"Toxic" ya sami nasararta ta farko da kawai Grammy Award a bikin 2005 a cikin rukunin Mafi Kyawun Rage. "Toxic" ya sami nasara a duk duniya, ya kai saman biyar a cikin kasashe 15, yayin da yake saman jadawalin a Ostiraliya, Kanada, Hungary, Ireland, Norway da United Kingdom. A Amurka, ya zama ta huɗu mafi girma guda goma, wanda ya kai lamba 9. Bidiyon kiɗan da ke rakiyar waƙar Joseph Kahn ne ya jagoranta kuma yana nuna nassoshi ga Blade Runner, The Seven Year Itch da fina-finan John Woo. Yana nuna Spears a matsayin wakili na sirri a cikin binciken vial na kore mai guba. Bayan ta saci shi, ta shiga wani gida kuma ta saci saurayin ta.
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