Isku darka hiddo-wadaha ayaa sidoo kale ku lug yeelan kara dayactirka DNA, gaar ahaan jawaabta unugyada ee jajabka labalaabka ah. Nooca ugu caansan ee iskudhafka hiddo-wadaha ayaa ah isku-darka isku midka ah, halkaas oo labada chromosomes ay ku lug leeyihiin taxane aad u la mid ah. Isku-darka aan isku midka ahayn wuxuu waxyeello u geysan karaa unugyada, maadaama ay soo saari karto isbeddellada hiddo-wadaha iyo cilladaha hiddo-wadaha. Falcelinta isku-darka waxaa kiciya enzymes loo yaqaan recombinases, sida RAD51.
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