Saka fluorine ndiyo yakanakisisa kusiya boka nokuda yokutsiva pamwe organolithium yeimwe. The nucleophilic kurwisa yeimwe anogona kuva alkoxides, thiolates, amines, uye ammonia (pa yakakwirira kumanikidzwa). Kazhinji, ari hydride Ion ari murombo kusiya boka uye kunoitika chete vashoma heterocyclic maitiro. Vanosanganisira Chichibabin maitiro, iyo inobereka pyridine zvinobva aminated panguva 2-chinzvimbo. Pano, sodium amide rinoshandiswa sezvo nucleophile zvibereko 2-pyrine. The hydride Ion akasunungura ichi maitiro rinobatanidza ane proton ane amino boka, achibvisa benzene boka, uye ipapo kuva achisiya boka.
nucleophile inobereka 2-aminopyridine