A kwanan nan m ka'idar mayar da hankali a kan abnormalities na IgA1 kwayoyin. IgA1 yana daya daga cikin biyu immunoglobulin subclasses (da sauran shi ne IgD) cewa shi ne O-glycosylated a kan wani yawan serine da threonine residues a cikin wani musamman proline-arziki hinge yankin. Aberrant glycosylation na IgA alama kai ga polymerisation na IgA kwayoyin a cikin kyallen takarda, musamman ma da glomerular mesangium. A irin wannan inji da aka yi iƙirarin zama a karkashin Henoch<unk>Schönpura purlein, a vasculitis cewa yafi rinjayar yara da kuma iya ƙunshi koda hannu cewa shi ne kusan indistinguishable daga IgA nephritis. Duk da haka, mutum karatu sun gano cewa degalactosylation na IgA1 faruwa a cikin hanji tare da IgA nephritis kawai a cikin wani musamman proline-arziki hinge yankin. Wannan ya nuna cewa IgA1 iya haifar da wani abu mai tsanani anti-glycosylated da anti-glycosylated antibodies a cikin marasa lafiya, maimakon
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