Kunyora kupfuurira kweiyi ndima - Muna 2015, Humphrey akatsigira gavhuna weOhio John Kasich semutungamiri wenyika muna 2016. Munguva ye2016 yeRepublican presidential primaries, Humphrey aive mutungamiri wekuedza kuvhara Donald Trump kubva mukuwana kusarudzwa kuRepublican National Convention
. Akati, "Ndaizovhotera Hillary [achireva Hillary Clinton, akasarudzwa neDemocratic] chete kana paizova nokukwikwidzana kwakasimba. Zvichakadaro, ndiri kutarisira kuti vatungamiri veRepublican, pakupedzisira, pakupedzisira vacharatidza ushingi uye nheyo dzokushora Trump uye kumuti arege kusarudzwa kana kutarisana nekugadziriswazve kwekokorodzano". Musi waNovember 6, 2016, mazuva maviri sarudzo dzisati dzaitwa, Humphrey akatsigira zviri pamutemo Clinton. Mumwedzi iwoyo, Humphrey akasiya Republican Party ndokuva akazvimirira.