Acetanilide wuxuu ahaa derivative aniline ugu horeeyay ee la ogaaday inuu leeyahay sifooyin xanuun yareeya iyo sidoo kale antipyretic, waxaana si dhakhso leh loogu soo bandhigay dhaqanka caafimaadka iyadoo la adeegsanayo magaca Antifebrin oo ay soo saareen Cahn & Hepp sanadkii 1886. Laakiin saameyntiisa sunta ah ee aan la aqbali karin <unk> ugu cabsida badan ee ay tahay cyanosis oo ay sabab u tahay methemoglobinemia <unk> ayaa ku booriyay raadinta noocyo aan sun ahayn oo ka soo jeeda aniline. North Harmon Morropse ayaa horeyba u soo saaray paracetamol Jaamacadda Johns Hopkins iyada oo loo marayo yareynta p-nitrophenol oo leh tin in glacial acetic acid sanadkii 1877, laakiin ma ahayn ilaa 1887 in farmashiistaha caafimaad ee Joseph von Mering uu isku dayay paracetamol aadanaha.
Sanadkii 1963