Sanadkii 2009, madaxweynihii dhawaan la doortay Barack Obama ayaa Panetta u magacaabay jagada Agaasimaha CIA. Panetta waxaa lagu ansixiyay Golaha Guurtida oo buuxa bishii Febraayo 2009. Maadaama uu ahaa agaasimaha CIA, Panetta wuxuu kormeeray howlgalkii lagu soo riday argagixisada caalamiga ah ee Osama bin Laden. Bishii Abriil 28, 2011, Obama wuxuu ku dhawaaqay magacaabista Panetta inuu noqdo Xoghayaha Difaaca, si uu u bedelo Robert Gates oo howlgab noqday. Bishii Juun Golaha Guurtida ayaa si aqlabiyad ah u ansixiyay Panetta wuxuuna xafiiska la wareegay bishii Luulyo 1, 2011. David Petraeus wuxuu la wareegay Agaasimaha Hay'adda Sirdoonka Dhexe bishii Sebtember 6, 2011. Tan iyo markii uu ka fariistay Xoghayaha Difaaca 2013, Panetta wuxuu ahaa Guddoomiyaha Machadka Panetta ee Siyaasadda Dadweynaha, oo ku yaal Jaamacadda California State, Monterey Bay, oo ah Jaamacadda California State oo uu ka caawiyay in la
Janaayo 2009