Kammala jumla mai zuwa: A ranar 16 ga Oktoba, a wasan kwaikwayo na 1000 na "SmackDown", Mysterio ya yi gasa a wasan farko da ya yi tare da kamfanin tun daga watan Afrilu na 2014, inda ya ci Shinsuke Nakamura don samun cancantar zuwa gasar cin kofin duniya ta WWE. A lokacin gasar a Crown Jewel, Mysterio ya ci Randy Orton a zagaye na farko, amma Orton ya kai masa hari bayan wasan. Daga baya a daren, Mysterio ya yi rashin nasara ga The Miz a wasan kusa da na karshe. A ranar 6 ga Nuwamba na "SmackDown Live", Mysterio ya ci Andrade "Cien" Almas don cancanta ga Team SmackDown a cikin wasan tsallakewa na 5-on-5 na Survivor Series a
Jerin tsira. A taron, Mysterio ya kawar da Finn Bálor kafin Braun Strowman ya kawar da shi, kuma Team SmackDown a ƙarshe ya rasa ga Team Raw. Bayan dare biyu a "SmackDown Live", Randy Orton ya kai wa Mysterio hari, kuma ya tsage abin rufe fuskar Mysterio daga fuskarsa. Biyu sun yi yaƙi a mako mai zuwa, tare da Orton samun sama-hannu. A shekara ta, Mysterio ya ci Orton a wasan kujerun, ya kawo karshen rikice-rikicen su. A ranar 27 ga Janairu, 2019, a Royal Rumble, Mysterio ya shiga wasan Royal Rumble a lamba 25, amma Orton ya fitar da shi.