An kira wannan cuta ne bayan Harry Klinefelter, wanda a 1942 ya yi aiki tare da Fuller Albright da EC Reifenstein a asibitin Massachusetts General Hospital a Boston, Massachusetts, kuma ya fara bayyana shi a wannan shekarar. An san asusun da Klinefelter ya bayar a matsayin cutar Klinefelter kamar yadda sunansa ya fara bayyana a kan takarda da aka buga, kuma ba a sake amfani da dysgenesis na seminiferous tubule ba. Idan aka yi la'akari da sunayen masu bincike guda uku, ana kuma kiran shi Klinefelter-Reifenstein-Albright.A 1956 an gano cewa cutar Klinefelter ta samo asali ne daga ƙarin chromosome. Plunkett da Barr sun gano jima'i na chromatin a cikin kwayar halitta na jikin mama. Wannan ya kara bayyana shi a matsayin XXYY a 1959 da John Jacobs da John Anderson Strong. Rahoton farko da aka buga game da mutum 47, tare da karyotype na Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Y
Shekara ta 1959