A cikin 2005, masana kimiyya sun sake gina endocast (kwafin) na wani Acrocanthosaurus cranial rami ta amfani da tomography na kwamfuta (CT scanning) don nazarin sararin samaniya a cikin holotype braincase (OMNH 10146). A rayuwa, yawancin wannan sararin zai cika da meninges da cerebrospinal ruwa, ban da kwakwalwa kanta. Duk da haka, ana iya ƙayyade siffofin kwakwalwa da jijiyoyin kwakwalwa daga endocast kuma idan aka kwatanta da sauran theropods wanda aka halicci endocasts. Yayin da kwakwalwa ta yi kama da yawancin theropods, ya fi kama da na duk theroposauroids. Ya fi kama da kwakwalwar Carcharodosaurus da Giganotosaurus fiye da na Alloposaurus ko Sinophorus, yana ba da goyon baya ga ra'ayin cewa Acrocanthosaurus ya kasance carcharodosaurid (OMNH 10146).
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