Ana amfani da shi a ƙarshen karni na 19, phenacetin ya kasance wani ɓangare na haɗin haɗin haɗuwa a cikin sassan Turai, Australia, da kuma Amurka. Wadannan haɗin haɗin sun ƙunshi aspirin ko wasu NSAIDs tare da phenacetin, paracetamol, ko salicylamide, da kuma maganin kafeyin ko codeine. A cikin shekarun 1950, Spühler da Zollinger sun ba da rahoton haɗuwa tsakanin koda da cutar koda na phenacetin.
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