Reining won the CNRS Silver Medal in 2003. She was elected as a Fellow of the American Physical Society (APS) in 2007, after a nomination from the APS Division of Computational Physics, "for her fundamental contributions to ab initio computation of spectroscopic properties of solids, employing many-electron Green's function and time-dependent density functional approaches".
She was the 2020 winner of the  of the Société Française de Physique and German Physical Society.