Kammala wannan jumla: Shi da abokan aikinsa na farar hula an cire su daga ofishin a cikin
15 Janairu 1966 juyin mulkin soja, kuma shi ne mafi shahararren dan siyasa don kauce wa kisan kai bayan juyin mulki. Azikiwe ya kasance mai magana da yawun Biafra kuma ya shawarci shugabanta, Chukwuemeka Odumegwu Ojukwu, a lokacin yakin Biafra (1967 <unk> 1970). Ya sauya amincinsa zuwa Najeriya a lokacin yakin, kuma ya yi kira ga Ojukwu da ya kawo karshen yakin a cikin takardu da tambayoyi. "The New York Times" ya ce game da siyasarsa, "A tsawon rayuwarsa, kawancen Dr. Azikiwe da mutanen arewa ya sanya shi cikin rikici da Obafemi Awolowo, shugaban mai son gurguzu na Yarbawa, wata muhimmiyar kungiyar kudancin kasar".