"Toxic" wani waka ne da aka rubuta da kuma samar da Pontus Winnberg (wanda aka sani da Bloodshy & Avant), tare da ƙarin rubuce-rubuce daga Cathy Dennis da Henrik Jonback. An saki waƙar a ranar 13 ga Janairu, 2004, ta Jive Records, a matsayin na biyu daga cikin Yankin. An ba da waƙar ga Kylie Minogue don kundin waƙarta na tara na Body Language (2003), amma ta ƙi shi. Bayan ƙoƙarin zaɓar tsakanin "I Got That) Boom Boom" da "Outrageous" don zama na biyu daga cikin Yankin, Spears ya zaɓi "Toxic" a maimakon haka.
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