Rubuta ci gaba don wannan sakin layi - A farkon yakin duniya na biyu, daga Mayu zuwa Yuni 1940, shi ne mafi ƙanƙanta Janar na Faransa. Ya jagoranci rundunarsa a lokacin yakin Faransa, a yakin Rethel, Champagne-Ardenne, da Loire kuma har zuwa Armistice na 22 Yuni 1940. A lokacin mulkin Vichy, ya kasance a cikin Sojojin Armistice, da farko a cikin mukaman umarni na yanki, sannan a matsayin babban kwamandan sojoji a Tunisia. Bayan saukar sojojin Allied a Arewacin Afirka, a ranar 11 ga Nuwamba 1942, Jamusawa sun mamaye yankin kyauta; de Lattre, Kwamandan Rundunar Soja ta 16 a Montpellier, ya ƙi umarnin kada ya yi yaƙi da Jamusawa kuma shi ne kawai janar mai aiki wanda ya umarci sojojinsa su yi adawa da masu mamaye. An kama shi amma ya tsere kuma ya yi hijira zuwa Charles de Gaulle's Free France a ƙarshen 1943. Daga 1943 zuwa 1945 ya kasance ɗaya daga cikin manyan shugabannin Sojojin 'Yanci, yana jagorantar sojojin da suka sauka a Kudancin Faransa a ranar 15 ga Agusta, 1944.
, sa'an nan ya yi yaƙi har zuwa Kogin Rhine da Danube. Shi ne kawai janar na Faransa na yakin duniya na biyu don ya jagoranci dakarun Amurka da yawa, lokacin da aka haɗa da Amurka XXI Corps zuwa rundunarsa ta farko a lokacin yakin Colmar Pocket. Ya kuma kasance wakilin Faransa a Berlin a ranar 8 ga Mayu, 1945, tare da Eisenhower, Zhukov da Montgomery.