Bayan mutuwar Lorenzo de' Medici a ranar 8 ga Afrilu, 1492 ya kawo sauyi a cikin yanayin Michelangelo. Michelangelo ya bar tsaro na kotun Medici kuma ya koma gidan mahaifinsa. A cikin watanni masu zuwa ya sassaƙa wani polychrome katako na gicciye (1493), a matsayin kyauta ga firaministan cocin Florence na Santo Spirito, wanda ya ba shi damar yin wasu nazarin ilimin lissafi na gawawwakin daga asibitin cocin. Tsakanin 1493 da 1494 ya sayi gungu na marmara, kuma ya sassaƙa wani mutum-mutumin Sixtus na Hercules, wanda aka aika zuwa Faransa kuma daga bisani ya ɓace a wani lokaci a karni na 18. A ranar 20 ga Janairu, 1494, bayan da Lorenzo ya mutu, magajinsa Piero de' Medici, ya ba da umurni ga wani mutum-mutumin dusar ƙanƙara, kuma Michelangelo ya shiga kotun Medici. A lokacin da aka binne shi a karkashin gidan mahaifinsa, a matsayin kyauta ga firaministan cocin cocin na St. Lorenzo de' Medici, wanda ya ba shi damar yin wasu nazarin ilimin lissafi na
8 ga Afrilu 1492