Hammes-Schiffer studies the effects of quantum tunnelling and hydrogen bonding on enzymatic reactions. Her work on Soybean Lipoxygenase-1 changed common perception of a previously proposed tunneling region diagram, finding that the temperature dependence of KIEs are inversely proportional to each other and that active environmental dynamics leads to less of the KIE and promotes catalysis. This finding should be applicable to any other enzymes which can transfer a proton due to the fact that there aren't as many enzymatic options for non-ionic transfer of a proton and therefore tunneling must be used throughout the process.