Kammala jumla mai zuwa: Cavani ya zira kwallaye a wasan farko na Uruguay da Colombia a ranar 6 ga Fabrairun 2008, kuma tun daga wannan lokacin ya sami wasanni 123 kuma ya zira kwallaye 53 na kasa da kasa, kawai a bayan abokin wasan Luis Suárez a tsakanin 'yan wasan Uruguay. Ya halarci manyan wasannin duniya guda tara: FIFA World Cup a 2010, 2014 da 2018, Copa América a 2011, 2015,
2016, 2019 da 2021, da kuma FIFA Confederations Cup a 2013. Ya zura kwallaye sau daya a gasar cin kofin duniya ta 2010 don taimakawa Uruguay zuwa matsayi na hudu a gasar, kuma a 2011 ya kasance wani ɓangare na tawagar Uruguay da ta lashe lambar yabo ta goma sha biyar ta Copa América. Ya gama a matsayin CONMEBOL 2018 gasar cin kofin duniya mai cin kwallaye tare da kwallaye goma.