A ranar 22 ga watan Janairun 2005, Clapton ya yi wasan kwaikwayo a Tsunami Relief Concert da aka gudanar a filin wasa na Millennium a Cardiff, don taimakawa wadanda ke fama da girgizar kasa na 2004 a Tekun Indiya. A watan Mayu 2005, Clapton, Jack Bruce, da Ginger Baker sun sake haɗuwa a matsayin Cream don jerin kide kide a Royal Albert Hall a London. An sake yin rikodin kide-kide a kan CD da DVD. Daga baya, Cream ya yi a New York a Madison Square Garden. An saki kundin farko na Clapton na sabon kayan asali a kusan shekaru biyar, Back Home, a kan Reprise Records a ranar 30 ga Agusta. Tambaya: A ina ne wuri na ƙarshe da Cream ya yi?
Gidan shakatawa na Madison Square