Rubuta ci gaba don wannan sakin layi - Shiga tsakani a Latin Amurka ya kasance ƙaramin batun kamfen; Harding ya yi magana game da shawarar Wilson na aika sojojin Amurka zuwa Jamhuriyar Dominican da Haiti, kuma ya kai wa dan takarar mataimakin shugaban kasa na Democrat, Franklin Roosevelt hari saboda rawar da ya taka a cikin shiga tsakani na Haiti
Ka yi haƙuri. Da zarar an rantsar da Harding, Hughes ya yi aiki don inganta alaƙar da ke tsakanin ƙasashen Latin Amurka waɗanda suka yi taka tsantsan game da amfani da Amurka na Monroe Doctrine don ba da hujjar sa hannu; a lokacin rantsar da Harding, Amurka kuma tana da sojoji a Cuba da Nicaragua. Sojojin da ke zaune a Cuba don kare bukatun Amurka sun janye a 1921; Sojojin Amurka sun kasance a cikin sauran ƙasashe uku ta hanyar shugabancin Harding. A watan Afrilu na 1921, Harding ya sami amincewa da Yarjejeniyar Thomson <unk> Urrutia tare da Colombia, yana ba wa wannan al'umma dala miliyan 25 (daidai da dala miliyan a cikin) a matsayin sasantawa don juyin juya halin Panamanian da Amurka ta jawo na 1903. Kasashen Latin Amurka ba su gamsu sosai ba, kamar yadda Amurka ta ƙi yin watsi da shiga tsakani, kodayake Hughes ya yi alƙawarin iyakance shi ga ƙasashen da ke kusa da Canal na Panama, da kuma bayyana abin da burin Amurka yake.