<unk> <unk> <unk> <unk> <unk>  Passage: Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. <unk> Passage: Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is rapidly absorbed through the cell membrane in the acidic conditions of the stomach.<unk> Acetylsalicylic acid is rapidly absorbed through the cell membrane in the acidic conditions of the stomach.<unk> Acetylsalicylic acid is rapidly absorbed through the cell membrane in the acidic conditions of the stomach. ️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️ 80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration- dependent. <unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk><unk> 0. 2 L/ kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates. As much as 80% of therapeutic doses of salicylic acid is metabolized in the liver. <unk> <unk> <unk> <unk> <unk> <unk> <unk> <unk> <unk> <unk> These metabolic pathways have only a limited capacity. <unk> <unk> <unk> <unk> ️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️<unk>️ When small doses (less than 250 mg in an adult) are ingested, all pathways proceed by first- order kinetics, with an elimination half- life of about 2. 0 h to 4. 5 h. When higher doses of salicylate are ingested (more than 4 g), the half- life becomes much longer (15 h to 30...  Question: What is the volume distribution of aspirin?
0.2 L/kg