Pedzisa mutsara unotevera: Charles paakagara pachigaro choumambo cheSpain, nyika dzokuSpain dzaiva mhiri kwemakungwa muNew World dzaiva muCaribbean neSpanish Main uye dzaiva nevanhu vomunyika dzacho vakanga vava kuderera nokukurumidza, zvinhu zvishomanana zvaikosha kumuchinda, uye vanhu vashoma vaibva kuSpain. Mamiriro acho ezvinhu akachinja zvinoshamisa neboka raHernán Cortés, uyo, aine ukama nemaguta-hurumende akanga asingafariri vaAztec uye zviuru zvevarwi vokuMexico,
vakakunda Umambo hweAztec muna 1521. Vachitevera muenzaniso wakagadzwa muSpain mukati meReconquista uye muCaribbean, nzanga dzokutanga dzeEurope muAmerica, vakundi vakakamura vagari vomunzvimbomo muzvinhu zvomunhu oga "encomiendas" uye vakashandisa zvisina kufanira basa ravo. Pakati peMexico uye gare gare Umambo hweInca hwePeru hwakapa Spain nzanga huru itsva dzomunzvimbomo kuti dzitendeukire kuchiKristu uye kutonga savashandiri voumambo. Charles akagadza Council of the Indies muna 1524 kuti itarisire zvinhu zvose zveCastile zvaiva mhiri kwemakungwa. Charles akagadza mutevedzeri wamambo muMexico muna 1535, achigumisa kutonga kwamambo kwedare repamusoro, "Real Audiencia", uye vakuru vehomwe nemukuru mukuru wamambo. Pashure pokukunda Peru, muna 1542 Charles akagadzawo mutevedzeri wamambo. Vakuru vakuru vose vari vaviri vakanga vari pasi pesimba reDare reIndia. Charles akazivisa Mitemo Mitsva ya1542 kuti asimbise simba reboka ravakundi rokuumba hurumende yaitongwa nomunhu mumwe chete yaigona kupikisa simba rekorona.