Waxyaabaha biochemical ee antigen-antibody-ku xirnaanta isdhexgalka waxaa lagu baaray si faahfaahsan ee 1930s soo daahay by John Marrack. horumarka weyn ee soo socda waxay ahayd in 1940s, markii Linus Pauling xaqiijiyay mabda'a qufulka-iyo-furaha soo jeediyay by Ehrlich by muujinaya in isdhexgalka u dhexeeya antibodies iyo antibodies badan ku xiran yihiin ay qaab ka badan ay isku-darka kiimikada. In 1948, Astrid Fagreaus ogaaday in unugyada B, ee qaab unugyada plasma, ayaa mas'uul ka ah soo saarida antibodies. shaqada dheeraad ah ee ku lug leh tilmaamidda of proteins antibody. horumarinta badan ee kuwan daraasadaha waxaa lagu ogaaday horraantii 1960s by John Marrack.
waxay tilmaamaysaa qaab dhismeedka borotiinka antibody-ga.