Kammala jumla mai zuwa: A ranar 23 ga Agusta, 1951, Wisner ya yi nasara da Allen W. Dulles kuma ya zama Mataimakin Daraktan na biyu na Shirye-shiryen, tare da Richard Helms a matsayin babban jami'in aikinsa. A wannan matsayi, ya taimaka wajen tallafawa sojojin Amurka da ke goyon bayan Amurka.
ya hambarar da Mohammed Mossadegh a Iran a 1953 da Jacobo Arbenz Guzmán a Guatemala a 1954. Wani aikin da ya shiga shi ne game da shugabannin 'yan sanda na Belarus, wani sashi da aka haɗa a cikin wani bangare na SS na Jamus, wanda aka taimaka wa Amurka bayan yakin duniya na biyu, saboda yawancin kokarinsa. Dangane da dokar tarayya, John Loftus ya yi iƙirarin, Ofishin Kula da Tsarin Mulki ya taimaka wajen samun biza ga masu haɗin gwiwar Nazi daga Belarus <unk> waɗanda aka yi imanin sun sauƙaƙe ayyukan zalunci da yawa da Nazi Jamus ta yi. A cewar Loftus, duk wani bangare ne na shirin Yakin Cacar Baki don gudanar da yakin basasa a Turai da Soviet ta mamaye, wanda masu haɗin gwiwar Nazi za su taka muhimmiyar rawa. Lokacin da aikin ya rushe, duk da haka, Belarusians da sauri suka zauna kuma suka sami 'yancin Amurka <unk> kuma hukumomin leken asiri sun kare su daga fallasa shekaru da yawa.