Kufanana nemamwe marudzi akawanda ekenza, kenza yemapapu inotanga kana nekushanda kwe oncogenes kana kusashanda kwegomarara re tumor suppressor genes. Carcinogens inokonzera mutations mune idzi genes dzinokonzera kukura kwekenza. Mutations muK-ras proto-oncogene inokonzera inenge 10-30% yemapapu adenocarcinomas. Inenge 4% yevasiri-diki-sero remapapu carcinomas inosanganisira EML4-ALK tyrosine kinase fusion gene. Epigenetic shanduko dzakadai sekushandurwa kweDNA methylation, histone muswe, kana microRNA kugadzirisa kunogona kukonzera kusashanda kwegomarara re tumor suppressor genes. Zvakakosha, kenza yemapapu maseru kusagadzikana kune oxidative kusagadzikana, izvo zvinoita kuti vakwanise kutsungirira uye kuwedzera kusagadzikana kunokonzera kusagadzikana kwechirwere chechirwere chemu. Mutations muK-ras proto-oncogene inokonzera inenge 10-30% yemapapu adenocarcinomas.
c-MET, NKX2-1, LKB1, PIK3CA, uye BRAF