Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: Kamar sauran cututtukan daji, cutar kansa ta huhu tana farawa ne ta hanyar kunna kwayoyin halittar kansar ko kuma rashin kunna kwayoyin halittar da ke hana ciwon ya tashi. Carcinogens suna haifar da maye gurbi a cikin waɗannan kwayoyin halittar da ke haifar da ci gaban cutar kansa. Mutations a cikin K-ras proto-oncogene suna haifar da kusan 10-30% na adenocarcinomas na huhu. Kusan kashi 4% na ƙananan ƙwayoyin cuta na huhu sun haɗa da EML4-ALK tyrosine kinase fusion gene. Canje-canje na epigenetic kamar canjin methylation na DNA, gyaran wutsiyar histone, ko tsarin microRNA na iya haifar da rashin aiki na kwayoyin cututtukan tumo. Abu mai mahimmanci, ƙwayoyin kansa suna haɓaka juriya ga damuwa na oxidative, wanda ke ba su damar jurewa da haɓaka yanayin kumburi wanda ke hana aikin tsarin rigakafi game da ƙwayar cuta. Mai karɓar haɓakar haɓakar epidermal (EGFR) yana daidaita haɓakar ƙwayoyin cuta, apoptosis, angiogenesis, da mamayar ƙwayar cuta. Canje-canje da haɓakar EGFR na yau da kullun ne a cikin ƙananan ƙwayoyin carcinoma na huhu, kuma suna samar da tushe don magani tare da masu hana EGFR. Her2/neu yana shafar sau da yawa. Sauran kwayoyin halittar da suke sau da yawa suna canzawa ko ƙarfafawa sun haɗa da c-MET, NKX2-1, LKB1, PIK3CA, da BRAF. Ba a fahimci layin sel na asali ba. Tsarin na iya haɗawa da kunnawar ƙwayoyin cuta na al'ada. A cikin hanyoyin numfashi na kusa, ƙwayoyin jijiyoyin da ke bayyana keratin 5 suna iya kamuwa da cutar, wanda yawanci ke haifar da cutar sankarar huhu. A cikin hanyoyin numfashi na tsakiya, ƙwayoyin ƙwayoyin cuta sun haɗa da ƙwayoyin ƙwayoyin cuta da ƙwayoyin neuroepithelial waɗanda ke bayyana furotin mai ɓoye ƙwayoyin cuta. Ƙananan ƙwayoyin carcinoma na huhu na iya samo asali daga waɗannan layin sel ko ƙwayoyin neuroendocrine, kuma yana iya bayyana CD44. Metastasis na ciwon daji na huhu yana buƙatar sauyawa daga nau'in epithelial zuwa nau'in sel mesenchymal. Wannan na iya faruwa ta hanyar kunna hanyoyin sigina kamar Akt / GSK3Beta, MEK-ERK, Fas, da Par6.  Tambaya: Waɗanne kwayoyin halitta ne sau da yawa za su iya canzawa?
c-MET, NKX2-1, LKB1, PIK3CA, da kuma BRAF