Nyora kupfuurira kweiyi ndima - Chikoro chakakamurwa kuva zvikamu zveCzech neGerman muna 1882, uye Chikoro cheScience Sciences chakava sangano rakaparadzana pakati pa1920-1939. Muna 1939, chikoro chacho chakavharwa nemauto aitonga eNazi Germany, uye kutambudzwa kwoutsinye kwavadzidzisi nevadzidzi kwakatevera. Zvichitevera kuguma kwekugara muna 1945, Faculty of Arts yakabudirira zvakare kwemakore mashomanana; izvi zvakagumiswa nechisimba muna 1948 neCommunist coup muna 1948. Mukurumbira wechikoro wakaderera nokukurumidza somugumisiro wokumanikidzwa kuenda kwevadzidzisi vakawanda vanoremekedzwa uye kuiswa kwezvidzidzo zveMarxist-Leninist. Muma1960, fakaroti yakatanga kuvhurika zvishoma nezvishoma kune vanofunga vakakurumbira venguva yacho, asi maitiro aya akachinjwa nehutongi hweSoviet muna 1968, iyo Jan Palach, mudzidzi wechikoro, akaratidzira nekuzvipisa. Pashure pokuguma kwehurumende yechiKomonisiti muCzechoslovakia
muna 1989, uye kubuda kwevamiririri vayo muchikoro, yakadzorerwa seimwe yemasangano epamusoro epamusoro munyika.