A tserensa na farko tare da Alpine, Alonso ya yi ritaya bayan da tarkacen filastik ya shiga tashar birki. A cikin
2021 Emilia Romagna Grand Prix ya gama a P11 bayan ya cancanci P15, tare da abokin aikinsa Ocon wanda ya gama a P10, amma dukansu sun haɓaka matsayi ɗaya bayan an hukunta Kimi Räikkönen, yana ba Alonso maki na farko na kakar. A gasar Grand Prix ta Hungary ta 2021, Alonso ya jagoranci tseren na ɗan lokaci kafin ya shiga rami kuma ya sauka zuwa na huɗu, a gaban Lewis Hamilton. Abokin aikinsa Ocon ya yaba da tsaron Alonso a kan Hamilton tare da ba shi damar cimma nasarar tserensa na farko. A watan Agusta 2021, Alonso ya yi amfani da zaɓi don tsawaita kwantiraginsa na kakar wasa.