Ramba uchinyora ndima iyi - Pashure peHondo yeChitanhatu yeChechi, Frederick II akadzvinyirira kupandukira kwaitungamirirwa nomwanakomana wake Henry muGermany uye nokukurumidza akapinda muLombardy neuto guru. Papa Gregory IX akaedza kumisa kupinda nehurumende asi akakundikana. Frederick akakunda Lombard League muHondo yeCortenuova uye akaramba chibvumirano chipi nechipi chorugare nechimwe cheGuelph States. Akabva akomba Brescia asi akamanikidzwa kuibvisa. Iye akabva abviswa muchechi naPapa, uye achipindura akadzinga mamongi kubva kuLombardy ndokuisa mwanakomana wake Enzo semumiriri weImperial muItari; akakurumidza kubatanidza Romagna, Marche, iyo Duchy yeSpoleto, uye chikamu chePapal States. Munguvayo Frederick akafamba nomuTuscany achitarisira kubata Roma, zvisinei, akamanikidzwa kudzokera shure, achipamba guta reBenevento. Nokukurumidza zvisinei guta reGhibelline reFerrara rakawa uye Frederick kamwezve akafamba achipinda muItaly achitora Ravenna neFaenza. Papa akadaidza kanzuru asi ngarava dzeumambo dzePisa dzakakunda ngarava dzePope dzaitakura makadhinari nemabhishopu aibva kuGenoa muHondo yeGiglio
uye ipapo Frederick akapfuurira kufamba akananga kuRoma. Zvisinei Pope Gregory akakurumidza kufa uye Frederick, achiona hondo ichinangidzirwa kuChechi uye kwete papa, akabvisa mauto ake, achisunungura makadhinari maviri kubva kuCapua, kunyange zvazvo Frederick akafambazve achipesana neRoma kakawanda mukati me1242 ne1243.