Rubuta ci gaba ga wannan sakin layi - Blondell ya koma Hollywood a 1950. Ayyukanta a fim dinta na gaba, "The Blue Veil" (1951), ya ba ta lambar yabo ta Academy
Nomination ga mafi kyawun 'yar wasan mata a cikin wani Supporting Role. Ta taka rawar gani a cikin "The Opposite Sex" (1956), "Desk Set" (1957), da kuma "Shin Success Spoil Rock Hunter?" (1957). Ta sami yabo sosai saboda rawar da ta taka a matsayin Lady Fingers a Norman Jewison's "The Cincinnati Kid" (1965), wanda ya sami lambar yabo ta Golden Globe da kuma Hukumar Kula da Kasa ta Kasa don lashe kyautar Mata mafi kyau. John Cassavetes ya jefa ta a matsayin mai tsufa, mai wasan kwaikwayo a cikin fim dinsa "Opening Night" (1977). An ga Blondell a cikin fina-finai biyu da aka saki ba da daɗewa ba kafin mutuwarta <unk> "Grease" (1978), da kuma sake yin fim na "The Champ" (1979) tare da Jon Voight da Rick Schroder. Ta kuma bayyana a fina-finai biyu da aka saki bayan mutuwarta <unk> "The Glove" (1979), da kuma "The Woman Inside" (1981).