Ramba uchinyora ndima iyi - Charles V paaitungamirira Diet of Worms, Francis I weFrance akatumira mukuru wake Robert de la Marck kuti apinde muBurgundian Low Countries uye akatsigira Henry II weNavarre muhondo yekudzorera Navarre yeIberia. Mambo akapindura nokuzivisa kuti Francis akatorerwa Milan ndokuumba mubatanidzwa unorwisana neFrance naPapa Leo X (8 May 1521), uyo aifarira kubatanidza nzvimbo dzakakosha dzeParma nePiacenza, zvose zviri zviviri chikamu cheMilan yaitongwa neFrance. Nokudaro, Hondo Yamakore Mana yakavamba. Munguvayi, Cortés akakomba (May 26) ndokutora (August 13) Tenochtictlan
, achipedza kukunda Umambo hweAztec. Ngarava yakanga yakatakura pfuma huru yaMambo Cuauhtémoc yakabatwa nomufambisi wengarava wechiFrench Jean Fleury, asi ndarama inokosha madhuketi 120,00 yakasvika muhomwe yeUmambo mukati mokurwisana kweItaly. Nguva yeRenaissance muItaly yakatsanangurwa naMercurino di Gattinara se"nheyo huru youmambo" uye vose vari vaviri Francis I naCharles V, avo vaionekwa samadzimambo ane simba zvikurusa eEurope yenguva yacho, vaida kuva vakuru mupeninsula yakapfuma. Seizvo wezvenhau weRenaissance Francesco Guicciardini akatsanangura, kuti: