Whakaotihia te rerenga e whai ake nei: I te tau 1813, i marenatia a Ruffin ki a Susan Hutchings Travis o Williamsburg. I neke te tokorua ki tetahi tipu i riro i a Ruffin mai i tana tupuna ingoa, i Coggin's Point, i te taha o te Awa o James i Prince George County, i kiia ko te waahi wehe o Benedict Arnold i muri i tana huri i nga pono me te whakaeke i te awa o James (tae atu ki Richmond) i te 1781. Tekau mā tahi ā rāua tamariki i mua i te matenga o Susan Ruffin i te tau 1846, ahakoa ko te nuinga ka mate i mua i te mutunga o te Pakanga Taketake o Amerika, ā, ka whakamomori tō rāua pāpā: Edmund Ruffin Jr. (1814-1875), Agnes Ruffin Beckwith (1816<unk>1865), Julian Calx Ruffin (1821<unk>1864, i mate i te
Ko te Pakanga o Drewry's Bluff), Elizabeth Ruffin Sayre (1821<unk>1860), Rebecca Ruffin Bland (1823<unk>1855), Jane Ruffin Dupuy (1829<unk>1855), Charles Lorraine Ruffin (1832<unk>1870; VMI paetahi i ora i te pakanga), Ella Ruffin (1832<unk>1855), Ann Ruffin (1844<unk>1863) me George Champion Ruffin (1845-1913).