Kammala jumla mai zuwa: Heche ya bayyana a cikin karamin fim mai suna "Rayuwar Jima'i" (2005), wanda ke ba da labarin rayuwar soyayya ta zamani tare da Azura Skye da Elizabeth Banks. An nuna fim ɗin a cikin zauren bikin fim kuma ya sami fitowar talabijin. A cikin 2006 Heche ya fara aiki a kan jerin kansa, "Men in Trees". A cikin wasan kwaikwayon, ta taka rawa a matsayin marubuciya ta New York, wanda bayan gano cewa angonta yana cin amanarta, ya koma wani ƙaramin gari a Alaska, wanda ya zama mai yalwa da maza marasa aure da 'yan mata. An soke "Men in Trees" a watan Mayu na shekara ta 2008, bayan da aka rage lokacin da
yajin aikin marubuta. A lokacin watsa shirye-shiryen wasan kwaikwayon, Heche ya fito a cikin fim mai ban tsoro mai ban tsoro "Suffering Man's Charity" (2007), wasan kwaikwayo na soyayya "What Love Is" (2007), da kuma fim mai ban sha'awa na kimiyya "Toxic Skies" (2008), duk abin da masu sauraro ba su gani ba.