Trepanation, kuchera maburi mumusoro, kwaiitwa kare kare se7000 BCE. Kunyange zvazvo dzimwe nguva vanhu vaipona, vazhinji vangadai vakafa kubva pakurapwa nekuda kwehutachiona. Zvaifungidzirwa kuti zvinoshanda kuburikidza "nekurega mweya yakaipa kutiza". William Harvey akakurudzira trepanation semushonga wemigraine muzana ramakore rechi17. Kunyange zvazvo kurapwa kwemigraine kwakawanda kwakaedzwa, kwakanga kusati kwave kusvika muna 1868 kuti kushandiswa kwechinhu chakazopedzisira chabuda kuti chinoshanda chakatanga. Chinhu ichi chaiva fungus ergot kubva kune iyo ergotamine yakasarudzwa muna 1918. Methysergide yakagadzirwa muna 1959 uye yekutanga triptan, sumatriptan, yakagadzirwa muna 1988. Munguva yezana ramakore rechi20 nekudzidza kwakanaka uye matanho ekudzivirira akawanikwa uye akasimbiswa. Mubvunzo: Gore ripi iro ergotamine yakasarudzwa kubva kune fungus ergotamine?
Muna 1918