Nyorai mberi kweiyi ndima - Mascherano akaita 147 kuoneka kwechikwata chenyika yeArgentina uye ndiye wechipiri mutambi ane zvibodzwa zvakanyanya munhoroondo yenyika (mushure meLionel Messi). Kubva paakatanga kutamba muna 2003 kusvika paakasiya basa muna 2018, akamiririra nyika pamakwikwi mashanu eCopa América, achipedzisa runner-up muna 2004, 2007, 2015, na2016
, uye ina FIFA World Cups, kusvika kumagumo e2014. Akakunda menduru yegoridhe kaviri kumaOlympics ezhizha, muna 2004 na2008, achiva mutambi wenhabvu wekutanga kuwana mbiri mbiri iyi kubvira mudziviriri weHungary Dezső Novák muna 1968. Pakati pa2008 na2011, Mascherano akashanda semutungamiriri weArgentina.