Magaca Ioannina wuxuu u muuqdaa markii ugu horreysay 879, qoraallada Golaha Afaraad ee Constantinople, kuwaas oo tixraacaya mid ka mid ah Zacharias, Bishop of Ioannine, oo ah sufragan of Naupaktos. Ka dib markii ay reer Byzantine qabsadeen Bulgaria
, sanadkii 1020 Emperor Basil II () wuxuu hoggaamiyay hoggaanka kiniisadda maxalliga ah ee Archbishopric of Ohrid. Heshiiskii qeybinta dhulka Byzantine kadib Dagaalkii Saddexaad ee Saliibiyiinta, Ioannina waxaa loo ballanqaaday dadka Venetians, laakiin dhacdada, waxay noqotay qayb ka mid ah boqortooyadii cusub ee Epirus, oo uu aasaasay Michael I Komnenos Doukas.