A shekara ta 2005, Chad Hurley, Jawed Karim da Chen sun kafa YouTube, tare da Chen yana da matsayi na babban jami'in fasaha. A watan Yunin 2006, Chen ya zama ɗaya daga cikin "Mutane 50 da suke da mahimmanci a yanzu" a cikin kasuwanci.A ranar 16 ga Oktoba, 2006, Chen da Hurley sun sayar da YouTube ga Google, Inc. don dala biliyan 1.65. Chen ya sami hannun jari 625,366 na Google da ƙarin 68,721 a cikin amana a matsayin wani ɓangare na siyarwar. Kamar yadda na 2018, an kimanta hannun jari na Google a dala miliyan 729. Shi da Hurley sun fara AVOS Systems wanda ya sami Delicious daga Yahoo! Inc. Tambaya: Wanene ya yi aiki a Facebook a baya?
Chen da shi