Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Hanyar wucewa: Cutar Alzheimer tana da alamun asarar ƙwayoyin cuta da synapses a cikin ƙwayar kwakwalwa da wasu yankuna na subcortical. Wannan asarar tana haifar da mummunan atrophy na yankunan da abin ya shafa, gami da lalacewa a cikin lob na temporal da lob na parietal, da kuma sassan ɓangaren gaba da cingulate gyrus. Rashin lalacewa kuma yana cikin kwakwalwar kwakwalwar kwakwalwa kamar locus coeruleus. Nazarin da aka yi ta amfani da MRI da PET sun tabbatar da raguwar girman wasu yankuna na kwakwalwa a cikin mutanen da ke fama da cutar Alzheimer yayin da suka ci gaba daga raunin hankali zuwa cutar Alzheimer, kuma idan aka kwatanta da irin wannan hotunan daga tsofaffi masu lafiya. Dukansu amyloid plaques da neurofibrillary tangles suna bayyane a fili ta hanyar microscopy a cikin kwakwalwar waɗanda ke fama da cutar Alzheimer. Plaques suna da yawa, galibi ba za a iya narkar da su ba na beta-amyloid peptide da kayan ƙwayoyin cuta a waje da kewaye da ƙwayoyin cuta. Tangles (neurofibrillary tangles) sune haɗuwa da microtubule-haɗin protein tau wanda ya zama hyperphosphorylated kuma ya tara a cikin sel kansu. Kodayake mutane da yawa tsofaffi suna haɓaka wasu allurai da tangles sakamakon tsufa, kwakwalwar mutanen da ke da AD suna da adadi mai yawa a cikin takamaiman yankuna na kwakwalwa kamar lob na temporal. Jikin Lewy ba abin mamaki ba ne a cikin kwakwalwar mutanen da ke da AD.  Tambaya: daga menene aka yi allon?
ajiyar beta-amyloid peptide da kayan salula a waje da kewaye da neurons