Kammala jumla mai zuwa: Weis ya zama mataimakin shugaban farko na sabuwar kungiyar Tarayyar Mata ta Republican Republican kuma ya zama shugabanta a 1941. Ta kasance wakili ne a cikin 1940, 1944,
1948, 1952 da kuma 1956 Republican National Conventions. A shekara ta 1948 Weis ta goyi bayan zaben Thomas E. Dewey a matsayin shugaban kasa, mace ta farko da ta yi hakan. Ta ci gaba da aiki a matsayin mataimakin manajan kamfen na Jam'iyyar Republican a zaben 1948.