Kammala wannan jumla: Babban shirin manufofin kasashen waje na wa'adin farko na Roosevelt shi ne Manufofin Kyakkyawan Makwabta, wanda shine sake nazarin manufofin Amurka game da Latin Amurka. Amurka ta sha shiga tsakani a Latin Amurka bayan da aka gabatar da koyarwar Monroe a 1823, kuma Amurka ta mamaye kasashe da yawa na Latin Amurka a cikin Yaƙin Banana wanda ya faru bayan Yaƙin Mutanen Espanya na Amurka na 1898. Bayan da Roosevelt ya hau mulki, ya
ya janye sojojin Amurka daga Haiti kuma ya cimma sabbin yarjejeniyoyi tare da Cuba da Panama, yana kawo karshen matsayin su a matsayin masu kare Amurka. A watan Disamba na shekara ta 1933, Roosevelt ya rattaba hannu kan Yarjejeniyar Montevideo kan Hakkoki da Ayyukan Jihohi, yana watsi da haƙƙin shiga tsakani a cikin harkokin ƙasashen Latin Amurka. Roosevelt kuma ya daidaita dangantakar da Tarayyar Soviet, wanda Amurka ta ƙi amincewa tun daga shekarun 1920. Ya yi fatan sake yin shawarwari game da bashin Rasha daga Yaƙin Duniya na I da kuma bude dangantakar kasuwanci, amma ba a sami ci gaba ba a kan kowane batun kuma "dukkanin al'ummomin sun yi takaici da yarjejeniyar".