O le tele o meaola ola e masani ona aafia i vailaau e le mafai ona latou faʻaaogaina o ni meaʻai ma o le a leaga pe a faʻaputuputu i totonu o sela, aua e leai se latou gaioiga metabolic. O nei vailaʻau e ono afaina ai e taʻua o xenobiotics. Xenobiotics e pei o vailaʻau faʻapitoa, vailaʻau oona ma vailaʻau faʻamaʻi e faʻamamaina e se seti o xenobiotic-metabolizing enzymes. I tagata, o nei mea e aofia ai cytochrome P450 oxidases, UDP-glucuronosyltransferases, ma glutathione S-transferases. O lenei faiga o enzymes i ni laʻasaga se tolu e muamua faʻapipiʻi le xenobiotic (phase I) ona faʻapipiʻi lea i luga o le vai-soluble molecule (phase II). O le vai-soluble xenobiotic e mafai ona faʻaaogaina i fafo atu o sela ma faʻaleagaina i totonu o sela ma e mafai ona faʻaleagaina i fafo atu
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