Kammala jumla mai zuwa: Darmian ya fara fitowa a kakar 2017-18 a ranar 8 ga Agusta 2017 a kan Real Madrid a cikin
UEFA Super Cup, wanda United ta rasa 1<unk>2. Farkon wasan Premier na kakar wasa ya kasance a ranar 9 ga Satumba, a wasan da suka yi da Stoke City. Bai sake bayyana a gasar ba har zuwa ranar 14 ga Oktoba a wasan da suka tashi 0-0 da Liverpool a Anfield. Duk da yake ba a cikin gasar ba, Darmian ya taka leda a gasar zakarun Turai ta UEFA a wasan da suka ci Benfica da ci 2-0 a ranar 31 ga Oktoba da kuma rashin nasara da Basel da ci 1-0 a ranar 22 ga Nuwamba. A ranar 20 ga Disamba, ya taka leda a wasan da United ta doke Bristol City da ci 2-1. Darmian ya fara buga wasansa na farko tun daga watan Oktoba a ranar 18 ga Afrilu, 2018, yana wasa da Bournemouth a wasan da suka ci 2-0. Kwana uku bayan haka, ya fito daga benci a minti na 80 don ganin nasarar United ta 2 zuwa 1 a kan Tottenham Hotspur a wasan kusa da na karshe a gasar cin kofin FA a filin wasa na Wembley. Darmian ya fara a wasan United na karshe na gasar a kakar wasa ta 13 a ranar 13 ga Mayu, yana lura da nasarar 1 <unk> 0 a kan Watford a Old Trafford. An bar shi a benci don rashin nasarar Manchester United da Chelsea a wasan karshe na gasar cin kofin FA a ranar 19 ga Mayu. Bayan rashin amincewa da José Mourinho, Darmian ya yi nasarar buga wasanni takwas ne kawai a cikin kakar wasa ta bana, biyar daga cikinsu sun fara.