Ka cika wannan jumla: An kafa San Francisco a ranar 29 ga Yuni, 1776, sa'ad da 'yan mulkin mallaka daga Spain suka kafa Presidio na San Francisco a Golden Gate da Mission San Francisco de Asís 'yan mil kaɗan, duka an sa musu suna Francis na Assisi. California Gold Rush na 1849 ya kawo ci gaba mai sauri, yana mai da shi birni mafi girma a Yammacin Yamma a lokacin. San Francisco ya zama birni-gundumar da aka haɗu a cikin 1856. Matsayin San Francisco a matsayin birni mafi girma a Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yammacin Yamma. Bayan da aka lalata kashi uku cikin hudu na birnin da
1906 girgizar kasa da wuta, San Francisco an sake gina shi da sauri, yana karɓar bakuncin Panama-Pacific International Exposition shekaru tara bayan haka. A cikin Yaƙin Duniya na II, San Francisco babban tashar jirgin ruwa ne don membobin sabis da ke zuwa filin wasan Pacific. Sai ya zama wurin da aka kafa Majalisar Ɗinkin Duniya a shekara ta 1945. Bayan yakin, haɗuwa da ma'aikatan da suka dawo, ƙaura mai yawa, halayen sassaucin ra'ayi, tare da haɓakar "beatnik" da "hippie" countercultures, juyin juya halin jima'i, Ƙungiyar Zaman Lafiya da ke girma daga adawa da shigar Amurka a cikin Yakin Vietnam, da sauran abubuwan da suka haifar da Summer of Love da kuma 'yancin' yancin 'yan luwadi, suna ƙarfafa San Francisco a matsayin cibiyar' yancin 'yanci a Amurka. A siyasance, birni yana yin zaɓe sosai tare da layin Liberal Democratic Party.