Kutaura: Sezvo kudzora kwakasimba kwebasa re enzyme kuchikosha kuti homeostasis, chero kusashanda (mutation, overproduction, underproduction kana kubviswa) kweimwe enzyme yakakosha kunogona kutungamira kuchirwere chemajini. Kusashanda kweimwe chete mhando ye enzyme kubva kuzviuru zvemhando dziripo mumuviri wemunhu kunogona kuuraya. Muenzaniso wechirwere chinouraya chemajini nekuda kwekushomeka kweenzyme chirwere cheTay<unk>Sachs, umo varwere vanoshaya enzyme hexosidaminase. Mumwe muenzaniso wekushomeka kweenzyme ndiyo yakajairika mhando ye phenylketonuria. Kuwanda kwakasiyana kweimwechete amino acid mutations mu enzyme phenylalanine hydroxase, iyo inokonzeresa danho rekutanga mukudzikisira phenylalanine, zvichikonzera kuunganidzwa kwe phenylalanine uye shanduko dzakabatana. Mimwe mishonga iri kukanganisa zvakananga kugona kwayo kushanda, uye kukanganisa kushanda kwayo, asi mishonga yakawanda inokonzera kusagadzikana kweprotein kana ichikanganisa chimiro chemuviri.
kusagadzikana