Tuhia he tohutoro mō tēnei wāhanga - I noho a Panama e ngā iwi taketake i mua i te taenga mai o ngā kaipupuri Paniora i te rau tau 16. I wehe mai i Spain i te tau 1821 ka uru ki te Republic of Gran Colombia, he uniana o Nueva Granada, Ecuador, me Venezuela. I muri i te whakakorenga o Gran Colombia i te tau 1831, ka riro a Panama me Nueva Granada hei Republic of Colombia. Na te tautoko a te United States, i wehe atu a Panama i a Colombia i te tau 1903, i whakaaetia ai te hanganga o te Canal Panama kia oti i te US Army Corps of Engineers i waenga i te 1904 me te 1914. I whakaaetia e nga Tiriti Torrijos-Carter o te tau 1977 te whakawhiti i te awa mai i te United States ki Panama i te Tihema 31, 1999. Ko te rohe e karapoti ana
i whakahokia mai i te tau 1979.