U fiirso qoraalka hoose ka dibna ka jawaab su'aasha kadib isla luqadda qoraalka:  Gudbinta: Badal badan oo nucleophilic ah ayaa si sahlan u dhaca oo aan ku jirin pyridine saafi ah laakiin leh pyridine wax laga beddelay qaybaha bromine, chlorine, fluorine, ama sulfonic acid oo markaa noqda koox ka baxsan. marka Fluorine waa kooxda ugu wanaagsan ee badalida isku darka organolithium. Isku darka weerarka nucleophilic wuxuu noqon karaa alkoxides, thiolates, amines, iyo ammonia (cadaadis sare). Guud ahaan, ion hydride waa koox ka baxsan oo liita waxayna ku dhacdaa kaliya dhowr falcelin heterocyclic ah. Waxay ka mid yihiin falcelinta Chichibabin, oo soo saarta derivatives pyridine aminated at 2-position. Halkaan, sodium amide waxaa loo isticmaalaa sida nucleophile oo soo saarta 2-aminopyridine. Ion hydride ee la sii daayo falcelintan wuxuu isku daraa proton oo ah koox amino ah oo la heli karo, wuxuuna sameeyaa molecule hydrogen. Si la mid ah benzene, beddelaadda nucleophilic ee pyridine waxay keeni kartaa sameynta dhexdhexaadka pyridyne sida heteroaryne. Ujeedadaas awgeed, derivatives pyridine waxaa laga saari karaa kooxaha wanaagsan ee ka tagaya iyadoo la adeegsanayo saldhigyada adag sida sodium iyo potassium tert-butoxide. Ku darista nucleophile-ka ee ku xiga xidhiidhka saddex-geesoodka ah ayaa leh xulashada hoose, natiijaduna waa isku-darka labada waxyaalood ee suurtagalka ah.  Su'aal: Sodium-ka maxaa loo isticmaalaa?
nucleophile oo soo saara 2-aminopyridine