Proteasomes ari chikamu chikuru mashandiro ayo masero kudzora wevasungwa chaiwo mapuroteni uye kuderedza misfolded mapuroteni. Mapuroteni vari tagged kuti kuora ane duku puroteni inonzi ubiquitin. The tagging maitiro iri catalyzed ne makemikari inonzi ubiquitin ligases. Kamwe puroteni iri tagged pamwe chete ubiquitin mamorekuru, ichi chiratidzo vamwe ligases kuti batanidza mamwe ubiquitin mamorekuru. Mugumisiro ari polyubiquitin cheni kuti akasungirirwa kubudikidza proteasome, kubvumira kuti kuora tagged puroteni. The kuora muitiro unobereka peptides anenge manomwe kusvika masere amino acids refu, izvo zvinogona ipapo mberi kuora kupinda mapfupi amino acid akatevedzana uye kushandiswa synthesizing mapuroteni matsva.
ubiquitin ligases