Nyorai mberi kweiyi ndima - Muna 219BC Hannibal akakomba, akabata uye akapamba guta reSaguntum raitsigira Roma, zvichikonzera kuti Roma izivise hondo kuCarthage muchirimo cha 218BC. Gore iroro, Hannibal akashamisa vaRoma nokufora neuto rake nomugungwa kubva kuIberia, achipfuura nomuGaul uye pamusoro peAlps
kuCisalpine Gaul (mazuva ano kuchamhembe kweItaly). Achisimbiswa nevatsigiri vake vechiGaul, akakunda vaRoma zvinotyisa muhondo dzeTrebia (218) neLake Trasimene (217). Achienda kumaodzanyemba kweItaly muna 216, Hannibal akakundazve vaRoma muHondo yeCannae, kwaakaparadza uto guru kupfuura ose akanga ambounganidzwa nevaRoma. Pashure pokufa kana kuti kutapwa kwemauto eRoma anopfuura 120 000 mumakore asingasviki maviri, vazhinji vavaItaly vaimbobatana neRoma, zvikurukuru Capua, vakatiza vachipinda muCarthage, zvichiita kuti Hannibal atonge rutivi rukuru rwokumaodzanyemba kweItaly. Sezvo Sirakuse neMakedhonia zvakabatana neCarthage pashure peCannae, kurwisana kwakapararira. Pakati pa215 na210 BC vaCarthage vakaedza kutora Sicily neSardinia, asi havana kubudirira. VaRoma vakatora matanho akasimba okuunganidza mapoka matsva, vachinyoresa varanda, matsotsi, uye avo vakanga vasingasviki zvinodiwa zvomugariro wenguva dzose uye nokudaro vachiwedzera zvikuru chiverengero chavarume vavaiva navo pasi pezvombo. Kwemakore gumi akatevera hondo yokumaodzanyemba kweItaly yakaramba ichienderera mberi, mauto eRoma achidzorera zvishoma nezvishoma maguta akawanda eItaly akanga abatana neCarthage.