I le amataga, naive B sela faʻaalia naʻo sela-luga IgM ma IgD ma tutusa antigen-noatia itulagi. Taʻitasi isotype ua fetuʻunaʻi mo se eseʻese gaioiga; o lea, a maeʻa le faʻagaoioiga, o se antibody ma le IgG, IgA, poʻo le IgE effector gaioiga ono manaʻomia e faʻateʻa lelei ai se antigen. Vasega faʻatagaina eseese afafine sela mai le tutusa B sela faʻagaoioia e gaosia eseese antibodies. Naʻo le vaega o le mamafa antibody suiga suiga i le taimi o vasega taʻitasi, ma o lea effector gaioiga, o loʻo faʻamatalaina e le tumau (C) itulagi o le immunoglobulin mamafa filifili. O lenei faʻafitauli e tupu i le taimi nei e faʻamoemoe i le faʻaaogaina o se faʻapitoa enzyme auala e toe faʻafesoʻotaʻi ai le DNA i ni vaega eseese e lua e leʻi suia. O lenei gaioiga e faʻalagolago i le gaioiga o le toe faʻaaogaina o le DNA i le
faʻataʻitaʻiga o le nucleotide faʻasaoina