A ranar 22 ga Janairu, 2006, Bryant ya zira kwallaye 81 a cikin wasan da ya yi nasara da 122 <unk> 104 a kan Toronto Raptors. Bugu da ƙari, ya karya rikodin rikodin rikodi na 71 da Elgin Baylor ya kafa, Bryant na 81-point game shi ne karo na biyu mafi girma a cikin tarihin NBA, wanda ya wuce kawai ta hanyar Chamberlain ta 100-point game a 1962. Yayin da Chamberlain ya ci gaba da ciyar da shi daga cikin 'yan wasa don harbi a cikin nasara a cikin nasara, Bryant ya kirkiro kansa daga waje a cikin wasan da Lakers suka ragu a rabi ta 14 kuma ba su janye ba har zuwa kashi na hudu.
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