Rimwe basa rinokosha rehurongwa hwekuzvidzivirira kwemuviri nderokuziva nekubvisa mavanga. Izvi zvinonzi immune surveillance. Masero akashandurwa emamota anoratidza maantigen asingawanikwe pamasero akajairika. Kune immune system, aya maantigen anoratidzika kunge ari ekunze, uye kuvapo kwavo kunokonzeresa maseru ekudzivirira kurwisa maseru emamota akashandurwa. Maantigen anoratidzwa nemamota ane masosi akati wandei; mamwe anobva kumavhairasi eoncogenic senge papillomavirus yemunhu, iyo inokonzeresa chibereko chechibereko, nepo mamwe ari mapuroteni emuviri anoitika pamatanho akaderera mumasero akajairika asi anosvika pamatanho akakwirira mumasero emamota. Mumwe muenzaniso i enzyme inonzi tyrosincrase iyo, kana ichiratidzwa pamatanho akakwirira, inoshandura mamwe maseru eganda (semuenzaniso melanocytes) kuita melanomas. Chikamu chechitatu chemapuroteni e tumor anowanzo kuve akakosha pakudzora kukura uye kushanduka, izvo zvinobvumira maseru ekudzivirira
maantigen