Kammala jumla mai zuwa: Cleopatra ya yi tafiya zuwa Roma a matsayin sarauniyar abokin ciniki a cikin 46 da 44 BC, yana zama a villa. Bayan kisan gillar Kaisar a 44 BC Cleopatra ya yi ƙoƙari ya sanya Caesarion a matsayin magajinsa. Octavian (wanda aka sani da Augustus ta 27 BC, lokacin da ya zama sarki na farko na Roma) ya hana wannan. Cleopatra sa'an nan kuma ya kashe ɗan'uwansa Ptolemy XIV kuma ya ɗaukaka ɗanta Caesarion a matsayin mai mulki. A cikin
Yaƙin basasa na 'yanci na 43<unk>42 BC, Cleopatra ya kasance tare da Roman Triumvirate na biyu wanda Octavian, Mark Antony, da Marcus Aemilius Lepidus suka kafa. Ta haɓaka dangantaka ta sirri tare da Mark Antony wanda daga ƙarshe zai haifar da yara uku: tagwaye Alexander Helios da Cleopatra Selene II, da Ptolemy Philadelphus. Antony ya yi amfani da ikonsa a matsayin mai nasara don aiwatar da hukuncin kisa na Arsinoe IV a kan bukatar Cleopatra. Ya zama mai dogaro da Cleopatra don duka tallafin kuɗi da taimakon soja yayin mamayar Daular Parthian da Masarautar Armenia. Ko da yake mamayar da ya yi wa Parthia bai yi nasara ba, ya yi nasarar mamaye Armenia. Ya dawo da Sarki Artavasdes II zuwa Alexandria a shekara ta 34 kafin haihuwar Yesu a matsayin fursuna a cikin nasarar da ya yi na Roman wanda Cleopatra ya shirya. Wannan ya biyo bayan Kyautar Alexandria, wanda 'ya'yan Cleopatra tare da Antony suka sami yankuna daban-daban a ƙarƙashin ikon nasara na Antony. An kira Cleopatra Sarauniyar Sarakuna kuma Caesarion Sarkin Sarakuna. Wannan taron, tare da auren Antony da Cleopatra da saki na Octavia Minor, 'yar'uwar Octavian, sun nuna wani juyi wanda ya kai ga Yakin Ƙarshe na Jamhuriyar Roma.