I-122, yakagadzwa muna 1925 seSubmarine No. 49 uye inozivikanwa seI-22 kubva panguva yekuvakwa kwayo kusvika munaJune 1938, yaive yeImperial Japanese Navy yakashanda panguva yeChipiri Sino-Japanese Hondo uye Hondo Yenyika II. Munguva yokurwisana kwokupedzisira, akaitisa mabasa mukutsigira kupinda kweJapan kweMalaya
, kupindirwa kwePhilippines neJapan, kubhombwa kweDarwin, Hondo yeMidway, hondo yeGuadalcanal, Hondo yeEastern Solomons, uye hondo yeNew Guinea. Yakanyura muna 1945.