On 21 December 2010, Virgin Racing akasimbisa kuti d'Ambrosio aizomhanya nokuda chikwata muna. Mumakwikwi ake ekutanga gumi nematatu echikwata, d'Ambrosio akapedza gumi nerimwe rawo nekurega kwake chete kuuya kuMalaysia nekuda kwedambudziko nemagetsi emota yake uye kuItaly
nemhaka yezvinetso zvegiyabhokisi. Kuguma kwake kwakanaka kwave kuri nzvimbo mbiri dzechi14, muAustralia neCanada. Munhangemutange yake yomumba, muBelgian Grand Prix, akapedza ari wechi17, achikunda waaitamba naye Timo Glock.