Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: Acetylsalicylic acid acid ne mai rauni, kuma kadan daga cikin shi ne ionized a cikin ciki bayan da aka ba da baki. Acetylsalicylic acid yana saurin sha ta cikin membrane na sel a cikin yanayin acidic na ciki. Ƙara yawan pH da kuma babban yanki na ƙananan hanji yana sa aspirin ya sha a hankali a can, kamar yadda ya fi yawa. Saboda samuwar takaddama, aspirin yana sha sosai a hankali yayin yawan shan magani, kuma yawan ƙwayar jini na iya ci gaba da ƙaruwa har zuwa awanni 24 bayan cinyewa. Kimanin 50<unk>80% na salicylate a cikin jini yana da alaƙa da furotin albumin, yayin da sauran ya kasance a cikin aiki, yanayin ionized; haɗin furotin ya dogara da maida hankali. Cikewar wuraren da ake ɗaurewa yana haifar da ƙarin salicylate kyauta da ƙara yawan guba. Yawan rarraba shi ne 0. 1<unk> 0. 2 L/ kg. Acidosis yana kara yawan rarrabawa saboda karuwar shigar salicylates cikin nama. Har zuwa kashi 80% na maganin maganin salicylic acid ana maye gurbinsa a cikin hanta. Haɗuwa tare da glycine yana samar da salicyluric acid, kuma tare da glucuronic acid don samar da esters glucuronide daban-daban guda biyu. Ana kiran conjugate tare da rukunin acetyl ba tare da lalacewa ba azyl glucuronide; conjugate da aka cire shi shine glucuronide na phenolic. Waɗannan hanyoyin narkar da abubuwa suna da iyaka. Hakanan ana amfani da ƙananan adadin salicylic acid zuwa acid na gentisic. Tare da manyan allurai na salicylate, kinetics suna canzawa daga tsari na farko zuwa tsari na sifili, yayin da hanyoyin narkewa suka zama cikakke kuma fitarwa ta koda ta zama mafi mahimmanci. Salicylates ana fitar da su ne ta hanyar koda a matsayin salicyluric acid (75%), salicylic acid kyauta (10%), salicylic phenol (10%), da acyl glucuronides (5%), gentisic acid (< 1%), da 2,3-dihydroxybenzoic acid. Lokacin da aka cinye ƙananan allurai (ƙasa da 250 mg a cikin balagagge), duk hanyoyin suna ci gaba ta hanyar kinetics na farko, tare da rabin rabi na kusan awa 2. 0 zuwa 4.5 h. Lokacin da aka sha salicylate da yawa (fiye da 4 g), rabin rayuwar ya zama ya fi tsayi (sa'o'i 15 zuwa 30).  Tambaya: Mene ne rarrabawar ƙarar aspirin?
0.1 zuwa 0.2 L/kg