Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: A cikin 1920s, Michael Heidelberger da Oswald Avery sun lura cewa antigens za a iya ƙaddamar da su ta hanyar maganin rigakafi kuma sun ci gaba da nuna cewa an yi maganin rigakafi da furotin. Abubuwan da ke tattare da kwayoyin halittar antigen-antibody-daurewa sun bincika dalla-dalla a ƙarshen 1930s ta John Marrack. Babban ci gaba na gaba ya kasance a cikin 1940s, lokacin da Linus Pauling ya tabbatar da ka'idar kulle-da-maɓalli da Ehrlich ya gabatar ta hanyar nuna cewa hulɗar tsakanin ƙwayoyin cuta da antigens sun dogara da siffar su fiye da abubuwan da suke da shi. A cikin 1948, Astrid Fagreaus ya gano cewa ƙwayoyin B, a cikin nau'i na ƙwayoyin plasma, suna da alhakin samar da kwayoyin cuta. Ƙarin aiki ya mai da hankali kan nuna halayen tsarin sunadarai na antibody. Babban ci gaba a cikin waɗannan nazarin tsarin shine ganowa a farkon shekarun 1960 ta Gerald Edelman da Joseph Gally na sarkar haske na antibody, da kuma fahimtarsu cewa wannan furotin iri ɗaya ne da furotin Bence-Jones wanda Henry Bence Jones ya bayyana a cikin 1845. Edelman ya ci gaba da gano cewa kwayoyin rigakafi sun ƙunshi sarƙoƙi masu nauyi da haske waɗanda ke da alaƙar disulfide. Kusan lokaci guda, Rodney Porter ya bayyana yankunan antibody-binding (Fab) da kuma antibody tail (Fc) na IgG. Tare, waɗannan masana kimiyya sun ƙaddamar da tsari da kuma cikakken jerin amino acid na IgG, wani abin da aka ba su lambar yabo ta Nobel a 1972 a Physiology ko Medicine. David Givol ne ya shirya kuma ya bayyana fasalin Fv. Duk da yake yawancin waɗannan karatun na farko sun mai da hankali kan IgM da IgG, an gano sauran isotypes na immunoglobulin a cikin shekarun 1960: Thomas Tomasi ya gano kwayar cutar kwayar cutar (IgA); David S. Rowe da John L. Fahey sun gano IgD; kuma Kimishige Ishizaka da Teruko Ishizaka sun gano IgE kuma sun nuna cewa rukuni ne na kwayoyin cutar da ke cikin halayen rashin lafiyar. A cikin jerin gwaje-gwajen tarihi da suka fara a 1976, Susumu Tonegawa ya nuna cewa kayan kwayar halitta na iya sake tsara kanta don samar da ɗimbin magungunan ƙwayoyin cuta.  Tambaya: Menene masu bincike suka yi nazari a kai bayan sun gano cewa ƙwayoyin B suna ƙera ƙwayoyin cuta?
wanda ke nuna tsarin sunadarai na antibody.