Whakaotihia te rerenga e whai ake nei: I te mahi i te Rockefeller Institute for Medical Research i waenga i te 1915<unk>1919, ka ripoata a Israel Kleiner i nga kitenga pono mo te paanga o nga rongoa pancreatic i runga i nga taumata huka toto, ma te whakamahi i nga mana whakamatautau tino kaha e "teoretically... tautoko [i] te whakapae o te haumanu o roto o te putake o te mate huka" me "te mahi... [i] taunakihia he whakamahinga rongoa pea". I whakamutua e ia tenei mahi i tana wehenga mai i te whare wananga o Rockefeller i te 1919, mo nga take kaore i tino mohiotia. Ko te kaipūtaiao Romanian a Nicolae Paulescu, tetahi atu tangata rongonui i roto i te rapu mo te take anti-tawhito, i timata ki te whakamatau i te tau 1916 ma te whakamahi i te otinga pancreatic iti-te tote rite ki a Kleiner. Whai muri i te whakamutua e te
Ko te Pakanga o Bucharest me te raru o muri o te pakanga, i whakaputaina e ia ana hua tuatahi i te reo French i te tau 1920 me te 1921. Ko ana tangohanga i hua ai te whakahekenga o te toto me te huka urine i roto i nga kuri i whakamatautauria, engari kaore i whai hua tonu i roto i ana tuuroro tangata (ma te werohanga rectal) kaore e taea te taarua e nga horopeta o te saline anake. I tangohia e Paulescu he mana Romanian mo tana otinga (i kiia e ia ko "pancréine") me te tikanga whakaputa, engari i te tau e whai ake nei, kaore i tino pai tana mahi na te kore o te tahua.