An haifi Isaac Newton (bisa ga kalandar Julian, wanda aka yi amfani da shi a Ingila a lokacin) a ranar Kirsimeti, 25 ga Disamba, 1642 (NS 4 Janairu 1643) "sa'a daya ko biyu bayan tsakar dare", a Woolsthorpe Manor a Woolsthorpe-by-Colsterworth, wani ƙauye a cikin gundumar Lincolnshire. Mahaifinsa, wanda ake kira Isaac Newton, ya mutu watanni uku kafin. An haife shi da wuri, Newton ɗan ƙarami ne; mahaifiyarsa Hannah Ayscoughly ta ba da rahoton cewa zai iya shiga cikin kwata kwata. Lokacin da Newton ya kasance uku, mahaifiyarsa ta sake yin aure kuma ta tafi ta zauna tare da sabon mijinta, Reverend Barnabas Smith, ta bar ɗanta a kula da mahaifiyarsa, Margery Ayscough.
kakarsa ta mahaifiyarsa, Margery Ayscough