Kammala wannan jumla: Aikin Blaine a matsayin dan jaridar Republican ya kai ga shiga cikin siyasar jam'iyyar Republican. A shekara ta 1856, an zaba shi a matsayin wakili ga
Babban Taron Jam'iyyar Republican na farko. Daga farkon kwanakin jam'iyyar, Blaine ya bayyana tare da reshe mai ra'ayin mazan jiya, yana goyon bayan Babban Kotun Koli John McLean don zaben shugaban kasa a kan John C. Frémont, wanda ya fi tsattsauran ra'ayi, wanda aka zaba. A shekara mai zuwa, an ba Blaine editan "Portland Daily Advertiser", wanda ya karɓa, ya sayar da sha'awarsa a cikin "Journal" ba da daɗewa ba. Har yanzu yana kula da gidansa a Augusta, duk da haka, tare da danginsa masu girma. Ko da yake ɗan fari na Blaine, Stanwood, ya mutu a jariri, shi da Harriet suna da 'ya'ya maza biyu ba da daɗewa ba bayan haka: Walker, a 1855, da Emmons, a 1857. Za su sami 'ya'ya hudu a cikin shekaru masu zuwa: Alice, James, Margaret, da Harriet. A wannan lokacin ne Blaine ya bar cocin Presbyterian na ƙuruciyarsa kuma ya shiga sabon sunan matarsa, ya zama memba na Ikilisiyar Ikilisiya ta Kudu a Augusta.