Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Kuchinjaniswa kwakawanda kwenucleophilic kunoitika nyore nyore kwete ne pyridine isina chinhu asi ne pyridine yakagadziridzwa ne bromine, chlorine, fluorine, kana kuti sulfonic acid zvidimbu zvinozova boka rinobva. Naizvozvo fluorine iboka rinosiya rakanakisisa nokuda kwokutsiviwa nemakemikari e organolithium. Nucleophilic kurwisa makemikari anogona kuva alkoxides, thiolates, amines, uye ammonia (pa yakakwirira kumanikidzwa). Kazhinji, hydride Ion ari murombo kusiya boka uye kunoitika chete vashoma heterocyclic maitiro. Zvinobatanidza Chichibabin reaction, iyo inobereka pyridine derivatives aminated pa 2-chinzvimbo. Pano, sodium amide inoshandiswa senucleophile inobereka 2-aminopyridine. Iyo hydride ion inosunungurwa mune izvi zvinopindirana inosanganiswa neproton yeboka rinowanikwa amino, kuumba hydrogen molecule. Zvakafanana ne benzene, nucleophilic substitutions kune pyridine inogona kuguma nekuumbwa kwe pyridyne intermediates se heteroaryne. Nokuda kwechinangwa ichi, pyridine derivatives inogona kubviswa nemapoka akanaka anosiya achishandisa zvikonzero zvakasimba zvakadai sesodium uye potassium tert-butoxide. Kuwedzerwa kwechinhu chinonzi nucleophile kune chisungo chetatu kune kusarudzwa kwakaderera, uye mugumisiro musanganiswa wezvinhu zviviri zvinogoneka.  Mubvunzo: Sodium inoshandiswa nokuda kwechii?
nucleophile inobereka 2-aminopyridine