Rubuta ci gaba ga wannan sakin layi - A ranar 27 ga Fabrairu 2010, Cotillard shi ne Shugaban girmamawa na lambar yabo ta César ta 35
bikin. Ta taka leda Mal Cobb, wani tsinkaya na halin Leonardo DiCaprio, marigayi matar Dom Cobb a cikin fim din Christopher Nolan "Inception", wanda kuma ya hada da Tom Hardy, Joseph Gordon-Levitt, Cillian Murphy, Ken Watanabe, Michael Caine da Elliot Page, wanda aka saki a ranar 16 ga Yuli 2010. Nolan ya bayyana Mal a matsayin "mahimmancin mace mai banƙyama", kuma DiCaprio ya yaba da aikin Cotillard yana cewa "tana iya zama mai ƙarfi da rauni da bege da ɓacin rai duk a lokaci guda, wanda ya dace da duk saɓani na halinta". Cotillard da Leonardo DiCaprio sun kasance a matsayi na 8 a jerin Forbes na "Ma'aurata Mafi Girma a Hollywood" don "Farawa", wanda ya sami dala miliyan 825 a ofishin akwatin duniya. A wannan shekarar, ta kuma taka rawa a wasan kwaikwayo na Guillaume Canet "Little White Lies" ("Les petits mouchoirs"), tana wasa da mai kare muhalli Marie, tare da Jean Dujardin da François Cluzet.