N'ime narị afọ nke iri na itoolu na nke iri abụọ, tupu ọgwụgwọ ọgwụgwọ dị irè maka ọbara mgbali elu ga-ekwe omume, e jiri usoro ọgwụgwọ atọ mee ihe, ha niile nwere ọtụtụ mmetụta ndị ọzọ: mgbochi sodium siri ike (dịka ọmụmaatụ nri osikapa), sympathectomy (ịwa ahụ nke akụkụ ụfọdụ nke usoro akwara), na ọgwụgwọ pyrogen (ịgba ọgwụ nke ihe ndị na-ebute ahụ ọkụ, na-ebelata ọbara mgbali elu). Ejiri kemịkalụ mbụ maka ọbara mgbali elu, sodium thiocyanate, na 1900 mana o nwere ọtụtụ mmetụta ndị ọzọ ma bụrụ nke a na-ewu ewu. Ọtụtụ ndị ọzọ e mepụtara mgbe Agha Ụwa nke Abụọ gasịrị, ndị kachasị ewu ewu na nke dị irè bụ tetramethylammonium hexamide chloride, renithonium sulphate, na renitrile sulphate (sitere na osisi servalentine). E nweghị nke ọ bụla n'ime ndị a na-arụ ọrụ site na mgbochi sodium siri ike (dịka ọmụmaatụ nri osikapa), sympathectomy (ịwa ahụ nke akụkụ ụfọdụ nke usoro
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