A lokacin yakin Gettysburg, an nada shi ya zama kwamandan Sojojin Potomac kwana uku kafin yakin Gettysburg. Da ya isa filin bayan ranar farko ta aiki a ranar 1 ga Yuli, Meade ya shirya sojojinsa a kan ƙasa mai kyau don yin yakin basasa a kan Robert E. Lee na Arewacin Virginia, yana kawar da jerin hare-haren da aka yi a cikin kwanaki biyu masu zuwa. An tilasta Lee ya koma Virginia, ya kawo karshen fatansa na lashe yakin ta hanyar mamaye Arewa. Wannan nasarar ta lalace ne ta hanyar bin Meade ba tare da tasiri ba yayin ja da baya, yana ba Lee da sojojinsa damar tserewa maimakon lalata su gaba ɗaya. Har ila yau, rundunar sojojin ta kasa bin nasarar da ta samu a lokacin yakin Bristoe da
Yaƙin Mine Run a wannan kaka, wanda ya ƙare ba tare da yanke hukunci ba. Meade ya sha wahala daga tsananin rikice-rikicen siyasa a cikin Sojoji, musamman tare da Manjo Janar Daniel Sickles, wanda ya yi ƙoƙarin ɓata rawar da ya taka a nasarar Gettysburg.