Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Passage: Imwe rondedzero ichangobva kufambiswa mberi inotaura nezvokusaenzana kwemorekuru reIgA1. IgA1 ndeimwe yezvikamu zviviri zveimmunoglobulin (imwe yacho IgD) iyo O- glycosylated pane imwe nhamba ye serine uye threonine residues mune yakasarudzika proline- yakapfuma hinge nharaunda. Kugadziriswa kwakaipa kweIgA kunoratidzika kuti kunotungamirira kupolymerization yemamolekyu eIgA mumatumbu, zvikurukuru glomerular mesangium. Nzira yakafanana inonzi ndiyo inokonzera Henoch-Schönlein purpura, chirwere chinonzi vasculitis chinonyanya kubata vana uye chinogona kuva nechirwere cheitsvo chinenge chisingagoni kusiyaniswa neIgA nephritis. Zvisinei, zvidzidzo zvevanhu zvakawana kuti degalactosylation yeIgA1 inoitika muvarwere vane IgA nephropathy mukupindura chete kune gut antigen exposures (kwete systemic), uye inoitika muvanhu vane hutano kusvika pamwero muduku. Izvi zvinoratidza zvakasimba kuti degalactosylation yeIgA1 inokonzerwa nechinhu chisingazivikanwi (kusagadzikana kweantigene mu mucosal) uye kwete chikonzero chikuru cheIgA nephropathy. Uchapupu huripo hunoratidza kuti zvose zviri zviviri galactose-deficient o-glycans iri munharaunda yeIgA1 uye synthesis nekusunga kweantibodies inopesana neIgA1 inodiwa kuti immunoglobulin complexes igadzire nekuunganidza mu glomeruli. Kubva pachokwadi chekuti IgAN inogona kudzokazve mushure mekuisirwa itsvo, zvinogona kufungidzirwa kuti chirwere chinokonzerwa nedambudziko mu immune system kwete itsvo pachayo. Sezvineiwo, IgA1 inoungana muitsvo inoratidzika kuva isingabvi munyama inonzi mucosa- associated lymphoid tissue (MALT), inova ndiyo nzvimbo inowanikwa utachiona hwakawanda hwomumigwagwa yokufema yokumusoro, asi mumaronda emapfupa. Ikokuwo kunoratidzira hosha dzokudzivirira zvirwere panzvimbo pokupindira kwakananga kwezvinhu zvokunze.  Mubvunzo: Ndivanaani vanonyanya kubatwa nevasculitis?
vana