The Keller–Miksis formulation is an equation derived for the large, radial oscillations of a bubble trapped in a sound field. When the frequency of the sound field approaches the natural frequency of the bubble, it will result in large amplitude oscillations. The Keller–Miksis equation takes into account the viscosity, surface tension, incident sound wave, and acoustic radiation coming from the bubble, which was previously unaccounted for in Lauterborns calculations. Lauterborn solved the equation that Plesset, et al. modified from Rayleighs original analysis of large oscillating bubbles.  Keller and Miksis obtained the following formula:
where  is the radius of the bubble, the dots indicate first and second time derivatives,  is the density of the liquid,  is the speed of sound through the liquid,   is the pressure on the liquid side of the bubble's interface,  is time, and  is the time-delayed driving pressure.