Mushure mokunge chirwere ichi chatsanangurwa naHarry Klinefelter, uyo muna 1942 akashanda naFuller Albright naEC Reifenstein paMassachusetts General Hospital muBoston, Massachusetts, uye akatanga kuzvitsanangura mugore iroro. Nhoroondo yakapiwa naKlinefelter yakazozivikanwa seKlinefelter syndrome sezvo zita rake rakatanga kuonekwa pane pepa rakabudiswa, uye seminiferous tubule dysgenesis yakanga isingachashandisirwi. Tichifunga mazita evatsvakurudzi vatatu, dzimwe nguva inonziwo Klinefelter-Reifenstein-Albright. Muna 1956 zvakawanikwa kuti chirwere cheKlinefelter chinokonzerwa nekromosome yakawedzerwa. Plunkett naBarr vakawana kuti bonde chromatin mumuviri wemuviri wemuviri wemuviri. Izvi zvakajekeswa seXXYY muna 1959 naJohn Jacobs naJohn Anderson Strong.
Gore ra1959