Matsayi: Edwin Klebs shine farkon wanda ya lura da kwayoyin cuta a cikin hanyoyin numfashi na mutanen da suka mutu daga ciwon huhu a shekara ta 1875. Aikin farko na gano abubuwan da ke haifar da kwayoyin cuta guda biyu, Streptococcus pneumoniae da Klebsiella pneumoniae, Carl Friedländer da Albert Fraenkel ne suka yi a 1882 da 1884. Aikin farko na Friedländer ya gabatar da Gram stain, gwajin gwaji na yau da kullum da ake amfani da shi a yau don ganowa da kuma rarraba kwayoyin cuta. Takardar Christian Gram ta bayyana tsarin a shekara ta 1884 ya taimaka wajen rarrabe kwayoyin biyu, kuma ya nuna cewa cutar huhu na iya haifar da kwayoyin cuta fiye da ɗaya. Sir William Osler, wanda aka sani da "mahaifin likitancin zamani", ya nuna godiya ga mutuwa da rashin lafiya ta hanyar ciwon huhu, ya bayyana shi a matsayin "shugaban mutuwar mutane" a shekara ta 1918, kamar yadda ya shawo kan tarin fuka a matsayin daya daga cikin manyan cututtukan da ke haifar da mutuwa, wanda Carl Friedländer da Albert Fraenkel suka yi a 1882 da 1884.
Carl Friedländer da kuma Albert Fraenkel