Whakakiia te rerenga e whai ake nei: I whānau a Fabrizio i mua i te tau 1452. I marenatia ia ki a Agnese da Montefeltro te tamahine a Federico da Montefeltro, 1st Duke o Urbino, me Battista Sforza. I mohiotia a Fabrizio hei kaute o Tagliacozzo me te kaitiaki nui o te rangatiratanga o Naples. I te Pakanga Itari o te 1499<unk>1504, i whai wāhi nui ia ki te
Te Pakanga o Cerignola i te tau 1503. He rangatira ia i roto i te Rōpū Tapu i whawhai ki a Louis XII o France mai i te 1509 ki te 1515, a i te Pakanga o Ravenna, i whakahau ia i te ope o nga Papal States ki France.