I roto i te 19th me te 20th rau, i mua i te maimoatanga pharmacological whai hua mo te mate toto tiketike i taea, i whakamahia e toru tikanga maimoatanga, katoa ki maha-nga painga taha: te herenga sodium tino (hei tauira, te kai raihi), sympathectomy (whakakorea ablation o nga wahi o te pūnaha neura sympathetic), me te maimoatanga pyrogen (te werohanga o ngā matū e meinga te werawera, āta whakaiti pēhanga toto). i whakamahia te matū tuatahi mō te mate toto tiketike, konutai thiocyanate, i roto i te 1900 engari i maha ngā pānga taha, me te he unpopular. i whakawhanakehia e rave rahi atu kaihoko i muri i te Pakanga Tuarua o te Ao, te tino rongonui, me te whaitake whaitake o nei ko tetramethylammonium hexamide, chlorethonium, Rau hydralazine, me te sulfiazine (i ahu mai i te tipu subpineal Serpentin). i tutuki kahore o enei i roto i te maha-nga painga taha. i roto i te
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