Pedzisa mutsara unotevera: The Know Nothing National Convention yakasarudza Fillmore kuti ave purezidhendi, asi kusabvumirana pamusoro pechimiro chepurogiramu yebato pauranda kwakakonzera kuti vakawanda veNorthern Know-Nothings vasiye bato racho. Munguvayi,
1856 Republican National Convention yakasarudza John C. Frémont somumiriri wepurezidhendi webato racho. Kupanduka kwevakawanda veNorthern Know-Nothings, pamwe chete nekurohwa kwaCharles Sumner nezvimwe zviitiko zvakamutsa kusawirirana pakati pemapoka, zvakasimbisa maRepublicans muNorth yose. Mukati mokutsvaka kwake, Fillmore akarerutsa nhau ye nativism, panzvimbo pokuedza kushandisa mushandirapamwe wake sepuratifomu yekubatana uye kumutsidzirwa kweWhig Party.