Proteasomes waa qeyb ka mid ah habka ugu weyn ee unugyada ay u xakameeyaan cufnaanta borotiinka gaarka ah iyo burburinta borotiinka qalad ah. Borotiinka waxaa lagu calaamadeeyay burburka borotiinka yar ee loo yaqaan ubiquitin. Falcelinta calaamadeynta waxaa kiciya enzymes loo yaqaan ubiquitin ligases. Marka borotiinka lagu calaamadeeyo hal unug oo ubiquitin ah, tani waa calaamad u ah ligases kale si ay ugu dhejiyaan molecules ubiquitin dheeraad ah. Natiijadu waa silsilad polyubiquitin ah oo ay ku xidhan tahay proteasome, taas oo u oggolaanaysa inay burburiso borotiinka la calaamadeeyay. Nidaamka burburka wuxuu soo saaraa peptide qiyaastii toddobo ilaa siddeed amino acids dheer, kuwaas oo markaa loo sii burburin karo taxanaha amino acid gaagaaban oo loo isticmaali karo synthesizing protein cusub.
isku xidhka 'ubiquitin'