Mezue ahịrịokwu na-esonụ: Ntinye aka na Latin America abụrụla obere okwu mkpọsa; Harding kwuru okwu megide mkpebi Wilson iziga ndị agha US na Dominican Republic, ma wakpo onye nnọchi anya onye isi ala Democratic, Franklin D. Roosevelt maka ọrụ ya na
Ntinye aka nke ndị Haiti. Onye odeakwụkwọ nke steeti Hughes rụrụ ọrụ iji meziwanye mmekọrịta ya na mba Latin America ndị na-akpachara anya banyere ojiji ndị America na-eji Monroe Doctrine eme ihe iji kwado itinye aka; n'oge nhọpụta Harding, US nwekwara ndị agha na Cuba na Nicaragua. A chụpụrụ ndị agha nọ na Cuba iji chebe ọdịmma ndị America na 1921, mana ndị agha US nọgidere na mba atọ ndị ọzọ site na ọchịchị Harding. N'April 1921, Harding nwetara nkwado nke Thomson <unk> Urrutia Treaty na Colombia, na-enye mba ahụ $ 25,000,000 dị ka mmezi maka mgbanwe mgbanwe nke Panamanian nke 1903 nke US kpalitere. Mba ndị Latin America enweghị afọ ojuju, dịka US jụrụ ịhapụ itinye aka, ọ bụ ezie na Hughes kwere nkwa na ọ ga-ejedebe ya na mba ndị dị nso na Canal Panama ma mee ka o doo anya ihe ebumnuche US bụ.