A cikin 1913 Leonor Michaelis da Maud Leonora Menten sun gabatar da ka'idar ƙididdiga na enzyme kinetics, wanda ake kira Michaelis <unk> Menten kinetics. Babban gudunmawar Michaelis da Menten shine suyi tunanin halayen enzyme a matakai biyu. A cikin farko, substrate ya haɗu da reversibly zuwa enzyme, yana samar da enzyme-substrate complex. Wannan wani lokaci ana kiransa Michaelis-Menten complex a cikin girmamawa. Enzyme sa'an nan kuma yana ƙaddamar da sinadaran a cikin mataki na amsawa kuma ya saki samfurori. Wannan aikin ya ci gaba da ci gaba da G. E. Briggs da S. B. J. Haldane, waɗanda suka samo asali na kinetic daga gwaje-gwajen enzyme.
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