Ramba uchiverenga ndima iyi - Basa raBlaine semutori wenhau weRepublican rakaita kuti apinde mune zvematongerwo enyika dzeRepublican Party. Muna 1856, akasarudzwa senhume kuRepublican National Convention yokutanga
. Kubva pamazuva okutanga ebato, Blaine akazvizivisa nesangano rezvematongerwe enyika, achitsigira Mutongi Mukuru weDare Repamusorosoro John McLean nokuda kwekusarudzwa kwemutungamiri wenyika pamusoro peJohn C. Frémont, mutungamiri wepamusoro. Gore rakatevera racho, Blaine akapihwa chinzvimbo che "Portland Daily Advertiser", icho chaakagamuchira, achitengesa kufarira kwake mu "Journal" nguva pfupi yapfuura. Zvisinei, akaramba achigara muAugusta, nemhuri yake yakanga ichikura. Kunyange zvazvo mwanakomana wokutanga waBlaine, Stanwood, akafa achiri mucheche, iye naHarriet vakava nevamwe vanakomana vaviri nokukurumidza pashure pacho: Walker, muna 1855, uye Emmons, muna 1857. Ivo vaizova navana vamwe vana mumakore aizouya: Alice, James, Margaret, uye Harriet. Yakanga iri nguva iyi apo Blaine akasiya chechi yePresbyterian yehuduku hwake uye akabatana nesangano idzva romudzimai wake, achiva nhengo yeSouth Parish Congregational Church muAugusta.