Tare da Yardbirds, Clapton ya buga Fender Telecaster, Fender Jazzmaster, Gretsch 6120 mai sau biyu, da kuma 1964 Cherry-Red Gibson ES-335. Ya zama dan wasan Gibson ne kawai na wani lokaci da ya fara a tsakiyar 1965, lokacin da ya sayi wani guitar Gibson Les Paul daga wani kantin sayar da guitar a London. Clapton yayi sharhi game da bayanan sirri na bakin ciki, wanda zai nuna cewa samfurin 1960 ne. Da farko a lokacin da yake zaune a Foothill, an sace wuyansa na farko na Paul Clapton.
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