His research covers a wide range of areas in chemical physics and biological physics, including the kinetics of biological systems, quantum dynamics of energy flow within molecules, and optically assisted scanning tunneling microscopy. A common theme of his research is the implementation of state-of-the-art laser and microscopy techniques to interrogate and manipulate complex systems, coupled with quantum or classical simulations. 
He has published over 300 articles, books and patents on topics ranging from quantum computing, to RNA and protein folding in the test tube and inside cells, to fish swimming behavioral studies, and ultra-distance cycling.