Dheweke minangka anak kaping pitu saka 13 anak sing lair saka pendeta Calvinist Lyman Beecher. Ibune yaiku garwane sing pertama, Roxana (Foote), wanita sing religius banget sing tilar donya nalika Stowe mung umur limang taun. Kakek ibune Roxana yaiku Jenderal Andrew Ward saka Perang Revolusi. Sedulur-sedulur sing misuwur kalebu adhine, Catharine Beecher, sing dadi pendidik lan penulis, uga sedulur sing dadi menteri: kalebu Henry Ward Beecher, sing dadi pendeta lan abolitionist sing misuwur, Charles Beecher, lan Edward Beecher.
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