Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: Yawancin maye gurbin nucleophilic ya fi sauƙi ba tare da pyridine ba amma tare da pyridine da aka gyara tare da bromine, chlorine, fluorine, ko gutsuttsuran acid na sulfonic wanda ya zama rukunin barin. Don haka fluorine shine mafi kyawun rukunin barin don maye gurbin tare da mahaɗan organolithium. Abubuwan haɗarin nucleophilic na iya zama alkoxides, thiolates, amines, da ammoniya (a matsin lamba). Gabaɗaya, ion hydride rukuni ne mara kyau kuma yana faruwa ne kawai a cikin 'yan halayen heterocyclic. Sun haɗa da halayen Chichibabin, wanda ke haifar da abubuwan da aka samo na pyridine wanda aka aminated a 2-matsayi. Anan, ana amfani da sodium amide azaman nucleophile wanda ke haifar da 2-aminopyridine. Hydride ion da aka saki a cikin wannan halayen ya haɗu da proton na ƙungiyar amino da ke akwai, yana samar da kwayar hydrogen. Daidai da benzene, maye gurbin nucleophilic zuwa pyridine na iya haifar da samuwar tsaka-tsakin pyridyne kamar heteroaryne. Don wannan dalili, ana iya kawar da abubuwan da aka samo na pyridine tare da ƙungiyoyi masu kyau ta amfani da tushe mai ƙarfi kamar sodium da potassium tert-butoxide. Ƙari na gaba na nucleophile zuwa nau'i na uku yana da ƙananan zaɓi, kuma sakamakon shine cakuda biyu masu yiwuwa.  Tambaya: Me ake amfani da sodium?
nucleophile mai ba da 2-aminopyridine