Rubuta ci gaba don wannan sakin layi - Birnin yana da ƙarfi sosai, kuma, a lokacin Yaƙe-yaƙe na Italiya, ya haɗu da Faransa. An kewaye shi
sau biyu ta sojojin Paparoma a karkashin Julius II (1511), wanda da kansa ya kai wa ganuwar hari, da Julius III (1551<unk>1552). A karo na biyu, sansanin soja ya yi nasara a karkashin umurnin Ludovico Pico da Piero Strozzi. A cikin 1597, bayan ya dawo ƙarƙashin laimar masarauta, Mirandola ya sami taken birni kuma an kira Picos sarakunan Mirandola da marquesses na Concordia. A shekara ta 1617 Alessandro I ya zama duke.