Kammala jumla mai zuwa: Pirlo ya kammala kakar wasa ta lashe gasar 2011-12 Serie A, bayan ya taimaka wa Juventus ta samu nasara a kan Cagliari da 2-0. Ya samar da mafi yawan taimako a Serie A a wannan kakar, tare da 13, kuma ya kuma sami bayan raga sau uku a gasar. Pirlo ya ƙirƙiri dama sama da 100 kuma ya kammala wucewa 2643 a wannan kakar, tare da ƙimar kammalawar wucewa 87%, ya kammala wucewa 500 fiye da kowane ɗan wasa a Serie A; dan wasa daya tilo a duniya da ya kammala wucewa fiye da shi a wannan kakar shine Xavi. Sakamakon wasan kwaikwayonsa a duk tsawon kakar, da kuma babban rawar da ya taka wajen jagorantar Juventus zuwa taken Serie A na farko a cikin shekaru tara, an sanya shi a cikin Serie A Team of the Year, tare da abokin wasan tsakiya na Juventus Vidal. Pirlo da Juventus suma sun gama tsere zuwa Napoli a wasan karshe na Coppa Italia a wannan kakar. Kyakkyawan yanayin Pirlo a kakar 2011-12, wanda ya jagoranci Juventus zuwa gasar zakarun Turai,
Supercoppa Italiana da Coppa Italia Final, tare da jagorantar Italiya zuwa wasan karshe na Euro 2012, ya ga an zaɓe shi don Kyautar Mafi Kyawun Playeran wasa a Turai na UEFA na 2012, wanda ya gama na 4. An kuma zaɓe shi ya kasance wani ɓangare na 2012 ESM Team of the Year da 2012 UEFA Team of the Year.