Pedzisa mutsara unotevera: Nemitambo 167 yenyika yose, Casillas ane yechipiri kuoneka kwakawanda kwechikwata chenyika cheSpain, achimuita mutambi wenhabvu wechigumi-akazara kwazvo wenguva dzose. Mutambi asina kushandiswa pa UEFA Euro 2000, Casillas akava muchengeti wepagedhi wekutanga wenyika pa 2002 World Cup, uye akaenderera mberi achitamba pa
UEFA Euro 2004 uye 2006 World Cup. Muna 2008, akaitwa kaputeni, uye akaenderera mberi kutungamira timu kumutambo weEuropean Championship gore iro. Casillas akatungamirawo Spain kuhwina mukombe wavo wekutanga weWorld Cup muna 2010, kwaakachengeta rekodhi yemubatanidzwa mashanu machira akachena, kuhwina mubairo weYashin weakanakisa muchengeti wemagariro emutambo. Spain yakava nyika yokutanga kuchengeta European Championship, kuhwina zita zvakare muna 2012, apo akaisa rekodhi kwemaminitsi akawanda akatevedzana pasina kugamuchira chinangwa mumakwikwi (509). Muna 2014, Casillas akava mumwe wevatambi vana kuti vamiririre Spain paMakwikwi eNyika mana.