Kammala wannan jumla: A shekara ta 2005, Buehrle ya fara kakar wasa tare da rikodin 10<unk>3, 2.58 ERA da 1.11 WHIP. A ranar 16 ga Afrilu, ya gama wasa da Seattle Mariners a cikin awa 1 da mintuna 39, ya ba da gudu ɗaya kawai da hits uku (duk ga Ichiro Suzuki), kuma ya goyi bayan White Sox biyu ne kawai, duka homers na Paul Konerko. A wasan, ya jefa kwallo 106 kawai. Rage lokacin da aka kashe tsakanin innings, wasan ya ɗauki mintuna kaɗan don wasa. An zabi Buehrle a cikin kungiyar ta American League All-Star Team, kuma an sanya shi a matsayin mai farawa bayan Roy Halladay ba zai iya yin wasa ba saboda karyewar kafa kuma ya jefa innings biyu, ba da izinin gudu ba kuma ya buga 'yan wasa uku yayin samun nasara. Buehrle ya fara farawa 49 na jere na shida ko fiye da innings ya ƙare a ranar 1 ga Agusta, 2005 bayan da aka fitar da shi don buga Baltimore Orioles outfielder B. J. Surhoff. A lokacin wasan White Sox na wasan kwaikwayo, Buehrle ya buga cikakken wasa a kan Los Angeles Angels na Anaheim a Game 2 na
ALCS, na farko daga cikin wasanni hudu a jere na White Sox starters. A ranar 25 ga Oktoba, 2005, Buehrle ya zama dan wasa na farko a tarihin World Series don farawa da kuma ceton wasanni na gaba, yana samun rashin yanke shawara a Game 2 da kuma aikinsa na farko a Game 3 na 2005 World Series, wanda Sox ya shafe daga Houston Astros, ya lashe gasar zakarun duniya ta farko tun 1917.