Ocean Optics miniature spectrometers have been used on the Mir Space Station, the Space Shuttle, and the Mars rover Curiosity'.
In 2009, an Ocean Optics QE65000 Spectrometer named "ALICE" was modified by Aurora Design & Technology for use in NASA's Lunar CRater Observation and Sensing Satellite (LCROSS) mission. ALICE measured ultraviolet light resulting from the impact of the Centaur upper rocket stage on the floor of the crater Cabeus.  This confirmed that  water ice is present on the moon.
The Rocky 7 Rover prototype used an Ocean Optics point spectrometer which was sensitive in the range of 350-800 nm.
Three Ocean Optics HR2000 spectrometers were customized as part of the ChemCam unit of the NASA Mars Science Laboratory rover, Curiosity, which was launched November 26, 2011. The spectrometers were configured to measure different wavelengths  of light, in the ranges of 240-336 nm, 380-470 nm, and 470-850 nm. The Laser Induced Breakdown Spectrometer (LIBS) used a laser to fire a series of very short pulses at a nearby target. The initial shots cleared away any dust, while the later ones heated the rock to create a flash of ionized gas or plasm. The resulting light was measured by the spectrometers and the spectra were analyzed to determine the composition of Martian rock and soil.
Since landing, the ChemCam has identified hundreds of thousands of samples, including calcium, gypsum and bassanite.
The incorporation of an instrument for Raman spectroscopy is being planned by NASA's Mars 2020 Rover Science Definition Team.