Muzvinafundo wechiremba wechiChirungu wezana ramakore rechi19 Sydney Ringer akagadzira munyu une chloride ye sodium, potassium, calcium uye magnesium yakakodzera kuchengetedza kurova kwemoyo wemhuka iri kunze kwemuviri. Muna 1885, Wilhelm Roux akabvisa chikamu cheplate medullary ye embryo yehuku uye akaichengeta mune inodziya saline solution kwemazuva akati wandei, achimisikidza musimboti wehutachiona hwehutachiona. Ross Granville Harrison, achishanda paJohns Hopkins Medical School uyezve paYale University, akaburitsa mhedzisiro yezvaakaedza kubva muna 1907 kusvika 1910, achimisikidza nzira yekurima tishu. Maitiro ekurima maseru akafambira mberi zvakanyanya muma1940 nema1950 kutsigira kutsvagisa muhutachiona hwehutachiona. Kurima mumasero maseru kwakabvumidza kugadzirwa kwemasero akacheneswa ekugadzira majekiseni.
kuma1940 nema1950