Rubuta ci gaba don wannan sakin layi - Mazaunan Pennsylvania gabaɗaya sun goyi bayan zanga-zangar gama gari ga duk yankuna 13 bayan da aka zartar da Sanarwar 1763 da Dokar Stamp, kuma Pennsylvania ta aika da wakilai zuwa Majalisar Dokokin Stamp a 1765 Philadelphia ta karbi bakuncin na farko da na biyu
Majalisa na Continental, wanda ya haifar da amincewa da Yarjejeniyar Independence a Independence Hall a 1776. Pennsylvania shine wurin da aka yi yaƙe-yaƙe da ayyukan soja da yawa a lokacin Juyin Juya Halin Amurka, gami da tsallaka kogin Delaware na George Washington, Yaƙin Brandywine, da Yaƙin Germantown. A lokacin yakin Philadelphia, sojojin 'yan tawaye na George Washington sun shafe hunturu na 1777-78 a Valley Forge, Pennsylvania. A shekara ta 1781, an rubuta da kuma amince da Yarjejeniyar Yarjejeniyar a York, Pennsylvania, kuma Philadelphia ta ci gaba da zama babban birnin kasar har zuwa lokacin da Pennsylvania Mutiny na 1783. Manyan mutanen Pennsylvania da suka goyi bayan juyin juya halin sun hada da Benjamin Franklin, John Dickinson, Robert Morris, Anthony Wayne, Samuel Van Leer, James Wilson, da Thomas Mifflin. Duk da haka, Pennsylvania kuma gida ne ga masu biyayya da yawa, ciki har da Joseph Galloway, William Allen, da Doan Outlaws.