Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Vanenge 90% veavo vane utachiona hweM. tuberculosis vane utachiona hweTB husingaratidzi zviratidzo, husingaoneki (dzimwe nguva hunonzi LTBI), ne10% chete yenguva youpenyu hwose yokuti utachiona husingaoneki huchafambira mberi kuva chirwere cheTB chakajeka, chinoshanda. Muvaya vane HIV, ngozi yokurwara neTB inoshanda inowedzera kusvika ku10 muzana pagore. Kana pasina kurapwa kunobudirira, mwero wekufa kwevanenge vabatwa neTB unosvika pa66%. Utachiona hweTB hunotanga kana mycobacteria yasvika mumasaga emhepo ari mumapapu, kwainopinda uye kuwanda mukati me endosomes yema alveolar macrophages. Macrophage anoziva utachiona hwacho sehusiri hwomuviri uye anoedza kuubvisa kupfurikidza nephagocytosis. Munguva iyi, utachiona hunoputirwa ne macrophage uye hunochengeterwa kwenguva pfupi muchikamu chinonzi phagosome. Phagosome inobva yabatanidzwa ne lysosome kuti igadzire phagolysosome. Mu phagolysosome, sero rinoedza kushandisa marudzi eoksijeni anoshanda uye asidhi kuuraya utachiona. Zvisinei, M. tuberculosis ine kapsule yeacid mycolic yakakora uye yakaita semucheka inodzivirira zvinhu izvi zvine chepfu. M. tuberculosis inokwanisa kubereka mukati me macrophage uye pakupedzisira inouraya sero rokuzvidzivirira.  Mubvunzo: Ngozi yokuva neTB inowedzera zvakadini kana une HIV?
10% pagore