This invention is directed to the treatment of a group of disorders marked by repetitive, intrusive thoughts and/or ritualistic behaviors, i.e., obsessive-compulsive disorder, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism.
Obsessive-compulsive disorder (xe2x80x9cOCDxe2x80x9d), recognized to be among the most common of all psychiatric disorders, occurs in 2 to 3% of the U.S. population. OCD is characterized by anxiety-provoking and intrusive thoughts (e.g., fear of contamination and germs, doubt and uncertainty about future harm, need for symmetry, etc.) which lead to ritualistic and/or irrational behavior (e.g., constant checking, washing, touching, counting, etc.). See Hollander, et al., J. Clin Psychiatry 57 (Suppl. 8), pp. 3-6 (1996).
Somatoform disorders (e.g., body dysmorphic disorder and hypochondriasis) are characterized by abnormal preoccupation with one""s appearance or physical condition. For example, body dysmorphic disorder is a preoccupation with an imagined or slight defect in appearance. Many sufferers of body dysmorphic disorder are severely debilitated by their abnormal preoccupation, with significant impairment in social, occupational, or other important aspects of daily life. See Phillips, J. Clin Psychiatry 57 (suppl. 8), pp. 61-64 (1996). Hypocondriasis is characterized by a persistent conviction that one is, or is likely to become ill. Many hypochondriacs are unable to work or engage in ordinary activities due to their preoccupation with illness.
Dissociative disorders (e.g., depersonalization) are characterized by sudden temporary alterations in identity, memory, or consciousness, segregating normally integrated memories or parts of the personality from the dominant identity of the individual. Depersonalization disorder, which is a dissociative disorder, is characterized by one or more episodes of depersonalization (feelings of unreality and strangeness in one""s perception of the self or one""s body image).
Eating disorders (e.g., anorexia nervosa, bulimia, and binge eating) are characterized by abnormal compulsions to avoid eating or uncontrollable impulses to consume abnormally large amounts of food. These disorders affect not only the social well-being, but the physical well-being of sufferers.
Impulse control disorders (e.g., pathological gambling, compulsive buying, sexual compulsions and kleptomania) are characterized by a preoccupation with, and an inability to refrain from repeatedly engaging in various behaviors that are either socially unacceptable, or abnormally excessive by societal norms.
Autism is a disorder characterized by a preoccupation with one""s own self and a severe impairment of the ability to perceive or react to outside stimuli in a normal fashion. Many autistics are incapable of even communicating with others.
In view of the tragic and debilitating effects of these disorders, there is a strong need for a drug therapy which can effectively treat such disorders.
There have been some reports that certain D1 antagonists: inhibit L-DOPA-induced self-mutilatory behavior in neonatal-6-hydroxypropamine lesioned rats; are able to block amphetamine-induced locomotor activity and apomorphine-induced stereotypy in rats; inhibit grooming and oral activities induced by the administration of D1 agonists to marmosets; inhibit apomorphine induced stereotypy in mice; and reverse extrapyramidal side effects in monkeys treated with haloperidol. See Criswell, et al., Neuropsychopharmacology, 7 (2) pp. 95-103 (1992); Kerkman, et al., European Journal of Pharmacology, 166 (3) 481-91 (1989); Gnanalingham, et al., Psychophamacology, 117 (4), pp. 403-12 (1995); Acri, et al., Drug Dev. Res. 37 (1), pp. 39-47 (1996); McHugh, et al., European Journal of Pharmacology 202, pp. 133-134 (1991); Coffin, et al., Neurochem. Int., Vol. 20, Suppl., pp. 141S-145S (1992); Waddington, Gen. Pharmac. Vol. 19, No. 1, pp. 55-60 (1988); and Beaulieu, Can. J. Neurol. Sci., 14: 402-406 (1987).
The present invention provides a method for treating a human suffering from obsessive compulsive disorder, a somatoform disorder, a dissociative disorder, an eating disorder, an impulse control disorder, or autism by administering an effective amount of a D1/D5 antagonist.
As used herein, the following terms have the meanings set forth below.
xe2x80x9cD1/D5 antagonistxe2x80x9d is a compound that selectively binds to the D1 receptors and/or the D5 receptors in the brain, thereby decreasing or preventing dopamine access to these sites. A compound xe2x80x9cselectively bindsxe2x80x9d to the D1 and/or D5 receptors when it exhibits greater binding to either the D1 or D5 receptors than it does to the D2 receptors. D1/D5 antagonists include compounds that bind only to the D1 receptor (pure D1 antagonists), only to the D5 receptor (D5 antagonists), as well as compounds that bind to both the D1 and D5 receptors.
Non-limitative examples of D1/D5 antagonists include: SCH 39166 [(xe2x88x92)-trans-6,7,7a, 8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5-H-benzo[d]naphtho{2,1-b}azepine HCl]; SCH23390 [(R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol maleate]; BTS-73-947 [(S)-1-(1 -(2-chlorophenyl)cyclopropyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline]; A-69024 [1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline]; JHS-271 [8-chloro-3-[6-(dimethylamino)hexyl]-2,3,4,5-tetrahydro-5-phenyl-1H-3-Benzazepin-7-ol]; JHS-198 [8-chloro-3-[6-(dimethylamino)hexyl]-2,3,4,5-tetrahydro-5-phenyl-1H-3-Benzazepin-7-ol in a 1:1 complex with cyanoborane]; JHS-136 [8-chloro-3-[4-(dimethylamino)butyl]-2,3,4,5-tetrahydro-5-phenyl-1H-3-Benzazepine-7-ol]; and NNC-22-0010 [S(+)-8-chloro-5-(5-bromo-2,3-dihydrobenzofuran-7-yl)-7-hydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-Benzazepine]. The foregoing D1/D5 antagonists can be prepared by known methods, e.g., by the methods described in U.S. 5,302,716, WO 93/13073, WO 93/1702, WO 95/25102, and J. Med. Chem 38 (21) pp. 4284-93 (1995), the contents of which are incorporated herein by reference. SCH 39166 and SCH 23390 are particularly preferred, with SCH 39166 being most preferred.
It will be appreciated by those skilled in the art that the doses effective for treating obsessive-compulsive disorder, somatoform disorders, dissociative disorders, eating disorders, impulse control disorders, and autism will vary depending on the particular individual treated, and the relative severity of the disorder. The D1/D5 antagonists are preferably administered at daily doses of 0.01 to 500 mg/kg of bodyweight, more preferably 0.01 to 150 mg/kg, most preferably 0.01 to 10 mg/kg. The daily dose may be administered in a single dose, or divided equally into several doses.
For preparing pharmaceutical compositions with the D1/D5 antagonists used in this invention, inert, pharmaceutically acceptable carriers can be either solid or liquid. Solid form preparations include powders, tablets, dispersible granules, capsules, cachets and suppositories. The powders and tablets may be comprised of from about 5 to about 70 percent active ingredient. Suitable solid carriers are known in the art, e.g. magnesium carbonate, magnesium stearate, talc, sugar, lactose. Tablets, powders, cachets and capsules can be used as solid dosage forms suitable for oral administration.
For preparing suppositories, a low melting wax such as a mixture of fatty acid glycerides or cocoa butter is first melted, and the active ingredient is dispersed homogeneously therein as by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool and thereby solidify.
Liquid form preparations include solutions, suspensions and emulsions. As an example may be mentioned water or water-propylene glycol solutions for parenteral injection.
Liquid form preparations may also include solutions for intranasal administration.
Aerosol preparations suitable for inhalation may include solutions and solids in powder form, which may be in combination with a pharmaceutically acceptable carrier, such as an inert compressed gas.
Also included are solid form preparations which are intended to be converted, shortly before use, to liquid form preparations for either oral or parenteral administration. Such liquid forms include solutions, suspensions and emulsions.
The D1/D5 antagonists may also be deliverable transdermally. The transdermal compositions can take the form of creams, lotions, aerosols and/or emulsions and can be included in a transdermal patch of the matrix or reservoir type as are conventional in the art for this purpose.
Preferably, the D1/D5 antagonists are administered orally.
USPTO Backgrounds
USPTO Backgrounds