Cika wannan jumla: A Rio de Janeiro, Adrian ya lashe lambar yabo guda hudu. Ya lashe lambar yabo ta farko a matsayin anga don gudun mita 4 × 100 tare da Caeleb Dressel, Michael Phelps, da Ryan Held. Amurkawa, tare da Dressel da Held a matsayin masu fafatawa a gasar Olympics a karon farko, sun gama da lokacin 3:09.92, sai Faransa da Ostiraliya. Ƙarshen Adrian ya kasance 46.97 seconds, mafi sauri a filin. A gasarsa ta farko,
A tseren mita 100, Adrian ya kasa kare kambinsa na Olympics, inda ya zo na uku a bayan Kyle Chalmers da Pieter Timmers a cikin dakika 47.85. Adrian ya sake samun lambar tagulla a tseren mita 50 na 'yanci, ya gama a cikin dakika 21.49. Wani Ba'amurke, Anthony Ervin, ya ci nasara a cikin dakika 21.40 kuma mai kare gasar Olympic Florent Manadou ya zama na biyu. Ya kammala wasannin Olympics tare da wata lambar zinare a tseren mita 4x100 a ranar karshe ta gasar, yana iyo tare da Ryan Murphy, Cody Miller, da Michael Phelps. Ya kafa relay tare da raba 46.74 don kawo gida zinariya a cikin 3: 27.95, sabon rikodin wasannin Olympics.