Caffeine inogonawo kutorwa ne rectally, inoratidzwa ne suppositories ye ergotamine tartrate uye caffeine (yekusunungurwa kwemigraine) uye chlorobutanol uye caffeine (yekurapa hyperemesis). Zvisinei, rectal absorption isingashande zvakanyanya kupfuura yemuromo: iyo yakanyanya kuwanda (Cmax) uye huwandu hwakazara hunowanikwa (AUC) zvese zviri zviviri ingangoita 30% (i.e., 1/3.5) yeiyo yemuromo huwandu.Caffeine's biological half-life <unk> iyo nguva inodiwa kuti muviri ubvise hafu yeawa imwe neimwe inosiyana zvakanyanya mukati maawa 1<unk>2 pakati pevanhu. Inobviswa nefirst-order kinetics. Caffeine inogona zvakare kutorwa ne rectally, inoratidzwa ne suppositories ye ergotamine tartrate uye caffeine (yekurerutsa kwemigraine) uye chlorobutanol uye caffeine (yekurapa hyperemesis). Zvisinei, rectal absorption isingashande zvakanyanya kupfuura yemuromo: iyo yakanyanya kuwanda (Cmax) uye huwandu hwakazara hunowanikwa
pakati pemaawa 3<unk>7