Offer your thoughts or opinion on the input financial query or topic using your financial background.

HELOC vs. Parental Student Loans vs. Second Mortgage?
First of all, I'm happy that the medical treatments were successful. I can't even imagine what you were going through.  However, you are now faced with a not-so-uncommon reality that many households face. Here's some other options you might not have thought of:   I would avoid adding more debt if at all possible.  I would first focus on the the cost side.  With a good income you can also squeeze every last dollar out of your budget to send them to school.   I agree with your dislike of parent loans for the same reasons, plus they don't encourage cost savings and there's no asset to "give back" if school doesn't work out (roughly half of all students that start college don't graduate) I would also avoid borrowing more than 80% of your home's value to avoid PMI or higher loan rates.  You also say that you can pay off the HELOC in 5 years - why can you do that but not cash flow the college?   Also note that a second mortgage may be worse that a HELOC - the fees will be higher, and you still won't be able to borrow more that what the house is worth.