Nyorai mberi kweiyi ndima - Nemakumi manomwe nenomwe emakapu epasi rose, Casillas ane wechipiri anoonekwa zvakanyanya kuchikwata chenyika cheSpain, zvichimuita iye wechi gumi-anotamba nhabvu nhabvu yenguva dzese. Mutambi asina kushandiswa pa UEFA Euro 2000, Casillas akazova muchengeti wepagedhi wekutanga wenyika pa 2002 World Cup, uye akaenderera mberi achitamba pa UEFA Euro 2004
uye World Cup ya2006. Muna 2008, akaitwa kaputeni, uye akaenderera mberi kutungamira timu kumutambo weEuropean Championship gore iro. Casillas akatungamirawo Spain kuhwina mukombe wavo wekutanga weWorld Cup muna 2010, kwaakachengeta rekodhi yemubatanidzwa mashanu machira akachena, kuhwina mubairo weYashin weakanakisa muchengeti wemagariro emutambo. Spain yakava nyika yokutanga kuchengeta European Championship, kuhwina zita zvakare muna 2012, apo akaisa rekodhi kwemaminitsi akawanda akatevedzana pasina kugamuchira chinangwa mumakwikwi (509). Muna 2014, Casillas akava mumwe wevatambi vana kuti vamiririre Spain paMakwikwi eNyika mana.