Nhengo youmambo hwepamusoro hweByzantium uye muzukuru wemadzimambo Isaac II Angelos naAlexios III Angelos, Kamytzes akashanda semukuru mukuru wemauto muBalkan, aine chinzvimbo che"protostrator", kubva muna 1185/86 kusvika muna 1199. Nokuda kwaIsaac II akarwa nevanopinda muNorman muna 1185 uye kumuka kwaAlexios Branas muna 1186/87. Kamytzes akarwisa kumukira kwevaVlach-vaBulgaria kaviri
kuchamhembe kweBalkans, pamwe chete nokurwisa vapambi veCuman munharaunda iyoyo. Muna 1189, akasangana neuto reGermany reThird Crusade, raitungamirirwa naFrederick I Barbarossa, sezvavaiyambuka nharaunda yeByzantium.