Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Passage: Isotype kana class switching inzira inoitika mushure mekushanda kwesero reB, iyo inobvumira sero kuti ribudise makirasi akasiyana eantibody (IgA, IgE, kana IgG). Mapoka akasiyana-siyana emuviri anorwisa utachiona, uye nokudaro mabasa eefektor, anoratidzwa nenzvimbo dzisingachinji (C) dzeketani rinorema reimmunoglobulin. Pakutanga, maB cell asina kukwana anoratidza chete IgM neIgD dzomumusero dzine nzvimbo dzakafanana dzinosunga antigen. Chimwe nechimwe chinoshandiswa kuti chiite basa rakasiyana; nokudaro, pashure pokunge chaitwa, antibody ine basa reIgG, IgA, kana kuti IgE effector ingada kubvisa antigen. Kuchinjanisa makirasi kunobvumira masero emwanasikana akasiyana-siyana anobva musero rimwe chete reB rakaitwa kuti ribudise maantibody ezvinyorwa zvakasiyana-siyana. Nzvimbo dzisingachinji chete dzetambo inorema yemapiritsi emuviri ndidzo dzinongochinja panguva yokuchinjwa kwemakirasi; nzvimbo dzinosiyana-siyana, uye nokudaro antigen specificity, dzinoramba dzisina kuchinja. Nokudaro vana vomusero mumwe chete weB vanogona kubudisa maantibody, ose chaiwo nokuda kweantigen imwe chete, asi ane mano okubudisa basa reeffector rakakodzera nokuda kwedambudziko rimwe nerimwe reantigenic. Kuchinjana kwemakirasi kunokonzerwa nemacytokines; isotype inogadzirwa inotsamira pane ma cytokines aripo mumasero eB environment. Kuchinjana kwemakirasi kunoitika mu heavy chain gene locus nenzira inonzi class switch recombination (CSR). Nzira iyi inotsamira pazvirongwa zve nucleotide zvakachengetedzwa, zvinonzi switch (S) nzvimbo, zvinowanikwa muDNA iri kumusoro kwenzvimbo imwe neimwe inogara iripo (kunze kweiyo δ-chain). Tambo yeDNA inoputswa nebasa renhevedzano yemaenzyme munzvimbo mbiri dzakasarudzwa dzeS. Iyo inoshanduka domain exon inosanganiswazve kuburikidza nemaitiro anonzi asiri-homologous end kubatana (NHEJ) kunzvimbo inodiwa isingachinji (γ, α kana ε). Muitiro uyu unoguma ne immunoglobulin gene inonyora antibody yeimwe isotype.  Mubvunzo: Chinhu ichi chinotsamira pachii?
zviratidzo zve nucleotide zvakachengetedzwa