Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Passage: Acetanilide ndiyo yaive yekutanga aniline yakatorwa serendipitously yakawanikwa iine analgesic pamwe neantipyretic zvivakwa, uye yakakurumidza kuunzwa mune zvekurapa pasi pezita reAntifebrin naCahn & Hepp muna 1886. Asi migumisiro yaro ine chepfu isingagamuchiriki - inotyisa zvikurusa ichiva cyanosis inoparirwa nemethemoglobinemia - yakakurudzira kutsvaka zvinobva muaniline zvisina chepfu zvikuru. Harmon Northrop Morse akanga atogadzira paracetamol paJohns Hopkins University kuburikidza nokuderedza p-nitrophenol netini muacetic acid muna 1877, asi kwakanga kusati kwava muna 1887 kuti chiremba wemishonga Joseph von Mering akaedza paracetamol pavanhu. Muna 1893, von Mering akabudisa pepa raitaura nezvezvakabuda pakurapwa kweparacetamol nephenacetin, imwe aniline derivative. Von Mering akataura kuti, kusiyana nephenacetin, paracetamol yaive nechishuvo chiduku chokugadzira methemoglobinemia. Paracetamol ipapo yakakurumidza kuraswa mukuda phenacetin. Kutengeswa kwephenacetin kwakasimbisa Bayer sekambani inotungamirira yemishonga. Yakanyanyiswa neaspirin, yakaunzwa mukurapa naHeinrich Dreser muna 1899, phenacetin yaizivikanwa kwemakumi emakore, kunyanya mu "musanganiswa wemusoro" unoshambadzirwa zvakanyanya, kazhinji une phenacetin, aminopyrine inotorwa neaspirin, caffeine, uye dzimwe nguva barbiturate. Paracetamol ndiyo inoshanda metabolite ye phenacetin uye acetanilide, ese ari maviri akambove akakurumbira semishonga inorwisa marwadzo uye antipyretics pachavo. Zvisinei, kusiyana nephenacetin, acetanilide nemubatanidzwa wadzo, paracetamol hairangarirwi seinokonzera kenza pamadosi anorapa. Zvaitaurwa naVon Mering zvakaramba zvisina kupikiswa kwehafu yezana remakore, kusvikira zvikwata zviviri zvevanzveri vanobva kuUnited States zvaongorora mashandisirwo emuviri weacetanilide neparacetamol. Muna 1947 David Lester naLeon Greenberg vakawana uchapupu hwakasimba hwokuti paracetamol yaiva metabolite huru yeacetanilide muropa romunhu, uye mufundo yakatevera vakashuma kuti madosi makuru eparacetamol akapiwa kumakonzo ealbino haana kukonzera methemoglobinemia. Mukati...  Mubvunzo: Paracetamol yakabatanidzwa rini muBritish Pharmacopoeia?
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