Muzhizha ra1944, paCold Spring Harbor Laboratory, McClintock akatanga zvidzidzo zvakarongeka pamusoro pemaitiro emhando yemhando yemhando yembeu yechibage uye nhaka isina kugadzikana yeiyi mosaicism. Akaona maviri matsva uye anobatana majini loci ayo aakatumidza kuti Dissociation (Ds) uye Activator (Ac). Akawana kuti Dissociation haina kungoparadzanisa kana kukonzera kuti chromosome iputswe, yaivewo nemhedzisiro dzakasiyana pamajini akavakidzana apo Activator yaivepowo, iyo yaisanganisira kuita kuti dzimwe shanduko dzisina kugadzikana. Mukutanga kwa1948, akawana kushamisika kwekuti zvese zviri zviviri kushamwaridzana uye Activator zvaigona, kana chinzvimbo, pane chromosome.
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