RNAP an gano shi da kansa ta Charles Loe, Audrey Stevens, da Jerard Hurwitz a 1960. A wannan lokacin, an ba Severo Ochoa rabin kyautar Nobel a 1959 a Medicine don gano abin da aka yi imanin cewa RNAP ne, amma a maimakon haka ya zama polynucleotide phosphorylase. Tambaya: Wanene ya gano RNAP?
Charles Loe, Audrey Stevens, da kuma Jerard Hurwitz