A lokacin da toad ne barazana, da gabobin secrete wani milky-fari ruwa da aka sani da bufotoxin. Abubuwa na bufotoxin ne mai guba ga dabbobi da yawa; ko da mutum mutuwar da aka rubuta saboda da amfani da cane toads. Karnuka ne musamman m da za a guba da licking ko biting toads. Idan ka rayu a kusa da cane toads da Pet nuna wuce kima drooling, musamman ja gumis, head-shaking, kuka, asarar coordination, da / ko convulsions, kai shi zuwa ga wani likitan dabbobi. Bufotenin, daya daga cikin sunadarai samar da cane toad, an classified a matsayin aji-1 a karkashin Western Australian doka, da kuma sauran gland a fadin baya. A Australia, a baya bayan nan, a 2011, Ma'aikatar kiyaye muhalli ta Australia ta yi amfani da kwayoyi masu guba don kare dabbobi daga ciwon huhu, wanda zai iya haifar da mutuwar dabbobi masu tasowa, da kuma ciwon daji.
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