Muchidimbu: Mumakore ekuma1920, Michael Heidelberger naOswald Avery vakacherechedza kuti maantigen aigona kugadzirwa nemaantibodies uye vakaenderera mberi kuratidza kuti maantibodies akagadzirwa nemapuroteni. Zvimiro zve biochemical zveantigen-antibody-binding interactions zvakaongororwa zvakadzama mukupera kwema1930 naJohn Marrack. Kufambira mberi kukuru kwakatevera kwaive muma1940, apo Linus Pauling akasimbisa dzidziso yekukiya-uye-kiyi yakapihwa naEhrlich nekuratidza kuti kudyidzana pakati peantibodies nemaantibodies kunoenderana nechimiro chavo kupfuura chimiro chavo chemakemikari. Muna 1948, Astrid Fagreaus akawana kuti masero eB, muchimiro chemasero eplasma, aive nebasa rekugadzira maantibodies. Rimwe basa rakaenderera mberi rakaisa pfungwa pakuratidzira mapuroteni eantibodies. Zvidzidzo izvi zvakatangira mukutanga kwema1960 zvakawanikwa naJohn Marrack.
kurondedzera maumbirwo emapuroteni eantibody.