Kammala wannan jumla: A ranar 8 ga watan Agusta 2017, Isco ya ci kwallo a gasar
2017 UEFA Super Cup, wanda ya ba da gudummawa ga nasarar 2 × 1 ta Real Madrid a kan Manchester United. Ayyukansa ya sa ya sami lambar yabo ta wasan. A watan Satumbar 2017, ya sanya hannu kan sabuwar yarjejeniya tare da Real Madrid har zuwa Yuni 2022. A lokacin gasar zakarun Turai ta 2017-18, ya buga wasanni goma sha daya, lokacin da Madrid ta lashe kofin Zakarun Turai na uku a jere kuma na 13 a gaba daya yayin da suka doke Liverpool 3-1 a Kyiv. Ya buga wasanni 23 a lokacin gasar, yayin da Real Madrid ta lashe gasar La Liga ta 2019-20.