A tsakiyar shekara ta 2005, Mustaine shirya wani shekara-shekara thrash karfe festival yawon shakatawa, Gigantour a Buenos Aires. Megadeth headlined da kaddamarwa yawon shakatawa tare da ayyukan kamar Dream Theater, Nevermore, Anthrax, da kuma tsõro Factory. Performances a Montreal da kuma Vancouver nuna da aka filmed da kuma rubuta ga wani live DVD-da-CD sa fito a karo na biyu kwata na 2006. A Oktoba 9, bin nasarar The System ya kasa da kuma Blackmail da Universe duniya yawon shakatawa, Mustaine sanar da wani sayar da taron a Pepsi Rock Music Festival a Argentina cewa Megadeth zai ci gaba da rikodin da kuma yawon shakatawa.
Shekarar 2006