Margaret Huggins learnt the basic skills of photography early on in her life, and used these skills to assist her research at the Tulse Hill observatory. In 1875, Margaret and her husband William began photographic experiments, which were meticulously documented in observatory notebooks. Their early experiments photographed Sirius and Venus, and they used different techniques to capture them such as using wet and dry plates. Margaret made great improvements to their observatory equipment, and Margaret and William quickly rose to the forefront of spectroscopic astrophotography.
Margaret worked alongside her husband William at the Tulse Hill observatory. At first, she is documented to being an assistant, but after extensive research into their observatory notebooks, this has been disproven. She conducted many of her own research projects, and was a collaborative assistant to William. After 1875, Margaret and William began a meticulous program of photographic experiments. During the 1880s, the pair were devoted to two projects; the first attempting to photograph the solar corona, and the second examining different nebulae. The second project marked a milestone for Margaret, it was the first time she would be mentioned as the co-author of the paper alongside William. The Huggins' worked together for thirty-five years as equal collaborative investigative partners.