Kammala jumla mai zuwa: Löhr ya gaji Janar der Pioniere Walter Kuntze a matsayin Babban Kwamandan Sojoji na 12 a ranar 3 ga Yuli 1942. An nada shi Kwamandan Wehrmacht a kudu maso gabashin Turai a ranar 1 ga Agusta, 1942, kuma daga ranar 28 ga Disamba, 1942, an sake sanya wannan matsayin a matsayin Babban Kwamandan a kudu maso gabashin Turai. An kuma sanya sojojin da ke karkashin umurninsa a matsayin Army Group E, kuma an nada shi a matsayin kwamandansa. A wannan matsayin, Löhr ya mallaki dukkan kwamandojin da ke karkashinsa a kudu maso gabashin Turai, gami da janar mai ba da umarni a Serbia (Paul Bader), kwamandan soji a yankin Salonika-Aegean, kwamandan soji a kudancin Girka, kwamandan Crete, kwamandan sojin ruwa a Tekun Aegean, Janar mai cikakken iko na Jamus a cikin Independent State of Croatia, kwamandan janar na sojojin Jamus a Croatia, da kuma soja attaché a Sofia, Bulgaria. Löhr ya shirya na huɗu da
karo na biyar na hare-hare kan 'yan tawayen Yugoslav a shekarar 1943, wanda a lokacin da yawancin wadanda aka kama, ciki har da wadanda suka ji rauni, aka kashe su a wurin. A matsayinsa na Babban Kwamandan Army Group E, Löhr ya kula da yakin Dodecanese. A ranar 26 ga Agusta, 1944, tare da Allies suna motsawa kan Jamus a bangarori uku, Hitler ya umarci Löhr ya fara kwashe Army Group E daga Girka kuma ya koma arewa don kare Fatherland.