Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Sezvo kudzora kwakasimba kwebasa reenzyme kuchikosha nokuda kwehomeostasis, kusashanda zvakanaka kupi nokupi (mutation, kugadzirwa kwakawandisa, kugadzirwa kwakaderera kana kuti kubviswa) kweimwe enzyme inokosha kunogona kutungamirira kuchirwere chemavara okugara nhaka. Kusashanda zvakanaka kworudzi rumwe chete rweenzyme pamhando dzine zviuru dziripo mumuviri womunhu kunogona kuuraya. Muenzaniso wechirwere chinouraya chinokonzerwa nemaenzymes chinonzi Tay<unk>Sachs disease, umo varwere vanoshaya enzyme inonzi hexosaminidase. Kuchinja kwakasiyana-siyana kweimwe amino acid mu enzyme phenylalanine hydroxylase, iyo inokonzera danho rokutanga mukuparara kwephenylalanine, kunoguma nokuunganidzwa kwephenylalanine nezvimwe zvinogadzirwa. Dzimwe shanduko dziri munzvimbo inoshanda, dzichikanganisa zvakananga kusunga uye catalysis, asi dzakawanda dziri kure nenzvimbo inoshanda uye dzinoderedza kushanda nekusagadzikana kweprotein, kana kukanganisa oligomerisation yakarurama. Izvi zvinogona kutungamirira kukundikana kushanda zvakanaka mupfungwa kana chirwere chacho chisingarapwi. Mumwe muenzaniso kushayikwa kwepseudocholinesterase, umo kukwanisa kwomuviri kuputsa mishonga yecholine ester kwakakanganiswa.  Mubvunzo: Utano husina chirwere hunonzi chii?
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