Rubuta ci gaba ga wannan sakin layi - A 1901, Hughes ya kammala 32 daga cikin 35 ya fara don Chicago, ciki har da innings. Duk da alamarsa 10<unk>23, a wani ɓangare saboda ƙarancin tallafi, ya yi rikodin 3.24 ya sami nasarar cin nasara yayin da ya buga abokan hamayya 225, na uku mafi kyau a kowane lokaci don rookie na National League. Ya yi tsalle zuwa gasar zakarun Amurka a kakar wasa ta gaba, yayin da yake raba lokacinsa tsakanin Baltimore da Boston. A 1903, ya zama na uku mai farawa a cikin jujjuyawar Boston, a bayan Cy Young da Bill Dinneen. Hughes ya amsa tare da alamar 20<unk>7 da 2.57 ERA, yana taimaka wa tawagarsa ta lashe taken AL. Ya buga a gasar cin kofin duniya ta farko
, rasa wasan uku.