Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Ụzọ e si abanye ya: Acetylsalicylic acid bụ acid na- esighị ike, ọ bụkwa nanị obere akụkụ ya ka a na- eme ka ọ ghọọ ion n'ime afọ mgbe a ṅụsịrị ya. A na - amịnye acid acetylsalicylic ngwa ngwa site na akpụkpọ ahụ cell n'ọnọdụ acidic nke afọ. Mmụba nke pH na ebe ka ukwuu n'ime eriri afọ na-eme ka ọgwụ aspirin jiri nwayọọ nwayọọ banye n'ime ya, ebe ọ bụ na ọ na-adịkwu ionic. N'ihi ihe ndị na-eme n'ahụ́, a na-eji nwayọọ nwayọọ amịkọrọ ọgwụ aspirin mgbe e ji ya mee ihe gabiga ókè, ọ pụkwara ịnọgide na-arị elu ruo awa 24 mgbe a ṅụsịrị ya. Ihe dị ka 50<unk>80% nke salicylate dị n'ọbara na-ejikọta na protein albumin, ebe ihe fọdụrụ na-anọgide n'ọnọdụ dị irè, nke ionized; ijikọta protein na-adabere n'ọbara. Ịba ụba nke ebe ndị a na- ejikọta ihe na- eduga n" inwekwu salicylate n" onwe ya na ịba ụba nke nsí. Mpịakọta nke nkesa bụ 0. 1 <unk> 0. 2 L/ kg. Acidosis na- eme ka ọnụọgụ nke nkesa dịkwuo elu n'ihi mmụba nke ịbanye n'ime anụ ahụ nke salicylates. Ihe ruru 80% nke ọgwụgwọ ọgwụgwọ nke salicylic acid na- agbanwe n'ime imeju. Njikọ ya na glycine na-emepụta salicyluric acid, yana glucuronic acid iji mepụta esters glucuronide abụọ dị iche iche. A na-akpọ conjugate na acetyl otu dị ọcha dị ka acyl glucuronide; conjugate deacetylated bụ phenolic glucuronide. Ụzọ ndị a e si eme mgbanwe n'ahụ́ nwere nanị ikike a kpaara ókè. A na-ejikwa obere mmiri salicylic acid mee hydroxylated ka ọ bụrụ gentisic acid. Site na nnukwu salicylate, kinetics na-agbanwe site na nke mbụ gaa na nke efu, ka ụzọ metabolic na-aghọ nke jupụtara na mkpochapụ akụrụ na-aghọwanye ihe dị mkpa. A na-ewepụ salicylates site na akụrụ dị ka salicylic acid (75%), salicylic acid (10%), salicylic phenol (10%), na acyl glucuronides (5%), gentisic acid (< 1%), na 2,3-dihydroxybenzoic acid. Mgbe e riri obere ọgwụ (ihe na- erughị 250 mg n" onye toruworo ogo mmadụ), usoro nile na- aga n' ihu site na kinetics nke mbụ, na ọkara ndụ nke ihe dị ka awa 2. 0 ruo 4. 5 h. Mgbe a na- aṅụ nnukwu ọgwụ salicylate (karịa 4 g), ọkara ndụ ya na- adị ogologo karị (site n' awa 15 ruo awa 30).  Ajụjụ: Olee otú e si ekesa aspirin?
0.1<unk>0.2 L/kg