Dhagaxyada isku dhafan (dhagaxyada midabka bunni ah) sida caadiga ah waxay ka kooban yihiin 20<unk>80% kolestarool (ama 30<unk>70%, sida ku xusan nidaamka kala soocida Japan). Waxyaabaha kale ee caadiga ah waa kaalshiyam kaarboonaat, palmitate phosphate, bilirubin iyo pigments kale ee bile (kaalshiyam bilirubinate, kaalshiyam palmitate iyo kaalshiyam stearate). Sababtoo ah ay kaalshiyam content, waxay inta badan yihiin radiographically arki karo. Waxay sida caadiga ah ka dhashaan labaad ee caabuq ee habka biliary taas oo keenta in sii daayo ee β-glucuridase (by hepatocytes dhaawacmay iyo bakteeriyada) taas oo hydrolyzes bilirubin glucuronides oo keliya iyo kordhiyaa xaddiga bilirubin unconjugated ee bile. Inta u dhaxaysa 4% iyo 20% ee dhagaxyada ayaa isku dhafan. Gallstones kala duwanaan karaan cabbirka iyo qaabka sida hadhuudhka weyn ee ciidda si wadajir ah si ay
kaalshiyam karboonaat, kaalshiyam fosfateet ah