Multiple sclerosis (MS) and its variants comprise a distinct group of demyelinating diseases. A typical MS plaque or lesion is an area of grossly visible, well demarcated, demyelinated white matter.
Immunocytochemical studies with monoclonal antibodies against T-cells and other inflammatory components have demonstrated that T.sub.4 + (helper, inducer) T-cells are involved in lesion extension.
EAE (experimental allergic encephalomyelitis) is an animal model used to study: (a) immunological effector and suppressor mechanisms in demyelination; (b) acute MS; (c) therapeutic approaches to acute demyelination. This model has been used for several decades as a model for MS. (Raine, C. S.: Biology of Disease, Analysis of Autoimmune Demyelination: Lab. Inv. 50:608-635, 1984, No. 6).
EAE is a condition induced in rats, guinea pigs, and other animals as a model for the study of brain lesions and symptoms resembling MS in humans. (Fleming, J. O.: Animal models of multiple sclerosis. Mayo Clin. Proc. 60:490-492, 1985.) The condition of EAE has proven to be a useful model for the investigation and detection of drugs with possible utility in the treatment of MS patients, acute disseminated encephalomyelitis, and other conditions classified with the primary demyelinating diseases.
USPTO Backgrounds
USPTO Backgrounds