Mezue ahịrịokwu na-esonụ: Obodo a bụ "municipium" nke ndị Rom oge ochie, bụrụkwa ebe azụmahịa na imepụta ihe ndị kasị mkpa n'ógbè ahụ ruo ọtụtụ narị afọ. Mgbe ọdịda nke Alaeze Ukwu Rom gasịrị, Casale ghọrọ obodo nweere onwe ya, na narị afọ nke 15 na mmalite nke 16, ọ bụ isi obodo nke ụlọ nke Palaiologos. E mesịa, na 1536, obodo ahụ gafere n'aka ndị Gonzagas bụ́ ndị ji nnukwu ụlọ e wusiri ike wusie ya ike. Na narị afọ nke 17, Casale tinyere aka nke ukwuu n'ihe omume ndị a na - eme n'ebe ahụ.
Agha nke Mantuan Succession na ndị agha France na Spanish nọchibidoro ya. N'oge agha nke ijikọ Italytali, obodo ahụ bụ ebe nchebe megide Alaeze Ukwu Austria.