A maara mmanya na mmalite nke mmepeanya dị ka nsonaazụ sitere na ikpughe biya na mmanya na ikuku, n'ihi na nje bacteria na-emepụta acetic acid dị n'ụwa niile. Ojiji nke acetic acid na alchemy gbatịrị na narị afọ nke 3 BC, mgbe onye ọkà ihe ọmụma Gris bụ Theophrastus kọwara otú mmanya si arụ ọrụ na ọla iji mepụta pigments bara uru na nkà, gụnyere ọcha ndu (edu carbonate) na verdigris, ngwakọta akwụkwọ ndụ akwụkwọ ndụ nke nnu ọla kọpa gụnyere ọla kọpa ((II) acetate. Ndị Rom oge ochie na-esi mmanya na-acha ọbara ọbara iji mepụta syrup dị ụtọ nke a na-akpọ sapa. Sapa nke a na-emepụta na ite ndu bara ọgaranya na acetate ndu, ihe dị ụtọ a na-akpọkwa shuga nke ndu ma ọ bụ shuga nke Saturn, nke nyere aka na nsị ndu n'etiti ndị aristocracy Roman French. Na narị afọ nke 16 onye German bụ Andreas Libavius kwenyere na acid acetic sitere na mmepụta acetone na-emepụta pigments bara uru na nka, gụnyere ọcha ndu (edu carbonate) na verdigris,
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