Muzana ramakore rechi18, Pierre-Louis Moreau de Maupertuis akaita ongororo nehupfu hwescorpion ndokuona kuti dzimwe imbwa nemakonzo zvakanga zvisina kudzivirirwa nehupfu uhwu. Muzana ramakore rechi10, chiremba wechiPersia al-Razi (anozivikanwawo saRhazes) akanyora dzidziso yekutanga yakanyorwa yekudzivirirwa kwekudzivirira, achicherechedza kuti diki diki inogona kupukunyuka kubva kuzvirwere zvenguva yemberi. Kunyangwe hazvo yaive yekutanga kuzivikanwa nezvekudzivirirwa kwakanga kuri panguva yechirwere cheAtene muna 430 BC. Thucydides akacherekedza kuti vanhu vakanga vapora kubva pakurwara kwechirwere chepamberi vaigona kuchengeta varwere vasina kubata chirwere kechipiri. Muzana ramakore rechi18, Pierre-Louis Moreau de Maupertuis akaita ongororo nehupfu hwescorpion ndokuona kuti dzimwe imbwa nemakonzo vakanga vasina kudzivirirwa nehupfu uhwu. Muzana ramakore rechi10, chiremba wechiPersia al-Razi (anozivikanwawo saRhazes) akanyora dzidziso yekutanga yakanyorwa yekudzivirirwa,
430 B.C.E.