Pedzisa mutsara unotevera: Chikoro chacho chakakamurwa kuva zvikamu zveCzech neGermany muna 1882, uye Faculty of Natural Sciences yakava sangano rakaparadzana pakati pa 1920-1939. Muna 1939, chikoro chacho chakavharwa nemauto aitonga eNazi Germany, uye kutambudzwa kwoutsinye kwavadzidzisi nevadzidzi kwakatevera. Zvichitevera kuguma kwekugara muna 1945, Faculty of Arts yakabudirira zvakare kwemakore mashomanana; izvi zvakagumiswa nechisimba muna 1948 neCommunist coup muna 1948. Mukurumbira wechikoro wakaderera nokukurumidza somugumisiro wokumanikidzwa kuenda kwevadzidzisi vakawanda vanoremekedzwa uye kuiswa kwezvidzidzo zveMarxist-Leninist. Muma1960, fakaroti yakatanga kuvhurika zvishoma nezvishoma kune vanofunga vakakurumbira venguva yacho, asi maitiro aya akachinjwa nehutongi hweSoviet muna 1968, iyo Jan Palach, mudzidzi wechikoro, akaratidzira nekuzvipisa. Mushure mokunge
Kuguma kwehurumende yechiKomonisiti muCzechoslovakia muna 1989, uye kubuda kwevamiriri vayo muchikoro, yakagadzwazve seimwe yemasangano epamusoro epamusoro munyika.