Ex situ conservation, while helpful in humankinds efforts to sustain and protect our environment, is rarely enough to save a species from extinction. It is to be used as a last resort, or as a supplement to in situ conservation because it cannot recreate the habitat as a whole: the entire genetic variation of a species, its symbiotic counterparts, or those elements which, over time, might help a species adapt to its changing surroundings. Instead, ex situ conservation removes the species from its natural ecological contexts, preserving it under semi-isolated conditions whereby natural evolution and adaptation processes are either temporarily halted or altered by introducing the specimen to an unnatural habitat. In the case of cryogenic storage methods, the preserved specimens adaptation processes are (quite literally) frozen altogether. The downside to this is that, when re-released, the species may lack the genetic adaptations and mutations which would allow it to thrive in its ever-changing natural habitat.
Furthermore, ex situ conservation techniques are often costly, with cryogenic storage being economically infeasible in most cases since species stored in this manner cannot provide a profit but instead slowly drain the financial resources of the government or organization determined to operate them. Seedbanks are ineffective for certain plant genera with recalcitrant seeds that do not remain fertile for long periods of time. Diseases and pests foreign to the species, to which the species has no natural defense, may also cripple crops of protected plants in ex situ plantations and in animals living in ex situ breeding grounds. These factors, combined with the specific environmental needs of many species, some of which are nearly impossible to recreate by man, make ex situ conservation impossible for a great number of the world's endangered flora and fauna.