Mezue ahịrịokwu na-esonụ: N'afọ 2005, Buehrle malitere oge ahụ na ndekọ 10<unk>3, 2.58 ERA na 1.11 WHIP. N'April 16, o mechara egwuregwu megide Seattle Mariners na naanị 1 awa na nkeji 39, na-enye naanị otu ọsọ na atọ hits (niile ka Ichiro Suzuki), na-akwado naanị abụọ White Sox na-agba ọsọ, ma homers site Paul Konerko. N'egwuregwu ahụ, ọ tụbara naanị otu narị na isii. Ọ bụrụ na e wepụ oge e ji mee ihe n'agbata innings abụọ ahụ, ọ bụ nanị minit ole na ole ka e ji mee egwuregwu ahụ. A họpụtara Buehrle na American League All-Star Team, ma kpọọ ya onye na-ebido mgbe Roy Halladay enweghị ike igwu egwu n'ihi ụkwụ gbajiri agbaji ma tụba innings abụọ, na-enyeghị ohere ọ bụla ma na-eti ndị batrị atọ mgbe ha na-enweta mmeri. Buehrle nke 49 na-amalite nke isii ma ọ bụ karịa innings kwụsịrị na August 1, 2005 mgbe a chụpụrụ ya maka ịkụda Baltimore Orioles outfielder B. J. Surhoff. N'oge White Sox playoff na-agba ọsọ, Buehrle gbara egwuregwu zuru ezu megide Los Angeles Angels nke Anaheim na Egwuregwu 2 nke
ALCS, nke mbụ n'ime egwuregwu anọ zuru oke maka ndị White Sox na-amalite. N'October 25, 2005, Buehrle ghọrọ onye mbụ na-agba na akụkọ ihe mere eme nke World Series ịmalite ma chekwaa egwuregwu ndị na-esote, na-enweta mkpebi na-enweghị mkpebi na Egwuregwu 2 na ọrụ mbụ ya na-azọpụta na Egwuregwu 3 nke World Series 2005, nke Sox kpochapụrụ na Houston Astros, na-emeri mmeri mbụ ha n'ụwa kemgbe 1917.