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HELOC vs. Parental Student Loans vs. Second Mortgage?
Thank God you have your child back, it is so awesome that you finally found a medical treatment that worked.  It must have been a truly trying time in your lives.   That situation is an important template in personal finance.  Through no fault of your own, a series of events occurred that caused you to spend far more money then you anticipated.  Per your post this was complicated by lost income due to economic situations.   What is to say that this does not happen again in the future?  While we can all hope that our child does not get sick, there are other events that could also fit into this template. Because of this I hate all options you present.  Per your post, you are pretty thin with free cash flow and have high income, and yet you are looking to borrow more.  That is a recipe for disaster with it being made worse as you are considering putting your home at risk. The 20K per year per kid sounds like a live at the university state school; or, a close by private school.  Your finances do not support either option.  There are times when the word "No" is in order when answering questions.   Doing a live at home community college to university will cost you a total of about 30K per kid rather than the 80K you are proposing.  Doing this alone will greatly reduce the risk you are attempting to assume.  Doing that and having your child work some, you could cash flow college.  That is what I would recommend. Given that you are so thin, you will also have to put constraints on college attendance.  No changing major three times, only majors with an employable skills, and studying before partying.  It may be worth it to wait a year of two before attending if a decision cannot be made. I was in a similar situation when my son started college.  High income, but broke.  He worked and went to a community college and was able to pay for the bulk of it himself.  From there he obtained a job with a healthy salary and completed his degree at the University.  It took him a little longer, but he is debt free and has a fantastic work ethic.