Ka cika wannan jumla: Blondell ya koma Hollywood a shekara ta 1950. Ayyukanta a cikin fim dinta na gaba, "The Blue Veil" (1951), ya ba ta lambar yabo ta Nobel don aikinta.
Nomination na Kyautar Kwalejin don Kyauta Mafi Kyawun Mata a Matsayi na Taimako. Ta taka rawar gani a cikin "The Opposite Sex" (1956), "Desk Set" (1957), da kuma "Shin Success Spoil Rock Hunter?" (1957). Ta sami yabo sosai saboda rawar da ta taka a matsayin Lady Fingers a Norman Jewison's "The Cincinnati Kid" (1965), wanda ya sami lambar yabo ta Golden Globe da kuma Hukumar Kula da Kasa ta Kasa don lashe kyautar Mata mafi kyau. John Cassavetes ya jefa ta a matsayin mai tsufa, mai wasan kwaikwayo a cikin fim dinsa "Opening Night" (1977). An ga Blondell a cikin fina-finai biyu da aka saki ba da daɗewa ba kafin mutuwarta <unk> "Grease" (1978), da kuma sake yin fim na "The Champ" (1979) tare da Jon Voight da Rick Schroder. Ta kuma bayyana a fina-finai biyu da aka saki bayan mutuwarta <unk> "The Glove" (1979), da kuma "The Woman Inside" (1981).