Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: A tsakiyar shekara ta 2005, Mustaine ya shirya yawon shakatawa na shekara-shekara, Gigantour. Megadeth ya jagoranci yawon shakatawa na farko tare da ayyukan kamar Dream Theater, Nevermore, Anthrax, da kuma Factory Factory. An yi fim da kuma rikodin wasan kwaikwayon a wasan kwaikwayon Montreal da Vancouver don DVD-da-CD da aka saki a cikin kwata na biyu na shekara ta 2006. A ranar 9 ga Oktoba, bayan nasarar The System Has Failed da Blackmail the Universe yawon shakatawa na duniya, Mustaine ya sanar da taron jama'a a Pepsi Music Rock Festival a Argentina cewa Megadeth zai ci gaba da yin rikodi da yawon shakatawa. Wasan, wanda aka gudanar a filin wasa na Obras Sanitarias a Buenos Aires a gaban magoya baya 25,000, an yi fim kuma an sake shi a DVD a matsayin That One Night: Live a Buenos Aires a 2007. A watan Fabrairun 2006, bassist James MacDonough ya bar ƙungiyar saboda "bambance-bambance na sirri". An maye gurbinsa da James LoMenzo, wanda ya yi aiki tare da David Lee Roth, White Lion, da Black Label Society. Sabon tsarin Megadeth ya fara rayuwa kai tsaye a bikin Dubai Desert Rock Festival a Hadaddiyar Daular Larabawa tare da Alkawari. A watan Maris, Capitol ya fitar da faifan DVD guda biyu, Arsenal na Megadeth, wanda ya haɗa da hotunan ajiya, hira, raye-raye, da yawancin bidiyon kiɗan ƙungiyar. Saboda batutuwan lasisi, ba a haɗa waƙoƙin sauti da bidiyo na Capitol ba. Na biyu Gigantour ya fara ne a cikin kwata na uku na 2006; Megadeth ya sake yin taken, a wannan karon tare da Lamban Rago na Allah, Opeth, Arch Enemy da Overkill. Yawon shakatawa na 2006 ya haɗa da ranakun uku a Ostiraliya, wanda Soulfly, Arch Enemy, da Caliban suka tallafawa.  Tambaya: A wace shekara ce wannan kwata na biyu?
Shekarar 2006