Kammala wannan jumla: An sanar a lokacin rani na 2012 cewa Tito Vilanova, mataimakin kocin Barcelona, zai maye gurbin Pep Guardiola a matsayin koci. Bayan nadin sa, Barcelona ta ci gaba da tafiya mai ban mamaki wanda ya gan su suna riƙe da matsayi na farko a teburin gasar don tsawon lokacin, suna yin asara biyu kawai kuma suna tara maki 100. Babban mai zira kwallaye na kungiyar shi ne Lionel Messi, wanda ya ci kwallaye 46 a La Liga, ciki har da kwallo biyu. A ranar 11 ga Mayu, 2013, an naɗa Barcelona a matsayin zakarun ƙwallon ƙafa na Spain a karo na 22, har yanzu tare da wasanni huɗu da za a buga. A ƙarshe, Barcelona ta ƙare kakar wasa ta maki 15 a gaban abokan hamayyarsu Real Madrid, duk da cewa sun yi rashin nasara 2 zuwa 1 a farkon Maris. Sun kai wasan kusa da na karshe na duka biyu
Copa del Rey da Champions League, suna zuwa Real Madrid da Bayern Munich bi da bi. A ranar 19 ga Yuli, an sanar da cewa Vilanova yana yin murabus a matsayin kocin Barcelona saboda cutar sankararsa ta dawo, kuma zai sami magani a karo na biyu bayan hutun likita na watanni uku a watan Disamba na 2012.