Nyorai kupfuurira kweiyi ndima - Pasinei zvapo nokushaya simba kwake kwokurapa, Wilson aida kumhanya kwenguva yechitatu. Nepo Kokorodzano yeDemocratic National Convention ya1920
vaitsigira zvakasimba mitemo yaWilson, vatungamiriri veDemocratic vakaramba, vachidoma panzvimbo pezvo tikiti raiumbwa naGavhuna James M. Cox uye Mutevedzeri woMunyori weNavy Franklin D. Roosevelt. VaRepublican vakaisa mushandirapamwe wavo pakushora mitemo yaWilson, naSenator Warren G. Harding vachivimbisa "kudzokera kumamiriro ezvinhu akajairika". Wilson haana kubatanidzwa zvikuru mumushandirapamwe wacho, kunyange zvazvo akatsigira Cox uye akaramba achitsigira kuti United States ive nhengo yeLeague of Nations. Harding akahwina nechisimba, achikunda zvinopfuura 60% zvemavhoti akakurumbira uye nyika dzose dziri kunze kweSouth. Wilson akasangana naHarding kuti vanwe tii pazuva rake rokupedzisira ari muhofisi, March 3, 1921. Nemhaka yeutano hwake, Wilson akanga asingakwanisi kupinda muchitsauko chokutanga.