Kammala jumla mai zuwa: M4A1 Sherman ya fara gwagwarmaya a Yaƙin El Alamein na biyu a watan Oktoba 1942 tare da rundunar sojojin Burtaniya ta 8. Shermans na farko na Amurka a cikin yaƙi sun kasance M4A1s a
Operation "Torch" a wata mai zuwa. A wannan lokacin, Shermans sun yi nasarar shiga cikin Panzer IIIs na Jamus tare da dogon bindigogi na 50mm L60, da kuma Panzer IVs tare da gajeren bindigogi na 75mm L24. Ƙarin M4 da M4A1s sun maye gurbin M3 Lees a cikin battalion na Amurka a lokacin yakin Arewacin Afirka. Duk da haka, a watan Yunin 1944, yawancin tankunan Jamus sun yi amfani da bindigogi kuma 75 mm Shermans sun kasance masu bindigogi. M4 da M4A1 sune manyan nau'ikan a cikin rukunin Amurka har zuwa ƙarshen 1944, lokacin da Sojojin suka fara maye gurbin su da M4A3 da aka fi so tare da injin sa mai ƙarfi. Wasu M4s da M4A1s sun ci gaba da aiki a Amurka don sauran yakin.