Mezue nkebi ahịrịokwu a: Mgbe e chiri ya eze na Germany, Charles kwadoro Popu Leo nke Iri ma kwuo na Martin Luther bụ onye iwu na-akwadoghị ná Nzukọ Ndị Isi Chọọchị e nwere na Worms (1521). N'otu afọ ahụ, Francis nke Mbụ nke France, nke ihe ndị Habsburg nwere gbara gburugburu, malitere agha na Lombardy nke dịruru ruo Agha Pavia (1525), nke dugara n'ịkpọchi eze France ruo nwa oge. Esemokwu ndị Protestant maliteghachiri n'afọ 1527 mgbe ndị agha nnupụisi nke Charles, bụ́ ndị ihe ka ọtụtụ n'ime ha na-ekpe okpukpe Lutheran, wakporo Rom. Mgbe ndị agha ya hapụsịrị ógbè ndị popu, Charles nke Ise
gbachitere Vienna site n'aka ndị Turkey ma nweta okpueze dịka Eze na Ịtali site n'aka Pope Clement nke Asatọ. N'afọ 1535, o weghaara Duchy nke Milan na Tunis. N'agbanyeghị nke ahụ, ọnwụ Buda n'oge ọgụ maka Hungary na njem njem Algiers na mbido 1540s kụdara usoro ndọrọ ndọrọ ọchịchị ya megide Ottoman. Ka ọ dịgodị, Charles nke Ise na Popu Paul nke Atọ kwekọrịtara ịhazi Kansụl Trent (1545). Ọjụjụ Njikọ Schmalkaldic nke okpukpe Lutheran jụrụ ịnakwere ịdị irè nke kansụl ahụ dugara n'agha, nke Charles nke Ise meriri site n'itinye ndị isi Protestant n'ụlọ mkpọrọ. Otú ọ dị, Henry nke Abụọ nke France nyere nkwado ọhụrụ maka ọdịmma ndị Lutheran ma mee ka ya na Sultan Suleiman Onye Ukwu ahụ, bụ́ onye chịrị Alaeze Ukwu Ottoman kemgbe 1520, dịkwuo ná mma.