The reaction of C-5 mercurated pyrimidine nucleosides with palladium (II) and olefins is to be investigated. The C-5 substituted derivatives of 2'-deoxyuridine obtained by this method are potential antiviral and antitumor agents. The structure of the C-5 side chain will be varied to obtain derivatives for exploratory studies as inhibitors and reporter molecules for the enzymes thymidine phosphorylase, thymidine kinase, and thymidylate synthetase. 14C-Labeled thymidine analogs are to be synthesized for biosynthetic and nucleic acid incorporation studies. The reaction or organopalladium intermediates, derived from mercurated nucleotides and polynucleotides, with olefins will be explored.
NIH ExPorter
NIH ExPorter