Kammala jumla mai zuwa: A cikin kakar 2010 Patrick ya dawo ya tuka tare da sabon sunan Andretti Autosport a cikin IndyCar Series, da kuma iyakantaccen jadawalin tare da JR Motorsports a cikin NASCAR Nationwide Series (yanzu Xfinity Series). Kamar yadda a shekarar da ta gabata, lokacinta ya fara da rauni kamar yadda kawai ta sami damar kammala na 15 a farkon São Paulo Indy 300 bayan ta juya a cikin mummunan yanayi. Duk da haka, a zagaye na biyu na kakar wasa, wanda aka jinkirta Honda Grand Prix na St. Petersburg, Patrick ya fara fitowa a saman a cikin bakwai. A cikin
Indianapolis 500, ta cancanci mafi ƙarancin aiki na 23rd; a cikin tseren, Patrick ya yi gwagwarmaya da motarta a kan hanyar zuwa na shida. Firestone 550 a Texas Motor Speedway mako guda daga baya shine mafi kyawun wasan ta na kakar, wanda ya gan ta ta jagoranci zagaye daya kuma ta gama a matsayi na biyu. A Indy Grand Prix na Sonoma, Patrick ya kafa sabon rikodin jerin don mafi yawan tseren da ke gudana a ƙarshe tare da taron ta na 29 da ke wucewa ba tare da ta kasa gamawa ba. Ta ƙare lokacinta ta hanyar daidaita sakamakon da ta fi kyau a kakar wasan a tseren IndyCar na ƙarshe a Homestead-Miami Speedway wanda ya ba ta damar kammala na goma a matsayin direbobi tare da maki 367.