Mezue ahịrịokwu na-esonụ: A kpọrọ Núñez na ndị isi maka oge mbụ na August 19, 2010 mgbe edepụtara Lance Berkman na ndepụta ndị nwere nkwarụ ụbọchị 15. Núñez bidoro n'otu ụbọchị ahụ, dochie Jeter n'agba nke asaa ma mebie n'ime naanị ọdịdị ya. Núñez natara oge egwu dị ka ihe ndochi maka Jeter na Alex Rodriguez merụrụ ahụ. N'August 21, Núñez dekọtara egwuregwu mbụ ya, otu RBI na-aga n'ihu n'ọhịa aka nri. Núñez gbara agba nke mbụ ya na Chicago White Sox na August 28, 2010. Ọ zụkwara bọọlụ mbụ ya n'otu ụbọchị ahụ. N'egwuregwu 30 maka Yankees, Núñez gbara.280, na otu ụlọ na-agba ọsọ, asaa RBIs, wee gbaa ọsọ 12. Mgbe Mark Teixeira merụrụ ahụ n'oge
2010 American League Championship Series, ndị Yankees dochie ya na postseason roster ha na Núñez. Mgbe oge ahụ gachara, "Baseball America" kwuru na ọ bụ ya bụ onye nke asatọ kachasị mma na nzukọ Yankees, ebe ọ na-akpọkwa ya "Best Defensive Infielder" na "Best Infield Arm" na nzukọ Yankees.