Kammala wannan jumla: De Silvestro ya yi gasa a cikakken lokaci a cikin IndyCar Series don HVM Racing don kakar 2010. A ranar 22 ga Mayu, 2010, ta cancanci a matsayi na 22 don gasar cin kofin duniya.
2010 Indianapolis 500. Ta gama tseren a matsayi na 14, kuma ta sami lambar yabo ta Rookie of the Year na Indianapolis 500. Ta sha wahala a hannun dama na hannun dama bayan wani hadari mai tsanani a Firestone 550 a Texas Motor Speedway a ranar 5 ga Yuni 2010. Tawagarta ta soki jami'an tsaron IndyCar Series sosai saboda yadda suka amsa wannan hatsarin. A wannan kakar, de Silvestro ya fara tsere 17, ya gama goma, kuma ya yi rikodin biyu a saman 10, tare da mafi kyawun karshe na takwas a Mid-Ohio. Ta gama ta 19 a gaba ɗaya a cikin jerin jerin kuma ta kasance ta biyu ga Alex Lloyd don girmamawa na rookie na shekara.