Kammala jumla mai zuwa: Don kakar 2010, ya ji Penske ya kai ga yiwuwar tsufa Dallara-Honda mota, kuma ya ji tsoron sauran kungiyoyi za su yi amfani da wannan don rufe rata. Castroneves ya lashe gasar Indy Grand Prix na Alabama don fadada rikodinsa na lashe tseren zuwa yanayi goma a jere. Bayan da ya cancanci matsayi na farko don
Indianapolis 500, wani stall a cikin wani pit tsayawa relegated shi zuwa tara. Gasar biyar daga baya, a Honda Indy Edmonton, Castroneves shine farkon wanda ya gama, amma an sauke shi zuwa na goma bayan an dauke shi ya toshe abokin aikinsa Power. Ya lashe tsere biyu a jere, a Kentucky Speedway da Motegi, kafin ya ƙare kakar tare da na biyar a Homestead-Miami. Tare da maki 531, Castroneves ya kasance na huɗu a matsayin direbobi.