Nyorera kupfuurira kweiyi ndima - Pasinei nokusiyana kwavo pamusoro pemitemo yokunze, Bryan akatsigira mushandirapamwe waWilson wokusarudzwazve muna 1916. Kunyange zvazvo asina kupinda senhume yepamutemo, 1916 Democratic National Convention
yakamisa mitemo yayo kuti ibvumire Bryan kutaura kukokorodzano; Bryan akapa hurukuro yakagamuchirwa zvakanaka iyo yakadzivirira zvakasimba zvinyorwa zvepamusha zvaWilson. Bryan akashanda semumiriri waWilson mumushandirapamwe wa1916, achipa hurukuro dzakawanda, kunyanya kune vateereri kumadokero kwerwizi rweMississippi. Pakupedzisira, Wilson akakunda zvishoma mukwikwidzi weRepublican, Charles Evans Hughes. Apo United States yakapinda muHondo yeNyika I muna April 1917, Bryan akanyorera Wilson, "Ndichitenda kuti ibasa romugari kutakura mugove wake wemutoro wehondo uye mugove wake wengozi, ndinopa mabasa angu kuHurumende. Ndapota ndinyoresei somurwi chero nguva ipi zvayo pandinenge ndichidiwa uye ndipei basa ripi neripi randinogona kuita". Wilson akaramba kugadza Bryan pachinzvimbo chehurumende, asi Bryan akabvuma chikumbiro chaWilson chekupa rutsigiro rwevanhu kuhondo kuburikidza nehurukuro dzake nezvinyorwa. Pashure pehondo, pasinei zvapo nokumwe kusava nechokwadi, Bryan akatsigira nhamburiko yaWilson isina kubudirira yokuunza United States muSangano Renyika.