Zvirwere zveAlzheimer zvinoratidzwa nekurasikirwa kwema neurons uye synapses mu cerebral cortex uye dzimwe nzvimbo dze subcortical. Kurasikirwa uku kunoguma nekuora kwakanyanya kwenzvimbo dzakakanganiswa, kusanganisira degeneration mu temporal lobe uye parietal lobe, uye zvikamu zve frontal cortex uye cingulate gyrus. Degeneration iripowo mu brainstem nuclei se locus coeruleus. Zvidzidzo zvinoshandisa MRI uye PET zvakanyora kuderedzwa kwehukuru hwezvimwe zvikamu zvehuropi muvanhu vane AD sezvavanofambira mberi kubva pakunzwisisa zvishoma kusvika kuAlzheimer's disease, uye mukuenzanisa nemifananidzo yakafanana kubva kune vakwegura vane hutano. Zvose amyloid plaques uye neurofibrilles zvinoonekwa zvakajeka ne microscopy muuropi dzeavo vanotambudzwa neAD.
deposits of beta-amyloid peptide and cellular material outside and around neurons