Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Tuberculosis inorongwa sechimwe chezvirwere zvinoputika zvinokonzerwa nemagranulomatous. Macrophages, T lymphocytes, B lymphocytes, uye fibroblasts anoungana kuti aumbe granulomas, ane lymphocytes akapoteredza macrophages ane utachiona. Apo mamwe macrophage anorwisa macrophage ane utachiona, anosanganiswa pamwe chete kuti aumbe sero guru rine ma-multinucleated mualveolar lumen. Granuloma inogona kudzivisa kupararira kwemiycobacteria uye kugovera nzvimbo yomunzvimbomo yekubatana kwemasero ehurongwa hwomuviri hwokurwisa zvirwere. Zvisinei, uchapupu hwazvino uno hunoratidza kuti utachiona hunoshandisa granulomas kudzivisa kuparadzwa nehurongwa hwomuviri hwokudzivirira zvirwere. Macrophages nemasero edendritic ari mumagranulomas haakwanisi kupa antigen kuma lymphocyte; nokudaro immune response inodzvinyirirwa. Mabhakitiriya ari mukati megranuloma anogona kupera simba, zvichikonzera utachiona husingaoneki. Chimwe chinhu chinoratidzwa nemagranulomas kukura kworufu rwemasero rusina kururama (necrosis) pakati pemapundu. Kana utachiona hweTB hukapinda muropa uchibva panzvimbo ine tsinga dzakakanganiswa, hunogona kupararira mumuviri wose uye hunogona kutapukira, hwose huchioneka semabundu machena maduku ari mumatumbu. Rudzi urwu rwakakomba rwechirwere cheTB, runowanzoitika muvana vaduku uye vaya vane HIV, runonzi miliary tuberculosis. Vanhu vane TB yakapararira iyi vane mwero wakakwirira wokufa kunyange kana varapwa (inenge 30%). Kuparadzwa kwemasero uye kuora mwoyo kunowanzoenzaniswa nokupora uye fibrosis. Tsinga dzakakanganiswa dzinotsiviwa nemaronda uye makomba anozadzwa nezvinhu zvinenge zvafa. Muchirwere chinenge chichienderera mberi, dzimwe dzenzvimbo idzi dzinosanganiswa nemigwagwa yokufema (bronchi) uye zvinhu izvi zvinogona kukweva. Rine utachiona hunorarama, uye nokudaro rinogona kuparadzira utachiona. Kurapa nemishonga inorwisa mabhakitiriya kunoparadza mabhakitiriya uye kunobvumira kupora kuti kuitike. Pakupora, nzvimbo dzakakanganiswa pakupedzisira dzinotsiviwa noronda.  Mubvunzo: Zvinhu zvipi zvipenyu zviduku zvine sero rimwe chete zvinogona kuwanikwa mugranuloma?
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