma wasan kwaikwayo na Alpha Dog (2006). Ta kuma yi rawar gani a kan jerin shirye-shiryen talabijin na UPN Veronica Mars (2004<unk>06).
'Yan mata masu mugunta