Kammala jumla mai zuwa: Babban rikicin farkon mulkinsa shine Yaƙin Bar Confederation (1768<unk>1772) wanda ya haifar da Raba na Farko na Poland (1772). A ƙarshen mulkinsa ya ga gyare-gyaren da Diet (1788 <unk> 1792) da Kundin Tsarin Mulki na 3 ga Mayu 1791 suka yi. Wadannan gyare-gyare sun rushe ta Targowica Confederation na 1792 da kuma
Yakin Poland-Rasha na 1792, wanda ya kai tsaye zuwa Raba na Biyu na Poland (1793), Kościuszko Rising (1794) da na ƙarshe da Raba na Uku na Poland (1795), wanda ke nuna ƙarshen Commonwealth. An cire shi daga kowane iko mai ma'ana, Poniatowski ya yi murabus a watan Nuwamba 1795 kuma ya yi shekaru na ƙarshe na rayuwarsa a matsayin fursuna a cikin Fadar Marmara ta Saint Petersburg.