Kammala jumla mai zuwa: Abubuwan da aka gano na farko game da mazaunin mutane a yankin Bay sun kasance daga 8000<unk>10,000 BC (daga ƙuƙwalwar ƙuƙwalwa a Coyote Hills). A cikin 1769, mutanen Ohlone sun zauna a yankin Bay lokacin da ƙungiyar binciken Mutanen Espanya da Gaspar de Portolà ya jagoranta suka shiga Bay - ziyarar Turai ta farko da aka rubuta a Bay Area. Bayan da Mexico ta sami 'yancin kai daga Spain a 1821, gwamnatin Mexico ce ke kula da yankin na ɗan lokaci har sai Amurka ta kwace yankin a 1846 yayin Yaƙin Mexico da Amurka. Ba da daɗewa ba bayan haka, gano zinariya a California ya jawo hankalin masu neman dukiya, da yawa suna amfani da tashar jiragen ruwa a Bay Area a matsayin wurin shiga. A farkon shekarun jihar California, ayyukan majalisa na jihar sun juya tsakanin wurare uku a Yankin Bay kafin a kafa babban birnin jihar na dindindin a Sacramento. A
Babban girgizar kasa ta rushe birnin San Francisco da kewaye a 1906, amma yankin da sauri ya sake ginawa a lokaci don karɓar bakuncin Panama-Pacific Exposition na 1915. A lokacin Yaƙin Duniya na II, Yankin Bay ya taka muhimmiyar rawa a ƙoƙarin yaƙin Amurka a Gidan wasan kwaikwayo na Asiya-Pacific, tare da Fort Mason na San Francisco da ke aiki a matsayin babban wurin shiga ga sojojin Amurka. A shekara ta 1945, an sanya hannu kan Yarjejeniyar Majalisar Dinkin Duniya a San Francisco, ta kafa Majalisar Dinkin Duniya, kuma a shekara ta 1951, Yarjejeniyar San Francisco ta sake kafa dangantakar lumana tsakanin Japan da Allied Powers. Tun daga wannan lokacin, Yankin Bay ya sami motsi na siyasa, al'adu da fasaha da yawa, yana haɓaka nau'ikan gida na musamman a cikin kiɗa da fasaha kuma ya kafa kansa a matsayin matattarar siyasa mai ci gaba. A fannin tattalin arziki, Bay Area bayan yakin ya ga babban ci gaba a masana'antar hada-hadar kudi da fasaha, wanda ya haifar da tattalin arziki mai ban sha'awa da bambancin tattalin arziki tare da yawan kuɗin cikin gida na fiye da dala biliyan 700, kuma gida ne ga na uku mafi girma na kamfanonin Fortune 500 a Amurka (kamar na 2018).