Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: MS hairangarirwi sechirwere chinogarwa nhaka; zvisinei, misiyano inoverengeka yezvinhu zvomuzvarirwo yakaratidzirwa kuwedzera ngozi yacho. Mamwe emagene aya anoita seane mwero wakakwirira wokuratidzira mumasero e microglial kupfuura zvaitarisirwa netsaona. Mikana yokuva nechirwere ichi yakakwirira kuhama dzomunhu ane chirwere chacho, uye ngozi yacho yakakura kune vaya vane ukama hwepedyo. Mapatya akaenzana ose ari maviri anokanganiswa inenge 30% yenguva, nepo inenge 5% yemapatya asiri akaenzana uye 2.5% yevanun'una vanokanganiswa nechikamu chakaderera chehafu-vanun'una. Kana vabereki vose vari vaviri vakakuvadzwa, ngozi yacho muvana vavo yakapetwa kagumi kupfuura yevanhu vose zvavo. MS yakajairikawo mune mamwe madzinza kupfuura mamwe. Majini chaiwo akabatanidzwa neMS anosanganisira misiyano iri muHuman Leukocyte Antigen (HLA) system - boka remajini ari pa chromosome 6 anoshanda sechikamu chikuru chehistocompatibility complex (MHC). Kuti misiyano iri munharaunda yeHLA yakabatana nekunzwa kwave kuchizivikanwa kubvira kuma1980, uye nharaunda imwe chete iyi yave ichibatanidzwawo mukukudziridzwa kwezvimwe zvirwere zve autoimmune zvakadai seshuga yerudzi I uye systemic lupus erythematosus. Kuwana kwakanyatsoenderana ndiko kubatana kuri pakati pe multiple sclerosis ne alleles dzeMHC dzinotsanangurwa seDR15 uye DQ6. Dzimwe nzvimbo dzakaratidza kudzivirira, dzakadai seHLA- C554 uye HLA- DRB1* 11. Pamwe chete, zvave zvichifungidzirwa kuti kusiyana kweHLA kunomirira pakati pe20% ne60% yechimiro chendangariro. Nzira dzemazuva ano dzokuberekwa nadzo (zvidzidzo zvokubatanidza genome yose) dzakabudisa pachena mamwe majini anopfuura gumi nemaviri kunze kweHLA locus ayo anowedzera zvishoma mukana weMS.  Mubvunzo: Chii chinonzi simba rokudzivirira rinoguma nenhamba ina?
HLA-C554