I le 1920s, na matauina ai e Michael Heidelberger ma Oswald Avery e faapea o antigens e mafai ona faʻatupuina e antibodies ma faʻaalia ai o antibodies e faia mai i le protein. O meaola o meaola o le antigen-antibody-binding interactions na suʻesuʻeina auiliili i le tuai o le 1930s e John Marrack. O le isi alualu i luma tele na faia i le 1940s, ina ua faʻamaonia e Linus Pauling le loka-ma-ki manatu na fuafuaina e Ehrlich e ala i le faʻaalia o fegalegaleaiga i le va o antibodies ma antigens e sili atu ona faʻalagolago i lo latou foliga nai lo latou vailaʻau. I le 1948, na maua ai e Astrid Fagreaus o sela B, i le tulaga o sela plasma, na nafa ma le gaosia o antibodies. O isi galuega na faʻatauaina i le faʻamalamalamaina o fausaga o antibodies. O nei suʻesuʻega tetele na faʻatautaia i le amataga o le 1960s na maua e John Mar
e faamatalaina ai le fausaga o polotini o le antibody.