The Duke of Milan Filippo Maria Visconti akatora simba we weakened republic pakati 1421 uye 1435.During the 1450s uye 1460s, Republic akava pawn mukurwa pakati France uye Aragon kuti simba uye simba muItaly. Christopher Columbus akaberekwa muna Genoa c. 1451, asi akatsvaka basa kumwewo. Kutyisidzirwa Alfonso V weAragon, Doge weGenoa muna 1458 akaisa Republic kuti French, zvichiita Duchy of Genoa pasi pekutonga kwaJohn of Anjou, mutongi weFrance. Zvisinei, nerutsigiro kubva kuGenoa, Milan yakapanduka uye yakadzorerwa Republic muna 1461. The Milan, kukunda Genoa muna 1464 uye akaramba ari pasi pekutonga kweGenoa muna May 30, 1578?
Genoa