Mee ka ahịrịokwu a zuo ezuo: Ọ bụ ndị agbụrụ Panama ka e bu ụzọ biri na Panama tupu ndị Spen ebido ịchị ya n'agbata afọ 1601 na afọ 1600. Ọ kewapụrụ onwe ya na Spain na 1821 ma sonye na Republic of Gran Colombia, njikọ nke Nueva Granada, Ecuador, na Venezuela. Mgbe e bibisịrị Gran Colombia na 1831, Panama na Nueva Granada mesịrị ghọọ Republic of Colombia. Site n'enyemaka nke United States, Panama kewapụrụ onwe ya na Colombia na 1903, na-enye ohere ka ndị US Army Corps of Engineers rụchaa owuwu nke Ọwa Mmiri Panama n'etiti 1904 na 1914. Nkwekọrịta Torrijos-Carter nke 1977 kwekọrịtara ịnyefe ọwa mmiri ahụ site na United States gaa Panama na December 31, 1999. Ihe
ala gbara ya gburugburu bụ nke mbụ e weghachiri na 1979.