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At what point is it most advantageous to cease depositing into a 401k?
You'd need to test the assumptions here - in effect you're saying that in 15 years your account will have a balance 10x your income. But normally you'd expect your income to grow over the years (e.g. promotions) and so you'd hope that your income in 15 years would be significantly larger than what it is now.   But, even in the case where your account eventually does grow to 10x your salary at that time, it may still be worth continuing to contribute. In effect, adding a further 1% to your account is boosting the "compounding return" on your account by 1% - after fees and risk free. This additional 1% "return" in effect makes your retirement plan safer - you either get a higher total return for the same investment mix, or you can get the same total return for a slightly safer investment mix. In effect, you're treating your salary as a "safe" annuity and each year putting 10% of the "return" from that into your more risky retirement account.