Hepburn akataura mumakore ake makumi masere, "Ini handityi rufu. Inofanira kunge yakanaka, senge kurara kwenguva refu". Hutano hwake hwakatanga kuora nguva pfupi mushure mekuonekwa kwake kwekupedzisira pachiratidziri, uye akaiswa muchipatara munaKurume 1993 nekuda kwekuneta. Muchando cha1996, akaiswa muchipatara nepneumonia. Pakazosvika 1997, aive asisina simba, aitaura uye achidya zvishoma, uye zvaityirwa kuti achafa. Akaratidza zviratidzo zvekuora mwoyo mumakore ake ekupedzisira. Muna Chivabvu 2003, bundu rakashata rakawanikwa mumutsipa waHepburn. Sarudzo yakaitwa yekusatora nhengo, uye akafa nekurova kwemoyo muna Chikumi 29, 2003, mwedzi mushure mekuzvarwa kwake kwe96th kumba kwemhuri yaHepburn muFenwick, Connecticut. Akavigwa muCedar Hill Cemetery muHartford. Hepburn akaramba kuti pasave nemwenje yekuyeuchidza kufa kwake.
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