Reis is a researcher who has been involved in the field of biomaterials since 1990. He has worked with several universities and companies abroad.
Some of Reis' research has been on liver and neurological tissues regeneration, new strategies for antimicrobial materials, innovative high-throughput approaches for studying cell/materials interactions, as well as on TE approaches for developing different 3D disease models, including different cancer models, and therapies for treatment of diabetes and Alzheimers.
Reis has also been responsible for several cooperation programs with universities and companies worldwide. He has coordinated four major EU research projects, including the STREP "HIPPOCRATES".
Under HORIZON 2020, Reis was the coordinator of the ERA Chairs FoReCast grant for 3B's-UMinho. He has coordinated two TWINNING projects Gene2Skin and Chem2Nature, and is currently coordinating another TWINNING project. Until 2021, he was the coordinator of the 15 MEuros EC funded TEAMING proposal, "The Discoveries Centre for Regenerative and Precision Medicine" with UCL - University College London, UPorto, UAveiro, ULisboa, and UNova Lisboa. He is also the PI of a major project of the Portuguese roadmap for strategic infrastructures, TERM Research Hub.