Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Mashoko anokosha: Zvinodzvinyirira marwadzo rudzi rwemishonga inoshandiswa zvikuru mukurapa marwadzo. Zvinosanganisira aspirin nemimwe mishonga isiri yesteroid inorwisa kuzvimba (NSAIDs), pamwe chete nemishonga inorwisa kupisa inonzi paracetamol (inozivikanwa seacetaminophen muUnited States) uye phenacetin. Yakatangwa mukupera kwezana ramakore rechi19, phenacetin yaimbova chinhu chinowanzoshandiswa chemishonga inorwisa marwadzo yakasanganiswa mumativi eEurope, Australia, uye United States. Iyi mishonga inoderedza marwadzo ine aspirin kana imwe NSAID ine phenacetin, paracetamol, kana salicylamide, uye caffeine kana codeine. Muma1950, Spühler naZollinger vakashuma kuwirirana pakati pokukuvara kweitsvo nokushandiswa kwenguva refu kwephenacetin. Vakacherechedza kuti vanoshandisa phenacetin kwenguva refu vaiva nengozi yakakura yokukuvara kweitsvo, kureva renal papillary necrosis uye chronic interstitial nephritis. Mamiriro ezvinhu aya ainzi analgesic nephropathy uye ainzi anokonzerwa ne phenacetin, kunyange zvazvo pasina uchapupu hwokuti ndiyo inokonzera. Nemishumo yakawedzerwa yengozi yakawedzerwa yekukuvara kweitsvo nekushandisa kwenguva refu uye kwakanyanyisa kwephenacetin, zvisinei, phenacetin yakarambidzwa munyika dzinoverengeka pakati pemakore ekuma1960 nema1980. Sezvo kushandiswa kwephenacetin kwakaderera, ndizvo zvakaitawo kuwanda kweanalgic nephropathy sechikonzero chechirwere cheitsvo chekupedzisira. Mashoko anobva kuSwitzerland, somuenzaniso, akaratidzira kuderera kwechiitiko cheanalgic nephropathy pakati pevanhu vane chirwere cheitsvo chakapera, kubva pa28% muna 1981 kusvika ku12% muna 1990. Chidzidzo chemuviri chakaitwa muSwitzerland chakaratidza kuti kuwanda kwechirwere cheitsvo chinoderedza marwadzo muvanhu vose kwakadererawo; kuwanda kwacho kwakanga kuri 3% muna 1980 uye 0,2% muna 2000. Kunyange zvazvo mashoko aya achiratidza kuti chirwere cheitsvo chinoderedza marwadzo chakanga chabviswa zvachose mune dzimwe nzvimbo, mune dzimwe nzvimbo chirwere ichi chinoramba chiripo. Zvikurukuru, muBelgium, kupararira kweanalgic nephropathy pakati pevanhu vane dialysis kwakanga kuri 17.9% muna 1984 uye 15.6% muna 1990. Michielsen naDe Schepper vanokarakadza kuti nephropathy inorwadza inoramba iripo pakati pavanhu muBelgium vane dialysis kwete nemhaka ye...  Mubvunzo: Aspirin ndeorudzii rwekirasi yemishonga kunze kweiyo?
zvinodzikisira marwadzo