Kammala wannan jumla: Andy Murray ya fara kakar wasa ta 2016 ta hanyar wasa a
Kofin Hopman, ya sake haɗuwa da Heather Watson. Duk da haka, sun gama na biyu a rukunin su. Murray ya buga gasar gasa ta farko a shekarar 2016 a gasar Australian Open inda yake da burin lashe taken sa na farko a can bayan da ya zama na biyu sau hudu. Ya ci gaba da kaiwa wasan karshe na biyar na Australian Open amma ya yi rashin nasara a wasan karshe ga Novak Djokovic a cikin saiti. Ya zama mutum na biyu a cikin Open Era (bayan Ivan Lendl) don rasa wasan karshe na Grand Slam biyar a wani taron, kuma kawai wanda bai lashe taken ba. Daga nan Murray ya buga gasar cin kofin Davis inda ya doke Taro Daniel a cikin madaidaiciyar saiti da Kei Nishikori a cikin saiti biyar. Murray ya yi gasa a Indian Wells Masters da Miami Open amma ya sha wahala a zagaye na uku na kowane taron zuwa Federico Delbonis da Grigor Dimitrov, bi da bi. Murray ya fara kakar wasan sa a kotun yumbu a Monte-Carlo Rolex Masters da ya yi rashin nasara a hannun zakara Rafael Nadal a wasan kusa da na karshe duk da cewa ya lashe wasan farko. Daga nan Murray ya buga a gasar Mutua Madrid Open a matsayin mai lamba 2 kuma zakara mai karewa, amma ya sake rasa lambar 1 Djokovic a cikin saiti uku a wasan karshe. Ya nemi taken sa na farko na kakar wasa a Masters na Rome, inda ya sami nasararsa ta farko a kan Djokovic a kan yumbu, lokacin da ya doke Serbian a wasan karshe. Daga nan sai Murray ya koma gasar French Open, inda ya zama dan wasan Burtaniya na farko tun bayan Bunny Austin a 1937, don isa wasan karshe na French Open. Bai sami damar lashe wasan karshe na Faransanci na Faransanci ba, ya rasa Djokovic a cikin saiti hudu.