Ko Kelly's tuarua spaceflight i rite ki te misioni rangatira o STS-118, he misioni 12-ra Space Shuttle ki te ISS i roto i August 2007. Kelly's toru spaceflight i rite ki te kaimahi i runga i Expedition 25/26 i runga i te ISS. tae ia ki te ISS i runga i Soyuz TMA-01M i runga i Oketopa 9, 2010, a mahi rite te kaipūkaha rere tae noa riro ia whakahau o te teihana i runga i Noema 25, 2010 i te timatanga o Expedition 26. mutu Expedition 26 i runga i Maehe 16, 2011 ki te wehenga o Soyuz TMA-01M. I roto i te marama o Noema 2012, ko te toru o te misioni tiaki ki te Hubble Space Telescope, a roa hoki i te iti iho i te waru ra. i te tahi atu Astronaut Kelly i noho i runga i te ISS mo te tau-roa-roa misioni ki te Soyuz Soyuz International i te marama o Poutu-te-te-rangi 26, 2016, i te mea i pau hoki ia i runga i te Soyuz Soyuz, i runga i Soyuz
9 o Oketopa 2010