Nyorai kupfuurira kweiyi ndima - Muna 1499, Louis XII weFrance akatanga Hondo yechipiri yeItaly, achipinda muLombardy ndokutora Duchy yeMilan. Akabva aita chibvumirano naFerdinand I weSpain chokuti Naples igovaniswe. Pakazosvika 1502, mauto akabatana eFrance neSpain akanga atora Umambo; kusawirirana pamusoro pemitemo yokuparadzaniswa kwakatungamirira kuhondo pakati paLouis naFerdinand. Pakazosvika 1503, Louis, akanga akundwa muHondo yeCerignola
uye Hondo yeGarigliano, vakamanikidzwa kubva kuNaples, iyo yakasiiwa ichidzorwa nemutongi wechiSpanish, Gonzalo Fernández de Córdoba. Munguvayi, Papa Alexander VI akaedza kubvisa nyika yeBorgia muRomagna kupfurikidza nenhamburiko dzaCesare Borgia.