Pedzisa mutsara unotevera: Pashure pokubuda munhangemutange, Vilsack akatsigira Seneta Hillary Clinton kuti ave purezidhendi musi waMarch 25, 2007. Aitarisira kumukurudzira muIowa. Aimbova Gavhuna wacho akataura kuti Clinton ndiye aiva "nepfungwa dzakanakisisa, simba rakawanda, uye pfungwa dzakanaka dzokutungamirira nyika yedu". Nokukurumidza pashure pokutsigirwa, Clinton akadana mudzimai waVilsack Christie kuti ave sachigaro-mukuru wekambani yake muIowa. Mushandirapamwe waClinton wakazivisa kuti vaizobetsera Vilsack kubhadhara chikwereti chemushandirapamwe wake chemadhora 400,000. Vilsack akaita mushandirapamwe waClinton munyika yose semutungamiri wenyika, uye akaisa pfungwa pakumubatsira kukunda musangano weIowa. Pasinei nenhamburiko dzake, Clinton akapedza ari wechitatu mumisangano yekusarudza shure kwaBarack Obama naJohn Edwards.
Obama nokuda kwehutungamiri musi waJuly 15, 2008. Akanyora Obama se"mukwikwidzi bedzi" wevavhoti "vanorwisana nokurerekera kurutivi" kuti vachinje "izwi riri muWashington"