Kammala jumla mai zuwa: A ranar 21 ga Satumba, 2016, Santana ya buga wasan gida na 150 a cikin aikinsa, yana yin hakan a kan Kansas City Royals. A lokacin kakar wasa ta bana, Santana ya buga.259, 34 gidaje, 87 RBI da.865 OPS. Ya samar da gidaje 30 da 68 RBI lokacin da ya buga hagu. Santana ya buga gida sau biyu a cikin Wasannin Gasar Zakarun Amurka na 2016 da Toronto Blue Jays. Ya kuma rubuta karshe daga cikin Series ta kamawa Troy Tulowitzki pop-up a cikin ƙasa mara kyau, aika da Indians zuwa
Gasar cin kofin duniya. Chicago Cubs ta doke Cleveland a gasar cin kofin duniya a wasanni bakwai. 'Yan Indiya sun yi amfani da zabin da suka samu na dala miliyan 12 a shekara ta 2017.