Rubuta ci gaba don wannan sakin layi - Bayan mutuwar mijinta na farko, Thomas Henry Watkins, Preston ya fara aiki a matsayin mai zane don tallafawa kanta. Ta yi hulɗa da nunawa tare da masu zane-zane na Makarantar Ashcan kuma ta auri ɗaya daga cikin rukunin, James Moore Preston, a cikin 1903. Sun yi tafiya zuwa Turai tare, sun yi bazara a Long Island, kuma sun yi hoto tare da labarin mujallar. Ta zama mai zane mai nasara ga mujallu, kamar "Harper's Bazaar" da "The Saturday Evening Post", kuma ta kasance mai zane mai nasara. An yi la'akari da daya daga cikin manyan mata masu zane-zane tsakanin 1900 da 1940, Preston na ɗaya daga cikin 'yan mata da kuma masu nunawa na Society of Illustrators, an shigar da su a ranar 29 ga Maris, 1904 bayan takwarorinsu Florence Scovel Shinn, Elizabeth Shippen Green, Violet Oakley, da Jessie Willcox Smith. Kamar su, ta kasance memba ne kawai tunda ba a ba mata cikakken memba ba har zuwa 1920s. Ta nuna a 1913 Armory Show kuma ta lashe lambar yabo a Panama <unk> Pacific Exposition
a shekara ta 1915. Preston yana daya daga cikin manyan masu zane-zane. Ayyukanta suna cikin tarin kayan tarihi da yawa. Ta buga kanta babi na fim din "Our Mutual Girl" wanda aka nuna a cikin gidajen wasan kwaikwayo a 1915.