Reaksi iki dikatalisis dening enzim serine palmitoyl transferase lan minangka langkah sing mbatesi tingkat jalur. Sabanjure, 3-keto-dihydrosphingosine dikurangi dadi dihydrosphingosine, sing banjur diterusake dening acylation dening enzim (dihydro) ceramide synthase kanggo ngasilake dihydroceramide. Reaksi pungkasan kanggo ngasilake ceramide dikatalisis dening dihydroceramide desaturase. Sintesis de novo ceramide dumadi ing reticulum endoplasmic. Ceramide banjur diangkut menyang retikuler kanthi ngoperasikake ceramide utawa ngirim protein ceramingoid spingoid ing CERT. Sawise diprodhuksi ing apparatus, Golgi bisa diolah dadi dihydroceramide lan apa wae liyane. Pitakon: Apa sing bisa diprodhuksi dening kompleks dihydroceramide?
(dihidro) keramid sintase