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Merchant dispute with airline over changed itinerary
Are you on Twitter? If so, the first thing I'd do is tweet this question to @Orbitz and/or @AmericanAir (AA). I'll edit it to be a bit nicer english-wise.  Tweeting (or Facebooking or Instgramming or ...) is one of the most effective ways to get customer service in 'edge' cases.  Explain your case in a nice, tight narrative that has the pertinent facts, why you should get an exception.  Social media tends to get results that you can't get just talking on the phone; in part because you're effectively talking with a higher-up person, and because you can make your case a bit more clearly. You can actually tweet this StackExchange question directly, or word it yourself in a tweet/FB post/etc.  On Twitter i'd link to here or somewhere else (too short), with something like "@Orbitz @AmericanAir, you changed our trip and now it doesn't work with our special needs child.  Any way you can help us out? [link to this q or a blog post somewhere]".   As far as a merchant dispute; it would realistically depend on the agreement you signed with Orbitz when you bought the tickets.  Likely it includes some flexibility for them to change your plans if the airline cancels the flight.  If it does, and they followed all of their policies correctly, then technically you shouldn't dispute the charge. It is possible that Chase might have some recourse on your behalf, though I don't think this qualifies for Trip Cancellation Insurance (Which you have through your Sapphire card ).  It might be worth calling them, just to see.  In the future, I would recommend booking through their site - not only do you get 25% bonus rewards when you use miles through there, which often is enough to offset the advantages of discount travel sites, but they're quite good at helping deal with these sorts of problems (as Sapphire is one of their top cards).