Rubuta ci gaba don wannan sakin layi - Lokacin da Charles ya gaji gadon sarautar Spain, mallakar ƙasashen waje na Spain a Sabuwar Duniya sun dogara ne akan Caribbean da Mutanen Espanya na Mutanen Espanya kuma sun ƙunshi yawan 'yan asalin ƙasar da ke raguwa da sauri,' yan albarkatun da ke da daraja ga kambi, da kuma yawan mazauna Mutanen Espanya. Yanayin ya canza sosai tare da tafiyar Hernán Cortés, wanda, tare da ƙawance da biranen da ke adawa da Aztecs da dubban mayaƙan Mexico na asali, suka ci Daular Aztec
a shekara ta 1521. Da yake bin tsarin da aka kafa a Spain a lokacin Reconquista da kuma a Caribbean, mazauna Turai na farko a Amirka, masu cin nasara sun raba 'yan asalin zuwa gidaje masu zaman kansu "encomiendas" kuma sun yi amfani da aikinsu. Tsakiyar Mexico da kuma daga baya Daular Inca ta Peru ta ba Spain sabbin 'yan asalin ƙasar da za su tuba zuwa Kiristanci kuma su yi sarauta a matsayin masu sarauta na kambi. Charles ya kafa Majalisar Indiya a 1524 don kula da duk abubuwan mallakar Castile na ƙasashen waje. Charles ya nada mataimakin sarki a Mexico a 1535, yana iyakance mulkin masarauta na babban kotu, "Real Audiencia", da jami'an baitulmalin tare da babban jami'in masarauta. Bayan cin nasarar Peru, a cikin 1542 Charles kuma ya naɗa mataimakin sarki. Dukkanin jami'an biyu suna karkashin ikon Majalisar Indiya. Charles ya ba da Sabbin Dokokin 1542 don iyakance ikon ƙungiyar masu cin nasara don samar da aristocracy na gado wanda zai iya kalubalanci ikon kambi.