Sousa akadzokera kuDavis Cup munaGunyana kubatsira Portugal kukunda Belarus uye kuwana kukwidziridzwa kuEurope / Africa Zone's Group I muna 2016. Pasinei nokurasikirwa kwake kwekutanga rubber, akakunda rubber mbiri naElias uye rubber yekusarudza singles kurwisa Uladzimir Ignatik. PaSt. Petersburg Open, Sousa akasvika kumagumo ake echitatu emwaka. Mushure mekukunda Marcel Granollers, Simone Bolelli naDominic Thiem, Sousa aive wechipiri kuna Milos Raonic mumaseti matatu. Muna Gumiguru, Sousa akapinda mumutambo we1<unk>4 nekurasikirwa kwekutanga kuMalaysian Open, Japan Open, Shanghai Masters
uye mukombe weKremlin. PaValencia Open, Sousa akapedza mwaka aine rake rechipiri basa reATP zita uye rekutanga remwaka mune mana ekupedzisira kuyedza. Mushure mekurova vatambi vana vepamusoro-soro, kusanganisira Benoît Paire, Sousa akakunda 7th seed Roberto Bautista Agut mumutambo wekupedzisira mumaseti matatu. Akawana chinzvimbo chepamusoro chebasa rake muvhiki rakatevera paNhamba 34 yenyika. Sousa akapedza mwaka ari pachinzvimbo chepamusoro-soro pasi rose No. 33 aine 38 singles kuhwina. MunaNovember, akagamuchira mubairo weTennis Personality of the Year kechipiri kubva kuPortuguese Tennis Federation uye Confederação do Desporto de Portugal.