Filizola joined the Department of Physiology & Biophysics at Mount Sinai School of Medicine (MSSM) as an instructor in 2002. She continued in this role at Weill Medical College (WMC) of Cornell University, also in New York City, until she was promoted assistant professor in 2005. She returned to Mount Sinai as an assistant professor in the Department of Structural and Chemical Biology, where she was later promoted associate professor (with tenure since January 2013), and then full professor in 2014.
Following three years as co-director of the Structural/Chemical Biology and Molecular Design (SMD) Graduate Program, and one year as co-director of the Biophysics and Systems Pharmacology (BSP) Graduate Program, she was appointed dean of the graduate school of biomedical sciences at Mount Sinai in May 2016. Dr. Filizola has also served as grant reviewer for NIH and other agencies for over 10 years. Currently, she is a regular study section member of the Biophysics of Neural Systems (BPNS) study section of NIH.