Kuziva nekupedza mhando dzakasiyana dzehutachiona hunoda kusiyanisa pakati pemishonga inorwisa utachiona; maamino acid avo anosiyana zvichivabvumidza kudyidzana nemaantigen akasiyana siyana. Zvinofungidzirwa kuti vanhu vanogadzira mabhiriyoni gumi emishonga inorwisa utachiona, imwe neimwe inokwanisa kusunga epitope yakasiyana yeantigen. Kunyangwe hazvo huwandu hukuru hwemishonga inorwisa utachiona hwakasiyana hunogadzirwa mumunhu mumwe chete, huwandu hwejini dziripo kugadzira mapuroteni aya hwakaganhurirwa nehukuru hwegenome yemunhu. Maitiro akati wandei akaomarara ehutachiona akagadzirwa ayo anotendera maseru eBe vertebrate kugadzira dziva rakasiyana-siyana remishonga inorwisa utachiona kubva kunhamba diki yemagene emishonga inorwisa utachiona. Mubvunzo: Mhando ipi yemishonga inorwisa utachiona inogona kukonzera mhinduro?
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