Kammala jumla mai zuwa: Bayan zaben shugaban kasa na 2008, Pfeiffer ya gudanar da ofishin sadarwa na tawagar Obama-Biden Transition kuma an nada shi Mataimakin Darakta na Sadarwa na Fadar White House bayan da
rantsar da Barack Obama. Kasa da shekara guda daga baya, bayan ficewar Anita Dunn, an nada Pfeiffer Daraktan Sadarwar Fadar White House. Ya ci gaba da kasancewa a cikin rawar da aka yi a lokacin farko na shugabancin Obama. A farkon wa'adin Shugaba Obama na biyu, an daukaka Pfeiffer zuwa Babban Mashawarci na Dabarun da Sadarwa, inda ya karɓi mafi yawan fayil ɗin da David Axelrod da David Plouffe suka gudanar a Fadar White House. Ya bar fadar White House a ranar 6 ga watan Maris, 2015.