This proposal is concerned with the synthesis of new macromolecules for uses in medicine and biochemical research. Specifically, a new class of polymers, known as polyphosphazenes, will be explored both as biologically stable, water-insoluble materials for artificial organ or membrane research or as substrates for affinity chromatography or immobilized enzymes or cells, and as water-soluable or biodegradable polymers for controlled-release drug delivery. The program is divided into two parts; first, a fundamental study of syntheses, reaction mechanisms, and hydrolysis pathways of small-molecule cyclic phosphazenes used as models, and second, a utilization of the fundamental information for the synthesis of the more challenging macromolecular systems. The testing of these compounds will be accomplished through collaborative programs with other research groups.
NIH ExPorter
NIH ExPorter