N'afọ 2004, Seyfried mere ihe nkiri mbụ ya na ihe nkiri ntụrụndụ nke ndị nọ n'afọ iri na ụma bụ Mean Girls. Ọrụ nkwado ya na-esote bụ na ihe nkiri ndị nweere onwe ha, dị ka ihe nkiri Nine Lives (2005) na ihe nkiri mpụ Alpha Dog (2006). O nwekwara ọrụ na-aga n'ihu na usoro ihe nkiri UPN Veronica Mars (2004<unk>06). N'agbata afọ 2006 na 2011, Seyfried gbara na usoro ihe nkiri HBO Big Love. O gosikwara na ihe nkiri egwu egwu Mamma Mia! (2008) ma weghachite ọrụ ya na usoro, Mamma Mia! Lee Anyị Na-aga Ọzọ (2018). Ajụjụ: Gịnị bụ ihe nkiri mbụ Seyfried?
Ụmụ Nwanyị Ọjọọ