A cikin tsari na ciki, hanyar metabolic tana daidaita kanta don amsawa ga canje-canje a cikin matakan substrates ko samfurori; misali, rage yawan samfurin zai iya ƙara yawan ruwa ta hanyar hanya don ramawa. Wannan nau'in tsari yakan ƙunshi tsarin allosteric na ayyukan enzymes da yawa a cikin hanya. Kulawa na waje ya ƙunshi tantanin halitta a cikin kwayoyin halitta da ke canza metabolism a matsayin martani ga sigina daga wasu ƙwayoyin. Wadannan sigina suna yawanci a cikin nau'i na manzo mai narkewa kamar su hormones da kuma girma da kuma gano su ta hanyar takamaiman masu karɓa a kan farfajiyar. Wadannan sigina suna sa'an nan a cikin tantanin halitta ta hanyar manzo na biyu wanda ke da hannu a cikin phosphorylation na sunadarai.
allosteric tsari na ayyukan enzymes da yawa a cikin hanyar