U fiirso qoraalka hoose ka dibna ka jawaab su'aasha kadib isla luqadda qoraalka:  Isku soo wada duuboo: Nidaamka nololeed ee viruska hepatitis B aad buu u adag yahay. Hepatitis B waa mid ka mid ah pararetroviruses-yada yar ee la yaqaan: kuwa aan dib-u-noqnoqnoqnayn ee wali isticmaala transcription-ka dib-u-celinta ee habka ay u soo koobaan. Fayrasku wuxuu galayaa unugyada isagoo ku xidhanaya NTCP dusha sare iyo in la endocytosed. Sababtoo ah fayrasku wuxuu ku kordhaa RNA oo ay samayso enzyme-ka martida loo yahay, DNA-da hiddo-wadaha ee fayrasku waa in loo wareejiyaa nuqulka unugyada by borotiinka martida loo yahay ee loo yaqaan 'chaperones'. DNA-ga fayraska ee qeyb ahaan laba-geesoodka ah ayaa markaa si buuxda loogu sameeyaa laba-geesoodka by polymerase fayraska oo loo beddelaa DNA wareegsan oo covalently xiran (cccDNA). CccDNA-dani waxay u adeegtaa sida qaab-dhismeedka transcription-ka ee afar mRNAs viral by RNA polymerase. mRNA-da ugu weyn, (oo ka dheer genome-ka fayraska), waxaa loo isticmaalaa in lagu sameeyo nuqulada cusub ee genome-ka iyo in la sameeyo borotiinka udub dhexaadka ah ee loo yaqaan 'capsid core protein' iyo polymerase-ka DNA-ga fayraska. Afarta nooc ee fayraska ah waxaa lagu sameeyaa waxyaabo dheeraad ah oo ay ku sii socdaan si ay u sameeyaan virions oo laga sii daayo unugyada ama dib loogu celiyo nucleus-ka oo dib loo isticmaalo si loo soo saaro koobiyo badan. RNA-da dheer waxaa markaa dib loogu soo celiyaa cytoplasm-ka halkaas oo borotiinka virion P (DNA polymerase) uu ku soo saaro DNA iyada oo loo marayo dhaqdhaqaaqa beddelaadda transcriptase.  Su'aal: Waa kuwee fayrasyada aan dib-u-dhiska ahayn ee wali isticmaala habka bedelka difaaca?
cudurka hepatitis B