Nyorai mberi kweiyi ndima - Alonso akasainwa kuti atyaire Alpine F1 Team kwemwaka, pamwe naEsteban Ocon, neRenault ichinge yaitazve zita rechikwata ichi pasi pezita rayo idzva. Achigadzirira kudzoka kwake kuFormula One, Alonso akaita mazuva mana ekuyedza achityaira Renault R.S.18 uye akatungamira machati ekuyedza mumwaka we2020 wevechidiki mutyairi kuyedza achityaira Renault R.S.20 yeRenault. Munhangemutange yake yokutanga neAlpine, Alonso akamanikidzwa kurega pashure pokunge marara epurasitiki apinda mubrake duct yake. Pa2021 Emilia Romagna Grand Prix
Akapedza ari P11 mushure mokunge apedza P15, pamwe chete neOcon uyo akapedza mberi muP10, asi vose vakakwidziridzwa imwe nzvimbo mushure mekunge Kimi Räikkönen arohwa, achipa Alonso pfungwa dzake dzekutanga dzemwaka. Pa2021 Hungarian Grand Prix, Alonso akatungamira kwenguva pfupi mujaho asati apinda mumakomba uye achidonha kusvika pachinhanho chechina, pamberi paLewis Hamilton. Ocon akati kudzivirira kwaAlonso paHamilton ndiko kwakaita kuti akunde mumakwikwi aya. Muna Nyamavhuvhu 2021, Alonso akataura sarudzo yekuwedzera kondirakiti yake yemwaka.