Sezvo zana remakore rechi16 rakanga richipfuura, humwe hunhu hwevanhu hwakasvika parutivi rweCalvinism sechikoro chikuru chepfungwa; uye vanhu vakaita saPaul Schede, Jan Gruter, Martin Opitz, naMatthäus Merian vakadzidzisa kuyunivhesiti. Yakakwezva nyanzvi kubva kumativi ose ekondinendi uye yakagadziridzwa kuva nzvimbo yetsika uye yezvidzidzo. Zvisinei, nekutanga kweHondo Yemakore Makumi Matatu muna 1618, hupfumi hwepfungwa uye hwemari yeyunivhesiti yakadzikira. Muna 1622, Bibliotheca Palatina (raibhurari yeyunivhesiti) yaizivikanwa pasi rose yakabiwa kubva kuUniversity Cathedral ndokutorwa kuenda kuRoma. Kuedza kwekuvakazve mushure meizvozvo kwakakundwa nemauto aMambo Louis XIV, uyo akaparadza zvachose muna 1693. Semhedzisiro yeCounter-Reformation yekupedzisira, vadzidzi vePurotesitendi vakapotsa hunhu hweyunivhesiti, uye yakashandurwa nevadzidzi vayo.
upfumi hwepfungwa nehupfumi hweyunivhesiti hwakaderera