Rubuta ci gaba don wannan sakin layi - Kashi na biyu ya fara ne da isowar Khalid ibn al-Walid da sojojinsa zuwa Siriya a 634. A karkashin babban kwamandan Khalid, sojojin musulmi sun kewaye su kuma sun kama cibiyoyin biranen kudancin Siriya na Bosra, Damascus
, Beisan (Scythopolis), Pella, Gaza, da kuma na ɗan lokaci, Homs (Emesa) da Baalbek (Hierapolis). Heraclius ya amsa ta wurin tura rundunar sojojin daular da suka biyo baya a kan Musulmai. Byzantines sun yi nasara sosai a sakamakon manyan yaƙe-yaƙe na Ajnadayn a Falasɗinu da Fahl da Yarmouk a Transjordan, duk sun faru a cikin 634-636. Nasarar da Musulmai suka yi a fagen yaƙi ya kawo ƙarshen tsayayya ta Byzantines.