Whakaotihia te rerenga e whai ake nei: I mua i te kitenga o te take mate, i whakaarotia ko nga tohu o te mate pukupuku i puta mai i te nui o te pungawerewere i roto i te turoro; ko te ingoa o te mate pukupuku i ahu mai i te kupu Kariki "choler" te tikanga o te pungawerewere. He rite tenei ariā ki te whakahianga, a, i arahi ki nga mahi rongoa penei i te whakaheke toto. Ko te kitenga tuatahi o te huakita i te tau 1849 na Gabriel Pouchet, nana i kitea i roto i nga turanga mai i nga turoro mate pukupuku, engari kaore ia i aro ki te hiranga o tenei aroaro. Ko te kaipūtaiao tuatahi i mārama ki te hiranga o te "Vibrio cholerae" ko te kairangahau Itari a Filippo Pacini, nāna i whakaputa ngā pikitia taipitopito o te rauropi i roto i "Microscopical observations and pathological deductions on cholera" i te tau 1854. I whakaputahia e ia etahi atu tuhinga i te 1866, 1871, 1876 me te 1880, i kore e aro ki te hapori putaiao. I tika tana whakaahua i te āhua o te huaketo e pā ana ki te kōrerorero, ā, i whakawhanakehia e ia ngā rongoā i kitea he whai hua. Ahakoa i tino mohiotia nga mahere mate uruta o John Snow, a i arahi ki te tango i te ringa papu Broad Street, hei tauira.
1854 Te pakarutanga o te mate huka i Broad Street. I te tau 1874, ka pōti ngātahi ngā māngai pūtaiao mai i ngā whenua e 21 ki te whakatau ko te mate korikori i takea e ngā paitini taiao mai i ngā "miasmatas", he kapua rānei o ngā matū kino e rere ana i te hau. I te tau 1884, i kitea anō e Robert Koch te "Vibrio cholerae" hei huānga take i te mate huka. I whakahe ētahi kaipūtaiao ki te ariā hou, ā, i inu rātau i ngā hua o te korora hei whakakāhore i a ia: