Thoir iomradh air an earrann gu h-ìosal agus an uairsin freagair a 'cheist às deidh sin anns an aon chànan ris an earrann:  Passage: Bidh synthesis de novo de ceramide a 'tòiseachadh le tionndaidh palmitate agus serine gus 3-keto-dihydrosphingosine a chruthachadh. Tha an ath-bhualadh seo air a ghnàthachadh leis an enzyme serine palmitoyl transferase agus is e seo an ceum a tha a 'cuingealachadh astar an t-slighe. Air an làimh eile, tha 3-keto-dihydrosphingosine air a lughdachadh gu dihydrosphingosine, a tha an uairsin air a leantainn le acylation leis an enzyme (dihydro) ceramide synthase gus dihydroceramide a thoirt gu buil. Tha an ath-bhualadh mu dheireadh gus ceramide a thoirt gu buil air a ghnàthachadh le dihydroceramide desaturase. Tha synthesis de novo de ceramide a 'tachairt anns an reticulum endoplasmic. Tha ceramide an uair sin air a ghiùlan gu inneal Golgi le bhith a 'dol an sàs ann an vesicular no am pròtain gluasaid ceramide CERT. Aon uair's gu bheil e ann an inneal Golgi, faodar ceramide a mheataboladh tuilleadh gu sphingolipids eile, leithid sphingomyelin agus na glycosphingolipids iom-fhillte.  Ceist: Dè a rinn dihydroceramide
(dihydro) ceramide synthase