Rubuta ci gaba don wannan sakin layi - "Down the Volga:" Akwai yaƙe-yaƙe da yawa na Russo-Kazan, yawanci ya haɗa da Moscow da Crimea suna tallafawa masu neman sarautar Kazan daban-daban, amma Kazan (700e, 25s) ya yi nisa da za a iya magance shi cikin sauƙi. An gina sansanonin gaba a Vasilsursk a kan Volga a ƙarƙashin Nizhny Novgorod (1523: 533e) da Sviyazhsk (1551: 675e, 25s) kusa da Kazan. An ci Kazan da yaƙi a shekara ta 1552. A shekara ta 1554, Moscow ta naɗa ɗan sarki Nogai a kan gadon sarautar Astrakhan. Lokacin da ya yi tawaye, Rasha ta haɗu da Astrakhan (1556: 700e, 1000s). (Wannan babban fadada zuwa kudu maso gabas ya dogara ne akan jigilar kogin a kan Volga, amma wannan ba a bayyana daga tushen Ingilishi ba.) A Yaƙin Rasha da Turkiyya na Farko (1568<unk>1570)
, Ottomans sun yi ƙoƙari kuma sun kasa sake dawo da Astrakhan don Musulunci. Bayan yakin Livonian, an gina sansanonin matsakaici a kan Volga: Samara (1586: 300s, 800e), Saratov (1590: 450s, 500e), Tsaritsyn (Volgograd) (1589: 800s, 400e). Tsakanin Volga da Urals Ufa (350s, 1100e) an kafa shi ne a 1574.