Bayan nasarar Faransa a Pavia a 1525, wanda ya bar sojojin mulkin mallaka na Charles V na Spain a Italiya, Francesco ya shiga kungiyar Cognac da ke adawa da sarki tare da Venice, Florence Paparoma, da Faransanci. Wannan ya haifar da saurin fitar da kansa daga Milan ta sojojin mulkin mallaka, amma ya yi nasarar ci gaba da sarrafa wasu biranen daban-daban a cikin duchy, kuma an sake dawo da shi zuwa Milan kanta ta hanyar zaman lafiya da aka kammala a Cambrai a 1529. Tambaya: A wace shekara aka ci Faransanci a Pavia?
1525 da kuma