Ka dib markii ay muujiyeen in enzymes ay ka shaqeyn karaan meel ka baxsan unugyada nool, talaabada xigta waxay ahayd in la ogaado dabeecaddooda biochemical. Shaqaale badan oo hore ayaa xusay in waxqabadka enzymatic ay la xiriiraan borotiinka, laakiin saynisyahano badan (sida Nobel laureate Richard Willstätter) waxay ku doodeen in borotiinnadu ay yihiin uun kuwa xambaara enzymes-ka dhabta ah iyo in borotiinnada laftiisu aysan awood u lahayn catalysis. Si kastaba ha noqotee, 1926, James B. Sumner wuxuu muujiyey in enzyme urease uu ahaa borotiin saafi ah oo uu u sameeyay crystallized; Sumner wuxuu sidaas oo kale u sameeyay enzyme catalase 1937.
Abaalmarinta Nobel ee cilmiga kiimikada