Kufambisa: De novo synthesis ye ceramide inotanga ne condensation ye palmitate uye serine kuti iite 3-keto-dihydrosphingosine. Kuita uku kunogadziriswa ne enzyme serine palmitoyl transferase uye ndiyo nhanho yekugadzirisa nzira. Zvadaro, 3-keto-dihydrosphingosine inoderedzwa ku dihydrosphingosine, iyo inoteverwa ne acylation ne enzyme (dihydro) ceramide synthase kuti ibudise dihydroceramide. Kugadziriswa kwekupedzisira kugadzira ceramide kunogadziriswa ne dihydroceramide desaturase. De novo synthesis ye ceramide inoitika mu endoplasmic reticulum. Ceramide inozotakurwa kuenda kune vesicular trafficking ne ceramide kana kutapurirana kwe ceramingolipid protein. Ceramide inogona kuenderera mberi kugadzirwa mu ceramic apparatus, yakadai se Ceramylglycoside.
(dihydro) ceramide synthase