Nyora kupfuurira kweiyi ndima - Castellotti akaberekerwa muLodi, Italy. Akatenga motokari yainzi Ferrari paakanga ava nemakore makumi maviri, kubva kune mumwe munhu aipa rubatsiro, uye akatanga kumhanya nemotokari dzemitambo muna 1952. Gore iroro akakunda muPortuguese Grand Prix, akava wechitatu muBari uye wechipiri muMonaco iyo yakaitwa gore iroro nokuda kwemotokari dzemitambo. Muna 1953 akakunda mujaho unonzi 10 Hours of Messina uye akapedza ari wechitatu mujaho unonzi Carrera Panamericana muMexico. Muna 1954, akasaina kuLancia uye zvakare akafambisa motokari dzemitambo achimirira motokari yeGrand Prix. Iye pakupedzisira akaita kutanga kwake muGrand Prix muBuenos Aires
musi waJanuary 16, 1955, nokuda kweLancia, asi yakatambura mumatembiricha anodziya ndokuputsika. Zvisinei, akapedza ari wechipiri kuMonaco, asi pakati pemwaka timu yakabatanidzwa neScuderia Ferrari, iyo Castellotti yaityaira kune yakasara yebasa rake. Akatora chikamu mu14 World Championship Grands Prix, achiwana 3 podiums uye akawana huwandu hwe19.5 makwikwi emakwikwi. Akachengetedza nzvimbo yepamusoro, neLancia, pa1955 Belgian Grand Prix, achiva mutyairi wechidiki kuita kudaro (ane makore makumi maviri nemana, mwedzi minomwe nemazuva makumi maviri nematanhatu), rekodhi yakamira kwemakore gumi nematatu kusvika Jacky Ickx's nzvimbo yepamusoro pa1968 German Grand Prix.