Faasino i le vaega o loo i lalo ma tali le fesili mulimuli ane i le gagana lava lea e tasi e pei o le vaega:  O nisi enzyme e lē manaʻomia ni vaega faaopoopo ina ia matuā galue atoatoa ai. O isi e manaʻomia ni molecules e lē o ni polotini e taʻua o cofactors ina ia mafai ai ona galulue. E mafai ona avea cofactors ma inorganic (eg, uʻamea ion ma uʻamea-sulfur faaputuga) poʻo faʻalapotopotoga tuufaatasi (eg, flavin ma heme). O nei cofactors e tele ona faamoemoega; mo se faataʻitaʻiga, o ion uʻamea e mafai ona fesoasoani i le faʻamautuina o ituaiga nucleophilic i totonu o le nofoaga toaaga. E mafai ona avea cofactors faatulagaina ma coenzymes, lea e faamatuu mai i le enzyme's active site i le taimi o le tali atu, po o vaega faafoliga, lea e fusifusia lelei i se enzyme. E mafai ona covalently fusia vaega prosthetic faatulagaina (eg, biotin i enzymes e pei o pyruvate carboxylase).O se faataitaiga o se enzyme o loo i ai se cofactor o anhydrase carbonic, lea o loo faaalia i le ata i luga o le lipine i se zinc cofactor fusia o se vaega o lona nofoaga toaaga. O nei aniani po o ni vaega o loo fusifusia lelei, e masani lava ona maua i le vaega o loo iai le vaega o loo iai le vaega o loo iai le vaega o loo iai le vaega o loo iai le vaega o loo iai le vaega o loo iai le vaega o loo iai. O se faataʻitaʻiga, o le flavin ma le heme cofactors e masani lava ona aafia i tali o le redox. O enzyme e manaʻomia se cofactor ae leai se tasi e fesoʻotaʻi e taʻua o apoenzymes poʻo apoproteins. O se enzyme faatasi ai ma le cofactor ((s) e manaʻomia mo le gaioiga e taʻua o le holoenzyme (poʻo le haloenzyme). O le faaupuga holoenzyme e mafai foi ona faʻaaogaina i enzymes o loʻo iai le tele o polotini subunits, e pei o le DNA polymerases; iinei o le holoenzyme o le maeʻa faʻatumuina o loʻo iai uma subunits manaʻomia mo gaioiga.  Fesili: O le ā le vaega e aofia ai le flavin ma le heme?
tuufaatasiga faatulagaina