An yi imani da cewa yana aiki ta hanyar "barin mugayen ruhohi su tsere". William Harvey ya ba da shawarar trepanation a matsayin magani ga migraines a karni na 17. Duk da yake an yi ƙoƙari da yawa don maganin migraines, ba har zuwa 1868 cewa amfani da wani abu wanda a ƙarshe ya zama tasiri ya fara. Wannan abu shi ne naman gwari ergot daga wanda aka ware ergotamine a shekarar 1918. An kirkiro Methysergide a shekarar 1959 kuma an kirkiro triptan na farko, sumatriptan, a shekarar 1988.
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