An kuma gano cewa wasu tsoffin nau'ikan kwayar cutar hepatitis B har yanzu suna kamuwa da mutane, yayin da wasu suka mutu. Wannan ya karyata imanin cewa cutar hepatitis B ta samo asali ne daga Sabuwar Duniya kuma ta bazu zuwa Turai a kusan karni na 16. Wani binciken na 2018 na ragowar wani yaro da aka gano a cikin Basilica na San Domenico Maggiore a Naples ya kammala cewa yaron, wanda ya rayu a karni na 16, yana da nau'in HBV, kuma cewa kwayar cutar tana da alaƙa da nau'ikan zamani. An samo asali na farko na annobar cutar hepatitis B da David Baruch a cikin 1885. An gano cutar ta hanyar bindigar ya zama mafi tsufa da aka samu daga samfuran vertebrate. An kuma gano cewa wasu tsoffin nau'ikan kwayar cutar hepatitis B har yanzu suna kamuwa da mutane, yayin da wasu suka mutu daga cutar hepatitis A. Wannan binciken ya ba da tabbacin cewa an yi amfani da maganin rigakafin cutar ta hanyar maganin rigakafi a cikin ƙananan ƙwayoyin cuta daga ƙananan ƙwayoyin cuta, wanda aka gano a farkon shekara ta 1909. Daga baya, an sake amfani da maganin rigakafin
ƙwayar cutar hepatitis