Goldblum invented an algorithm for solving extremely complex combinatorial problems, called Iterative Stochastic Elimination (ISE).
Goldblum's ISE algorithm is the basis for two Hebrew University science-related companies that expand on his research and discovery of drug candidates, Pepticom,  and RebioticsRX, focusing on nanomedicine  He won first prize in the contest of the American Chemical Society Computers in Chemistry Division in the ACS meeting, Washington D.C. 2000 for his new algorithm, which was developed together with PhD student Meir Glick. Goldblum was awarded the Kaye Innovation Prize in 2017 for "dramatic improvements in drug discovery methods". Fraunhofer Institute, the leading European Application oriented research center  opened one of its two first project centers, "Fraunhofer Project center on Drug discovery and delivery" in the labs of Profs. Golomb (drug delivery) and Goldblum (Drug Discovery) at the Institute for Drug Research.
Goldblum's research is focused on the discovery of new drugs against SARS-CoV-2, on Cannabinoids and the CNS, and obesity.