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Is there any instance where less leverage will get you a better return on a rental property?
If you are calculating simple ROI, the answer is straightforward math.  See This Answer for some examples, but yes, with more leverage you will always see better ROI on a property IF you can maintain a positive cash flow.  The most complete answer is to factor in your total risk. That high ROI of a leveraged property is far more volatile and sensitive to any unexpected expenses. Additionally, a loss of equity in the property (or an upside-down mortgage) will further impact your long term position. To put this more simply (as noted in the comments below), your losses will be amplified. You cannot say a leveraged property will always give you a better ROI because you cannot predict your losses.