An ci gaba da Dorothy Wrinch a cikin marigayi 1930s, kuma ya dogara ne akan abubuwa uku. Da farko, ka'idar ta ɗauka cewa ƙungiyoyin peptide guda biyu za a iya haɗuwa da su ta hanyar halayen cyclol (Hoto na 1); waɗannan haɗin haɗin suna da alaƙa da halayen hydrogen ba tare da haɗuwa ba tsakanin ƙungiyoyin peptide. An lura da waɗannan halayen a cikin ergopeptides da sauran mahadi. Abu na biyu, yana ɗauka cewa, a ƙarƙashin wasu yanayi, amino acid zai haifar da mafi yawan adadin halayen cyclol, wanda ya haifar da kwayoyin cyclol (Hoto na 2) da kuma kayan cyclol (Hoto na 3).
ƙwayoyin cuta