IgA1 ndeimwe ye immunoglobulin subclasses (imwe yacho IgD) iyo O-glycosylated pane nhamba ye serine uye threonine residues mune yakasarudzika proline-yakapfuma hinge nharaunda. Aberrant glycosylation yeIgA1 inoita kunge inotungamira kune polymerization yeIgA mamorekuru mumatumbu, kunyanya glomerular mesangium. Maitiro akafanana anonzi ari pasi peHenoch<unk>Schönpura purlein, vasculitis inonyanya kukanganisa vana uye inogona kuratidza kubatanidzwa kweitsvo izvo zvinenge zvisingabviri kubva kuIgA nephritis. Zvisinei, zvidzidzo zvevanhu zvakawana kuti degalactosylation yeIgA1 inoitika mukukura kweIgA mumatumbo ne ne nephropathy (imwe yacho IgD) inowanikwa kunze kweO-glycosylated pane nhamba ye serine uye threonine residues mune yakasarudzika proline-yakapfuma hinge nharaunda.
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