Rubuta ci gaba don wannan sakin layi - An cire sarki mai suna Vandal mai suna Hilderic wanda dan uwansa Gelimer ya yi a 530. Tawaye da suka biyo baya a Sardinia da Tripolitania sun ba Justinian hujja don ya sa baki. Ya nada Belisarius ya jagoranci mamayar da
Mulkin Vandal a farkon 533. 'Yar Theodoric, Amalasuntha, wanda ya yi mulkin Masarautar Ostrogothic a Italiya a matsayin mai mulki ga ɗanta Athalaric, ya ba da izinin sojojin dakarun Roman su yi amfani da tashar jiragen ruwa na Syracuse a lokacin yakin. A cikin shekara guda, Belisarius ya kayar da Vandals tare da goyon bayan 'yan asalin ƙasar kuma ya ci masarautarsu. An yi shekaru da yawa ana neman kwanciyar hankali a yankunan da aka ci da yaƙi a arewacin Afirka, saboda tawaye da ƙabilu 'yan kabilar Berber suka yi da kuma haɗin kai da suka yi da sojojin Romawa masu tawaye. A Italiya, Athalaric ya mutu kuma dan uwan Amalasuntha Theodahad ya kashe ta a 535. Wani bala'in da ba a san shi ba, mai yiwuwa ƙura daga babban fashewar dutsen mai fitad da wuta, ya rufe rana tsakanin 24 ga Maris 535 da 24 ga Yuni 536. Rashin zafi ya haifar da mummunar lalacewar amfanin gona da kuma yunwa mai yawa. Bala'in bai hana Justinian ya yi yaƙi da Ostrogoths ba. A 535 Mundus ya ci Dalmatia kuma Belisarius ya kama Sicily. A cikin shekaru biyar masu zuwa, Belisarius ya mamaye kusan dukkanin Italiya, amma mulkin Ostrogothic ya tsira a arewa. Yin amfani da yawan sojojin Roma a Italiya, Bulgarian ya kaddamar da wani fashi na fashi a kan Balkans, kuma Khosrow ya ci gaba da yakin. Ya mamaye Siriya, ya kori Antakiya kuma ya dawo da ikon Sassanian akan Lazica.