Waɗannan sun bambanta da EBRT, wanda ake amfani da hasken wutar lantarki mai ƙarfi (ko kuma wani lokacin gamma-rays daga radioisotope kamar cobalt-60) a kan ciwon daji daga waje na jiki. Brachytherapy maimakon ya ƙunshi ainihin wuri na gajeren radiation-sources (radioisotopes, Iodine-125 misali) a wurin da ciwon daji. Wadannan suna rufe a cikin wani capsule ko waya, wanda ya ba da damar ionizing radiation don tserewa da kuma kashe kewaye brachytherapy amma ya hana caji na radiotherapy daga motsi da kewaye da nama da ake bukata lalacewa. Wannan kuma ya bambanta da EBRT, wanda high-makamashi x-haskoki (ko kuma wani lokacin gamma-haskoki daga radioisotope kamar cobalt-60) suna kai tsaye a kan ciwon daji daga waje na jiki.
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