Martins career has been almost exclusively with the division of Abbott Laboratories that was involved with preclinical drug discovery initiatives, a division that was spun off from that biomedical conglomerate to become the standalone pharmaceutical company, AbbVie. Martins career at Abbott and AbbVie extended over forty years, interrupted only a sabbatical year, 1967 to 1968, that she spent working with QSAR pioneer Corwin Hansch at Pomona College, after which she returned to Abbott Laboratories. Martin formally retired as a senior research fellow in 2006, but has continued to be associated with Abbott Laboratories on a contract basis, working on topics in which she is interested. She has also taught as a visiting professor at the University of Virginia.