Buuxi weedha soo socota: Sannadkii 58 BC, Cleopatra waxay u badan tahay inay la socotay aabeheed, Ptolemy XII Auletes, intii lagu jiray masaafurintiisii Rooma ka dib kacdoon ka dhacay Masar (dawlad Roman ah) oo u oggolaatay gabadhiisa Berenice IV inay sheegato carshiga. Berenice waxaa la dilay 55 BC markii Ptolemy uu ku soo laabtay Masar isagoo gacan ka helaya ciidamada Roomaanka. Markii uu geeriyooday 51 BC, xukunka wadajirka ah ee Cleopatra iyo walaalkeed Ptolemy XIII ayaa bilaabmay, laakiin khilaafka u dhexeeya iyaga ayaa horseeday dagaal sokeeye oo furan. Ka dib markii uu ku guuldareystay dagaalkii 48 BC ee Pharsalus ee Giriigga ka dhanka ah xafiiskiisa Julius Caesar (dictator iyo qunsul Roman) ee Caesar's Civil War, ninkii siyaasadda ee Roomaanka Pompey wuxuu u cararay Masar. Pompey wuxuu xulufo siyaasadeed la ahaa Ptolemy XII, laakiin Ptolemy XIII, oo uu ku boorriyay bohommadii maxkamadiisa, wuxuu ka dhigay in Pompey lala wareego oo la dilo ka hor inta uusan Caesar imaan oo uusan qabsan Iskanderiya. Caesar wuxuu isku dayay in uu dib u heshiisiiyo Ptolemy walaalihiis, laakiin la taliyaha ugu weyn ee Ptolemy, Potheinos, wuxuu u arkay shuruudaha Caesar inuu taageersan yahay Cleopatra, sidaa darteed ciidamadiisu
Waxay ku hareeraysnaayeen qasriga Ceesar. Wax yar ka dib markii weerarkii laga qaaday ciidamo xoojin ah, Ptolemy XIII wuxuu ku dhintay 47 BC Dagaalkii Niil; Cleopatra walaashiis Arsinoe IV ayaa ugu dambeyntii loo masaafuriyay Efesos doorkeeda fulinta weerarka. Caesar wuxuu ku dhawaaqay in Cleopatra iyo walaalkeed Ptolemy XIV ay wada taliyayaal yihiin laakiin wuxuu sii waday xiriir gaar ah oo uu la yeeshay Cleopatra oo dhalay wiil, Caesarion. Cleopatra waxay u safartay Rome sidii boqorad macmiil ah 46 iyo 44 BC, halkaas oo ay ku joogtay villa Caesar. Kadib dilkii Caesar iyo (amarradeeda) Ptolemy XIV ee 44 BC, waxay u magacowday Caesarion-ka-xukunka.