Ku sii qor faqradan - tartamayaasha Duesenberg waxay sii wadeen inay horumariyaan waxqabadkooda waxayna xukumayeen tartamada Indianapolis 500-mile sanadlaha ah ee 1920-meeyadii. Sanadkii 1920 Tommy Milton iyo Jimmy Murphy waxay ku guuleysteen kaalinta saddexaad iyo afaraad ee tartamayaasha Duesenberg ee sanadkaas Indianapolis 500. Tartanka tartanka ee 1921 waxaa ka mid ahaa sideed Duesenberg-dhisay tartanka. Gaariga kooxda Duesenberg, oo uu wado Roscoe Sarles, ayaa kaalinta labaad galay. Gawaarida tartanka ee ay dhistay Duesenberg waxay qaateen sideed ka mid ah tobanka boos ee ugu horeeya tartanka Indianapolis 500 ee 1922, oo ay kujirto gaariga guuleysta, oo uu wado Murphy, iyo kan labaad ee dhammeystiray, oo uu wado rookie Harry Hartz. Indianapolis 500 sanadkii 1923
waxay ahayd dhibicda ugu hooseysa ee kooxda Duesenberg. Wade Morton, darawalka kooxda Duesenberg, wuxuu bilaabay afar iyo labaatankii garoonka, laakiin wuxuu ku dhammaaday kaalinta tobnaad. Duulimaadyada dhisay Duesenberg waxay ku guuleysteen seddex ka mid ah afarta Indianapolis 500-mile tartanka u dhexeeya 1924 iyo 1927. Darawalka Lora L. Corum iyo darawalka gurmadka ah ee Joe Boyer ayaa ku guuleystay tartanka 1924; darawalka Pete DePaolo iyo darawalka gurmadka ah ee Norman Batten ayaa ku guuleystay tartanka 1925; iyo George Sanders ayaa ku guuleystay tartanka 1927 baabuur uu dhisay Duesenberg oo uu lahaa Bill White. Markii uu ku tartamayay Duesenberg sanadkii 1925, DePaolo waxa uu noqday qofkii ugu horeeyay ee ku guuleysta Indianapolis 500 miles oo celcelis ahaan ka badan. Tartanka 1926 DePaulo wuxuu ku dhammeeyey kaalinta shanaad tartankii roobku soo gaabiyey, halka gaariga kale ee kooxda Duesenberg, oo uu wado darawalkii rookie Ben Jones, uu la kulmay dhibaatooyin farsamo oo ku dhacay ka hor dhamaadka tartanka. Kooxda Duesenberg waxay sii waday inay tobanka ugu sareeya ka dhigto 1928 iyo 1929 Indianapolis 500-mile tartamada. Sanadkii 1928 tartanka Fred Frame wuxuu kaxeeyay Duesenberg si uu u dhammeeyo kaalinta siddeedaad, halka Jimmy Gleason uu kaxeeyay gaariga kooxda Duesenberg si uu u dhammeeyo kaalinta shan iyo tobnaad. Tartanka 1929 natiijooyinka kooxdu way fiicnaadeen Gleason wuxuu qaatay kaalinta saddexaad Freddy Winnai wuxuu dhammeeyey kaalinta shanaad.