Kammala jumla mai zuwa: 1st Manchesters sun shiga yakin Mesopotamian, tare da bindigogi na sojojin Indiya, daga Faransa a ƙarshen 1915. Rundunar ta shiga cikin yakin Dujaila a watan Maris na 1916, wanda aka yi niyyar sauƙaƙe sojojin Burtaniya a
Kut-al-Amara, wanda sojojin Ottoman ke kewaye da shi. A cikin yaƙin, Manchester na 1 sun kwace ramin Redoubt na Dujaila tare da 59th Scinde Rifles (Frontier Force); duk da haka, daga baya an kore su ta hanyar kai hari ga Ottoman, an tilasta su komawa layin farko. A lokacin da aka janye, Private Stringer ya rike matsayinsa da hannu daya, yana tabbatar da bangaren batalayinsa. An ba shi lambar yabo ta Victoria Cross. Sojojin Burtaniya da Indiya sun yi asarar rayuka 4,000. Bayan yunkurin da aka yi na sauƙaƙe garin sau biyar, Kut ya mika wuya ga sojojin Ottoman a ranar 29 ga Afrilu 1916. 1st Manchesters za su shiga cikin ƙarin ayyuka a Mesopotamiya, amma a watan Maris na 1918 rundunar ta koma Masar.