Denda reAlzheimer rakazivikanwa sechirwere cheprotein misfolding disease (proteopathy), chinokonzerwa nekuunganidzwa kweplaque yeprotein amyloid beta protein uye tau protein muuropi. Plaques inoumbwa nemapeptides madiki, 39<unk>43 amino acids pakureba, inonzi amyloid beta (Aβ). Aβ chidimbu kubva kune yakakura amyloid precursor protein (APP). APP ipuroteni ye transmembrane inopinda mukati memuroni's membrane. APP yakakosha pakukura kweuroni, kupona, uye mushure mekukuvara kugadzirisa. Muchirwere cheAlzheimer, gamma secretase uye beta secretase inoshanda pamwechete mune imwe nzira yeproteinolytic iyo APP inopatsanurwa kuita zvidiki zvidiki. Imwe yezvidimbu izvi inopa plaque kuunganidzwa kweamyloid beta mapuroteni, ayo akaomeswa kunze kweiyo neuronal mapuroteni, ayo anonzi amyloid beta (Aβ). Aya mapuroteni anoumbwa nemapuroteni madiki madiki madiki madiki madiki madiki, ayo anozivikanwawo seAβ.
microtubule-inobatanidza protein