Mu 2005, masayendisiti akavakazve endocast (replica) yeAcrocanthosaurus cranial cavity vachishandisa computed tomography (CT scanning) kuongorora nzvimbo mukati me holotype braincase (OMNH 10146). Muhupenyu, yakawanda yenzvimbo iyi ingadai yakazadzwa nemengines uye cerebrospinal fluid, mukuwedzera kuhuropi pachahwo. Zvisinei, hunhu hwakajairika hwehuropi uye tsinga dze cranial dzinogona kutsanangurwa kubva kune endocast uye kuenzaniswa nedzimwe theropods idzo endocasts dzakagadzirwa. Kunyange zvazvo uropi hwakafanana neanoverengeka theropods, hwakafanana neyavo vese theroposauroids. Inonyanya kufanana nehuropi hweCarcharodosaurus uye Giganotosaurus pane iyo yeAllopontosaurus kana Sinoptor, ichipa rutsigiro rweiyo hypothesis yekuti Acrocanthosaurus yaive holotype braincase.
meninges uye cerebrospinal fluid