Peirsol akahwina menduru yegoridhe mumakwikwi emamita 100 ekumhanya achidzokera kumashure uye mumakwikwi e4x100 ekumhanya achikwikwidzana
. Akakundawo sirivha munhangemutange yemamita 200 achimhanya neshure. Mumutambo wake wokutanga, wokumhanya kumashure kwemamita 100, Peirsol ndiye ainyanya kufarirwa kuti awane ndarama, iye ari iye akachengeta rekodhi yenyika uye ari kutsigira shasha yeOlympic. Pamutambo wokupedzisira wemamita 100 achimhanya achidzokera shure, Peirsol akanga achishambira mumugwagwa wechipiri, pashure pokunge apedza ari wechishanu mumakwikwi echikamu chokupedzisira. Pamakiromita 50 okutanga mumakwikwi okupedzisira emamita 100 achirohwa kumusana, Peirsol akanga ari panzvimbo yechipiri shure kwaLiam Tancock, uyo akazvibvisa muna 25.11. Peirsol akanga ari 0.54 s shure kwaTancock pakutendeuka. Zvisinei, pashure pokutendeuka, Peirsol akakunda Tancock, uyo pakupedzisira akaiswa wechitanhatu, uye akakunda ndarama. Nguva yokupedzisira yaPeirsol ye52.54 yakanga iri chinyorwa chitsva chenyika, ichivandudza chiratidzo chake chapakuvamba che52.89 chakagadzwa mwedzi wapfuura. Pashure pomutambo wacho, Peirsol akati, "Ndiri kufara zvishoma, ndakanzwa kurerukirwa zvishoma, ndafara zvikuru". Muchiitiko chake chechipiri, mamita mazana maviri kumusana, Peirsol akaiswa wechipiri kuna Ryan Lochte 1: 54.33 kusvika 1: 53.94. Mukukunda ndarama, Lochte akaputsa chinyorwa chenyika chaakabatana naPeirsol mumamita mazana maviri kumusana. Muchiitiko chake chokupedzisira, 4×100-metre medley relay, Peirsol akabatana naBrendan Hansen, Michael Phelps, naJason Lezak kuti vawane ndarama munguva yepasi rose ye3:29.34, vachideredza chiratidzo chekare che3:30.68 chakaiswa makore mana apfuura muAthens.