Agron an haife shi ne a Savannah, Georgia, kuma ya girma a San Antonio, Texas, da San Francisco, California, 'yar Maryamu (née Barnes) da Ronald S. Agron, babban manajan otal din Hyatt. Saboda aikin mahaifinta, Agron ta ce ita da iyalinta sun fara girma a otal-otal daban-daban. Tana da ƙaramin ɗan'uwa, Jason. An haifi mahaifinta ga dangin Yahudawa, yayin da mahaifiyarta ta koma addinin Yahudanci. Agron ya halarci makarantar Ibrananci kuma yana da Bat Mitzvah.
Makarantar Ibrananci