Biglia's first senior international call-up for Argentina was in 2011 and he previously played for the Argentina U20 national team, uyo akahwina 2005 FIFA World Youth Championship. Akamirira nyika yake paFIFA World Cups mbiri, achisvika kumagumo e2014 edition yemutambo, uye mumakwikwi matatu eCopa América, achikunda menduru dzevakwikwidzi muna 2015 na2016
shanduro dzomutambo wacho. Akasiya nhabvu yepasi rose mushure me2018 FIFA World Cup, aine makapu makumi mashanu nemasere uye chinangwa chimwe.