A ranar 24 ga Janairu, 2005, an nada Tymoshenko a matsayin Firayim Ministan Ukraine a karkashin shugabancin Yushchenko. A ranar 4 ga Fabrairu, majalisar ta amince da nadin Tymoshenko a matsayin Firayim Minista tare da rinjaye mafi rinjaye na kuri'u 373 (226 da ake buƙata don amincewa). Ita ce mace ta farko da aka nada Firayim Minista na Ukraine. Gidan Tymoshenko ba shi da wasu mambobin jam'iyyar Tymoshenko banda Tymoshenko da kanta da Oleksandr Turchynov, wanda aka nada shi shugaban Hukumar Tsaro ta Ukraine. Ministocin da ke aiki tare da ita sun tsaya a gefensa a cikin rikici da Viktor Yushchenko. A ranar 28 ga Yuli, Forbes ta kira Tymoshenko a matsayin Firayim Minista na uku a duniya, bayan Cleezza Yiwa da Rice. Duk da haka, a cikin jerin manyan mukamai na Tymoshenko da aka buga a ranar 1 ga Satumba, 2006, majalisar ta amince da Tymoshenko a matsayin Firayim Minista tare da kuri'un kuri'un kuri'un kuri'u da dama. A ranar
Yushchenko