A ƙarshen shekara ta 2002, Murphy ta fara saduwa da Ashton Kutcher, abokin aikinta a cikin Just Married. Da zarar ta yi aiki tare da mai kula da gwaninta Jeff Kwatinetz, Murphy ya yi alkawari da Joe Macaluso a watan Disamba na 2005, wani mataimakin mai samar da ta sadu da shi yayin aiki a kan fim din Little Black Book. A watan Agusta 2006, sun ƙare aikinsu. A watan Mayu 2007, Murphy ta auri marubucin wasan kwaikwayo na Burtaniya Simon Monjack a cikin wani bikin Yahudawa na sirri a Los Angeles. A cikin shekaru uku da rabi na rayuwarta, Murphy, mahaifiyarta da Monjack sun zauna tare a cikin gida ɗaya. A farkon shekarun 2000, Murphy ya rasa nauyi mai yawa, wanda ya haifar da jita-jita game da jarabar cocaine. A shekara ta 2005, Murphy ya yi jayayya da irin wannan da'awar ga mujallar Jane, yana cewa, "A'a, don rikodin ban taɓa gwada shi a rayuwata ba". A wannan lokacin, ta sanya hannu a matsayin mai magana da yawun Jordache jeans. Tambaya: Mene ne aka danganta da Murphy kwanan nan?
Jordache jeans