Holmes anoshandisa cocaine, iyo yaanoisa muchirongwa chechinomwe kubva muzana nesirinji yakachengetwa muhomwe yeganda reMorocco. Kunyange zvazvo Holmes anoedzawo morphine, anoratidza kusagutsikana kwakasimba paanoshanyira nzvimbo yeopium; zvose zvinodhaka zvaive zviri pamutemo muzana remakore rechi19 muEngland. Somurapi, Watson anoramba zvakasimba tsika yeshamwari yake yecocaine, achirondedzera se "mutsotsi chete", uye ane hanya nemigumisiro yaro pahutano hwepfungwa uye huchenjeri hwaHolmes. Mu "The Adventure of the Missing Three-Quarter", kunyange zvazvo Watson anoti "akasiya" Holmes kubva kune zvinodhaka, muongorori anoramba ari mutevedzeri ane tsika "akafa, asi kwete kurara". Mubvunzo: Ndeipi mhinduro yepesenti inoshandiswa?
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