The rabbit stomach metabolic precursor of PHLIP-8, a physalaemin-like octapeptide with the amino acid sequence less than Glu-Val-Asp-Pro-Asn-Ile-Gln-Ala, is apparently a glycoprotein, however, precise structural characterization has not been performed. In order to determine the nature of the precursor(s) in nerve and lung tissue, attempts have been made to raise antisera to thyroglobulin-PHLIP-8 complexes; characterization of the antisera has yet to be completed. Bioassays have indicated that, while PHLIP-8 does not possess typical tachykinin properties, relatively large concentrations of this peptide will facilitate enhanced contractile responsiveness in several smooth muscle preparations and, in the rabbit, it lowers blood pressure.
NIH ExPorter
NIH ExPorter