Pedzisa mashoko anotevera: San Francisco yakavambwa musi waJune 29, 1776, apo vagari vokuSpain vakatanga Presidio of San Francisco paGolden Gate uye Mission San Francisco de Asís makiromita mashomanana kubva ipapo, zvose zvichitumidzwa zita raFrancis wokuAssisi. California Gold Rush ya 1849 yakaunza kukura nokukurumidza, kuchiita guta gurusa paWest Coast panguva iyoyo. San Francisco yakava guta-dunhu rakabatanidzwa muna 1856. Chimiro cheSan Francisco seguta guru reWest Coast chakasvika pakakwirira pakati pa1870 na1900, apo vanenge 25% yevagari veCalifornia vaigara muguta chairo. Pashure pokunge zvikamu zvitatu zvezvikamu zveguta zvaparadzwa ne
Pashure pokudengenyeka kwenyika nomwoto muna 1906, San Francisco yakakurumidza kuvakwazve, ichigamuchira Panama-Pacific International Exposition makore mapfumbamwe gare gare. MuHondo Yenyika II, San Francisco yakanga iri chiteshi chikuru chokupinda kwevashandi vanobuda vachienda kuPacific Theater. Ipapo rakava nzvimbo yokuberekerwa kweChibatanwa chaMarudzi muna 1945. Mushure mehondo, kusangana kwevashandi vanodzoka, kutama kwakakosha, mafungiro akasununguka, pamwe nekukwira kwe "beatnik" uye "hippie" countercultures, Shanduko Yezvepabonde, Rwendo rweRunyararo rwakakura kubva pakushora kuUnited States kubatanidzwa muHondo yeVietnam, uye zvimwe zvinhu zvakatungamira kuZhizha reRudo uye iyo gay kodzero kufamba, kusimbisa San Francisco senzvimbo yekurwira rusununguko muUnited States. Mune zvematongerwe enyika, guta racho rinovhota zvakasimba maererano nemitemo yeDemocratic Party.