Rubuta ci gaba don wannan sakin layi - An kafa birnin a ƙarshen karni na 15 kuma an sa masa suna Nawab Ghazi Khan Mirani, ɗan Nawab Haji Khan Mirani, wani shugaban Balochi, wanda ya ayyana 'yancin kai daga Sultans na Langah na Multan. Tare da wasu "Deras" guda biyu watau ƙauyuka, Dera Ismail Khan da Dera Fateh Khan, sun ba da suna ga Derajat. Daga karshe Derajat ya shiga hannun Birtaniya bayan yakin Sikh.
a cikin 1849 kuma an raba shi zuwa gundumomi biyu: Dera Ghazi Khan da Dera Ismail Khan. Bayan samun 'yancin kai, yawancin mazaunan Hindu na birni sun zauna a cikin mulkin mallaka na Derawal Nagar na Delhi, Indiya. Daga baya aka fitar da gundumar Rajanpur daga gundumar Dera Ghazi Khan.