Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Kazhinji, vanhu vane haemoglobin A, iyo inoumbwa nemaketani maviri ealpha uye maviri ebeta, haemoglobin A2, iyo inoumbwa nemaketani maviri ealpha uye maviri edelta, uye haemoglobin F, inoumbwa nemaketani maviri ealpha uye maviri egamma mumiviri yavo. Pamhando nhatu idzi, hemoglobin F ndiyo inonyanya kushandiswa kusvikira vana vava nemavhiki matanhatu okuberekwa. Pashure pacho, hemoglobin A ndiyo inenge ichitonga muupenyu hwose. Muvanhu vanonzi vane chirwere che sickle cell, kanenge kamwe chete ke β-globin subunits kari muhemoglobin A kanotsiviwa neanonzi hemoglobin S. Mu sickle cell anemia, rudzi rwakajairika rwechirwere che sickle cell, hemoglobin S inotsiva zvose zviri zviviri zve β-globin subunits dziri muhemoglobin. Zvirwere zve sickle cell zvine autosomal recessive pattern of inheritance from parents. Marudzi ehemoglobin anogadzirwa nomunhu mumasero matsvuku eropa anoenderana nemagene ehemoglobin akagara nhaka kubva kuvabereki vake. Kana mumwe mubereki aine sickle cell anemia uye mumwe wacho aine sickle cell trait, ipapo mwana ane 50% mukana wokuva nechirwere che sickle cell uye 50% mukana wokuva ne sickle cell trait. Kana vabereki vose vane chirwere chechirwere chechirwere chechirwere chechirwere, mwana ane mukana we25% wekuva nechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere chechirwere che Mhando idzi dzinozivikanwa seCameroon, Senegal, Benin, Bantu, uye Saudi-Asian. Kukosha kwavo kwekiriniki imhaka yekuti vamwe vane hukama nematanho epamusoro eHbF, semuenzaniso, Senegal neSaudi-Asia misiyano, uye vanowanzo kuve nechirwere chakapfava.Kukanganisika kwejini ishanduko imwechete ye nucleotide (ona imwechete-nucleotide polymorphism <unk> SNP) (GAG codon inoshanduka kuita GTG) ye β-globin gene, iyo inokonzeresa glutamic acid (E / Glu) kutsiviwa ne valine (V / Val) panzvimbo 6. Haemoglobin S ine mutation iyi inonzi HbS, kusiyana neHbA yevanhu vakuru. Kazhinji kacho uku kushanduka kwakanaka, kusingakonzeri migumisiro inooneka pazvinhu zvechipiri, zvechitatu, kana kuti zvechina zvehemoglobin...  Mubvunzo: Vanhu vanowanzoita sei?
haemoglobin A