Kammala jumla mai zuwa: Musulunci ya fara isa Urfa a kusan 638 AD, lokacin da yankin ya mika wuya ga rundunar Rashidun ba tare da tsayayya ba, kuma ya zama muhimmiyar kasancewa a ƙarƙashin Ayyubids (duba: Saladin Ayubbi), Seljuks. A cikin 1144, jihar Crusader ta faɗi ga Janar Zengui na Turkiyya, wanda ya kashe yawancin mazaunan Kirista tare da babban bishop na Latin (duba
Siege na Edessa) da kuma Crusade na Biyu da suka biyo baya sun kasa dawo da birnin. Daga baya, Zengids, Ayyubids, Sultanate of Rum, Ilkhanids, Memluks, Akkoyunlu da Safavids suka mallaki Urfa kafin mamayar Ottoman a 1516.