A cikin karni na 1 BC, marubucin gine-ginen Roman Vitruvius ya bayyana yiwuwar tasirin miasma (Latin nebula fetus) daga filayen marmara lokacin ziyartar birni: Tambaya: Me yasa Miasm ya kasance tabbatacce?
cututtuka sun kasance sakamakon abubuwan muhalli kamar gurɓataccen ruwa, iska mara kyau, da yanayin rashin tsafta