Rambai muchinyora ndima ino - Pasati pawanikwa chinokonzera chirwere ichi, zviratidzo zvechirwere checholera zvaifungidzirwa kuti zvinokonzerwa nehuremu hwakawandisa hwechiropa mumuviri womurwere; chirwere checholera chinowana zita racho kubva pashoko rechiGiriki rokuti "choler" rinoreva chiropa. Iyi rondedzero yaipindirana nokusetsa, uye yakatungamirira kumitoo yokurapa yakadai sokudeura ropa. Utachiona uhwu hwakatanga kutaurwa nezvahwo muna 1849 naGabriel Pouchet, uyo akahuwana mumarara evarwere vaiva nekorera, asi haana kukoshesa kukosha kwokuvapo kwahwo. Musayendisiti wokutanga kunzwisisa kukosha kwe"Vibrio cholerae" akanga ari nyanzvi yokuItaly yokugadzira muviri Filippo Pacini, uyo akabudisa mifananidzo yakajeka yechimiro chacho mu"Microscopical observations and pathological deductions on cholera" muna 1854. Akabudisa mamwe mapepa muna 1866, 1871, 1876 na1880, ayo akaregeredzwa nenzanga yesayenzi. Akanyatsotsanangura kuti utachiona uhwu hunokonzera sei manyoka, uye akagadzira mishonga yakaonekwa kuti inoshanda. Nepo mepu dzaJohn Snow dzezvirwere dzakazivikanwa zvakanaka, uye dzakatungamirira kubviswa kweBroad Street pombi inobata, semuenzaniso 1854 Broad Street cholera kubuda
. Muna 1874, vamiririri vesayenzi vanobva kunyika 21 vakavhota pamwe chete kuti vagadzirise kuti korera yakaparirwa nemirimo yemhoteredzo inobva mu"miasmatas", kana kuti makore ezvinhu zvisina kunaka zvinoyangarara mumhepo. Muna 1884, Robert Koch akawanazve "Vibrio cholerae" sechinhu chinokonzera korera. Mamwe masayendisiti akapikisa rondedzero itsva, uye akatonwa michero yecholera kuiramba: