Dee ihe na-aga n'ihu maka paragraf a - Islam buru ụzọ rute Urfa n'ihe dị ka 638 AD, mgbe mpaghara ahụ nyefere ndị agha Rashidun n'enweghị nguzogide, wee bụrụ ọnụnọ dị mkpa n'okpuru Ayyubids (lee: Saladin Ayubbi), Seljuks. N'afọ 1144, ndị agha Crusader dara n'aka onye isi ndị Turkish Abassid bụ Zengui, onye gburu ọtụtụ ndị bi na ya bụ Ndị Kraịst na ndị bishọp Latin (lee Siege of Edessa
) na nke abụọ Crusade na-esote enweghị ike iweghachite obodo ahụ. Mgbe nke ahụ gasịrị, ndị Zengids, Ayyubids, Sultanate nke Rum, Ilkhanids, Memluks, Akkoyunlu na Safavids chịrị Urfa tupu mmeri Ottoman na 1516.