Rubuta ci gaba ga wannan sakin layi - Duk da rashin lafiyarsa, Wilson ya so ya gudu a karo na uku. Yayin da taron kasa na jam'iyyar Democrat na 1920
Shugabanni na Democrat sun ki amincewa da manufofin Wilson, sun ki amincewa, maimakon sun zabi tikitin da ya hada da Gwamna James M. Cox da Mataimakin Sakataren Navy Franklin D. Roosevelt. 'Yan Republican sun mayar da kamfen din su game da adawa da manufofin Wilson, tare da Sanata Warren G. Harding da ke alƙawarin "komawa ga al'ada". Wilson ya fi yawa daga cikin yakin, ko da yake ya goyi bayan Cox kuma ya ci gaba da ba da shawara ga membobin Amurka a cikin League of Nations. Harding ya lashe nasara, ya lashe fiye da kashi 60 cikin 100 na kuri'un jama'a da kuma kowace jiha a waje da Kudu. Wilson ya sadu da Harding don shayi a ranar karshe a ofishinsa, Maris 3, 1921. Saboda rashin lafiyarsa, Wilson bai iya halartar rantsarwar ba.