Dr. Witherspoon an haife shi ne a Georgia kuma ya yi aiki a matsayin mai kula da kansa a matsayin likitan ilimin likitancin har zuwa shekara ta 2012. Mahaifiyarta, Dr. Mary Elizabeth "Betty" (née Reese), ta fito ne daga Harriman, Tennessee. Dr. Betty Witherspoon ta sami digiri biyar a duka, ciki har da Ph.D a cikin aikin jinya. Ta zama farfesa a aikin jinya a Jami'ar Vanderbilt. Witherspoon ya yi iƙirarin cewa ta fito ne daga John Witherspoon, wanda ya sanya hannu a Yarjejeniyar 'Yancin Amurka; duk da haka, wannan ba a tabbatar da shi ba.
'Yar farin ciki