We will study the structure and function of Vesicular Stomatitis Virus (VSV) ribonucleoprotein complexes (RNPs) in vivo and in vitro using biochemical and electron microscopic techniques. We will attempt to establish a functional in vitro coupled translation-replication system. We will also study the roles of VSV NS protein and VSV envelope proteins (M and G) in regulating RNP function and in virion assembly.
NIH ExPorter
NIH ExPorter