Kubva muna 301 BC Armenia inosanganisirwa munharaunda yesimba reSeleucid Empire, asi yakaramba iine huwandu hwakakura hwekuzvitonga, ichichengetedza vatongi vayo vemuno. Sekureva kwaPolyaenus, muna 227 BC mambo anopandukira weSeleucid Antiochus Hierax akapotera munharaunda yeArmenian inotongwa naMambo Arsames, muvambi weguta reArsamosata. Pakupera kwa212 BC nyika yakakamurwa kuita humambo huviri, ese ari vassal nyika dzeSeleucids: Greater Armenia naSophene, kusanganisira Commagene kana Minor Armenia. Antiochus III Mukuru akafunga kudzvinyirira madzinza emuno, uye akakomberedza Arsamosata. Xerxes, satrap weCommagene naZariorene, akazvipira uye akatonga mambo weSeleucid, uyo akatambira kutonga kwake semutongi.
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