Ku dhawaad 4% kansarka sanbabada ee unugyada aan yarayn waxaa ku lug leh EML4-ALK tyrosine kinase fusion gene. Isbedelada epigenetic sida isbedelka methylation DNA, tail histone, ama maareynta microRNA waxay sababi karaan in la joojiyo firfircoonaanta unugyada asaasiga ah ee kansarka. Waxaa muhiim ah, unugyada kansarka waxay u adkeysan karaan culeyska oksidheer, taas oo u oggolaaneysa inay u adkeystaan oo ay sii xumeeyaan xaaladaha caabuqa ee nidaamka difaaca jirka.
c-MET, NKX2-1, LKB1, PIK3CA, iyo BRAF