Kammala wannan magana: Octavian, Mark Antony, da Lepidus sun kafa Triumvirate na biyu a 43 BC. An zabi kowannensu na tsawon shekaru biyar don dawo da tsari ga Jamhuriyar da kuma
kawo masu kisan Kaisar gaban shari'a. Cleopatra ta karbi sakonni daga Gaius Cassius Longinus, daya daga cikin masu kisan Kaisar, da kuma Publius Cornelius Dolabella, proconsul na Siriya da kuma Caesarian mai aminci, suna neman taimakon soja. Ta yanke shawarar rubuta wa Cassius uzuri cewa masarautarta tana fuskantar matsaloli da yawa na cikin gida, yayin da take aika da runduna huɗu da Kaisar ya bari a Masar zuwa Dolabella. Duk da haka, Cassius ya kama wadannan sojojin a Falasdinu, yayin da suke tafiya zuwa Siriya. Serapion, gwamnan Cleopatra na Cyprus, ya yi tawaye ga Cassius kuma ya ba shi jiragen ruwa. Cleopatra ya ɗauki rundunarsa zuwa Girka don taimaka wa Octavian da Antony. Jirginsa ya lalace sosai a cikin hadari na Bahar Rum, duk da haka, kuma ya isa marigayi don taimakawa cikin fadace-fadace. A lokacin kaka na 42 BC Antony ya ci nasara da sojojin Kaisar masu kisan kai a yakin Philippi a Girka, wanda ya haifar da kashe kansa na Cassius da Marcus Junius Brutus the Younger.