A cikin Amurka, ana kiyasta cutar mura ta yanayi yana haifar da matsakaicin matsakaicin tattalin arziƙin shekara-shekara na sama da dala biliyan 11, tare da ƙididdigar farashin likita kai tsaye sama da dala biliyan 3 a kowace shekara. An kiyasta cewa annoba ta gaba na iya haifar da ɗaruruwan biliyoyin daloli a cikin kai tsaye da kuma kai tsaye. Koyaya, ba a yi nazari sosai game da tasirin tattalin arziƙin annoba da suka gabata ba, kuma wasu marubutan sun ba da shawarar cewa cutar ta Spanish a zahiri tana da tasiri mai kyau na dogon lokaci akan haɓakar kuɗin shiga na kowane mutum, duk da raguwar yawan jama'ar da ke aiki da kuma mummunan tasirin ɓacin rai na ɗan gajeren lokaci. Sauran nazarin sun yi ƙoƙarin yin hasashen annobar cutar ta Spanish mai tsanani kamar 1918 a kan tattalin arzikin Amurka.
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