Ba a bayyana canje-canje a cikin morphology ko ƙungiyoyin salula a cikin waɗannan kwayoyin ba a cikin shekaru biliyan na gaba. Kwayoyin eukaryotic sun bayyana tsakanin shekaru biliyan 1.6 zuwa biliyan 2.7 da suka gabata. Babban canji na gaba a cikin tsarin tantanin halitta ya zo ne lokacin da kwayoyin cuta suka mamaye kwayoyin eukaryotic, a cikin wata ƙungiya mai haɗin gwiwa da ake kira endosymbiosis. Kwayoyin da aka mamaye da kwayar mai karɓa sun sami nasarar coevolution, tare da kwayoyin cuta suna haɓaka ko dai mitochondria ko hydrogenosomes. Wani mamayewa na cyanobacterial-kamar kwayoyin halitta ya haifar da samuwar chloroplasts a cikin algae da tsire-tsire. Tarihin rayuwa shine cewa unicellular eukary eukaryotes, prokaryotes da arthropods sun bayyana kimanin shekaru 610 da suka gabata lokacin da waɗannan kwayoyin multicellular suka fara bayyana a cikin yanayi mai zaman kanta a cikin kwayoyin cyanobacteria da yawa.
Babu canje-canje a bayyane a cikin ilimin halittar jiki ko tsarin salula