Mushure mokunge mwana wechidiki akabudiswa zvikuru nemishonga uye kunwa doro, Barrymore akabudisa nhoroondo yehupenyu hwake, Little Girl Lost, paakanga ava nemakore gumi nematanhatu muna 1991. Akaenderera mberi achionekwa mumutambo wemafirimu akabudirira mumakore gumi, kusanganisira Poison Ivy (1992), Boys on the Side (1995), Mad Love (1995), Scream (1996), Ever After (1998) uye The Wedding Singer (1998).
Pashure pouduku hwakashambadzirwa zvikuru hwakaratidzirwa nokushandisa zvisina kufanira zvinodhaka nedoro,