I-5 inoshanduka kupinda mukati uye inotungamira kuchamhembe kuburikidza neMission Viejo kuenda kuEl Toro Y kuchinjana kumaodzanyemba kwakadziva kumabvazuva kweIrvine. I-5 inova Santa Ana Freeway sezvo ichimhanya kumaodzanyemba kwakadziva kumabvazuva kuenda kuchamhembe kwakadziva kumadokero, ichipfuura nemaguta makuru nemaguta muOrange neSouthern Los Angeles makondinendi. MaCalifornia ekumaodzanyemba anozviti "iyo 5" kana seSanta Ana Freeway munzvimbo yeLos Angeles. Kubva pano, iyo San Diego Freeway inoenderera kuchamhembe seI-405. Mubvunzo: Ndeapi makondinendi akapfuura Santa?
Orange neSouthern Los Angeles