Rubuta ci gaba don wannan sakin layi - A shekara ta 58 kafin haihuwar Yesu, Cleopatra ya kasance tare da mahaifinta, Ptolemy XII Auletes, a lokacin da yake gudun hijira zuwa Roma bayan wani tawaye a Misira (ƙasar Romawa) ta ba da damar 'yarsa Berenice IV ta yi ikirarin kursiyin. An kashe Berenice a cikin 55 BC lokacin da Ptolemy ya koma Masar tare da taimakon sojojin Rome. Lokacin da ya mutu a shekara ta 51 kafin haihuwar Yesu, haɗin gwiwar Cleopatra da ɗan'uwanta Ptolemy XIII ya fara, amma faɗuwa tsakanin su ya haifar da yakin basasa. Bayan ya rasa yaƙin Pharsalus a Girka a shekara ta 48 kafin haihuwar Yesu a kan abokin hamayyarsa Julius Kaisar (dan mulkin kama karya na Roman da kuma wakili) a cikin Yaƙin Casar na Kaisar, ɗan siyasar Roman Pompey ya gudu zuwa Masar. Pompey abokin siyasa ne na Ptolemy na XII, amma Ptolemy na XIII, bisa ga roƙon bābānsa na fadarsa, ya sa aka yi wa Pompey kwanton bauna kuma aka kashe shi kafin Kaisar ya isa Iskandariya. Bayan haka, Kaisar ya yi ƙoƙari ya sulhunta 'yan'uwan Ptolemy da suke gāba da juna, amma babban mai ba da shawara na Ptolemy, Potheinos, ya ɗauki sharuddan da Kaisar ya bayar a matsayin wanda ya fi son Cleopatra, saboda haka sojojinsa suka kewaye ta da Kaisar a fadar
Ka yi haƙuri. Ba da daɗewa ba bayan da aka ɗaga kewaye da ƙarfafawa, Ptolemy XIII ya mutu a cikin 47 BC Battle of the Nile; Cleopatra ta rabin 'yar'uwar Arsinoe IV daga bisani aka fitar da shi zuwa Afisa don rawar da ta taka wajen aiwatar da kewaye. Kaisar ya ayyana Cleopatra da ɗan'uwanta Ptolemy XIV a matsayin masu mulki tare amma ya ci gaba da kasancewa tare da Cleopatra wanda ya haifi ɗa, Caesarion. Cleopatra ta yi tafiya zuwa Rome a matsayin sarauniya a cikin 46 da 44 BC, inda ta zauna a gidan Kaisar. Bayan kisan gillar Kaisar da (a kan umarninta) Ptolemy XIV a cikin 44 BC, ta sanya Caesarion a matsayin mai mulki.