Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Passage: SJS inonzi type IV hypersensitivity reaction umo mushonga kana kuti metabolite yawo inokurudzira cytotoxic T cells (i. e. CD8+ T cells) uye T helper cells (i. e. CD4+ T cells) kuti itange ma autoimmune reactions anorwisa tishu dzomuviri. Zvikurukuru, rudzi rwechina, subtype IVc, kunonoka hypersensitivity reaction inotsamira muchidimbu pamasero-anokuvadza maseru emagetsi. Izvi zvinopesana nedzimwe mhando dzezvirwere zveSCARs, kureva, DRESS syndrome inova Type IV, Subtype IVb, hypersensitivity drug reaction inotsamira muchidimbu pamabasa anokuvadza ehosinophils uye acute generalized exanthematous pustulosis inova Type IV, subtype IVd, hypersensitivity reaction inotsamira muchidimbu pamabasa anokuvadza ehutrophils. Zvidzidzo zvinoratidza kuti nzira iyo mushonga kana kuti zvinogadzirwa nawo zvinoita nayo izvi inosanganisira kukanganisa nzira dzinoshandiswa nemuviri kudzivirira zvirwere. Mushonga kana kuti metabolite yacho inobatana neprotein yomurwere kuti iite epitope isina chokuita nemushonga wacho. An antigen presenting cell (APC) inotora mapuroteni aya; inoapinza mumapeptide madiki; inoisa mapeptide mumukoto uri pahuman leukocyte antigen (i.e. HLA) chikamu cheiyo hombe histocompatibility complex (i.e. MHC); uye inopa mapeptide ane hukama neMHC kune maT-cell receptors paCD8 + T masero kana CD4 + T masero. Aya mapeptide anoratidza chirwere-chakabatanidzwa, chisiri epitope pane imwe yemhando dzavo dzakasiyana-siyana dzeHLA protein (HLA-A, HLA-B, HLA-C, HLA-DM, HLA-DO, HLA-DP, HLA-DQ, kana HLA-DR) inogona kusunga kune T-cell receptor uye nokudaro inokurudzira mubereki weT-cell anotakura receptor kuti atange kurwisa kune zvinyama. Zvimwewo, mushonga kana kuti metabolite yawo inogona kukurudzira masero aya T nokupinza mupuroteni yeHLA kuti ishande seepitope isiri yayo kana kuti kusunga kunze kwepuroteni iyi kuti ichinje puroteni yeHLA zvokuti inoumba epitope isiri yayo. Mune izvi zvose...  Mubvunzo: Kubatanidzwa mumhinduro kumishonga kunowanzoganhurirwa kuna vanaani?
vanhu vanotaurwa