Nyorai kuenderera mberi kweiyi ndima - Pakupera kwemwaka, Marchisio aive nyaya yekutumira runyerekupe sezvo kondirakiti yake yazvino yaifanira kupera zhizha rinotevera. Zvisinei, musi wa6 Chikunguru 2015, akasaina chibvumirano chemakore mashanu, achimuchengeta kukirabhu yekumusha kwake kusvika mwaka wa2019-2020. Marchisio akarambidzwa kwemwedzi mushure mekukuvara musuru ye adductor mumakumbo ake ekurudyi mumutambo wake wekutanga weligi mwaka uno musi wa12 Gunyana 2015, sezvo Juventus yakadhirowa 1<unk>1 kumba kuChievo. Musi wa24 Mbudzi, Marchisio akasarudzwa ku2015 UEFA Chikwata cheGore. Musi wa15 Kurume 2016 zvakaziviswa kuti Marchisio acharasikirwa nechikamu chechipiri che16 yeChampions League vachipesana neBayern Munich musi wa16 Kurume nekuda kwedambudziko remhasuru mumhuru yake yekuruboshwe. Akadzokera kunoshanda musi wa 2 Kubvumbi, mukukunda 1-0 kumba vachirwisa Empoli. Mavhiki maviri gare gare musi wa17 Kubvumbi, Marchisio akatambura nekukuvara kweanterior cruciate ligament panguva yekukunda kweJuventus 4-0 kumba pamusoro pePalermo mushure mekudonha kusinganzwisisike nekupokana naFranco Vázquez, izvo zvakamubvisa kunze kwemwaka wese pamwe nemutambo uri kuuya weUEFA Euro 2016. Mushure mekuvhiyiwa kwakabudirira pabvi rake reruboshwe musi wa 19 Kubvumbi, zvakasimbiswa kuti achange ari parutivi kwemwedzi mitanhatu. Mushure mokunge Juventus yawana rekodhi yavo yechishanu yakatevedzana Serie A
zita musi wa 25 Kubvumbi, kaputeni wekirabhu uye muchengeti wemagariro Buffon akapa kukunda kuna Marchisio.