4-tii Luulyo, 2010, Sabathia wuxuu helay doorashadiisii afaraad ee All-Star, iyo kii ugu horeeyay ee Yankee ah. Waqtiga nasashada All-Star, Sabathia wuxuu ahaa 12<unk>3 oo leh 3.09 ERA 131 wareeg (19 bilow). Bishii Ogosto 22, Sabathia wuxuu duubay bilowgiisii 16aad ee isku xigxiga ugu yaraan lix wareeg oo u oggolaanaya seddex dhibcood oo la kasbaday ama ka yar, isagoo jabiyay isku xirnaanta Ron Guidry (laga soo bilaabo xilli ciyaareedkii uu ku guuleystay abaalmarinta Cy Young Award ee 1978) ee taariikhda ugu dheer ee taariikhda xayeysiinta. Xilli ciyaareedkiisa ayaa la jabiyay bilowgiisii xigay ee 28-kii Ogosto, halkaas oo uu u ogolaaday shan kulan oo uu ku guuleystay toddobo wareeg oo uu u ciyaaray Chicago White Sox. Xilli ciyaareedkii 2010 wuxuu ahaa kii ugu horreeyay ee Sabathia uu ku guuleysto 20 kulan. Wuxuu xilli ciyaareedkii ku soo gabagabeeyey 21 guul, oo ah kuwa ugu badan horyaalada waaweyn, iyadoo kaliya 7 guuldaro ay soo gaareen. Innings ku dhaliyay, Sabathia wuxuu soo bandhigay 3.18 ERA iyo 1.19 WHIP, wuxuu ka tagay 209 hits, wuxuu garaacay 197 batters 74 socod, wuxuu tuuray laba ciyaarood oo dhameystiran, wuxuuna ku qabtay kuwa ka soo horjeeda.239 celcelis ahaan. 26 ka mid ah 34kii kulan ee uu ciyaaray waxa uu ahaa ciyaar tayo leh, taas oo aheyd tii ugu sareysay ee uu ciyaaro. Yankees waxay ku guuleysteen AL Wild Card ka dib markii ay ku dhammeeyeen kaalinta labaad ee AL East ee Tampa Bay Rays oo leh rikoor 95 <unk> 67. In kasta oo uu rikoor 2<unk>0 ah ku dhajiyay seddex kulan oo playoff ah sannadkaas, Sabathia wuxuu soo bandhigay 5.63 ERA 16 wareeg markii Yankees lagu guuleystay ALCS
waxaa laga badiyay Texas Rangers lix kulan. Wuxuu ku dhammeeyay kaalinta saddexaad ee codbixinta AL Cy Young Award oo ka dambeysa Félix Hernández iyo David Price, iyo sidoo kale kaalinta 13aad ee codbixinta MVP.