An kuma gano cewa wasu tsoffin nau'ikan kwayar cutar hepatitis B har yanzu suna kamuwa da mutane, yayin da wasu suka mutu. Wannan ya karyata imanin cewa cutar hepatitis B ta samo asali ne daga Sabuwar Duniya kuma ta bazu zuwa Turai a kusan karni na 16. Wani binciken na 2018 na ragowar wani yaro da aka gano a cikin Basilica na San Domenico Maggiore a Naples ya kammala cewa yaron, wanda ya rayu a karni na 16, yana da nau'in HBV, kuma cewa kwayar cutar tana da alaƙa da nau'ikan zamani. An samo asali na farko na cutar hepatitis B ta hanyar David Baruch Lurman a 1885. An gano cutar ta hanyar bindigar ya zama mafi tsufa da aka samu daga samfuran vertebrate.
Shekara ta 1909