Kammala jumla mai zuwa: Mariano ya sami ci gaba na ƙarshe ga babban tawagar ta mai horarwa Zinedine Zidane a ranar 20 ga Agusta 2016, bayan raunin da ya faru da mai kai hari Karim Benzema. Mako guda bayan haka, Mariano ya fara wasan farko a lokacin da suka ci Celta de Vigo 2-1, inda ya maye gurbin Álvaro Morata a minti na 77. A ranar 26 ga Oktoba, kuma daga benci, ya zira kwallaye na farko don "Merengues" don kammala nasarar 7 zuwa 1 a Cultural y Deportiva Leonesa a Copa del Rey. A mataki na biyu, ya kara da hat-trick don cin nasara 13<unk>2, ciki har da burin 23rd na biyu wanda shine burin da ya fi sauri a tawagarsa a gasar. Mariano ya zira kwallaye na farko a saman jirgin sama a ranar 10 ga Disamba, inda ya daidaita a nasarar dawowa 3<unk>2 a gida Deportivo de La Coruña. Daga baya a wannan watan, ya kasance cikin tawagar da ta lashe gasar
2016 FIFA Club World Cup a Japan, amma bai bayyana a kowane wasan Real Madrid ba. Mariano ya buga wasanni takwas lokacin da Madrid ta lashe La Liga a 2016-17. Ya kasance mai goyon baya lokacin da Madrid ta lashe gasar zakarun Turai ta 2016-17.