Kammala jumlar da ke gaba: A kakar wasa ta gaba Milan ta mamaye gasar. Milan ta karbi bakuncin Genoa a ranar 25 ga Satumba 2010, tare da Pirlo yana ba da kwallon da aka ɗaga a saman tsaron don sa dan wasan Zlatan Ibrahimović ya sami damar zira kwallaye a wasan. A ranar 2 ga Oktoba, Pirlo ya ci kwallo mai tsawon yadi 40 a kan Parma don baiwa Milan nasarar farko a waje a kakar 2010-11. A ranar 14 ga Mayu, 2011, Pirlo ya bayyana a wasan karshe na Milan, yana zuwa a matsayin mai maye gurbin Ambrosini yayin da kulob din ke murnar nasarar da suka samu a gasar zakarun Turai a shekarar 2011.
Gasar Serie A tare da nasara 4-1 a kan Cagliari. Kwana hudu bayan haka, Pirlo ya tabbatar da cewa zai bar Milan a karshen kakar 2010-11, bayan yanke shawara da ba za a sabunta kwantiraginsa ba. A kakar wasa ta karshe a Milan, Pirlo ya bayyana a gasar sau 17 ne kawai a karkashin kocin Massimiliano Allegri, inda ya zira kwallaye daya da kwallaye uku, inda ya lashe kofin Serie A na biyu tare da Milan a wannan kakar, ya kuma kai zagaye na 16 a gasar zakarun Turai, da kuma a wasan kusa da na karshe na Coppa Italia.