Keira Christina Knightley an haife ta ne a ranar 26 ga Maris, 1985, a Teddington, London, ga 'yan wasan kwaikwayo Sharman Macdonald da Will Knightley. Mahaifiyarta na asalin Scotland da Welsh, yayin da mahaifinta dan Ingilishi ne. An yi nufin a kira ta "Kiera", Ingilishi na "Kira", sunan da dan wasan tseren kankara na Rasha, Ivanova, wanda mahaifinta ya yaba. Duk da haka, Macdonald ya yi kuskure lokacin da ta je yin rajistar 'yarta, ta rubuta "e" kafin "i". Knightley yana da ɗan'uwa, Caleb. Macdonald kuma ya yi aiki a matsayin mai wasan kwaikwayo bayan aikinta a matsayin mai wasan kwaikwayo ya ƙare. Ta gabatar da 'ya'yanta zuwa ballet da kuma ballet a farkon shekaru. Wannan ya kara sha'awar Knightley a cikin aikin wasan kwaikwayo, kuma ta mayar da hankali a kan aikin wakili a cikin shekaru uku.
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