Daga baya, Isaac Newton ya gano dokokin kimiyyar lissafi wanda ya bayyana Dokokin Kepler, kuma ya haɗu da ra'ayoyin da aka sani yanzu a matsayin lissafi. Ba tare da izini ba, Gottfried Wilhelm Leibniz, wanda ake iya cewa yana ɗaya daga cikin mahimman masana lissafi na karni na 17, ya haɓaka lissafi da kuma yawancin lissafin lissafi har yanzu ana amfani da su a yau. Kimiyya da lissafi sun zama ƙoƙari na duniya, wanda ba da daɗewa ba zai yada a duk duniya. Baya ga aikace-aikacen ilmin lissafi ga nazarin sammai, ilimin lissafi ya fara fadada zuwa sababbin yankuna, tare da wasiƙar Pierre de Fermat da Blaise Pascal. Pascal da Fermat sun kafa tushe don binciken ka'idar yiwuwar da ka'idojin da suka dace da infinatorics a cikin tattaunawarsu game da wasan caca. Pascal, tare da wagerer, sun yi ƙoƙari su yi amfani da sabon ka'idar yiwuwar, suna jayayya cewa idan aka ba da gudummawa don ci gaba da wannan ka'idar, ko da a cikin ƙarni na 18th da 19th, wannan ya taimaka wajen yada sabon ilimin lissafi.
Pierre de Fermat da kuma Blaise Pascal