"Toxic" rwiyo rwakanyorwa uye rwakagadzirwa naPontus Winnberg (anozivikanwa pamwe chete seRopa & Avant), pamwe nekunyora kubva kuna Cathy Dennis naHenrik Jonback. Rwiyo rwakaburitswa musi waNdira 13, 2004, naJive Records, seyechipiri imwe kubva muNzvimbo. Rwiyo rwacho rwaive rwunopihwa Kylie Minogue wepfumbamwe studio album yake Muviri Mutauro (2003), asi akaruramba. Mushure mekuedza kusarudza pakati pe "I (((That Got) Boom Boom" uye "Outrageous" kuti ave wechipiri wechipiri kubva muNzvimbo, Spears akasarudza "Toxic" panzvimbo. Rwiyo rwekutamba rune zvinhu zvemimhanzi yeBhangra, "Toxic" rwunoratidzira mavhidhiyo akasiyana siyana, akadai sedhiramu, magitare uye surf. Inoperekedzwa neBollywood-yakagadziriswa, uye rwiyo rwakawedzerwa se "Toxic" kubva kuBollywood.
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