Rubuta ci gaba don wannan sakin layi - A ranar 20 ga Oktoba, 1944, "Isuzu" ya shiga cikin yakin Leyte Gulf
a matsayin wani ɓangare na Mataimakin Admiral Jisaburō Ozawa's Northern Mobile ("Decoy") Force. A cikin Yaƙin Cape Engaño a ranar 25 ga Oktoba 1944 <unk> 26 ga Oktoba 1944 jirgin saman TBM-1C na VT-21 daga Task Group 38.4 na jirgin sama da VT-51 daga suka kai wa sojojin Ozawa hari. Jirgin saman jirgin sama ya yi rauni sosai kuma "Isuzu" ya yi ƙoƙari ya ɗauki jirgin a cikin jirgin. Bayan da jirgin "Chitose" ya nutse, "Isuzu" ya ceci mutane 480 da suka tsira. Daga baya a wannan ranar, "Isuzu" yayi ƙoƙarin kare, wanda ya lalace ta hanyar hari na biyu ta jirgin sama daga "Lexington" da. Duk da haka, wani karfi na hudu Amurka cruisers da tara masu hallaka ya bayyana a kan scene da kuma sunk "Chiyoda" da dukan hannun. Yayin da yake ceton wadanda suka tsira, "Isuzu" kanta ta shiga cikin wuta daga rukunin Amurkawa kuma an kashe membobin ma'aikata 13.