Kammala jumla mai zuwa: Yayin da Charles V ya jagoranci Diet of Worms, Francis I na Faransa ya aika da Janar Robert de la Marck don mamaye ƙasashen ƙasashen Burgundian kuma ya goyi bayan Henry II na Navarre a cikin yakin neman sake dawo da Navarre na Iberian. Sarkin ya amsa ta hanyar ayyana Francis da aka hana shi Milan kuma ya kafa kawancen anti-Faransa tare da Paparoma Leo X (8 ga Mayu 1521), wanda ke da sha'awar haɗuwa da yankuna masu mahimmanci na Parma da Piacenza, duka bangare ne na Milan da Faransa ke riƙe. Ta haka ne aka soma Yaƙin Shekara Huɗu. A halin yanzu, Cortés ya kewaye shi (Mayu 26) kuma ya mallake shi (Agusta 13)
Tenochtictlan, kammala cin nasarar Daular Aztec. Jirgin ruwan da ke dauke da babban dukiyar sarki Cuauhtémoc ya kama shi ne daga dan Faransa Jean Fleury, amma 120,00 ducats na zinariya ya kai ga baitulmalin Imperial a lokacin rikicin Italiya. Renaissance Italiya ta bayyana ta Mercurino di Gattinara a matsayin "babban tushe na daular" kuma duka Francis I da Charles V, waɗanda aka ɗauka a matsayin mafi girman masarautar Turai a lokacin, sun yi burin samun fifiko a cikin tsibirin mai arziki. Kamar yadda masanin tarihin Renaissance Francesco Guicciardini ya bayyana: