January 2011, Mattek-Sands waxay heshay guushii ugu weyneyd ee xirfadeeda iyadoo ka adkaatay kaalinta 7-aad ee adduunka, Francesca Schiavone. Mattek-Sands ayaa markii dambe la midoobey John Isner oo ka tirsan USA waxayna gaareen finalka Hopman Cup
, oo ka adkaatay kooxda reer Belgium ee Justine Henin iyo Ruben Bemelmans.