Kammala wannan jumla: Lokacin da Charles ya gaji kursiyin Spain, mallakar Spain a ƙasashen waje a Sabuwar Duniya sun kasance a cikin Caribbean da Mutanen Espanya na Mutanen Espanya kuma sun ƙunshi yawan mutanen da ke raguwa da sauri, 'yan albarkatun da ke da daraja ga kambi, da kuma' yan mulkin mallaka na Mutanen Espanya. Yanayin ya canza sosai tare da balaguron Hernán Cortés, wanda, tare da kawance da biranen-jihohi masu adawa da Aztecs da dubban mayaƙan Mexico na asali,
ya ci Aztec Empire a shekara ta 1521. Da yake bin tsarin da aka kafa a Spain a lokacin Reconquista da kuma a Caribbean, mazauna Turai na farko a Amirka, masu cin nasara sun raba 'yan asalin zuwa gidaje masu zaman kansu "encomiendas" kuma sun yi amfani da aikinsu. Tsakiyar Mexico da kuma daga baya Daular Inca ta Peru ta ba Spain sabbin 'yan asalin ƙasar da za su tuba zuwa Kiristanci kuma su yi sarauta a matsayin masu sarauta na kambi. Charles ya kafa Majalisar Indiya a 1524 don kula da duk abubuwan mallakar Castile na ƙasashen waje. Charles ya nada mataimakin sarki a Mexico a 1535, yana iyakance mulkin masarauta na babban kotu, "Real Audiencia", da jami'an baitulmalin tare da babban jami'in masarauta. Bayan cin nasarar Peru, a cikin 1542 Charles kuma ya naɗa mataimakin sarki. Dukkanin jami'an biyu suna karkashin ikon Majalisar Indiya. Charles ya ba da Sabbin Dokokin 1542 don iyakance ikon ƙungiyar masu cin nasara don samar da aristocracy na gado wanda zai iya kalubalanci ikon kambi.