Mariano waxaa si rasmi ah ugu dallacay kooxda ugu weyn tababaraha Zinedine Zidane 20kii Ogosto 2016, ka dib dhaawac dhabarka ah oo soo gaaray weeraryahanka Karim Benzema. Hal usbuuc ka dib, Mariano wuxuu sameeyay kulankiisii ugu horreeyay ee ciyaartoyda da'da weyn intii lagu jiray guushii 2-1 ee Celta de Vigo, isagoo beddelay Álvaro Morata daqiiqadii 77-aad. Bishii Oktoobar 26, mar kale kursiga keydka, wuxuu dhaliyay goolkiisii ugu horreeyay ee "Merengues" si uu u soo gabagabeeyo guushii 7-1 ee Cultural y Deportiva Leonesa ee Copa del Rey. Ciyaartii lugta labaad, wuxuu ku daray hat-trick si uu ugu guuleysto 13<unk>2 wadarta guud, oo ay kujirto gool 23-kii labaad oo ahaa goolka ugu dhaqsaha badan kooxdiisa tartanka. Mariano wuxuu dhaliyay goolkiisii ugu horreeyay ee ugu sarreeya 10kii Diseembar, isagoo u dhigmay guushii soo noqoshada 3-2 ee uu ka gaaray Deportivo de La Coruña. Bishii la soo dhaafay, wuxuu qeyb ka ahaa kooxda ku guuleysatay Koobka Adduunka ee Kooxaha 2016.
Japan, laakiin kuma uusan soo muuqan mid ka mid ah kulamada Real Madrid. Mariano wuxuu sameeyay sideed kulan markii Madrid ay ku guuleysatay 2016 <unk> 17 La Liga. Wuxuu ahaa taageere markii Madrid ay ku guuleysatay 2016 <unk> 17 UEFA Champions League.