Maguire ya kasance mai cin ganyayyaki ne tun daga 1992; a shekara ta 2009, ya zama mai cin ganyayyaki. PETA ta ayyana shi a matsayin Mafi Girma a Duniya a shekara ta 2002. Ya yi canje-canje a cikin abincinsa don ko dai ya sami ko ya rasa nauyi don rawar fim: ya rage yawan adadin kuzari ga Seabiscuit, sannan ya karu da sauri don sake samun nauyi ga Spider-Man 2. Maguire ya kasance mai nutsuwa tun yana da shekaru 19 bayan da ya fuskanci "wasu matsaloli" tare da barasa a ƙarshen shekarunsa.Maguire ya sadu da mai zanen kayan ado Jennifer Meyer a 2003 yayin da yake harbi fim din Seabiscuit a Universal Studios, kuma sun yi aure a watan Afrilu na shekara ta 2006. An haifi 'yarsu a watan Nuwamba na shekara ta 2006. Maguire da Meyer sun yi aure a ranar 3 ga Satumba, 2007, a Hawaii. An haifi ɗansu na biyu, ɗa, a ranar 18 ga Mayu, 2016, bayan shekaru tara da suka rabu.
Kona, Hawaii