Ka cika wannan jumla: Bayan shekara ta 1850, an soma sake gina birnin Skopje bayan ya yi shekaru da yawa yana taɓarɓarewa. A wannan lokacin, garin ya sami jinkirin amma ci gaba da ƙaruwa na yawan jama'a, galibi saboda ƙauracewar ƙauyukan Slavic Macedonians. An kuma ciyar da shi ta hanyar ƙaura daga Musulmai daga Serbia da Bulgaria, waɗanda ke samun ikon mallaka da 'yanci daga Daular a wancan lokacin. A lokacin gyare-gyaren Tanzimat, kishin kasa ya tashi a cikin Daular kuma a cikin 1870 an kafa sabuwar Cocin Bulgarian kuma an kirkiro diocese ta daban, bisa asalin kabilanci, maimakon ka'idodin addini. Yawan mutanen Slavic na bishopric na Skopje sun jefa kuri'a a cikin 1874 da yawa, da kashi 91% a cikin goyon bayan shiga cikin Exarchate kuma ya zama wani ɓangare na Bulgarian Millet. An ba da izinin ci gaban tattalin arziki ta hanyar gina layin dogo na Skopje-Salonica a 1873. An gina tashar jirgin kasa a kudancin Vardar kuma wannan ya ba da gudummawa ga sake komawa ayyukan tattalin arziki a wannan gefen kogin, wanda ba a taɓa birgewa ba a baya. Saboda ƙaura daga ƙauyuka, adadin Kiristoci a cikin mazaunan birni ya ƙaru. Wasu daga cikin sababbin sun zama wani ɓangare na ƙwararrun 'yan ƙasa kuma sun taimaka wajen yada ra'ayoyin kasa. Skopje na ɗaya daga cikin manyan cibiyoyi biyar na Ƙungiyar Juyin Juya Halin Macedonia ta ciki lokacin da ta shirya 1903
Tashin hankali na Ilinden. Cibiyar sadarwa ta juyin juya hali a yankin Skopje ba ta ci gaba sosai ba kuma rashin makamai babbar matsala ce. A lokacin da aka fara tayar da kayar baya sojojin 'yan tawaye sun rushe wani jirgin soja. A ranar 3 ga Agusta da 5 ga Agusta, sun kai hari kan wani rukunin Ottoman da ke gadin gadar a kan kogin Vardar kuma sun yi yaƙi a cikin gidan sufi na "St. Jovan". A cikin 'yan kwanaki masu zuwa' yan Bashibozuks da yawa suka bi sahun kungiyar kuma suka koma Bulgaria.