Bayan fara aikinta a kan mataki, Anderson ta sami karbuwa a duniya saboda rawar da ta taka a matsayin FBI Special Agent Dana Scully a kan wasan kwaikwayo na wasan kwaikwayo na Amurka The X-Files. Ayyukan fim dinta sun hada da wasan kwaikwayo The Mighty Celt (2005), The Last King of Scotland (2006), Shadow Dancer (2012), Gidan Viceroy (2017) da kuma fina-finai biyu na X-Files: The X-Files: Fight the Future (1998) da kuma The X-Files: Ina so in yi imani (2008). Sauran sanannun fina-finai na talabijin sun hada da: Lady Dedlock a Bleak House (2005), Wallis a cikin Duk wani Simpson na Human Heart (2010), Miss Havisham a Great Expectations (2011), Dr. Maurilia Duer Hannibal (2013-2015), da kuma a kan Media Gods (2017).
X-Files