Pedzisa mutsara unotevera: Islam yakatanga kusvika muUrfa munenge muna 638 AD, apo dunhu rakazvipira kuhondo yeRashidun pasina kuramba, uye ikava huvepo hwakakosha pasi peAyyubids (ona: Saladin Ayubbi), Seljuks. Muna 1144, nyika yeCrusader yakawira kumukuru weAbassid weTurkey Zengui, uyo akaita kuti vagari vazhinji vechiKristu vaurayiwe pamwe chete nemubishopi mukuru wechiLatin (ona
Kurwiswa kweEdessa) uye Hondo yechipiri yeChikamu cheChechi yakatevera yakatadza kutorazve guta racho. Zvadaro, Urfa yakatongwa neZengids, Ayyubids, Sultanate of Rum, Ilkhanids, Memluks, Akkoyunlu uye Safavids pamberi pekukunda kweOttoman muna 1516.