Kammala wannan jumla: Wheldon ya kasance tare da Panther Racing don kakar 2010. A lokacin bude kakar São Paulo Indy 300, ya tuntubi Alex Tagliani, wanda ya tura shi zuwa Kanaan; ya dawo ya gama na biyar. Wasanni uku daga baya a Toyota Grand Prix na Long Beach, Wheldon ya ɗauki sakamako na biyu a saman goma tare da tara. A cikin
Indianapolis 500, Wheldon ya fara daga goma sha takwas. Ya ci gaba ta hanyar filin a kan dabarun tsayawa don zama na biyu a shekara ta biyu a jere. Wheldon ya kasance mai gasa a duk shekara; kalubalanci don cin nasara a kan waƙoƙi na oval. Duk da nuna karfi, bai iya samun nasarar tsere ba a lokacinsa tare da Panther Racing, wanda ya bata wa John Barnes rai. A cikin Indy Grand Prix na Sonoma a Infineon Raceway (yanzu Sonoma Raceway), Wheldon ya tuntuɓi motar Bertrand Baguette yayin zagayen dumama kafin fara taron. Ya juye da baya kuma ya juya sau da yawa amma ya fito ba tare da rauni ba. Mafi kyawunsa na shekara shine na biyu a cikin Peak Antifreeze &amp; Motor Oil Indy 300 a Chicagoland Speedway. Ya zo na tara a ƙarshen kakar Cafés do Brasil Indy 300 a Homestead Miami Speedway, don zama na tara a matsayin direbobi tare da maki 388.