Kelly ta uku sararin samaniya ya kasance a matsayin kwamandan tawagar na STS-118, a 12-day Space Shuttle manufa ga ISS a watan Agusta 2007. Kelly ta uku sararin samaniya ya kasance a matsayin ma'aikacin jirgin sama a kan Expedition 25/26 a kan ISS. Ya isa ISS a kan Soyuz TMA-01M a ranar 9 ga Oktoba 2010, kuma ya yi aiki a matsayin injiniyan jirgin sama har sai ya karbi umurnin tashar a ranar 25 ga Nuwamba 2010 a farkon Expedition 26. Expedition 26 ya ƙare a ranar 16 ga Maris 2011 tare da tashi daga Soyuz TMA-01M. A watan Nuwamba 2012, da kuma Rasha cosmonaut Korni Mikhailko ya kasance a matsayin kwamandan jirgin sama na uku zuwa Hubble Space Telescope, kuma ya ɗauki kusan kwanaki takwas. Kelly ta uku sararin samaniya ya kasance a matsayin kwamandan jirgin sama na STS-118, wani jirgin sama na Space Shuttle na kwanaki 12 zuwa ISS a watan Agusta 2007. Kelly ta uku sararin samaniya ya kasance a matsayin ma'aikacin jirgin sama na Expedition 25/26 a kan ISS a ranar 9 ga Oktoba 2010, kuma ya yi aiki a matsayin
9 ga watan Oktoba 2010