Pedzisa mutsara unotevera: Musi wa11 Chikunguru 2010, zvakaziviswa kuti Matteo Darmian aizobatana nePalermo musasa wekudzidzira mwaka muAustria, mushure mekunge Milan neSicilian Serie A kirabhu vabvumirana musimboti pamusoro pekuchinjana kwekufambisa kunosanganisira iye. Kufamba, kwakaratidzwa sechibvumirano chekubatana, kwakaziviswa zviri pamutemo nePalermo zuva rakatevera. Mutero wacho wakanga uri €800 000. Darmian akaita kutanga kwake kwe "Rosanero" musi wa16 Gunyana 2010, mumutambo weEuropa League vachipesana neSparta Prague, iyo yakamuwanisawo kutanga kwake mumakwikwi eEuropean. Kutanga kwake muPalermo League kwaive mumutambo wechina wemwaka, achiuya kuJavier Pastore mukukunda 3-1 vachipesana neJuventus. Musi waFebruary 6, 2011, akatamba mutambo wake wekutanga semutambi muligi mukukunda kwe4 × 2 yePalermo kure kuLecce, asi akatsiviwa muminiti yechi33 nekuda kwekukuvara. Akapedza mwaka wacho aine mitambo 16 pakati pe
Serie A, Europa League uye Coppa Italia.