In intrinsic regulation, the metabolic pathway self-regulates to respond to changes in the levels of substrates or products involved; for example, a decrease in the amount of product can increase the flux through the pathway to compensate. This type of regulation often involves allosteric regulation of the activities of multiple enzymes in the pathway. Extrinsic control involves a cell in a multicellular organism changing its metabolism in response to signals from other cells. Zviratidzo izvi zvinowanzova muchimiro chevatumwa vanogadziriswa vakadai semahomoni uye kukura kwezvinhu uye vanoonekwa nevanogamuchira chaiwo ari pamusoro. Zviratidzo izvi zvinozoendeswa mukati mechitokisi nevatumwa vechipiri vanobatanidzwa mu phosphorylation yemapuroteni.
allosteric regulation yemabasa emaenzyme akawanda ari munzira