Zvirwere zveItai-itai (イタイイタイ病, itai-itai byō, "zvinorwadza-zvinorwadza chirwere") raive zita rakapihwa kuwanda kwecadmium chechirwere cheToyama Prefecture, Japan, kutanga kutenderera 1912. Izwi rekuti "itai-itai chirwere" rakagadzirwa nevanhu vemuno nekuda kwekurwadziwa kwakanyanya (Japanese) vanhu vane mamiriro akanzwa musana uye majoini. Cadmium chepfu inogona zvakare kukonzera kunyorova kwemapfupa uye kukundikana kwetsvo. Iyo cadmium yakaburitswa munzizi nemakambani emigodhi mumakomo, ayo akabudirira kumhan'arwa nekuda kwekukuvara. I-tai-itai chirwere chinozivikanwa seimwe yeBig Four Pollution Diseases yeJapan. Mubvunzo: Ndeupi chirwere chinozivikanwa muJapan sechiitiko chine chekuita nekusvibisa?
Itai-itai