A lokacin da yake a Cornell, ya ba da jerin laccoci goma sha tara kuma ya kammala mafi yawan littafinsa mai suna The Nature of the Chemical Bond. Ya dogara ne akan aikinsa a wannan yanki wanda ya karbi kyautar Nobel a Chemistry a 1954 "don bincikensa game da yanayin haɗin sinadarai da kuma aikace-aikacensa don bayyana tsarin abubuwa masu rikitarwa". Littafin Pauling an dauke shi "littafin ilmin sunadarai mafi tasiri na wannan karni da kuma littafi mai tsarki". A cikin shekaru 30 bayan da aka buga littafinsa na farko a 1939, an buga littafin fiye da sau 16,000 a yau. Ko da yake a Cornell, ya gabatar da jerin laccoci goma sha tara kuma ya kammala mafi yawan littafinsa mai suna The Nature of the Chemical Bond.
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