Kammala wannan magana: Higuaín ya fara aikinsa tare da kulob din Argentine River Plate, kafin ya koma Real Madrid a watan Janairun 2007 don € 12 miliyan. Lokacinsa a Spain ya ga ya lashe lambobin yabo na gida da yawa, gami da taken La Liga uku, kuma ya zira kwallaye 107 a wasanni 190 na gasar. Ya koma kungiyar Italiya ta Napoli akan Yuro miliyan 40 a watan Yulin 2013, inda ya lashe Coppa Italia a kakar wasa ta farko. A cikin
A cikin kakar 2015-16, ya zira kwallaye 36 a gasar, inda ya lashe taken "Capocannoniere" kuma ya daidaita rikodin shekaru 87 na Gino Rossetti na kwallaye a cikin kakar wasan Italiya. Sakamakon burinsa na cin kwallo a Naples, zakarun Italiya Juventus sun sanya hannu a kan shi don € 90 miliyan a cikin 2016, ya zama ɗayan mafi girman canja wurin ƙwallon ƙafa na kowane lokaci kuma mafi girman canja wuri ga ƙungiyar Italiya. Ya lashe sau biyu a cikin gida a farkon shekarunsa biyu tare da Juventus, kuma ya kai wasan karshe na gasar zakarun Turai na 2017 tare da kulob din. A cikin 2018, an ba shi aro zuwa Milan, kuma daga baya zuwa Chelsea ta Ingila a watan Janairun 2019, inda ya lashe gasar UEFA Europa League, kafin ya koma Juventus a lokacin rani na wannan shekarar, yana ƙara wani taken Serie A a cikin majalisar kujerarsa ta gaba a kakar wasa ta gaba.