A watan Afrilun 1863, ya jagoranci wata runduna a karkashin Stonewall Jackson. Saboda ya san Colston daga lokacin da duka biyu sun kasance farfesa a VMI, Jackson ya ba da shawarar Colston ya jagoranci wani bangare. A yakin Chancellorsville a ranar 2 ga watan Mayu, Colston ya jagoranci daya daga cikin rundunonin da ke cikin hare-haren Jackson a kan sojojin Union na dama. An sanya sashinsa a cikin layi na biyu a ranar 3 ga Mayu. A cikin kwanaki biyu na gwagwarmaya, rabonsa ya rasa kashi 31 cikin dari. Duk da haka, a ranar 3 ga Mayu, "Raleigh Colston, wanda ya fi ƙwarewa a cikin janar-janar na Lee, ya tabbatar da jinkirin jinkirin jagorancin mutanensa a cikin aikin". Lee ya sauke Colston daga umurnin rundunar a ranar 20 ga Mayu. A watan Nuwambar 1863, dan uwansa Raleigh T. Colston, wanda ya kammala karatun VMI a 1850 wanda ya zama colonel na 2nd Virginia Infantry (kuma wani ɓangare na Stonewall Brigade), ya zama ɗaya daga cikin 'yan mutuwar da aka yi a lokacin yakin.
Yaƙin Mine Run.