Kammala wannan jumla: A cikin jerin wasannin da aka yi da Houston Astros a watan Yunin 2010, Posada ya zama dan wasan Yankee na farko tun Bill Dickey a 1937 don buga babban wasa a wasannin baya-baya. A ranar 23 ga Yuli, 2010, Posada ya rubuta aikinsa na 1,000 na RBI a kan Kansas City Royals. Posada ya gama shekara ta 2010 yana buga.248 tare da gida 18 da 57 RBIs. Yankees sun sake shiga wasan karshe amma sun yi rashin nasara a hannun Texas Rangers a
ALCS na shekara ta 2010.