Nyorai kupfuurira kweiyi ndima - Akazvarwa mumhuri yevashandi vekuIreland vanobva kuTranmere, Cheshire, O'Grady akatamira kuLondon mukupera kwema1970, achitanga kushanda semukuru anoona nezvekutarisirwa kwevanhu kuCamden Council. Ikoko akavandudza chiito chake chokukweva muna 1978, achivakira hunhu hwaLily Savage pahunhu hunowanikwa pakati pehama dzechikadzi. Achifamba muEngland sechikamu chevakadzi vaviri, Playgirls, O'Grady akazoenda ega semunhu anomira-kumusoro. Achiridza saSavage kwemakore masere muSouth London gay pub, Royal Vauxhall Tavern (RVT), akawana vateveri vakakurumbira pakati penharaunda yeguta yegay uye akashandisa hunhu hwake kutaura nezvekodzero dzevane ngochani. Pashure pokuva akasarudzwa nokuda kwe 1992 Perrier Award
, O'Grady akakwezva kutarisisa kukuru uye akaita akasiyana terevhizheni, redhiyo, uye mitambo yemitambo. SaSavage, akapa kuratidzira "The Big Breakfast" (1995<unk>1996), "Blankety Blank" (1997<unk>2002), uye "Lily Live!" (2000<unk>2001), achiwana mibairo yakasiyana uye achiva munhu anozivikanwa weveruzhinji.