Mezue ahịrịokwu na-esonụ: Mgbe Armstrong dị afọ iri na isii, ọ malitere ịgba ọsọ n'egwuregwu triathlon, ọ bụkwa onye mmeri na-agba ọsọ ọsọ ọsọ n'egwuregwu triathlon n'afọ 1989 nakwa n'afọ 1990. Na 1992, ọ malitere ọrụ ya dị ka onye na-agba ígwè ọkachamara na ndị otu Motorola. O nwere ihe ịga nke ọma n'etiti 1993 na 1996 na World Championship na
1993, Clásica de San Sebastián na 1995, Tour DuPont na 1995 na 1996, na mmeri ole na ole na Europe, gụnyere usoro 8 nke 1993 Tour de France na usoro 18 nke 1995 Tour de France. N'afọ 1996, a chọpụtara na ọ na-arịa ọrịa cancer testicular nke nwere ike igbu ya. Mgbe ọ gbakere, o guzobere Lance Armstrong Foundation (ugbu a Livestrong Foundation) iji nyere ndị ọzọ lanarịrị ọrịa kansa aka.