Mezue nkebi ahịrịokwu a: N'afọ 1500, Louis nke Iri na Abụọ, bụ́ onye ya na Ferdinand nke Abụọ nke Aragọn kwekọrịtara ka e kewaa Naples, si Milan gawa ebe ndịda. Ka ọ na-erule afọ 1502, ndị agha France na Aragon jikọtara aka chịkwaa alaeze ahụ; nghọtahie banyere usoro nkewa ahụ dugara n'agha n'etiti Louis na Ferdinand. Ka ọ na-erule afọ 1503, e meriela Louis n'agha ahụ.
Agha nke Cerignola na Agha nke Garigliano, a manyere ya ịhapụ Naples, nke a hapụrụ n'okpuru nchịkwa nke Viceroy Spanish, Ramón de Cardona. Ndị agha France nọ n'okpuru Gaston de Foix meriri ndị agha Spain n'agha nke Ravenna na 1512, mana Foix nwụrụ n'oge agha ahụ, a manyekwara ndị France ịhapụ Italytali site na mwakpo ndị Switzerland wakporo Milan, bụ ndị weghachiri Maximilian Sforza n'ocheeze ducal. Njikọ Dị Nsọ, bụ́ nke e mere ka o merie, tisasịrị n'okwu banyere ikesa ihe ndị a kwatara n'agha, na 1513 Venice sooro France jikọọ aka, na-ekwenye ka ha kewaa Lombardy n'etiti ha abụọ.