Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Caffeine inobva mukapu yekofi kana kuti zvimwe zvinwiwa inopindwa nomudumbu duku mukati memaminiti 45 yokudya uye inoparadzirwa mumuviri wose. Nhamba yepamusoro yeropa inosvika mukati maawa 1 <unk> 2. Inobviswa nefirst-order kinetics. Caffeine inogonawo kutorwa nechepamberi, inoratidzwa ne suppositories ye ergotamine tartrate uye caffeine (nokuda kwekunyaradza migraine) uye chlorobutanol uye caffeine (nokuda kwekurapa hyperemesis). Zvisinei, kunwiwa nomuromo kunoshanda zvishoma kupfuura nomuromo: uwandu hukuru (Cmax) uye uwandu hwose hunonwiwa (AUC) zvose zviri zviviri inenge 30% (kureva, 1/3.5) yemari inonwiwa nomuromo. Muvanhu vakuru vane utano hwakanaka, hafu youpenyu hwecaffeine iri pakati pemaawa 3<unk>7. Kusvuta kunoderedza hafu youpenyu ne30<unk>50%, nepo mishonga yokudzivirira kubata pamuviri inogona kuipeta kaviri uye pamuviri kunogona kuikudza kusvika kumaawa 15 mukati mechitatu trimester. Muvana vachangoberekwa hafu yenguva inogona kuva maawa 80 kana kupfuura, ichiderera nokukurumidza zvikuru nezera, zvichida kusvika pazasi pemutengo wevakuru pazera remwedzi 6. Fluvoxamine (Luvox) inorwisa kuora mwoyo inoderedza kucheneswa kwe caffeine neanopfuura 90%, uye inowedzera hafu- yenguva yayo yekubvisa inopfuura kagumi; kubva pa4, 9 maawa kusvika kumaawa 56. Caffeine inoshandurwa muchiropa ne cytochrome P450 oxidase enzyme system, kunyanya, neCYP1A2 isozyme, kuva matatu dimethylxanthines, imwe neimwe ine zvainoita pamuviri:  Mubvunzo: caffeine inogara kwenguva yakareba sei mumuviri womunhu mukuru?
pakati pemaawa 3<unk>7