Kammala jumla mai zuwa: A ƙarshen kakar wasa, Marchisio ya kasance batun maganganun canja wuri yayin da kwangilarsa ta yanzu za ta ƙare a bazara mai zuwa. A ranar 6 ga Yuli 2015, duk da haka, ya sanya hannu kan yarjejeniyar tsawaita shekaru biyar, yana ajiye shi a kulob din garinsa har zuwa kakar 2019-2020. An cire Marchisio na tsawon wata guda bayan ya sami rauni a cikin tsoka na adductor a ƙafarsa ta dama a farkon bayyanarsa a gasar a ranar 12 ga Satumba, 2015, yayin da Juventus ta yi wasa 1<unk>1 a gida da Chievo. A ranar 24 ga Nuwamba, an zabi Marchisio don Teamungiyar UEFA ta shekara ta 2015. A ranar 15 ga Maris 2016 an sanar da cewa Marchisio zai rasa zagaye na biyu na wasan 16 na gasar zakarun Turai da Bayern Munich a ranar 16 ga Maris saboda matsalar tsoka a cikin maraƙin hagu. Ya dawo cikin aiki a ranar 2 ga Afrilu, a cikin nasarar gida 1-0 a kan Empoli. Makonni biyu bayan haka a ranar 17 ga Afrilu, Marchisio ya sami rauni a ligament na gaba a lokacin nasarar 4 × 0 ta Juventus a Palermo bayan wani mummunan faɗuwa tare da ƙalubale kan Franco Vázquez, wanda ya cire shi har zuwa sauran kakar wasa da kuma gasar cin kofin UEFA Euro 2016. Bayan nasarar aikin tiyata a gwiwarsa ta hagu a ranar 19 ga Afrilu, an tabbatar da cewa zai yi jinyar watanni shida. Bayan da Juventus ta kafa tarihinta na biyar a jere
A gasar Serie A a ranar 25 ga Afrilu, kyaftin din kungiyar kuma mai tsaron gida Buffon ya sadaukar da nasarar ga Marchisio.