A cikin ƙarni na 19 da 20, kafin ingantaccen magani na magani don hauhawar jini ya zama mai yiwuwa, an yi amfani da hanyoyi uku na jiyya, duk tare da sakamako masu yawa: ƙuntataccen sodium (alal misali abincin shinkafa), sympathectomy (cirewar tiyata na ɓangarorin tsarin juyayi), da kuma maganin pyrogen (injection na abubuwan da ke haifar da zazzabi, kai tsaye rage karfin jini). An yi amfani da sinadarin farko don hauhawar jini, sodium thiocyanate, a cikin 1900 amma yana da sakamako masu illa da yawa kuma ba a san shi ba. An kirkiro wasu magunguna da yawa bayan Yaƙin Duniya na biyu, mafi mashahuri da kuma inganci mai inganci wanda shine tetramethylammonium hexamide, chloronium, hydralazine, da renia sulphate (wanda aka samo daga tsire-tsire na tsire-tsire).
ƙuƙwalwa