Rubuta ci gaba ga wannan sakin layi - A Wisconsin, Chase ya shiga siyasa. Ya halarci taron Jam'iyyar Republican na farko
a 1856 a matsayin wani ɓangare na tawagar daga Wisconsin. Taron ya zabi John C. Frémont a matsayin dan takarar Republican ga shugaban kasa a zaben 1856. A wannan shekarar, Chase ya yi takarar Sanata na Jihar Wisconsin kuma an zabe shi zuwa wa'adin shekaru biyu, yana wakiltar gundumar Racine.