Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Hanyar wucewa: Kofin da ke cikin kofi ko kuma wasu abubuwan sha yana shiga cikin ƙananan hanji a cikin minti 45 bayan an sha shi kuma ya shiga dukan ɓangarorin jiki. An kai ga mafi girman jini a cikin awa 1 <unk> 2. An kawar da shi ta hanyar kinetics na farko. Hakanan ana iya shan maganin kafeyin ta hanyar rectally, wanda aka nuna ta hanyar suppositories na ergotamine tartrate da maganin kafeyin (don sauƙaƙe migraine) da chlorobutanol da maganin kafeyin (don maganin hyperemesis). Koyaya, sha na rectal ba shi da inganci kamar na baki: matsakaicin maida hankali (Cmax) da jimlar adadin da aka sha (AUC) duka kusan kashi 30% ne (watau 1/3.5) na adadin da aka sha. Rayuwar kwayar halitta ta maganin kafeyin <unk> lokacin da ake buƙata don jiki ya kawar da rabin kashi <unk> ya bambanta sosai tsakanin mutane dangane da dalilai kamar juna biyu, wasu magunguna, matakin aikin enzyme na hanta (da ake buƙata don maganin kafeyin) da shekaru. A cikin lafiyayyun manya, rabin rayuwar maganin kafeyin yana tsakanin 3<unk>7 hours. Shan sigari yana rage rabin rayuwa da kashi 30 zuwa 50%, yayin da maganin hana daukar ciki na baki zai iya ninka shi kuma ciki zai iya ɗaga shi har zuwa awanni 15 a cikin watanni uku na uku. A cikin jarirai rabin rayuwar zai iya zama sa'o'i 80 ko fiye, yana raguwa da sauri tare da shekaru, watakila zuwa ƙasa da ƙimar manya ta watanni 6. Maganin antidepressant fluvoxamine (Luvox) yana rage tsabtace maganin kafeyin da fiye da 90%, kuma yana ƙaruwa rabin rabin rayuwarsa fiye da sau goma; daga sa'o'i 4. 9 zuwa sa'o'i 56. Ana amfani da maganin kafeyin a cikin hanta ta hanyar tsarin cytochrome P450 oxidase enzyme, musamman, ta hanyar CYP1A2 isozyme, zuwa dimethylxanthines uku, kowannensu yana da nasa tasirin akan jiki:  Tambaya: tsawon wane lokaci ne maganin kafeyin ke wanzuwa a jikin manya?
tsakanin 3<unk>7 hours