Rubuta ci gaba don wannan sakin layi - Bayan Babban Rikici Ikklisiyar Orthodox ta daukaka shi zuwa babban birni a farkon karni na sha huɗu. A wannan lokacin Tenedos ya kasance wani ɓangare na yankin Venetian, amma wurinsa ya sanya shi babbar manufa ta Venetians, Genoese da Daular Ottoman. Rashin ƙarfi na Daular Byzantine da yaƙe-yaƙe tsakanin Genoa da Venice don hanyoyin kasuwanci sun sa Tenedos ya zama wuri mai mahimmanci. Kodayake a cikin 1304, Andrea Morisco, wani dan wasan Genoese, wanda ya goyi bayan taken daga sarkin Byzantine Andronikos III, ya karɓi Tenedos kuma daga baya, yana jin tashin hankali na siyasa a cikin daular Byzantine kafin yakin basasa na biyu na Byzantine
, Venetians sun ba da ducats 20,000 a cikin 1350 ga John V Palaiologos don ikon Tenedos, ba a kafa wani bishop na Latin ba.