Dalilin da ya sa tsire-tsire irin su Arabidopsis thaliana suna nuna RNA mai yawa na dicer homologs wanda ke da ƙwarewa don amsawa daban-daban lokacin da aka fallasa shuka zuwa ƙwayoyin cuta daban-daban. Ko da kafin a fahimci hanyar RNAi gaba ɗaya, an san cewa yin shiru na kwayar halitta a cikin tsire-tsire na iya yaduwa a cikin tsire-tsire a cikin tasirin tsarin kuma za a iya canja shi daga hannun jari zuwa tsire-tsire ta hanyar dasa. Tun daga wannan lokacin an gane wannan yanayin a matsayin fasalin tsarin tsarin rigakafi na tsire-tsire kuma yana ba da damar dukkanin tsire-tsire don amsawa ga kwayar cuta bayan haɗuwa ta farko. A cikin amsawar farko, yawancin tsire-tsire sun samar da matakai masu mahimmanci don hana amsawar RNAi. Wadannan sun hada da RNA mai rikitarwa na RNA mai rikitarwa tare da RNA mai rikitarwa na RNA mai rikitarwa wanda ke da kwarewa don amsawa daban-daban lokacin da aka fallasa shuka zuwa nau'in ƙwayoyin cuta daban-daban. Duk da haka
hana yaduwar kai na transposons