Disclosed herein is the discovery that there are alpha-2B adrenergic receptors on a subtype of T cells, and that alpha-2 receptor agonists may be used to modulate the activity of such T cells and thereby treat those diseases in which T cell dysfunction plays a role, including neuritis, Guillan-Barre syndrome, rheumatoid arthritis, type I diabetes, multiple sclerosis (MS), graft-versus-host disease (GVHD), autoimmune uveitis, ocular inflammation, keratoconjunctivitis sicca (dry eye syndrome), sjogren's syndrome, atopic dermatitis, psoriasis, inflammatory bowel disease, irritable bowel syndrome, asthma, and aplastic anemia.
USPTO Backgrounds
USPTO Backgrounds