Kammala wannan jumla: A ranar 27 ga Yuli, 2012, an yi musayar Scutaro, tare da la'akari da tsabar kudi, zuwa San Francisco Giants don mai kunnawa Charlie Culberson. A cikin wasa da St. Louis Cardinals a Busch Stadium a ranar 8 ga Agusta, 2012, Scutaro ya yi tseren tsere bakwai a cikin aikinsa ciki har da babban slam. Ya buga.306 don kakar wasa ta yau da kullun, gami da.362 a matsayin Giant, yana taimaka wa Giants cin nasarar taken League League na Yamma. An ba shi lambar yabo ta NLCS MVP bayan da ya daidaita rikodin NLCS tare da 14 hits kuma kuma ya buga.500 (14 don 28) tare da gudu shida da gudu huɗu a lokacin
jerin wasanni bakwai da Cardinals. A ranar 28 ga Oktoba, a cikin wasan na goma na wasa na 4 na Wasannin Duniya na 2012, Scutaro ya kori Ryan Theriot don nasarar nasara, yayin da Giants suka kori Detroit Tigers.