Kammala jumla mai zuwa: Cikin Makidoniya ya kasance a hannun Slavic kuma daga baya Bulgarian har zuwa
yaƙe-yaƙe na Basil II, wanda ya kawo ƙarshen wanzuwar jihar Bulgaria kuma ya faɗaɗa ikon Byzantine a tsakiyar da arewacin Balkans. Bayan haka Makidoniya ta kasance a ƙarƙashin ikon Byzantine har zuwa Crusade na Hudu (1204). An kafa wani ɗan gajeren mulkin Latin na Thessalonica wanda ya tsira har zuwa 1224, lokacin da Epirus ya kama shi. Yawancin Makidoniya sun kasance ƙarƙashin ikon Daular Nicaea a 1246, kodayake yankunan arewacin ta kasance suna jayayya da Serbs da Bulgarians. Yawancin yankin da Serbs suka ci nasara a ƙarƙashin Stephen Dushan a lokacin yakin basasa na Byzantine na 1341 <unk> 1347. Tasalunika da kewayenta ne kawai suka kasance a hannun Byzantine. A ƙarshen ƙarni na 14, Turks na Ottoman sun ci yankin, ko da yake Thessalonica ta kasance a ƙarƙashin ikon Byzantine kuma daga baya Venetian har zuwa 1430.