It is the goal of this proposal to further our understanding of the biochemical mechanism of hormone dependence in breast cancer. We will investigate the interrelationship of biochemical events following estrogen and prolactin binding to hormone dependent and autonomous rat mammary carcinomas. We will correlate the presence of biochemical lesions in the subcellular pathways of prolactin and estrogen action with the response of tumor growth to endocrine therapies.
NIH ExPorter
NIH ExPorter