In 1913 Leonor Michaelis iyo Maud Leonora Menten soo jeediyay aragti tiro of kinetics enzyme, kaas oo loo yaqaan kinetics Michaelis <unk> Menten. ka qayb weyn ee Michaelis iyo Menten ahaa in ay ka fekeraan of falcelin enzyme laba marxaladood. In ugu horeysay, substrate ku xidhan yahay reversibly in enzyme, sameynta enzyme-substrate adag. Tani waxaa mararka qaarkood loo yaqaan Michaelis-Menten adag ay sharafta u. Enzyme ka dibna catalyzes falcelinta kiimikada ee tallaabada iyo sii daayo wax soo saarka.
Ensaamyada