In September 1821, Wheatstone brought himself into public notice by exhibiting the Enchanted Lyre, or Acoucryptophone, at a music shop at Pall Mall and in the Adelaide Gallery. It consisted of a mimic lyre hung from the ceiling by a cord, and emitting the strains of several instruments – the piano, harp, and dulcimer. In reality it was a mere sounding box, and the cord was a steel rod that conveyed the vibrations of the music from the several instruments which were played out of sight and ear-shot. At this period Wheatstone made numerous experiments on sound and its transmission. Some of his results are preserved in Thomsons Annals of Philosophy' for 1823.
He recognised that sound is propagated by waves or oscillations of the atmosphere, as light was then believed to be by undulations of the luminiferous ether. Water, and solid bodies, such as glass, or metal, or sonorous wood, convey the modulations with high velocity, and he conceived the plan of transmitting sound-signals, music, or speech to long distances by this means. He estimated that sound would travel  through solid rods, and proposed to telegraph from London to Edinburgh in this way. He even called his arrangement a telephone. (Robert Hooke, in his Micrographia, published in 1667, writes: I can assure the reader that I have, by the help of a distended wire, propagated the sound to a very considerable distance in an instant, or with as seemingly quick a motion as that of light. Nor was it essential the wire should be straight; it might be bent into angles. This property is the basis of the mechanical or lover's telephone, said to have been known to the Chinese many centuries ago. Hooke also considered the possibility of finding a way to quicken our powers of hearing.)
A writer in the Repository of Arts for 1 September 1821, in referring to the Enchanted Lyre, beholds the prospect of an opera being performed at the King's Theatre, and enjoyed at the Hanover Square Rooms, or even at the Horns Tavern, Kennington. The vibrations are to travel through underground conductors, like to gas in pipes.
: And if music be capable of being thus conducted, he observes, perhaps the words of speech may be susceptible of the same means of propagation. The eloquence of counsel, the debates of Parliament, instead of being read the next day only, – But we shall lose ourselves in the pursuit of this curious subject.
Besides transmitting sounds to a distance, Wheatstone devised a simple instrument for augmenting feeble sounds, to which he gave the name of Microphone. It consisted of two slender rods, which conveyed the mechanical vibrations to both ears, and is quite different from the electrical microphone of Professor Hughes.
In 1823, his uncle, the musical instrument maker, died, and Wheatstone, with his elder brother, William, took over the business. Charles had no great liking for the commercial part, but his ingenuity found a vent in making improvements on the existing instruments, and in devising philosophical toys. He also invented instruments of his own. One of the most famous was the Wheatstone concertina. It was a six sided instrument with 64 keys, logically arranged for simple chromatic fingerings. The English concertina became increasingly famous throughout his lifetime, however it didn't reach its peak of popularity until the early 20th century.
In 1827, Wheatstone introduced his kaleidophone, a device for rendering the vibrations of a sounding body apparent to the eye. It consists of a metal rod, carrying at its end a silvered bead, which reflects a spot of light. As the rod vibrates the spot is seen to describe complicated figures in the air, like a spark whirled about in the darkness. His photometer was probably suggested by this appliance. It enables two lights to be compared by the relative brightness of their reflections in a silvered bead, which describes a narrow ellipse, so as to draw the spots into parallel lines.
In 1828, Wheatstone improved the German wind instrument, called the Mundharmonika, creating the symphonium (or symphonion), a mouth-blown free-reed instrument with a logical layout of button keys, patented on 19 December 1829, prefiguring the bellows-blown English concertina. The portable harmonium is another of his inventions, which gained a prize medal at the Great Exhibition of 1851. He also improved the speaking machine of De Kempelen, and endorsed the opinion of Sir David Brewster, that before the end of this century a singing and talking apparatus would be among the conquests of science.
In 1834, Wheatstone, who had won a name for himself, was appointed to the Chair of Experimental Physics in King's College London. His first course of lectures on sound were a complete failure, due to his abhorrence of public speaking. In the rostrum he was tongue-tied and incapable, sometimes turning his back on the audience and mumbling to the diagrams on the wall. In the laboratory he felt himself at home, and ever after confined his duties mostly to demonstration.