Rubuta ci gaba don wannan sakin layi - Mascherano ya buga wasanni 147 ga tawagar 'yan wasan Argentina kuma shi ne na biyu mafi yawan' yan wasa a tarihin kasar (bayan Lionel Messi). Daga farkonsa a 2003 har zuwa lokacin da ya yi ritaya a 2018, ya wakilci kasar a gasar cin kofin Copa América guda biyar, inda ya zama na biyu a 2004
, 2007, 2015, da 2016, da kuma gasar cin kofin duniya ta FIFA guda hudu, inda suka kai wasan karshe a shekarar 2014. Ya lashe lambar zinare sau biyu a wasannin Olympics na bazara, a 2004 da 2008, ya zama dan wasan kwallon kafa na farko da ya cimma wannan nasarar sau biyu tun bayan Dezső Novák na Hungary a shekarar 1968. Tsakanin 2008 da 2011, Mascherano ya yi aiki a matsayin kyaftin na Argentina.