Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Passage: De novo synthesis yeceramide inotanga nekudzvanywa kwepalmitate uye serine kuumba 3-keto-dihydrosphingosine. Kuita uku kunogadziriswa ne enzyme serine palmitoyl transferase uye ndiyo nhanho inoderedza mwero yenzira. Zvadaro, 3- keto- dihydrosphingosine inoderedzwa kuva dihydrosphingosine, iyo inoteverwa neacylation ne enzyme (dihydro) ceramide synthase kuti ibudise dihydroceramide. Kugadziriswa kwekupedzisira kugadzira ceramide kunokonzerwa ne dihydroceramide desaturase. De novo synthesis yeceramide inoitika mu endoplasmic reticulum. Ceramide inobva yaendeswa kumuchina waGolgi ne vesicular trafficking kana kuti neprotein inopfuudza ceramide inonzi CERT. Kamwe muchiridzwa cheGolgi, ceramide inogona kupfuurira kugadziriswa kune mamwe ma sphingolipids, akadai se sphingomyelin uye glycosphingolipids yakaoma.  Mubvunzo: Chii chinogadzira dihydroceramide
(dihydro) ceramide synthase