Kelly's second spaceflight was as mission commander of STS-118, a 12-day Space Shuttle mission to the ISS in August 2007. Kelly's third spaceflight was as a crew member on Expedition 25/26 on the ISS. O rutere na ISS n'ụgbọ Soyuz TMA-01M na 9 Ọktoba 2010, wee jee ozi dị ka onye injinia ụgbọ elu ruo mgbe ọ weghaara iwu nke ọdụ ụgbọ elu na 25 Nọvemba 2010 na mmalite nke Expedition 26. Njem 26 nke March 2011 kwụsịrị na ọpụpụ nke Soyuz TMA-01M. Na November 2012, onye Russia na-ahụ maka mbara igwe na-ahụ maka mbara igwe na Hubble Space Telescope, wee nọrọ ihe na-erughị ụbọchị asatọ. Kelly's nke abụọ spaceflight bụ dị ka onye isi ọrụ nke STS-118, njem njem njem ụgbọ elu nke ụbọchị 12 na ISS na August 2007. Kelly's nke atọ spaceflight bụ dịka onye ọrụ ụgbọ elu na njem 25/26 na ISS. O rutere na ISS n'ụgbọ Soyuz TMA-01M na 9 Ọktoba 2010, wee jee ozi dị
Ọktoba 9, 2010