Fasalka hoose ka dibna ka jawaab su'aasha ka dibna afka la mid ah sida marinka: Passage: bedelka nucleophilic badan oo ka dhaca si fudud ma la pyridine qaawan laakiin la pyridine wax laga beddelay la bromine, chlorine, fluorine, ama qaybo acid sulfonic in ka dibna noqday koox ka tagay. sidaas fluorine waa koox ka tagay ugu fiican ee bedelka la organolithium xeryahooda. xeryahooda weerar nucleophilic noqon kartaa alkoxides, thiolates, amines, iyo ammonia (mararka cadaadis sare). Guud ahaan, ion hydride waa koox ka tagay saboolka ah oo ka dhacdaa oo kaliya in dhowr falcelin heterocyclic. Waxay ka mid yihiin falcelinta Chichibabin, taas oo soo saarta derivatives pyridine aminated at booska 2-. Halkan, amide sodium waxaa loo isticmaalaa sida nucleophile soo saaro 2-yropyrine. ion hydride sii daayay in falcelinta this isku daraa proton ah amino group heli karo, ka saarida hetero benzene,
nucleophile oo soo saara 2-aminopyridine