Pfupisa nyaya yacho:  Varume vane kenza yeprostate yakakura vanogona kubatsirwa nomushonga mutsva wakatanga kugadzirirwa vakadzi. Miedzo yekiriniki inoratidza kuti olaparib inogona kunonoka nguva apo chirwere chinopinda munjodzi. Mushonga wacho unotoita pavakadzi vane kenza inokonzerwa nemutauro unonzi BRCA gene mutation, chirwere chakaita kuti mutambi wenhau Angelina Jolie abvisirwe mazai ake. Tsvakurudzo itsva <unk>inonakidza<unk> itsva inoratidza kuti mushonga uyu, watoshandiswa kare kurapa vakadzi vane kenza yemazamu, unogonawo kubatsira varume vane zvikanganiso zvemajini mumakemikari avo ekenza yeprostate (ari pamufananidzo). Vanosvika 30 muzana yevarume vane kenza yeprostate yapfuurira vane mamota ane kukanganiswa kweDNA uye aya anopindura zvakanaka kwazvo kune olaparib. Muedzo weLondon weolaparib, iyo iri yeAstraZeneca, wakatungamirirwa nevatsvakurudzi vepaInstitute of Cancer Research uye pachipatara cheRoyal Marsden. Vakawana kuti varume 16 pa49 vaiva nekenza yeprostate yakanga yakura vakabvuma mushonga wacho, unozivikanwawo seLynparza. Yakamisa kukura kwekenza yeprostate, ichikonzera kuderera kwenhamba dzemasero emamota muropa uye kuvandudzwa kwemhinduro mumascan ekurapa. Mushonga wacho - unonzi olaparib - unogona kuwedzera urefu hwenguva iyo murwere ane kenza yeprostate anorarama nehosha yacho pasina kuipa, maererano nemiedzo mitsva yekiriniki. Olaparib ndiwo mushonga wokutanga unorwisa kenza unonanga kuchinja kunoita majini. Ndeimwe yemishonga yokutanga yerudzi rutsva rwemishonga inonzi PARP inhibitors. PARP inhibitors inoshanda nokuvhara simba remasero ekenza rokugadzirisa zvinenge zvakuvadzwa. Masero ekenza ane mutation muBRCA gene anotsamira chose chose papuroteni yePARP kuti agadzirise kukuvara kwacho. Mishonga inodzivisa PARP inodzvinyirira puroteni iyi uye inogona kumisa masero ane mutation yeBRCA kukura zvokuti anozofa. Migumisiro yakaipa inobva mukurapa kwakajairika kunorwisa kenza inoderedzwa nokuti masero ekenza ane zvikanganiso zvemavara anogarwa nhaka chete ndiwo anonangwa. Varume vakawanda vakanga vane DNA inodzoreredza mutations yakanga ine kudzora chirwere kunotora nguva yakareba kupfuura zvaitarisirwa. Izvi zvinoratidza kuti varume vangangobatsirwa zvikuru nomushonga wacho vanogona kuzivikanwa nokuongororwa kuti vaone kana pane mutations. Olaparib akava...
Olaparib ndiyo mushonga wokutanga unorwisa kenza unonanga kuchinja kwemagene kunogarwa nhaka. Vanosvika 30 muzana yevarume vane kenza yeprostate yapfuurira vane mamota ane kukanganiswa kwokuberekwa nakwo - uye vakapindura zvakanaka kuolaparib. Mishonga inowedzera nguva iyo munhu anorwara anogona kurarama pasina chirwere ichi kuwedzera kuipa.