Don haka fluorine shine mafi kyawun rukunin barin don maye gurbin tare da mahaɗan organolithium. Abubuwan haɗarin nucleophilic na iya zama alkoxides, thiolates, amines, da ammonia (a matsin lamba). Gabaɗaya, ion hydride rukuni ne mara kyau kuma yana faruwa ne kawai a cikin 'yan halayen heterocyclic kaɗan. Sun haɗa da halayen Chichibabin, wanda ke haifar da abubuwan da aka samo na pyridine a matsayin 2-position. Anan, ana amfani da sodium amide a matsayin nucleophile mai samar da 2-opyrine na gaba. Ion hydride da aka saki a cikin wannan halayen yana haɗuwa tare da proton na amino na benzene, wanda ke haifar da ƙungiyar barin.
nucleophile mai ba da 2-aminopyridine