Pedzisa mutsara unotevera: Higuaín akatanga basa rake nekirabhu yeArgentina River Plate, asati aendeswa kuReal Madrid muna Ndira 2007 nemamiriyoni gumi nemaviri emadhora. Nguva yake muSpain yakamuona achikunda kukudzwa kwakati wandei mudzimba, kusanganisira mazita matatu eLa Liga, uye akarova zvibodzwa 107 mumitambo yeligi zana nemakumi mapfumbamwe. Akabatana nechikwata cheItaly cheNapoli nemari inosvika €40 miriyoni muna Chikunguru 2013, uko akakunda Coppa Italia mumwaka wake wekutanga. Mu
Mumwaka wa2015-16, akarova zvibodzwa makumi matatu nezvitanhatu, akahwina mukombe we "Capocannoniere" uye akaenzana naGino Rossetti's 87-gore rekodhi yezvinangwa mumwaka wepamusoro-wekubhururuka weItaly. Somugumisiro wechinangwa chake chekuisa zvibodzwa muNaples, vakwikwidzi veItaly Juventus vakamusayina nokuda kwe € 90 mamiriyoni mu2016, achiva mumwe wevatambi vepamusoro-soro vebhora nguva dzose uye yepamusoro-soro yekutengeswa kwechikwata cheItaly. Akakunda madhigirii maviri mumwaka wake wokutanga neJuventus, uyewo akasvika muChampions League yekupedzisira ye2017 nekambani. Muna 2018, akapiwa chikwereti kuMilan, uye gare gare kuChirungu cheChelsea muna Ndira 2019, kwaakakunda UEFA Europa League, asati adzokera kuJuventus muzhizha regore iro, achiwedzera imwe Serie A zita kune rake kabhineti kabhineti mwaka unotevera.