Pedzisa mutsara unotevera: Mwaka wakatevera wakaona Milan ichidzora ligi. Milan yakatambira Genoa musi wa 25 Gunyana 2010, naPirlo achipa bhora rakasimudzwa pamusoro pekudzivirira kuti asunungure mutambi Zlatan Ibrahimović kuti awane chinangwa chega chemutambo. Musi wa2 Gumiguru, Pirlo akarova chinangwa chemamirimita makumi mana kurwisa Parma kupa Milan kukunda kwavo kwekutanga kunze kwemwaka wa2010-11. Musi wa14 Chivabvu 2011, Pirlo akaonekwa mumutambo wake wekupedzisira weMilan, achiuya semutambi wehafu yenguva yeAmbrosini sezvo kirabhu yaipemberera yavo
Mukombe weSerie A nekukunda Cagliari 4-1. Mazuva mana gare gare, Pirlo akasimbisa kuti aizosiya Milan pakupera kwemwaka wa2010-11 mushure mekunge sarudzo yekusavandudza kondirakiti yake. Mumwaka wake wekupedzisira kuMilan, Pirlo akaonekwa muligi ka17 chete pasi pemaneja Massimiliano Allegri, achirova chibodzwa chimwe chete uye matatu anobatsira, achikunda zita rake rechipiri reSerie A neMilan mwaka iwoyo, zvakare achisvika padanho re16 muEFAFA Champions League, uye muCoppa Italia semi-fainari.