Isku darka hiddo-wadaha waxaa ka qayb qaadan kara dayactirka DNA-da, gaar ahaan jawaabta unugyada ee jahawareerka laba-geesoodka ah. Qaabka ugu caansan ee iskudhafka hiddo-wadaha waa isku-darka isku-dhafan, halkaas oo labada chromosome ay wadaagaan taxaneyaal aad u la mid ah. Isku-darka aan isku-dhafka ahayn wuxuu waxyeello u geysan karaa unugyada, maadaama uu soo saari karo is-beddellada chromosomal iyo cillad-darrada hiddo-wadaha. Isku-darka dib-u-habeynta waxaa kiciya enzymes loo yaqaan recombinases, sida RAD51.
labo