Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Chirwere cheAlzheimer chinoratidzwa nokurasikirwa nemasero etsinga uye synapses mucerebral cortex uye dzimwe nzvimbo dzepasi petsinga. Kurasikirwa uku kunoguma nokuora kwakakomba kwenzvimbo dzakakanganiswa, kubatanidza kuderera mu temporal lobe uye parietal lobe, uye zvikamu zve frontal cortex uye cingulate gyrus. Kuparara kuripowo muzvigadziko zvomusoro womusoro zvakadai se locus coeruleus. Zvidzidzo zvinoshandisa MRI nePET zvakaratidza kuderera kwehukuru hwenzvimbo dzomusoro muvanhu vane AD sezvavanenge vachifambira mberi kubva pakukanganisika kwepfungwa kusvika kuchirwere cheAlzheimer, uye zvichienzaniswa nemifananidzo yakafanana kubva kuvanhu vakuru vane utano. Zvose zviri zviviri amyloid plaques uye neurofibrillary tangles zvinooneka zvakajeka nemicroscopy muuropi hweavo vanotambudzwa neAD. Maplate akaoma, anowanzova deposits dzisinganyunguduki dzebeta-amyloid peptide uye zvinhu zvemasero kunze uye kumativi enuroni. Zvirukwa (neurofibrillary tangles) zvikamu zvepuroteni yakabatana ne microtubule tau iyo yakava hyperphosphorylated uye inounganidza mukati memasero pachawo. Kunyange zvazvo vanhu vakawanda vakwegura vanova nemaplakes uye tangles somugumisiro wokukwegura, uropi hwevanhu vane AD hune huwandu hukuru hwahwo munzvimbo dzakananga dzeuropi dzakadai se temporal lobe. Muviri waLewy hausi chinhu chisingawanzoitiki muuropi hwevanhu vane AD.  Mubvunzo: plaque inoumbwa nei?
deposits of beta-amyloid peptide and cellular material outside and around neurons