Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Trepanation, kuchera namaune maburi muganda, kwakanga kuchirovedzwa pakuvamba sa7 000 BCE. Nepo pane dzimwe nguva vanhu vaipona, vakawanda vangadai vakafa nokuvhiyiwa nemhaka yeutachiona. Kwakadavirwa kuti kunoshanda kupfurikidza noku"bvumira midzimu yakaipa kutiza". William Harvey akakurudzira kuti trepanation ishandiswe pakurapa migraine muzana remakore rechi17. Kunyange zvazvo mishonga yakawanda yekurapa migraine yakaedzwa, kwakanga kusati kwava kusvika muna 1868 apo kushandiswa kwechinhu icho pakupedzisira chakaratidza kuva chinobudirira kwakatanga. Chinhu ichi chakanga chiri fungi ergot kubva uko ergotamine yakaparadzaniswa muna 1918. Methysergide yakagadzirwa muna 1959 uye triptan yokutanga, sumatriptan, yakagadzirwa muna 1988. Mukati mezana ramakore rechi 20 nokuronga kwakanaka kwefundo, matanho anodzivirira anobudirira akawanwa ndokusimbiswa.  Mubvunzo: Mugore ripi ergotamine yakabviswa mufungus ergot?
Muna 1918