Ka cika wannan jumla: Duk da rashin lafiyarsa, Wilson yana son ya sake tsayawa takara a karo na uku. Yayin da
Taron kasa na Jam'iyyar Democrat na 1920 ya goyi bayan manufofin Wilson, shugabannin Democrat sun ki, maimakon haka sun zabi tikitin da ya hada da Gwamna James M. Cox da Mataimakin Sakataren Navy Franklin D. Roosevelt. 'Yan Republican sun mayar da kamfen din su game da adawa da manufofin Wilson, tare da Sanata Warren G. Harding da ke alƙawarin "komawa ga al'ada". Wilson ya fi yawa daga cikin yakin, ko da yake ya goyi bayan Cox kuma ya ci gaba da ba da shawara ga membobin Amurka a cikin League of Nations. Harding ya lashe nasara, ya lashe fiye da kashi 60 cikin 100 na kuri'un jama'a da kuma kowace jiha a waje da Kudu. Wilson ya sadu da Harding don shayi a ranar karshe a ofishinsa, Maris 3, 1921. Saboda rashin lafiyarsa, Wilson bai iya halartar rantsarwar ba.