A 1884, Faransanci microbiologist Charles Chamberland ƙirƙira wani tace (da aka sani a yau kamar yadda Chamberland tace ko da Pasteur-Chamberland tace) tare da pores karami fiye da kwayoyin. Ta haka ne, ya iya wucewa wani bayani dauke da kwayoyin ta cikin tace da kuma gaba daya cire su. A 1892, Rasha masanin ilmin halitta Dmitri Ivanovsky amfani da wannan tace don nazarin abin da yanzu aka sani da taba mosaic cutar. Ya gwaje-gwajen ya nuna cewa crushed ganye tsantsa daga kamuwa da taba shuka barbashi zama mai yaduwa bayan tacewa. Ivanovsky shawara da kamuwa da cuta zai iya zama ta hanyar toxin samar da kwayoyin, amma bai bi da ra'ayin. A lokacin da aka yi tunani cewa duk na kowa na iya zama na kamuwa da cuta agents za a iya riƙe da kwayar cutar da kuma girma a kan wani matsakaici fiye da kwayoyin cuta. A farkon karni na 20, Faransanci microbiologist Frederick F. Heckler ya gano cewa kwayoyin cuta sun kasance daidai da kwayoyin cuta da aka haifa ta hanyar kwayoyin cuta
Wendell Stanley