Rubuta ci gaba ga wannan sakin layi - Bayan janyewa daga tseren, Vilsack ya goyi bayan Sanata Hillary Clinton don shugabancin a ranar 25 ga Maris, 2007. Yana fatan ya samar mata da kwarin gwiwa a Iowa. Tsohon Gwamnan ya bayyana Clinton a matsayin dan takarar da ke da "mafi kyawun ra'ayoyi, mafi yawan kuzari, da dabi'u da hangen nesa don jagorantar kasarmu". Ba da daɗewa ba bayan amincewa, Clinton ta sanya sunan matar Vilsack Christie a matsayin mataimakin shugaban kamfen dinta a Iowa. Kungiyar yakin neman zaben Clinton ta sanar da cewa za su taimaka wa Vilsack ya biya bashin $400,000 na yakin neman zabensa. Vilsack ya yi yakin neman zabe ga Clinton a duk fadin kasar a matsayin mataimakin shugaban yakin neman zabe na kasa, kuma ya mai da hankali kan taimaka mata ta lashe zaben Iowa. Duk da kokarinsa, Clinton ya gama na uku a cikin caucuses bayan Barack Obama da John Edwards Bayan janyewar Clinton, Vilsack ya goyi bayan Obama don shugabancin
a ranar 15 ga Yuli, 2008. Ya lakafta Obama a matsayin "dan takara daya tilo" ga masu jefa kuri'a "a kan bangaranci" don canza "sautin a Washington"