Aniston an haife shi ne a ranar 11 ga Fabrairu, 1969, a unguwar Los Angeles na Sherman Oaks, 'yar wasan kwaikwayo na kasar Girka John Aniston da kuma actress Nancy Dow. Daya daga cikin kakanninta na mahaifiyarta, Louis Grieco, ya fito ne daga Italiya. Sauran mahaifiyarta sun hada da Ingilishi, Irish, Scottish, da kuma karamin Girkanci. Aniston yana da 'yan uwan biyu, John Melick, dan uwan mahaifiyarta, da kuma Alex Aniston, dan uwansa.
Birnin Los Angeles