Cika jumla mai zuwa:
Bayan tashin hankali na soja a Maroko a ranar 17 ga Yuli, 1936, an raba Spain cikin sauri zuwa biyu: "Jamhuriyar Republican" ko "Masu Aminci" Spain da ke kunshe da Jamhuriyar Mutanen Espanya ta Biyu, da kuma "Nationalist" Spain a ƙarƙashin janar janar, kuma, a ƙarshe, a ƙarƙashin jagorancin Janar Francisco Franco. Daga farkon lokacin yaƙin, Negrin ya haɗu da ayyukansa a matsayin mataimakin kuma, daga baya, a matsayin minista, tare da ziyartar sau da yawa a cikin motarsa ta sirri zuwa wurare daban-daban a layin gaba na Madrid don ƙarfafa mayakan da samar musu da abinci da kayayyaki. Negrín ya taimaka wa mutane da yawa su tsere daga juyin juya hali "" a watan Yuli da Agusta 1936. Wani abokinsa ya tabbatar da gaba gaɗin da ya nuna a yin wannan aikin, ya ce "ya yi iya ƙoƙarinsa, har ya sa kansa cikin haɗari... don ya ceci mutane a Madrid". A sakamakon haka, an kashe Negrin kusan anarchists amma ya sami ceto ta hanyar shiga tsakani na ma'aikatar tsaro na ma'aikatar kudi.