Shi ne a kan San Francisco Peninsula, a cikin arewa maso yammacin ɓangare na Santa Clara Valley (Silicon Valley) kimanin 37 miles (60 km) kudu maso gabashin San Francisco da kuma kimanin 20 miles (30 km) arewa maso yammacin San Jose. A shekara ta 2008, 60% na wannan ƙasa ya kasance undeveloped.Stanford ta babban harabar ya hada da wani ƙidaya-kaddara wuri a cikin unincorporated Santa Clara County, ko da yake wasu daga cikin jami'a ƙasar (kamar Stanford Shopping Center da Stanford Research Park) ne a cikin birnin iyaka na Palo Alto.
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