A cikin shekarar 2000, Jolie ta fara fitowa a cikin fim dinta na farko, Gone in 60 Seconds, wanda ya zama fim dinta mafi girma a duniya, inda ta sami dala miliyan 7.23. A maimakon haka, fim din ya nuna rawar da Jolie ta yi a Hollywood. Ta lashe lambar yabo ta Golden Globe ta uku, lambar yabo ta biyu ta Screen Actors Guild, da kuma lambar yabo ta Academy don Mataimakin Mataimakin Mataimakin Mata. Don iri-iri, Emanuel Levy ya lura, "Jolie tana tsaye a matsayin yarinya mai ban sha'awa, mara alhakin da ta zama mafi mahimmanci fiye da likitoci a cikin gyaran Susanna. "A shekara ta 2000, Jolie ta fara fitowa a cikin fim dinta na farko, Gone in 60 Seconds, wanda ya zama fim dinta mafi girma a duniya, inda ta sami dala miliyan 7.23.
Kyautar Golden Globe, lambar yabo ta biyu ta Screen Actors Guild, da kuma lambar yabo ta Academy don Kyautar Mataimakin Mataimakin Mata.