Dee ihe na-aga n'ihu maka paragraf a - Mgbe mmerụ ahụ sitere na ihe ọghọm ịgba ọsọ ya na 2001, Zanardi kpebiri ịlaghachi n'egwuregwu, na-ewere handcycling. N'afọ 2007, ọ nwetara ebe nke anọ na New York City Marathon na ngalaba handcycle, mgbe naanị izu anọ nke ọzụzụ. Kemgbe ahụ, ọ na-agba ịnyịnya ígwè n'ụzọ dị mkpa, ma soro asọmpi na Para-Cycling Road World Championships na 2009. O kwuru na ya na-achọ ịnọ n'otu ndị otu Ịtali maka asọmpi Paralympics nke afọ 2012
Ọ dị mma. N'afọ 2009, o meriri Marathon Venice n'ụdị ndị nwere nkwarụ, na-agba oche nkwagharị ya n'ime otu elekere, nkeji iri na atọ, sekọnd 56, ma merie Marathon Rome City na 2010, n'oge otu elekere, nkeji iri na ise, sekọnd 53. N'afọ 2011, na nke anọ ya, Zanardi meriri New York City Marathon na klas ya na-agba ịnyịnya ígwè.