PWS inokonzerwa neepigenetic phenomenon inozivikanwa se imprinting, inokonzerwa nekubviswa kwemakopi ababa veSNRPN uye NDN necdin genes pamwe chete nemapoka e snoRNAs: SNORD64, SNORD107, SNORD108 uye makopi maviri eSNORD109, 29 makopi eSNORD116 (HBII-85) uye 48 makopi eSNORD115 (HBII-52). Izvi zviri pa chromosome 15 iri munharaunda 15q11-13. Iyi inonzi PWS / AS nharaunda inogona kurasikirwa nechimwe chezvinhu zvinoverengeka zvemajini, izvo muzviitiko zvakawanda zvinoitika kuburikidza nesarudzo mutation. Zvimwe, zvisingawanzoitika maitiro zvinosanganisira uniparental disparomy, sporadic mutations, chromosome translocations, uye gene deletions.
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