Rubuta ci gaba don wannan sakin layi - A ranar 9 ga Fabrairun 1941, Iachino ya jagoranci rundunar sojan Italiya a cikin bin bin da ba a yi nasara ba na Sojan Burtaniya H, bayan da na baya ya harbe Genoa da La Spezia. Ya sake jagorantar rundunar sojojin Italiya a yakin Cape Matapan.
(26-29 Maris 1941), wanda ya haifar da babbar rashin nasara da Regia Marina ta taɓa sha wahala; watsi da rahotannin jiragen ruwa na Burtaniya da ke kusa da ba daidai ba ne ko ƙari, ya aika da Darakta na 1st Cruiser zuwa ceton jirgin ruwa mai suna "Pola", wanda ya haifar da rushewar Darakta ta uku na Admiral Andrew Browne Cunningham's Mediterranean Fleet. Ayyukansa a lokacin wannan yaƙin sun kasance batun sukar da yawa tun daga wannan lokacin; duk da wannan, ba a sauke Iachino daga umurnin ba.