Manchester United tana da kishiya da Arsenal, Leeds United, Liverpool, da Manchester City, waɗanda suke fafatawa da Manchester derby. Gasar da Liverpool ta samo asali ne daga gasar tsakanin biranen a lokacin Juyin Masana'antu lokacin da Manchester ta shahara da masana'antar yadi yayin da Liverpool babbar tashar jiragen ruwa ce. Kungiyoyin biyu sune kungiyoyin Ingila mafi nasara a duka gasar gida da ta Turai; kuma a tsakanin su sun lashe taken league 38, 9 Kofin Turai, 4 Kofin UEFA, 4 Kofin Super na UEFA, 19 Kofin FA, 13 Kofin League, 1 FIFA Club World Cup, 1 Intercontinental Cup da 36 FA Community Shields. Ana ɗaukarsa a matsayin ɗayan manyan abokan hamayya a cikin ƙungiyar ƙwallon ƙafa ta duniya kuma ana ɗaukarsa mafi shahararren abin da ya faru a ƙwallon ƙafa ta Turanci.
Arsenal, Leeds United, Liverpool, da kuma Manchester City