A matsayin dan takarar Jam'iyyar Republican na Mataimakin Shugaban Amurka a zaben shekarar 2008 tare da dan takarar shugaban kasa, Sanata Arizona John McCain, ita ce 'yar Alaska ta farko a tikitin kasa na wata babbar jam'iyyar siyasa kuma mace ta farko ta Republican da aka zaba a matsayin mataimakin shugaban kasa. Littafinta Going Rogue ya sayar da fiye da miliyan biyu. Tambaya: Yaushe ne Sara Palin ya zama Gwamnan Alaska?
2006 har zuwa lokacin da ta yi murabus a 2009