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What low-fee & liquid exchange-traded index funds / ETFs should I consider holding in a retirement portfolio?
If liquidity and cost are your primary objectives, Vanguard is indeed a good bet.  They are the walmart of finance and the absolute best at minimizing fees and other expenses. Your main portfolio holding should be VTI, the total stock market fund.  Highly liquid and has the lowest fees out there at 0.05%.  You can augment this with a world-minus-US fund if you want.  No need to buy sector or specific geography funds when you can get the whole market for less. Add some bond funds and alternative investments (but not too much) if you want to be fully diversified.