Rubuta ci gaba don wannan sakin layi - Lokacin da Ferdinando ya mutu a 1626, ɗan'uwansa Vincenzo II (1594<unk>1627), shi ma kardinal, ya gaje shi a matsayin Duke na Mantua da Montferrat. Duk da yin aure, bayan da Ferdinando ya yi murabus da kuma korar Vincenzo daga Kwalejin Cardinals (saboda keta dokar rashin aure), ba su haifi 'ya'ya na halal ba. Wani sabon rikici ya ɓarke lokacin da Vincenzo II ya mutu a ranar 26 ga Disamba, 1627, wanda ya haifar da Yaƙin Nasara na Mantuan
(1627 zuwa 1632).