Ka cika wannan magana: A farkon ƙarni na 15, Yahudawa suka soma zama a Łuków. Wasu sun ce Yahudawa sun zo a tsakiyar ƙarni na 13. A ƙarni na 16, an riga an kafa ƙungiyar Yahudawa. An gina majami'a ta farko a garin a karni na 16, kodayake daga baya ya ƙone a wuta. A shekara ta 1648, tawayen Khmelnytsky a matsayin wani ɓangare na Cossack Uprisings, wanda Bohdan Khmelnytsky ya jagoranta, ya haifar da hare-hare da asarar nauyi ga al'ummar Yahudawa na Łuków, wanda kuma ya ga tafiye-tafiye da yawa da dakarun sojoji. A shekara ta 1655, al'ummar Yahudawa sun fuskanci kisan kiyashi, wanda mutanen Muscovites suka shirya kuma ya shafi yankuna da yawa na Poland. Ƙungiyar gida ta Łuków ta sami mutuwar 1000. An ƙone sabon majami'ar kuma an lalata gidajen Yahudawa da yawa. Wannan ya biyo bayan Ruwan Ruwan Sweden (1657), a lokacin yakin tsakanin Poland da Sweden, wanda ya shafi
mamayewa da Sarki Carl Gustav da abokinsa na Transylvanian, yarima Rakocy suka umarta. Wannan lokacin ya kawo mummunan sakamako ga garin. A watan Afrilu na 1657, garin ya lalace gaba daya sakamakon mamayewar sojojin Sweden da Transylvanian, kuma kusan yahudawa 1000 suka rasa rayukansu.