Kammala wannan jumla: Sintians, Meadi da sauran mutane sun goyi bayan Perseus kuma sun yi yaƙi da Romawa da himma. Koyaya, a cikin Yaƙin Pydna (168 BC) Romawa sun ci nasara kuma sun ci masarautar Makidoniya. Bayan haka an raba masarautar zuwa kasashe hudu kuma an hada Sintice a cikin na farko tare da Amphipolis a matsayin babban birni. Daga bisani, bayan da
Yaƙin Philipi a cikin 42 BC tsohuwar babban birnin Sintice, Heraclea, an sanya shi "gari mai 'yanci" kamar yadda Titus Livy ya ambata. Har yanzu yana wanzu a ƙarni na 10 AD lokacin da Hierocles da Constantine VII Porphyrogennetos suka ambata shi a karo na ƙarshe.