Duba wurin da ke ƙasa sannan ka amsa tambayar daga baya a cikin harshe ɗaya kamar yadda wurin yake:  Passage: Wani ka'idar da aka gabatar kwanan nan ta mai da hankali kan rashin daidaito na kwayar IgA1. IgA1 yana ɗaya daga cikin ƙananan ƙananan immunoglobulin guda biyu (ɗayan shine IgD) wanda ke O- glycosylated akan adadin ragowar serine da threonine a cikin wani yanki na musamman mai wadataccen proline. Rashin daidaituwa na glycosylation na IgA ya bayyana yana haifar da polymerization na kwayoyin IgA a cikin kyallen takarda, musamman ma glomerular mesangium. An yi iƙirarin irin wannan tsari ya haifar da Henoch-Schönlein purpura, wani ƙwayar cuta wanda ke shafar yara kuma yana iya nuna halayen koda wanda kusan ba za a iya bambanta shi da nephritis na IgA ba. Koyaya, nazarin ɗan adam ya gano cewa degalactosylation na IgA1 yana faruwa a cikin marasa lafiya tare da IgA nephropathy a cikin martani kawai ga abubuwan da ke tattare da antigen na hanji (ba tsarin ba), kuma yana faruwa a cikin lafiyayyun mutane zuwa ƙarami. Wannan yana nuna cewa degalactosylation na IgA1 sakamakon sakamakon abin da ya faru ne (al'ada na mucosal antigen handling) kuma ba shine ainihin dalilin IgA nephropathy ba. Shaidar da ta fi dacewa ta nuna cewa duka galactose-deficient o-glycans a cikin yankin hinge na IgA1 da kira da kuma haɗuwa da kwayoyin cutar akan IgA1 ana buƙata don hadaddun immunoglobulin don samarwa da tarawa a cikin glomeruli. Daga gaskiyar cewa IgAN na iya sake dawowa bayan dasawar koda, ana iya ɗauka cewa cutar ta haifar da matsala a cikin tsarin rigakafi maimakon koda kanta. Abin mamaki, IgA1 da ke taruwa a cikin koda ba ya fitowa daga ƙwayoyin lymphoid da ke hade da mucosa (MALT), wanda shine wurin mafi yawan cututtukan na sama na numfashi, amma daga kashin kasusuwa. Wannan, ma, yana nuna rashin lafiyar rigakafi maimakon tsoma baki kai tsaye ta abubuwan waje.  Tambaya: Wanene ya fi kamuwa da ciwon jijiyoyin jini?
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