Kammala jumla mai zuwa: A watan Agusta 2005, ya koma Serie A tare da canja wuri zuwa Internazionale a kan kwangilar shekaru hudu don kudin da aka ruwaito na € 16 miliyan. Ya fara aikinsa na Inter ta hanyar lashe gasar
2005 Supercoppa Italiana da Juventus, suna shiga cikin minti na 63 kamar yadda "Nerazzurri" suka ci nasara a karin lokaci godiya ga wanda ya lashe Verón. Daga baya a ranar 13 ga Satumba, ya fara bugawa sabuwar kungiyarsa wasa a ranar 21 ga Satumba ta hanyar farawa a wasan da suka ci Chievo da ci 1-0. A ranar 24 ga Nuwamba, yayin wasan rukuni na gasar zakarun Turai da Petržalka, Samuel ya taka leda a cikin 'yan wasa 11 na kasashen waje a filin wasa, tare da Luís Figo ne kawai dan Turai. Ya gama kakar wasa ta farko a Inter ta hanyar buga wasanni 42 a duk gasa, tare da kungiyar da ta lashe kofin zakarun Turai bayan faduwar Juventus saboda wasan da aka shirya, da kuma Coppa Italia ta hanyar kayar da Roma 4<unk>2 a duka, tare da Samuel yana wasa a duka wasan karshe, ta haka ne ya kammala wasan da ba a zata ba.