Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Chirwere cheAlzheimer chakazivikanwa sechirwere cheprotein misfolding disease (proteopathy), chinokonzerwa nokuunganidzwa kweplaque yeprotein yeamyloid beta neprotein ye tau yakaoma muuropi. Maplate akaumbwa nemapeptides maduku, 39<unk>43 amino acids pakureba, anonzi amyloid beta (Aβ). Aβ chidimbu cheprotein yakakura inonzi amyloid precursor protein (APP). APP inonzi transmembrane protein inopinda nepakati pemembrane yeuroni. APP inokosha pakukura, kurarama, uye kugadzirisa mauropi kana akuvara. Muchirwere cheAlzheimer, gamma secretase ne beta secretase zvinoshanda pamwe chete muchirongwa chinonzi proteolytic chinoita kuti APP ipatsanurwe kuita zvidimbu zviduku. Chimwe chezvidimbu izvi chinokonzera fibrils yeamyloid beta, iyo inobva yaumba mapoka ayo anoiswa kunze kwemasero etsinga mumapoka akaoma anozivikanwa semaplakes akwegura. AD inoonekwawo se tauopathy nemhaka yokuunganidza zvisina kufanira kweprotein ye tau. Tsinga imwe neimwe ine cytoskeleton, chimiro chomukati chinotsigira chinoumbwawo nezvimiro zvinonzi microtubules. Aya ma microtubules anoita senzira, achitungamirira zvinovaka muviri nemamorekuru kubva mumuviri wesero kuenda kumigumo yeaxon nekudzoka. Puroteni inonzi tau inodzikamisa microtubules apo phosphorylated, uye naizvozvo inonzi microtubule-inobatanidza puroteni. MuAD, tau inoshandurwa nemakemikari, ichiva hyperphosphorylated; inobva yatanga kubatanidzwa nemamwe tambo, ichigadzira mapfundo eurofibrillary uye ichiputsa nzira yekufambisa yetsinga. Pathogenic tau inogonawo kukonzera kufa kwemasero etsinga kupfurikidza nokushomeka kwemirairo yezvinhu zvinoshandiswa.  Mubvunzo: nderipi rimwe zita rinopiwa puroteni inonzi phosphorylated?
microtubule-inobatanidza protein