Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Mumakore okuma1920, Michael Heidelberger naOswald Avery vakacherechedza kuti maantigen aigona kubudiswa nemishonga inorwisa mabhakitiriya uye vakaenderera mberi vachiratidza kuti mishonga inorwisa mabhakitiriya inogadzirwa nemapuroteni. Zvinhu zvebiochemical zveantigen-antibody-binding interactions zvakaongororwa zvakadzama mukupera kwema1930 naJohn Marrack. Kufambira mberi kukuru kwakatevera kwakaitika muma1940, apo Linus Pauling akasimbisa dzidziso ye"lock-and-key" yakatangwa naEhrlich nokuratidza kuti kudyidzana pakati pemishonga inorwisa mabhakitiriya nemaantigen kunotsamira zvikuru pachimiro chayo kupfuura pahunhu hwayo hwemakemikari. Muna 1948, Astrid Fagreaus akawana kuti masero eB, ari muchimiro chemasero eplasma, akanga ane mutoro wokugadzira masoja anorwisa utachiona. Basa rinotevera rakaiswa pakuenzanisa maumbirwo emapuroteni emishonga inorwisa utachiona. Kufambira mberi kukuru mune izvi zvidzidzo zvekuvakwa kwaive kuwanikwa mukutanga kwema1960 naGerald Edelman naJoseph Gally yetambo yechiedza cheantibody, uye kuziva kwavo kuti puroteni iyi yakafanana neproteni yeBense-Jones yakatsanangurwa muna 1845 naHenry Bence Jones. Edelman akaenderera mberi nokuwana kuti maantibody anoumbwa nemaketani anorema uye akareruka akabatanidzwa nechisungo che disulfide. Panenge panguva imwe cheteyo, nzvimbo dzinosunga antibody (Fab) uye antibody tail (Fc) dzeIgG dzakaratidzwa naRodney Porter. Pamwe chete, masayendisiti aya akawana chimiro uye kutevedzana kwakakwana kweamino acid kweIgG, basa ravakapiwa pamwe chete muNobel Prize yePhysiology kana kuti Medicine muna 1972. Chikamu cheFv chakagadzirirwa ndokurondedzerwa naDavid Givol. Kunyange zvazvo zvizhinji zvezvidzidzo zvokutanga izvi zvainyanya kutaura nezveIgM neIgG, mamwe ma immunoglobulin isotypes akaonekwa muma1960: Thomas Tomasi akawana secretory antibody (IgA); David S. Rowe naJohn L. Fahey vakawana IgD; uye Kimishige Ishizaka naTeruko Ishizaka vakawana IgE uye vakaratidza kuti yaiva kirasi yemaantibody anobatanidzwa mukusawirirana. Munhevedzano yedzidzo dzinokosha dzakatanga muna 1976, Susumu Tonegawa akaratidza kuti zvinhu zvemavara okugara nhaka zvinogona kuzvirongazve kuti zvigadzire nhevedzano huru yemishonga inorwisa utachiona inowanika.  Mubvunzo: Vaongorori vakadzidzei pashure pokuwana kuti masero eB anogadzira maantibody?
kurondedzera maumbirwo emapuroteni eantibody.