Pickthall ya yi tafiya a ƙasashen Gabas da yawa, yana samun suna a matsayin masanin Gabas ta Tsakiya. Kafin ya bayyana imaninsa a matsayin Musulmi, Pickthall ya kasance babban abokin tarayya na Daular Ottoman. Ya yi nazarin Gabas, kuma ya wallafa labarai da litattafai kan batun. Yayin da yake hidimar Nizam na Hyderabad, Pickthall ya wallafa fassararsa ta Turanci na Kur'ani mai taken Ma'anar Ma'anar Maɗaukaki. Jami'ar Al-Azhar ce ta ba da izini ga fassarar kuma Times Literary Supplement ya yaba da kokarinsa na rubuce-rubuce ta hanyar "sanannen mai fassarar Maɗaukaki Alkur'ani zuwa harshen Ingilishi, babban aikin wallafe-wallafe. "A lokacin da aka kaddamar da yakin basasa a Burtaniya a 1915 a kan kisan gillar Armeniya, Pickthall ya tashi ya yi jayayya da cewa ba za a iya sanya alhakin Musulmi a kan gwamnatin Ottoman ba. A lokacin da yake aiki da Nizam na Hyderabad, Pickthall ya wallafa fassararsa na Turanci na Kur'ani mai taken Ma
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