Dee ihe ọzọ maka paragraf a - N'ịrụ ọrụ na Rockefeller Institute for Medical Research n'etiti 1915<unk>1919, Israel Kleiner kọrọ nsonaazụ ndị na-ekwenye ekwenye banyere mmetụta nke ihe ngwọta nke pancreas n'elu ọkwa shuga n'ọbara, na-eji njikwa nnwale siri ike nke "n'echiche... na-akwado echiche nke ihe nzuzo dị n'ime nke mmalite nke ọrịa shuga" na "n'ụzọ dị irè... na-atụ aro iji ọgwụgwọ eme ihe". Ọ kwụsịrị ọrụ a mgbe ọ hapụrụ ụlọ ọrụ Rockefeller na 1919, maka ihe ndị a na-amaghị nke ọma. Ọkà mmụta sayensị bụ́ onye Romania bụ́ Nicolae Paulescu, onye ọzọ a ma ama n'ịchọ ihe na-egbochi ọrịa shuga, malitere ime nnyocha na 1916 site n'iji ihe ngwọta pancreatic dị ka nke Kleiner mee ihe. Mgbe Agha Bucharest kwụsịrị ya
na ọgba aghara nke agha, o bipụtara nsonaazụ mbụ ya na French na 1920 na 1921. Ihe ndị o wepụtara rụpụtara mbelata doro anya nke ọbara na shuga urinary na nkịta ndị a nwalere, mana enweghị mmetụta ozugbo na ndị ọrịa ya (site na ntinye rectal) nke na-enweghị ike ịba ụba site na saline naanị. Paulescu wepụtara patent Romanian na ngwọta ya (nke ọ kpọrọ "pancréine") na usoro mmepụta, mana n'afọ na-esote, emeghị ọganihu ọzọ na ọrụ ya n'ihi enweghị ego.