Mezue nkebi ahịrịokwu a: Mgbe Castro Sarmento nọ na London mụta banyere ọgwụ quinine, o mepụtara ọgwụ a maara dị ka Água de Inglaterra, bụ́ nke ghọrọ ihe a ma ama na Portugal, bụ́ ebe ọrịa ịba ka juru ebe nile n'ebe ndịda nke mba ahụ. N'afọ 1731, o mere atụmatụ maka ogige osisi dị na Coimbra. Castro Sarmento na ọtụtụ ndị ọkà mmụta, tinyere ndị ọzọ na Prọfesọ João Mendes Sachetti Barbosa nke Lisbon, bụ onye kọọrọ ya ihe dị egwu
ala ọma jijiji nke bibiri isi obodo Portugal na 1755, ya na onye Jesuit B. Soares, onye gwara ya ihe ndị ọ chọpụtara banyere mbara igwe n'ebe ndị Portugal na-achị Brazil. Ọ bụ onye na-akwado Newtonianism n'ụzọ siri ike ma gbalịsie ike ijikọta ya na nkà mmụta okpukpe ndị Juu. O bipụtara "Theorica verdadeira das marés, conforme à philosophia do incomparavel cavalhero Isaac Newton" (Akwụkwọ na-ekwu maka ezi echiche nke ebili mmiri, dị ka nkà ihe ọmụma nke nwoke a na-enweghị atụ bụ Isaac Newton), akwụkwọ mbụ n'asụsụ Portuguese iji kwado echiche Newton (London, 1737).