Kammala jumla mai zuwa: Ba har zuwa 879 cewa sunan Ioannina ya bayyana a karo na farko, a cikin ayyukan Majalisar ta huɗu ta Constantinople, wanda ke nufin wani Zacharias, Bishop na Ioannine, suffragan na Naupaktos. Bayan da
Bayan mamayewar Byzantine na Bulgaria, a cikin 1020 Emperor Basil II ya ba da bishop na gida ga Archbishopric na Ohrid. Masanin ilimin kimiyyar kayan tarihi na Girka K. Tsoures ya rubuta ganuwar birni na Byzantine da kuma arewa maso gabashin sansanin soja na Gidan Ioannina zuwa karni na 10, tare da ƙari a ƙarshen karni na 11, gami da sansanin soja na kudu maso gabas, wanda aka saba da shi ga ɗan gajeren lokaci. mamayar birni da mutanen Norman karkashin jagorancin Bohemond na Taranto a 1082. A cikin chrysobull ga Venetians a cikin 1198, an jera birni a matsayin wani ɓangare na lardinsa (" lardin Joanninorum " ko " Joaninon "). A cikin yarjejeniyar rarraba ƙasashen Byzantine bayan Yaƙin Crusade na Hudu, an yi wa Ioannina alkawarin zuwa ga Venetians, amma a cikin taron, ya zama wani ɓangare na sabuwar jihar Epirus, wanda Michael I Komnenos Doukas ya kafa.