Cika wannan jumla: Thatcher na Amurka a ziyarar gwamnati lokacin da shugaban Iraqi Saddam Hussein
sun mamaye Kuwait a watan Agustan 1990. A yayin tattaunawarta da Shugaba George H. W. Bush, wanda ya gaji Reagan a 1989, ta ba da shawarar shiga tsakani, kuma ta matsa lamba ga Bush don tura sojoji a Gabas ta Tsakiya don fitar da Sojojin Iraqi daga Kuwait. Bush ya damu game da shirin, wanda ya sa Thatcher ya yi masa magana a lokacin tattaunawa ta waya: "Wannan ba lokaci ba ne da za a yi rawar jiki!" Gwamnatin Thatcher ta ba da dakarun soji ga kawancen kasa da kasa a cikin ginin Yakin Gulf, amma ta yi murabus a lokacin da tashin hankali ya fara a ranar 17 ga Janairu, 1991. Ta yaba da nasarar hadin gwiwar a bangarorin baya, yayin da ta yi gargadin cewa "nasara ta zaman lafiya za ta dauki lokaci fiye da yaƙe-yaƙe na yaki". An bayyana a cikin 2017 cewa Thatcher ta ba da shawarar yin barazanar Saddam da makamai masu guba bayan mamayewar Kuwait.