Kammala wannan jumla: Bayan kakar 2011, Giants sun sake sanya hannu kan López zuwa kwangilar shekaru biyu, dala miliyan 8.5. A ranar 6 ga Yuli, 2012, López ya ba da gudummawar gida na farko tun lokacin da ya shiga Giants a 2010 lokacin da ya ba da izinin gida mai tsawon mita 457 ga Pedro Álvarez a cikin nasarar 6<unk>5 a kan Pirates. Wannan ya kawo ERA zuwa 4.00, amma ya buga 1.00 ERA a kan karshe 32 wasanni. Bayan gwagwarmayar da Santiago Casilla (wanda ya maye gurbin Wilson da ya ji rauni a matsayin mai kusa da Giants), manajan Giants Bruce Bochy ya sanar a ranar 7 ga watan Agusta cewa Giants za su je dabarar "bullpen ta kwamitin", tare da López, Sergio Romo, da Jeremy Affeldt suna jefa wasannin biyu na karshe na wasannin kusa, ya danganta da wadanda za su fuskanta. Romo da López sun sami mafi yawan damar ceto; Affeldt kawai yana da ceto bayan wannan lokacin. López ya sami damar ceto sau shida bayan Agusta 7 kuma ya canza kowannensu. A cikin wasanni 70, López yana da rikodin 3<unk>0, 2.50 ERA, da 28 strikeouts a cikin innings 36 yayin canza bakwai daga cikin tara damar ceto. Ya sha kashi 87.9% na masu tsere na gado, na uku mafi kyau a cikin NL. López ya yi wasanni biyar a NLDS da kuma
NLCS, ba tare da izinin gudu ba yayin da Giants suka lashe jerin biyu. Bai buga a Wasannin Duniya ba amma ya lashe zoben Wasannin Duniya na uku a lokacin da Giants suka kori Detroit Tigers.