O lenei tali e catalyzed e le enzyme serine palmitoyl transferase ma o le fua faatatau-faatapulaaina laasaga o le ala. i le isi itu, 3-keto-dihydrosphingosine ua faaitiitia i dihydrosphingosine, lea ua sosoo ai ma acylation e le enzyme (dihydro) ceramide synthase e maua dihydroceramide. O le tali mulimuli e maua ceramide ua catalyzed e dihydroceramide desaturase. De novo synthesis o ceramide tupu i le endoplasmic reticulum. ua mulimuli ane aveina Ceramide i le vesicular e ala i le fefaatauaiga o ceramide po o le siitia o le protein spingolipid. O le taimi lava e mafai ona toe gaosia dihydroceramide i le masini, e pei o le Glyceramide ma isi mea e mafai ona gaosia.
(dihydro) ceramide synthase