Rubuta ci gaba ga wannan sakin layi - A cikin yakin basasa na Liberators
Daga 43 zuwa 42 BC, Cleopatra ya kasance tare da Roman Triumvirate na biyu wanda babban dan uwan Kaisar da magaji Octavian, Mark Antony, da Marcus Aemilius Lepidus suka kafa. Bayan ganawarsu a Tarsus a 41 BC, sarauniyar ta yi lalata da Antony. Ya aiwatar da hukuncin kisa na Arsinoe a kan buƙatarta, kuma ya zama mai dogaro da Cleopatra don tallafin kuɗi da taimakon soja yayin mamaye Daular Parthia da Masarautar Armenia. Donations na Alexandria sun bayyana 'ya'yansu Alexander Helios, Cleopatra Selene II, da Ptolemy Philadelphus masu mulki a kan yankuna daban-daban na baya a ƙarƙashin ikon nasara na Antony. Wannan taron, aurensu, da sakin Antony na 'yar'uwar Octavian Octavia Minor ya haifar da Yaƙin Karshe na Jamhuriyar Roma. Octavian ya shiga cikin yakin farfaganda, ya tilasta wa abokan Antony a Majalisar Dattijan Roma su gudu daga Roma a shekara ta 32 kafin haihuwar Yesu, kuma ya yi yaƙi da Cleopatra. Bayan kayar da jiragen ruwa na Antony da Cleopatra a 31 BC Battle of Actium, sojojin Octavian sun mamaye Misira a 30 BC kuma sun kayar da Antony, wanda ya kai ga Antony ya kashe kansa. Lokacin da Cleopatra ta fahimci cewa Octavian ya shirya ya kawo ta zuwa ga nasarar da ya yi a Roma, ta kashe kanta ta hanyar guba, akasin yarda da cewa wani asp ya cije ta.