Kammala jumla mai zuwa: A karkashin Sultan Selim I (1512-1520), Ottomans sun kayar da Safavids a yakin Chaldiran (1514). Maigidansa, Suleiman the Magnificent (1520-1566), Daular Ottoman ta nuna mafi girman ƙarfinta da wadata da kuma mafi girman ci gaban gwamnati, zamantakewa, da tsarin tattalin arziki. Tuni da yake sarrafa Balkans, ya sami damar mamaye Hungary kuma ya ci nasara a Yaƙin Mohács (1526). Duk da haka, ƙarin ci gaba ya kasa bayan da
Siege na Vienna (1529). Bayan nasarar da aka yi a cikin yakin Preveza (1538) da yakin Djerba (1560), Ottomans kuma sun fito ne a matsayin babban iko na teku a cikin Bahar Rum. Wani jirgin ruwa ya kai Aceh Sultanate a shekara ta 1565. A farkon ƙarni na 17, daular ta ƙunshi larduna 32 da kuma jihohi masu yawa. Wasu daga cikin waɗannan daga baya aka shiga cikin Daular Ottoman, yayin da wasu aka ba su nau'ikan cin gashin kai daban-daban a cikin ƙarni.