Yitzhak Apeloig (יצחק אפלויג; born 1 September 1944 in Uzbekistan) is a pioneer in the computational chemistry field of the Ab initio quantum chemistry methods for predicting and preparing the physical and chemical properties of materials. He was the president of the Technion from 2001 until 2009 where the position was handed off to Peretz Lavie. Distinguished Prof. Apeloig currently holds the Joseph Israel Freund Chair in Chemistry and is the co-director of the Lise Meitner Minerva Center for Computational Quantum Chemistry at the Technion. He served as dean of the Faculty of Chemistry from 1995 to 1999, where he was named Teacher of the Year at three occasions.
During his Technion presidency, Apeloig recruited  more than 150 elite scholars and scientists worldwide to the Technion. He also established a number of interdisciplinary research centers such as the Russell Berrie Nanotechnology Institute. He also established the Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering. In 2010 was inducted to the American Academy of Arts and Sciences. The same year he also became a recipient of the Frederic Stanley Kipping Award in Silicon Chemistry.