Pedzisa mutsara unotevera: Nokutanga kweHondo Yenyika I muna 1914, Burdenko akazvipirazve kunzvimbo yokutanga uye akabatana neChikwata cheRed Cross cheNorthwestern Front, achitora chikamu muEast Prussian Operation uye
Hondo yeRwizi rweVistula. Mukuwedzera kumabasa echiremba wepamunda akabudisawo mauto akakuvadzwa pasi pemoto wehondo, akaronga kupatsanura, rubatsiro uye kupfeka zviteshi, kusanganisira zvikamu zvakakosha zvevarwi vane dumbu, mapapu uye maronda emusoro. Kwenguva yokutanga mukurapa munhandare yehondo Burdenko akashandisa kurapa kwokutanga nokuda kwokukakuvara kwepfupa romusoro. Kubva muna 1915 kusvika muna 1917, akashandawo sachiremba anopa mazano, kutanga kuKovno neVilna Governorates, ndokuzoenda ku2nd Army uye zvipatara zvakasiyana zveRiga. Muna Kurume 1917, akagadzwa Main Battlefield Medical Inspector, asi akasiya basa iri muna Chivabvu nekuda kwekusawirirana neRussia Provisional Hurumende ndokudzokera kumberi.