Ku qor sii socodka cutubkan - Oktoobar 22, 2018 dhacdo ee "Caw", Reigns wuxuu ku dhawaaqay in dib loogu helay kansarka dhiigga 11 sano kadib oo uu qaadan doono hakad si uu u daweeyo. Natiijo ahaan, wuxuu ka tanaasulay Horyaalka Caalamiga ah, isagoo soo afjaray xukunkiisii 64 maalmood. Reigns wuxuu markii hore helay falcelin kala duwan markii uu soo galay garoonka, laakiin waxaa lagu soo dhoweeyay soo dhaweyn wanaagsan iyo sidoo kale heeso ah "Waad ku mahadsan tahay, Roman!" kadib markii lagu dhawaaqay cudurka leukemia. Reigns wuxuu ku soo laabtay dhacdadii Febraayo 25, 2019 ee "Raw" si uu u shaaciyo in leukemia uu ku jiray cafis, halkaas oo uu ku helay bogaadin weyn oo ka timid dadkii badnaa. Qeybtii xigtay ee "Raw", Reigns wuxuu dib ula midoobi doonaa The Shield, taasoo keeneysa ciyaar u dhaxeysa Drew McIntyre, Bobby Lashley iyo Baron Corbin ee Fastlane
, taas oo ay The Shield ku guuleysan laheyd ciyaartii ugu horeysay ee Reigns tan iyo markii laga helay cudurka Leukemia. Labada marba, Reigns waxaa la kulmi jiray hambalyo. WrestleMania 35, Reigns wuxuu ka adkaaday Drew McIntyre kulankiisii ugu horreeyay ee keli ah tan iyo Oktoobar 2018. Si kastaba ha noqotee, wuxuu la kulmi lahaa falcelin kala duwan oo ay sameeyeen dadkii badnaa, iyadoo qoraaga "Pro Wrestling Dot Net" Jason Powell uu sheegayo in qiyaastii "70 boqolkiiba taageerayaasha ay booyeen Reigns halka kaliya 30 boqolkiiba ay u hambalyeeyeen ka hor kulanka". Waxa kale oo uu ku tilmaami jiray ciyaarta "mid niyad jab leh".