Rubuta ci gaba ga wannan sakin layi - An haifi Manuel c. 1516 a cikin Évora zuwa Joana de Vilhena da Dom Francisco na Fotigal (1485<unk>1549), 1st Count na Vimioso. Ya karɓi taken Comendador na Vimioso da na São Pedro de Calvelo, kuma John Manuel, Yariman Portugal, mahaifin sarki Sebastian na gaba na Portugal, ya ɗauke shi da daraja sosai. A lokacin mulkinsa, Sebastian ya nada shi Jakadan Fotigal a Castile. Bayan mutuwar Sarki Sebastian a yakin Alcácer Quibir
, Dom Manuel ya ɗauki gefen Dom António, Prior na Crato a cikin rikicin da ya biyo baya.