Kammala wannan jumla: An yi amfani da Crain a matsayin mutumin da aka kafa don 2013. Daga 17 ga Afrilu zuwa 22 ga Yuni, Crain ya buga wasanni 29 a jere ba tare da wata matsala ba, rikodin rikodi. A ranar 3 ga Yuli, an sanya Crain a cikin jerin nakasassu tare da raunin kafada na dama. A cikin wasanni 38 tare da Chicago, Crain ya tafi 2-3 tare da riƙe 19 da 0.74 ERA, yana buga 46 a cikin innings 36.2. An zabi Crain a cikin
All-Star Game, amma tun lokacin da ya ji rauni, Justin Masterson ya maye gurbinsa.