Rangarira ndima iri pasi apa uye ipapo pindura mubvunzo gare gare mumutauro mumwe chetewo sechikamu:  Kupfuura: Kufanana nemamwe marudzi akawanda ekenza, kenza yemapapu inotanga nokumutswa kwezvinhu zvinokonzera kenza kana kuti kusaitwa kwezvinhu zvinodzvinyirira bundu. Zvinhu zvinokonzera kenza zvinokonzera kushanduka kwemuzvarirwo muzvinhu izvi zvinokonzera kukura kwekenza. Kushanduka kwemuzvarirwo muK-ras proto-oncogene kunokonzera inenge 10<unk>30% yemapapu adenocarcinomas. Inenge 4% yemakenza emapapu asiri emasero maduku anobatanidza EML4-ALK tyrosine kinase fusion gene. Kuchinja kweepigenetic kwakadai sokushandurwa kweDNA methylation, kugadziriswa kwehistone tail, kana kuti microRNA regulation kunogona kuguma nokusaita basa kwemajini anodzvinyirira bundu. Chinokosha ndechokuti masero ekenza anokwanisa kurwisa oxidative stress, izvo zvinoita kuti akwanise kutsungirira uye kuwedzera kuzvimba kunoita kuti masoja omuviri asaita basa rinorwisa bundu racho. Epidermal growth factor receptor (EGFR) inodzora kuwedzera kwemasero, apoptosis, angiogenesis, uye kupinda kwebundu racho. Kuchinja uye kuwedzera kweEGFR kunowanzoitika mucancer yemapapu isiri-diki, uye zvinopa hwaro hwekurapa neEGFR inhibitors. Her2/neu inokanganiswa kashoma. Mamwe majini anowanzoshanduka kana kuwedzerwa anosanganisira c-MET, NKX2-1, LKB1, PIK3CA, uye BRAF. Madzinza etsinga anobva maari haanyatsonzwisiswi. Nzira yacho ingasanganisira kusashanda zvakanaka kwemasero embeu. Mumigwagwa yokufema iri pedyo, masero emadziro anobudisa keratin 5 angangokanganiswa, kazhinji achitungamirira ku squamous- cell carcinoma yemapapu. Mumigwagwa yepakati yokufema, masero emudumbu anobatanidzwa anosanganisira masero echikamu uye masero eepithelial anoratidza puroteni inobudisa masero echikamu. Small-cell lung carcinoma inogona kubva mumitsetse yemasero aya kana kuti neuroendocrine cells, uye inogona kuratidza CD44. Metastasis yekenza yemapapu inoda kuchinja kubva kuepithelial kuenda kune mesenchymal cell type. Izvi zvinogona kuitika nokushandiswa kwenzira dzokupa chiratidzo dzakadai seAkt/ GSK3Beta, MEK- ERK, Fas, uye Par6.  Mubvunzo: Majini api anowanzoshanduka?
c-MET, NKX2-1, LKB1, PIK3CA, uye BRAF