Rubuta ci gaba don wannan sakin layi - Yankin ya zama wani ɓangare na Daular Spain a ƙarƙashin sunan New Spain a 1535. Cortés ya sake gina Mexico City a hankali bayan faɗuwar Tenochtitlan
a shekara ta 1521. Yawancin ainihi, al'adu da gine-ginen Mexico sun bunkasa a lokacin mulkin mallaka na shekaru 300 daga 1521 zuwa 'yancin kai a 1821.