Acetanilide shine farkon aniline wanda aka samo asali wanda aka gano yana da magungunan analgesic da antipyretic, kuma an gabatar da shi cikin hanzari a cikin aikin likita a karkashin sunan Antifebrin ta Cahn & Hepp a 1886. Amma tasirinsa mai guba wanda ba a yarda da shi ba <unk> mafi yawan damuwa shine cyanosis saboda methemoglobinemia <unk> ya haifar da neman ƙananan magungunan aniline masu guba. North Harmon Morropse ya riga ya hada paracetamol a Jami'ar Johns Hopkins ta hanyar rage p-nitrophenol tare da tin a cikin glacial acetic acid a 1877, amma ba har zuwa 1887 da likitan likitancin likitancin Joseph von Mering ya gwada paracetamol a kan mutane ba. A 1893, Leon von Mering ya wallafa wata takarda da ke ba da rahoto game da sakamakon ilimin likitancin paracetamol tare da phenacetin, wani analgesic da ake kira phenacetin.
Shekara ta 1963