Pedzisa mutsara unotevera: Muna 58 BC, Cleopatra angangodaro akaperekedza baba vake, Ptolemy XII Auletes, panguva yeutapwa hwake kuRoma mushure mekumukira muEjipitori (nyika yeRoma yevatengi) ichibvumira mwanasikana wake Berenice IV kuti ataure chigaro. Berenice akaurayiwa muna 55 B.C. Ptolemy paakadzokera kuIjipiti achibatsirwa nemauto eRoma. Paakafa muna 51 B.C., Cleopatra nomukoma wake Ptolemy XIII vakatanga kutonga pamwe chete, asi kusawirirana pakati pavo kwakatungamirira kuhondo yevagari vemo. Pashure pokurasikirwa neHondo yePharsalus muna 48 BC muGreece mukurwisana nomukwikwidzi wake Julius Caesar (mudzvinyiriri weRoma uye mushumiri) muHondo yaKesari yeVanhu, mutongi weRoma Pompey akatizira kuEgipita. Pompey akanga ari mubatsiri wezvematongerwe enyika waPtolemy XII, asi Ptolemy XIII, achikurudzirwa nemachinda ake omudare, akaita kuti Pompey avharirwe uye aurayiwe Kesari asati asvika ndokutora Alexandria. Zvadaro Kesari akaedza kuyananisa hama dzaPtolemy dzaikwikwidzana, asi chipangamazano mukuru waPtolemy, Potheinos, akaona mashoko aKesari seanofarira Cleopatra, saka mauto ake
akamukomberedza naKesari pamuzinda. Nokukurumidza pashure pokunge kukombwa kwacho kwapedzwa nokuwedzera, Ptolemy XIII akafa mu47 BC Hondo yeNire; hanzvadzi yaCleopatra yokurera Arsinoe IV pakupedzisira akaendeswa kuEfeso nokuda kwebasa rake mukuita kukombwa. Caesar akazivisa Cleopatra nomunun'una wake Ptolemy XIV vatongi pamwe chete asi akachengeta ukama hwepachivande naCleopatra hwakabereka mwanakomana, Caesarion. Cleopatra akaenda kuRoma samambokadzi mutengi muna 46 na 44 BC, kwaakagara paimba yaKesari. Pashure pokuurawa kwaKesari uye (pazvakarayirwa naye) Ptolemy XIV muna 44 BC, akatumidza Caesarion mubatsiri-mutongi.