Pritzker akanga ari mutsigiri wokutanga webasa raObama rezvematongerwe enyika, achibatsira kutsigira mari yebasa rake reSenate ra2004. Pakuvamba mumakwikwi eDemocratic omutungamiri wenyika, mari yaPritzker yakabetsera kukwikwidza kwaObama kurarama apo Obama akanga achitevera Hillary Clinton muzvitsvakurudzo. Pritzker akaramba ari muunganidzi mukuru wemari yaObama panguva ye2008 Democratic primary uye akaunganidza mamirioni akazara nokuda kwebasa rake reWhite House. Akashanda semutungamiri wezvemari yenyika mushandirapamwe waObama wegore ra2008
. Achitungamirirwa naye, mushandirapamwe wacho wakaita kuti vanhu vashoma vaipa zvipo vawanewo rubatsiro. Pritzker akagamuchirawo kuunganidza mari kwakawanda sechikamu chekuedza kwake kuunganidza mari.