Michael Gerard Tyson an haife shi ne a Brownsville, Brooklyn, New York a ranar 30 ga Yuni, 1966. Yana da wani ɗan'uwa mai suna Rodney (an haife shi a shekara ta 1961) kuma yana da 'yar'uwa mai suna Denise, wanda ya mutu a wani ciwon zuciya a lokacin da yake da shekaru 24 a watan Fabrairun 1990. An rubuta mahaifin mahaifin Tyson a matsayin "Purcell Tyson" (wanda ya fito ne daga Jamaica) a kan takardar shaidar haihuwarsa, amma mutumin da Tyson ya san cewa mahaifinsa shi ne Jimmy Kirkpatrick. Kirkpatrick ya fito ne daga Grier Town, North Carolina (wani unguwa mai yawan baki da aka haɗe da birnin Charlotte), inda ya kasance ɗaya daga cikin manyan 'yan wasan baseball na unguwa. Kirkpatrick ya yi aure kuma yana da ɗa, ɗan'uwan ɗan'uwansa na Kirkpatrick Jimmie Lee Tyson, wanda zai taimaka wa Charlotte ya shiga cikin wasan kwallon kafa a 1965. A shekara ta 1959, Tyson ya zauna tare da 'yar'uwarsa mai suna Denise, wanda ya mutu a cikin wani ciwon zuciya a lokacin yaro.
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