The contact activation pathway begins with formation of the primary complex on collagen by high-molecular-weight kininogen (HMWK), prekallikrein, and FXII (Hageman factor). Prekallikrein is converted to kallikrein and FXII becomes FXIIa. FXIIa converts FXI into FXIa. Factor XIa activates FIX, which with its co-factor FVIIIa form the tenase complex, which activates to FXXa. Basa duku rinoitwa ne contact activation pathway mukutanga kuumbwa kwemakumbo rinogona kuratidzwa nenyaya yekuti varwere vane kushomeka kwakanyanya kweFXII, HMWK, uye prekallikrein havana chirwere chekubuda ropa. Panzvimbo pezvo, contact activation system inoita kunge inobatanidzwa zvakanyanya mukuzvimba, uye nekuzvidzivirira kwakazvarwa. Kunyangwe ichi chiitiko chinopesana, gungano iyi inogona kudzivirira kubva kune thrombosis pasina njodzi yakakosha.
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