Ia tusi se faaauauga o lenei palakalafa - Na toe foʻi Blondell i Hollywood i le 1950. O lana faatinoga i lana ata na sosoo ai, "The Blue Veil" (1951), na maua ai e ia le Academy Award
filifilia mo le tama'ita'i sili ona lelei i se vaega lagolago. Na ia faia ni vaega lagolago i le "The Opposite Sex" (1956), "Desk Set" (1957), ma le "Will Success Spoil Rock Hunter?" (1957). Na ia mauaina le tele o viiga mo lana faatinoga o le Lady Fingers i le Norman Jewison's "The Cincinnati Kid" (1965), ma maua ai se Golden Globe filifilia ma le National Board of Review manumalo mo le Best Supporting Actress. Na faia e John Cassavetes o ia o se tusitala taufaaleaga, ua matua i lana ata tifaga "Opening Night" (1977). Na vaaia lautele Blondell i ni ata se lua na tatalaina i se taimi puupuu ae leʻi maliu o ia <unk> "Grease" (1978), ma le toe faia o le "The Champ" (1979) ma Jon Voight ma Rick Schroder. Na aliali mai foi o ia i ata tifaga e lua na tatalaina ina ua mavae lona maliu <unk> "The Glove" (1979), ma le "The Woman Inside" (1981).