Kammala jumla mai zuwa: The Know Nothing National Convention ya zabi Fillmore a matsayin shugaban kasa, amma rashin jituwa game da matsayar jam'iyyar game da bautar ya sa yawancin Arewacin Know-Nothings suka watsar da jam'iyyar. A halin yanzu, da
Taron Jam'iyyar Republican na 1856 ya zabi John C. Frémont a matsayin dan takarar shugaban kasa na jam'iyyar. Rashin amincewa da yawancin Arewacin Know-Nothings, haɗe da bugun Charles Sumner da sauran abubuwan da suka haifar da tashin hankali, sun ƙarfafa 'yan Republican a duk Arewa. A lokacin yakin neman zabensa, Fillmore ya rage batun nativism, maimakon kokarin amfani da yakin neman zabensa a matsayin dandamali ga kungiyar kwadago da farfado da Jam'iyyar Whig.