Msezane's awards and honors include:
*1965: World University Service Scholarship, University of Saskatchewan 
*1998: Honorary Doctorate of Science degree from the University of Fort Hare (South Africa)
*1999: Fellow of the American Physical Society and Life Member.
*1999: Edward A. Bouchet Award of the American Physical Society
*2011: Fellow of the American Association for the Advancement of Science
*2016: Fellow of the Royal Society of Chemistry
*2011: Fellow of the Institute of Physics, London, UK
*Fellow of the National Society of Black Physicists
*2020: Fellow of the African Scientific Institute