Msezane has published more than 400 physics research papers and given more than 380 presentations at national and international conferences.
He carries out research in theoretical atomic and molecular physics, mathematical physics, condensed matter physics, and image processing.
Msezane developed a fundamental theory to better understand negative ion formation in complex heavy systems and applied it to negative ion catalysis.
He is the founding director of the Center for Theoretical Studies of Physical Systems (CTSPS) at Clark Atlanta University, which was established in 1991 through an approximately 5 million dollar grant by the NSF which was further renewed at the same funding level in 1996. The center focuses on low-energy scattering theory, solid-state theory, image processing and mathematical physics theory.