Nyorai kuenderera mberi kweiyi ndima - Islam yakatanga kusvika muUrfa munenge muna 638 AD, apo dunhu rakazvipira kuhondo yeRashidun pasina kuramba, uye ikava huvepo hwakakosha pasi peAyyubids (ona: Saladin Ayubbi), Seljuks. Muna 1144, nyika yeCrusader yakawira kumukuru weAbassid weTurkey Zengui, uyo akaita kuti vagari vazhinji vechiKristu vaurayiwe pamwe chete nemubishopi mukuru wechiLatin (ona Kukombwa kweEdessa
) uye Hondo yeCrusade yeChipiri yakatevera haina kukwanisa kutorazve guta racho. Zvadaro, Urfa yakatongwa neZengids, Ayyubids, Sultanate of Rum, Ilkhanids, Memluks, Akkoyunlu uye Safavids pamberi pekukunda kweOttoman muna 1516.