Rubuta ci gaba don wannan sakin layi - Sintians, Meadi da sauran mutane sun kasance tare da Perseus kuma sun yi yaƙi da Romawa da himma. Koyaya, a cikin Yaƙin Pydna (168 BC) Romawa sun ci nasara kuma sun ci masarautar Makidoniya. Bayan haka an raba masarautar zuwa kasashe hudu kuma an hada Sintice a cikin na farko tare da Amphipolis a matsayin babban birni. Daga baya, bayan yakin Philipi
a cikin 42 BC tsohuwar babban birnin Sintice, Heraclea, an sanya shi "gari mai 'yanci" kamar yadda Titus Livy ya ambata. Har yanzu yana wanzu a ƙarni na 10 AD lokacin da Hierocles da Constantine VII Porphyrogennetos suka ambata shi a karo na ƙarshe.