I le 1913 Leonor Michaelis ma Maud Leonora Menten fuafuaina se teori aofaiga o enzyme kinetics, lea ua taua o Michaelis <unk> Menten kinetics. O le saofaga autu o Michaelis ma Menten o le mafaufau i enzyme tali i laasaga e lua. I le muamua, o le substrate fusifusia reversibly i le enzyme, fausiaina o le enzyme-substrate lavelave. O lenei o nisi taimi e taʻua o le Michaelis-Menten lavelave i lo latou mamalu.
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