Rubuta ci gaba don wannan sakin layi - A matakin kasa da kasa, Pirlo ya buga wasanni 116 don kungiyar kwallon kafa ta Italiya, wanda shine na biyar a kowane lokaci. Ya fara wasan farko a shekarar 2002, kuma ya jagoranci kasarsa zuwa lambar tagulla a wasannin Olympics na 2004. Pirlo ya taka muhimmiyar rawa a nasarar da Italiya ta samu a gasar cin kofin duniya ta FIFA ta 2006, inda ya lashe Kwallon tagulla kuma aka zaɓe shi a cikin Team of the Tournament. Ya maimaita irin wannan nasarar yayin da ya jagoranci Italiya zuwa wasan karshe na gasar zakarun Turai ta 2012. Pirlo ya kuma wakilci kasarsa a gasar 2004
da kuma 2008 UEFA Turai Championship, da 2010 da kuma 2014 FIFA gasar cin kofin duniya, da kuma 2009 da kuma 2013 FIFA gasar cin kofin Confederations.