Rubuta ci gaba don wannan sakin layi - Duk da nasarar Pizarro da sauri, 'yan tawayen Indiya ba da daɗewa ba suka fara kuma suka ci gaba lokaci-lokaci a duk lokacin mulkin mallaka. A shekara ta 1537 Manco Inca, wanda Mutanen Espanya suka naɗa a matsayin sarki ɗan raɗaɗi, ya yi tawaye da sababbin sarakuna kuma ya sake kafa jihar "neo-Inca". Wannan jihar ta ci gaba da ƙalubalantar ikon Spain har ma bayan da Mutanen Espanya suka danne tawayen kuma suka fille kan Túpac Amaru a dandalin Cuzco a shekara ta 1572. Daga baya tawaye a tsaunukan Bolivia galibi dattawan al'umma ne ke shirya su kuma sun kasance na gida ne, ban da babban tawaye
na Túpac Amaru II a cikin karni na goma sha takwas.