Nyora kupfuurira kweiyi ndima - Antiochus haana kuwanazve umambo hwake kutozosvikira pakugadzwa kwaMambo weRoma Claudius muna 41. Muna 43 mwanakomana wake wedangwe, C. Julius Archelaus Antiochus Epiphanes, akaroorwa naDrusilla, mwanasikana waAgrippa I. Kunze kwaEpiphanes, Antiochus aive nevamwe vana vaviri naJotapa: Callinicus uye mudiki Iotapa. Muna 53, Antiochus akanyaradza kumukira kwemamwe madzinza evatorwa muKirikiya, ainzi Clitae. Muna 55 akagamuchira mirairo kubva kuna Nero mambo weRoma kuti aunganidze mauto kuti arwe
vaParthia, uye mugore ra 59 akashanda pasi paGeneral Cn. Domitius Corbulo achipesana naMambo Tiridates I weArmenia, munin'ina waMambo weParthia Vologases I weParthia. Somuuyo webasa rake muhondo iyi, mugore ra 61 akawana mativi eArmenia.