In dadka waaweyn, COPD, wadna xanuunka wadnaha, masaska hawada, iyo sidoo kale qufac daroogada keentay ay sabab u tahay ACE inhibitors waa in la tixgeliyaa. In labada dadweynaha codka xadhkaha laga yaabaa in si la mid ah soo bandhigaan cillad. Cudurka sambabka ee joogtada ah waxay la wadaagaan cudurka neef mareenka ee joogtada ah waxayna u dhici karaan sida dhibaato ka dhalata sigaarka joogtada ah. Ka dib da'da 65, dadka qaba cudurka neef mareenka ee joogtada ah waxay yeelan doonaan neefsashada jirka shisheeye, xadhkaha neef mareenka, laryngotracheomalacia, siddooyinka xididdada, qanjidhada xadhkaha neef mareenka ee la ballaariyay ama cufnaanta qoorta.
xannuunka sanka ee xasaasiga ah