Nyorera kuenderera kweiyi ndima - PaGumiguru 22, 2018 episode ye "Raw", Reigns akazivisa kuti akaongororwazve aine leukemia mushure memakore gumi nerimwe uye aizotora nguva yekurapa. Somugumisiro, akarega kuva Mukwikwidzi Wenyika Yose, achigumisa kutonga kwake kwemazuva 64. Reigns pakutanga akagamuchira mhinduro dzakasiyana-siyana paakapinda munhandare, asi akagamuchirwa nekugamuchirwa kwakanaka pamwe nekuimba kwe "Ndinokutendai, Roman!" mushure mekuziviswa kwake kweleukemia kwakaitwa. Reigns akaita kudzoka kwake musi waFebruary 25, 2019 episode ye "Raw" kuzivisa kuti leukemia yake yakanga iri kuregererwa, kwaakagamuchira kurumbidzwa kukuru kubva kuvanhu vazhinji. Muchikamu chinotevera che "Raw", Reigns aizobatanazve neThe Shield, zvichitungamira kumutambo pakati paDrew McIntyre, Bobby Lashley naBaron Corbin paFastlane
, iyo The Shield yaizokunda mumutambo wokutanga waReigns chifo chokuongororwa kwake leukemia. Nguva dzose mbiri, Reigns aigamuchirwa nokushevedzera. PaWrestleMania 35, Reigns akakunda Drew McIntyre mumutambo wake wekutanga wega kubva muna Gumiguru 2018. Zvisinei, aizosangana nemhinduro yakasiyana-siyana neboka revanhu, nemunyori we "Pro Wrestling Dot Net" Jason Powell achitaura kuti inofungidzirwa kuti "70 muzana yevateveri vakashora Reigns apo 30 muzana chete vakamukurudzira pamberi pemutambo". Aizorondedzerawo mutambo wacho so"unogumbura".